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  1. Article: Imaging of Endolymphatic Hydrops in Ménière's Disease: A Clinical Update.

    Kheok, Si Wei / Chan, Yew Meng / Chan, Ling Ling

    Annals of the Academy of Medicine, Singapore

    2021  Volume 49, Issue 12, Page(s) 1018–1024

    MeSH term(s) Contrast Media ; Diagnostic Imaging ; Endolymphatic Hydrops/diagnostic imaging ; Humans ; Magnetic Resonance Imaging
    Chemical Substances Contrast Media
    Language English
    Publishing date 2021-01-19
    Publishing country Singapore
    Document type Journal Article
    ZDB-ID 604527-3
    ISSN 0304-4602
    ISSN 0304-4602
    DOI 10.47102/annals-acadmedsg.2020267
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Superficial Middle Cerebral Vein: Tympanic Cavity Dehiscence Causing Pulsatile Tinnitus.

    Sing, Benjamin Wei Heng / Lim, Melvin Lin Aik / See, Anna / Lee, Shuhui Melissa / Kheok, Si Wei

    Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology

    2022  Volume 43, Issue 5, Page(s) e602–e604

    MeSH term(s) Cerebral Veins ; Ear, Middle/diagnostic imaging ; Humans ; Tinnitus/etiology
    Language English
    Publishing date 2022-02-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2036790-9
    ISSN 1537-4505 ; 1531-7129
    ISSN (online) 1537-4505
    ISSN 1531-7129
    DOI 10.1097/MAO.0000000000003495
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Olfactory Loss of Function as a Possible Symptom of COVID-19.

    Kheok, Si Wei / Teo, Neville W Y

    JAMA otolaryngology-- head & neck surgery

    2020  Volume 146, Issue 9, Page(s) 873–874

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Humans ; Olfaction Disorders/diagnosis ; Olfaction Disorders/epidemiology ; Olfaction Disorders/etiology ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-08-31
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2701825-8
    ISSN 2168-619X ; 2168-6181
    ISSN (online) 2168-619X
    ISSN 2168-6181
    DOI 10.1001/jamaoto.2020.1590
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  4. Article: Benign periarticular, bone and joint lipomatous lesions.

    Kheok, Si Wei / Ong, Keh Oon

    Singapore medical journal

    2017  Volume 58, Issue 9, Page(s) 521–527

    Abstract: Benign periarticular, bone and joint lipomatous lesions are rare entities that are increasingly being identified using current imaging techniques. This pictorial review illustrates the wide range of imaging presentations of these lesions at various sites ...

    Abstract Benign periarticular, bone and joint lipomatous lesions are rare entities that are increasingly being identified using current imaging techniques. This pictorial review illustrates the wide range of imaging presentations of these lesions at various sites and their pathognomonic features. The main lesions reviewed include intraosseous lipoma, liposclerosing myxofibrous tumour, lipoma arborescens and intra-articular lipoma.
    MeSH term(s) Adult ; Bone Neoplasms/diagnostic imaging ; Bone Neoplasms/pathology ; Bone and Bones/diagnostic imaging ; Bone and Bones/pathology ; Female ; Humans ; Lipoma/diagnostic imaging ; Lipoma/pathology ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Sacrum/diagnostic imaging ; Tibia/diagnostic imaging
    Language English
    Publishing date 2017-09-12
    Publishing country Singapore
    Document type Journal Article ; Review
    ZDB-ID 604319-7
    ISSN 0037-5675
    ISSN 0037-5675
    DOI 10.11622/smedj.2017087
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Case Report of Eustachian Tube Malignant Melanoma: 4 Year Follow-up of a Grave and Rare Condition.

    Tan, Barrie Yb / Kheok, Si Wei / Tan, Terence Wk / Tan, Hiang Khoon

    Annals of the Academy of Medicine, Singapore

    2020  Volume 49, Issue 9, Page(s) 694–698

    MeSH term(s) Eustachian Tube ; Follow-Up Studies ; Humans ; Melanoma/diagnosis ; Skin Neoplasms/diagnosis
    Language English
    Publishing date 2020-06-01
    Publishing country Singapore
    Document type Case Reports ; Journal Article
    ZDB-ID 604527-3
    ISSN 0304-4602
    ISSN 0304-4602
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  7. Article ; Online: Cardiovascular Hoarseness (Ortner's Syndrome): A Pictorial Review.

    Kheok, Si Wei / Salkade, Parag Ratnakar / Bangaragiri, Ajay / Koh, Natalie Si Ya / Chen, Robert Chun

    Current problems in diagnostic radiology

    2020  Volume 50, Issue 5, Page(s) 749–754

    Abstract: Ortner's syndrome, also known as cardiovocal syndrome, encompasses any cardiac or vascular process that affects the recurrent laryngeal nerve(s), subsequently leading to vocal cord palsy. Various causes of Ortner's syndrome have been described in the ... ...

    Abstract Ortner's syndrome, also known as cardiovocal syndrome, encompasses any cardiac or vascular process that affects the recurrent laryngeal nerve(s), subsequently leading to vocal cord palsy. Various causes of Ortner's syndrome have been described in the literature, which include but are not limited to aortic aneurysms, pulmonary hypertension, left atrial enlargement, and congenital cardiac disorders. We hereby present a pictorial review of the more commonly reported entities, which have been implicated in this syndrome. Ultimately, understanding the pathophysiology underlying Ortner's syndrome will help in diagnosis and institution of potentially life-saving treatment.
    MeSH term(s) Cardiovascular System ; Hoarseness/diagnostic imaging ; Hoarseness/etiology ; Humans ; Syndrome ; Vocal Cord Paralysis/diagnostic imaging
    Language English
    Publishing date 2020-09-23
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 198954-6
    ISSN 1535-6302 ; 0363-0188
    ISSN (online) 1535-6302
    ISSN 0363-0188
    DOI 10.1067/j.cpradiol.2020.09.015
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Olfactory Loss of Function as a Possible Symptom of COVID-19

    Kheok, Si Wei / Teo, Neville W. Y.

    JAMA Otolaryngology–Head & Neck Surgery

    2020  Volume 146, Issue 9, Page(s) 873

    Keywords Surgery ; Otorhinolaryngology ; covid19
    Language English
    Publisher American Medical Association (AMA)
    Publishing country us
    Document type Article ; Online
    ZDB-ID 632721-7
    ISSN 1538-361X ; 0886-4470 ; 2168-6181
    ISSN (online) 1538-361X
    ISSN 0886-4470 ; 2168-6181
    DOI 10.1001/jamaoto.2020.1590
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article: Application of artificial intelligence in the assessment of thyroid eye disease (TED) - a scoping review.

    Chng, Chiaw-Ling / Zheng, Kaiping / Kwee, Ann Kerwen / Lee, Ming-Han Hugo / Ting, Daniel / Wong, Chen Pong / Hu, Guoyu / Ooi, Beng Chin / Kheok, Si Wei

    Frontiers in endocrinology

    2023  Volume 14, Page(s) 1300196

    Abstract: Background: There is emerging evidence which suggests the utility of artificial intelligence (AI) in the diagnostic assessment and pre-treatment evaluation of thyroid eye disease (TED). This scoping review aims to (1) identify the extent of the ... ...

    Abstract Background: There is emerging evidence which suggests the utility of artificial intelligence (AI) in the diagnostic assessment and pre-treatment evaluation of thyroid eye disease (TED). This scoping review aims to (1) identify the extent of the available evidence (2) provide an in-depth analysis of AI research methodology of the studies included in the review (3) Identify knowledge gaps pertaining to research in this area.
    Methods: This review was performed according to the 2020 Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement (PRISMA). We quantify the diagnostic accuracy of AI models in the field of TED assessment and appraise the quality of these studies using the modified QUADAS-2 tool.
    Results: A total of 13 studies were included in this review. The most common AI models used in these studies are convolutional neural networks (CNN). The majority of the studies compared algorithm performance against healthcare professionals. The overall risk of bias and applicability using the modified Quality Assessment of Diagnostic Accuracy Studies 2 (QUADAS-2) tool led to most of the studies being classified as low risk, although higher deficiency was noted in the risk of bias in flow and timing.
    Conclusions: While the results of the review showed high diagnostic accuracy of the AI models in identifying features of TED relevant to disease assessment, deficiencies in study design causing study bias and compromising study applicability were noted. Moving forward, limitations and challenges inherent to machine learning should be addressed with improved standardized guidance around study design, reporting, and legislative framework.
    MeSH term(s) Humans ; Algorithms ; Artificial Intelligence ; Graves Ophthalmopathy/diagnosis ; Machine Learning ; Neural Networks, Computer
    Language English
    Publishing date 2023-12-20
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Systematic Review
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2023.1300196
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Neuroradiological Basis of COVID-19 Olfactory Dysfunction: A Systematic Review and Meta-Analysis.

    Tan, Claire Jing-Wen / Tan, Benjamin Kye Jyn / Tan, Xin Yan / Liu, Hui Ting / Teo, Chong Boon / See, Anna / Xu, Shuhui / Toh, Song Tar / Kheok, Si Wei / Charn, Tze Choong / Teo, Neville Wei Yang

    The Laryngoscope

    2022  Volume 132, Issue 6, Page(s) 1260–1274

    Abstract: Objective: Olfactory dysfunction (OD) is a common presenting symptom of COVID-19 infection. Radiological imaging of the olfactory structures in patients with COVID-19 and OD can potentially shed light on its pathogenesis, and guide clinicians in ... ...

    Abstract Objective: Olfactory dysfunction (OD) is a common presenting symptom of COVID-19 infection. Radiological imaging of the olfactory structures in patients with COVID-19 and OD can potentially shed light on its pathogenesis, and guide clinicians in prognostication and intervention.
    Methods: PubMed, Embase, Cochrane, SCOPUS were searched from inception to August 1, 2021. Three reviewers selected observational studies, case series, and case reports reporting radiological changes in the olfactory structures, detected on magnetic resonance imaging, computed tomography, or other imaging modalities, in patients aged ≥18 years with COVID-19 infection and OD, following preferred reporting items for systematic reviews and meta-analyses guidelines and a PROSPERO-registered protocol (CRD42021275211). We described the proportion of radiological outcomes, and used random-effects meta-analyses to pool the prevalence of olfactory cleft opacification, olfactory bulb signal abnormalities, and olfactory mucosa abnormalities in patients with and without COVID-19-associated OD.
    Results: We included 7 case-control studies (N = 353), 11 case series (N = 154), and 12 case reports (N = 12). The pooled prevalence of olfactory cleft opacification in patients with COVID-19 infection and OD (63%, 95% CI = 0.38-0.82) was significantly higher than that in controls (4%, 95% CI = 0.01-0.13). Conversely, similar proportions of cases and controls demonstrated olfactory bulb signal abnormalities (88% and 94%) and olfactory mucosa abnormalities (2% and 0%). Descriptive analysis found that 55.6% and 43.5% of patients with COVID-19 infection and OD had morphological abnormalities of the olfactory bulb and olfactory nerve, respectively, while 60.0% had abnormal olfactory bulb volumes.
    Conclusion: Our findings implicate a conductive mechanism of OD, localized to the olfactory cleft, in approximately half of the affected COVID-19 patients. Laryngoscope, 132:1260-1274, 2022.
    MeSH term(s) Adolescent ; Adult ; COVID-19/diagnostic imaging ; Humans ; Olfaction Disorders/diagnostic imaging ; Olfaction Disorders/etiology ; Olfactory Bulb/diagnostic imaging ; Olfactory Mucosa ; Smell
    Language English
    Publishing date 2022-03-22
    Publishing country United States
    Document type Journal Article ; Meta-Analysis ; Review ; Systematic Review
    ZDB-ID 80180-x
    ISSN 1531-4995 ; 0023-852X
    ISSN (online) 1531-4995
    ISSN 0023-852X
    DOI 10.1002/lary.30078
    Database MEDical Literature Analysis and Retrieval System OnLINE

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