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  1. Article ; Online: Venous Pulsatile Tinnitus: Turbulence or Dehiscence? : A New Endovascular Treatment of a Dehiscent Diploic Vein.

    Guédon, Alexis / Eliezer, Michael / Houdart, Emmanuel

    Clinical neuroradiology

    2022  Volume 32, Issue 4, Page(s) 1131–1134

    Language English
    Publishing date 2022-04-07
    Publishing country Germany
    Document type Letter
    ZDB-ID 2234662-4
    ISSN 1869-1447 ; 0939-7116 ; 1869-1439
    ISSN (online) 1869-1447
    ISSN 0939-7116 ; 1869-1439
    DOI 10.1007/s00062-022-01159-w
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    Zs.A 3413: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Membranous Labyrinth Dysplasia in Branchio-Oto-Renal Syndrome.

    Eliezer, Michael / Mamelle, Elisabeth / Hautefort, Charlotte

    Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology

    2022  Volume 43, Issue 8, Page(s) e861–e863

    MeSH term(s) Branchio-Oto-Renal Syndrome ; Ear, Inner/diagnostic imaging ; Humans ; Kidney ; Pedigree
    Language English
    Publishing date 2022-08-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2036790-9
    ISSN 1537-4505 ; 1531-7129
    ISSN (online) 1537-4505
    ISSN 1531-7129
    DOI 10.1097/MAO.0000000000003602
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    Zs.A 1554: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  3. Article ; Online: MRI Evaluation of the Olfactory Clefts in Patients with SARS-CoV-2 Infection Revealed an Unexpected Mechanism for Olfactory Function Loss.

    Eliezer, Michael / Hautefort, Charlotte

    Academic radiology

    2020  Volume 27, Issue 8, Page(s) 1191

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Humans ; Magnetic Resonance Imaging ; Olfaction Disorders ; Olfactory Bulb ; Pandemics ; Pneumonia, Viral ; Severe acute respiratory syndrome-related coronavirus ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-05-16
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 1355509-1
    ISSN 1878-4046 ; 1076-6332
    ISSN (online) 1878-4046
    ISSN 1076-6332
    DOI 10.1016/j.acra.2020.05.013
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    Zs.A 4594: Show issues Location:
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  4. Article ; Online: Pulsatile Tinnitus Revealing a Diploic Arteriovenous Fistula : About Two Cases.

    Guédon, Alexis / Eliezer, Michael / Houdart, Emmanuel

    Clinical neuroradiology

    2021  Volume 32, Issue 2, Page(s) 571–575

    MeSH term(s) Arteriovenous Fistula/complications ; Arteriovenous Fistula/diagnostic imaging ; Humans ; Intracranial Arteriovenous Malformations ; Tinnitus/diagnostic imaging ; Tinnitus/etiology
    Language English
    Publishing date 2021-08-31
    Publishing country Germany
    Document type Case Reports ; Letter
    ZDB-ID 2234662-4
    ISSN 1869-1447 ; 0939-7116 ; 1869-1439
    ISSN (online) 1869-1447
    ISSN 0939-7116 ; 1869-1439
    DOI 10.1007/s00062-021-01080-8
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  5. Article ; Online: pH and ROS Responsiveness of Polymersome Nanovaccines for Antigen and Adjuvant Codelivery: An In Vitro and In Vivo Comparison.

    Jäger, Eliézer / Ilina, Olga / Dölen, Yusuf / Valente, Michael / van Dinther, Eric A W / Jäger, Alessandro / Figdor, Carl G / Verdoes, Martijn

    Biomacromolecules

    2024  Volume 25, Issue 3, Page(s) 1749–1758

    Abstract: The antitumor immunity can be enhanced through the synchronized codelivery of antigens and immunostimulatory adjuvants to antigen-presenting cells, particularly dendritic cells (DCs), using nanovaccines (NVs). To study the influence of intracellular ... ...

    Abstract The antitumor immunity can be enhanced through the synchronized codelivery of antigens and immunostimulatory adjuvants to antigen-presenting cells, particularly dendritic cells (DCs), using nanovaccines (NVs). To study the influence of intracellular vaccine cargo release kinetics on the T cell activating capacities of DCs, we compared stimuli-responsive to nonresponsive polymersome NVs. To do so, we employed "AND gate" multiresponsive (MR) amphiphilic block copolymers that decompose only in response to the combination of chemical cues present in the environment of the intracellular compartments in antigen cross-presenting DCs: low pH and high reactive oxygen species (ROS) levels. After being unmasked by ROS, pH-responsive side chains are exposed and can undergo a charge shift within a relevant pH window of the intracellular compartments in antigen cross-presenting DCs. NVs containing the model antigen Ovalbumin (OVA) and the iNKT cell activating adjuvant α-Galactosylceramide (α-Galcer) were fabricated using microfluidics self-assembly. The MR NVs outperformed the nonresponsive NV in vitro, inducing enhanced classical- and cross-presentation of the OVA by DCs, effectively activating CD8+, CD4+ T cells, and iNKT cells. Interestingly, in vivo, the nonresponsive NVs outperformed the responsive vaccines. These differences in polymersome vaccine performance are likely linked to the kinetics of cargo release, highlighting the crucial chemical requirements for successful cancer nanovaccines.
    MeSH term(s) Animals ; Mice ; Nanovaccines ; Reactive Oxygen Species ; CD8-Positive T-Lymphocytes ; Dendritic Cells ; Antigens/chemistry ; Adjuvants, Immunologic/pharmacology ; Vaccines/chemistry ; Ovalbumin ; Hydrogen-Ion Concentration ; Mice, Inbred C57BL
    Chemical Substances Nanovaccines ; Reactive Oxygen Species ; Antigens ; Adjuvants, Immunologic ; Vaccines ; Ovalbumin (9006-59-1)
    Language English
    Publishing date 2024-01-18
    Publishing country United States
    Document type Journal Article
    ISSN 1526-4602
    ISSN (online) 1526-4602
    DOI 10.1021/acs.biomac.3c01235
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  6. Article ; Online: Measurement of stapes footplate thickness using ultra-high-resolution computed tomography: stapes axial plane correlates better with otosclerosis than lateral semicircular canal plane.

    Gillet, Romain / Eliezer, Michael / Hossu, Gabriela / Lombard, Charles / Boubaker, Fatma / Blum, Alain / Gondim Teixeira, Pedro Augusto / Parietti-Winkler, Cécile

    Acta oto-laryngologica

    2024  , Page(s) 1–7

    Abstract: Background, aims: Stapes footplate thickness measurement using ultra-high-resolution CT has been described only in the lateral semicircular canal plane. The purpose of this study was to compare stapes footplate thickness between the lateral semicircular ...

    Abstract Background, aims: Stapes footplate thickness measurement using ultra-high-resolution CT has been described only in the lateral semicircular canal plane. The purpose of this study was to compare stapes footplate thickness between the lateral semicircular canal and stapes axial planes in patients with otosclerosis compared to controls.
    Material and methods: We performed a retrospective single-center study of patients undergoing high-resolution temporal bone CT. Two radiologists measured stapes footplate thickness in both the lateral semicircular canal and stapes axial planes.
    Results: Between February 2020 and October 2022, we collected 81 ears from 49 patients (75% of women; mean age 51.22 ± 16.6 years, 17 otosclerosis, and 64 controls). In the stapes axial plane, there was a significant anterior thickening in otosclerosis patients (Reader 1: 0.52 ± 0.12 [0.3-0.7] vs. 0.41 ± 0.08 [0.3-0.6],
    Conclusion: The stapes footplate was thickened at its AC in otosclerosis patients using only the stapes axial plane.
    Significance: We propose to use the stapes axial plane instead of the lateral semicircular canal plane when analyzing the stapes.
    Language English
    Publishing date 2024-04-25
    Publishing country England
    Document type Journal Article
    ISSN 1651-2251
    ISSN (online) 1651-2251
    DOI 10.1080/00016489.2024.2340083
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    Ul II Zs 105: Show issues Location:
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  7. Article ; Online: Ultra-high-resolution CT of the temporal bone: The end of stapes prosthesis dimensional error and correlation with patient symptoms.

    Boukhzer, Sara / Eliezer, Michael / Boubaker, Fatma / Hossu, Gabriela / Blum, Alain / Teixeira, Pedro / Parietti-Winkler, Cécile / Gillet, Romain

    European journal of radiology

    2024  Volume 175, Page(s) 111467

    Abstract: Purpose: To describe the reliability of ultra-high-resolution computed tomography (UHR-CT) in the measurement of titanium stapes prostheses using manufacturer data as a reference.: Materials and methods: This retrospective study included patients ... ...

    Abstract Purpose: To describe the reliability of ultra-high-resolution computed tomography (UHR-CT) in the measurement of titanium stapes prostheses using manufacturer data as a reference.
    Materials and methods: This retrospective study included patients treated by stapedectomy with titanium prostheses who underwent UHR-CT between January 2020 and October 2023. Images were acquired using an ultra-high-resolution mode (slice thickness: 0.25 mm; matrix, 1024 × 1024). Two radiologists independently evaluated the length, diameter, and intra-vestibular protrusion of the prosthesis. Post-operative air-bone gaps (ABGs) were recorded.
    Results: Fourteen patients were enrolled (mean age, 44.3 ± 13.8 [SD] years, 9 females), resulting in 16 temporal bone UHR-CTs. The exact length was obtained in 81.3 % (n = 13/16) and underestimated by 0.1 to 0.3 mm in the remaining 18.7 % (n = 3/16) CT scans for both readers (mean misestimation: -0.02 ± 0.06 [SD] mm, overall underestimation of 0.43 %). The exact diameter was reported in 75 % (n = 12/16) and 87.5 % (n = 14/16) of the CT scans for readers 1 and 2, respectively, and was off by 0.1 mm in all discrepancies (mean misestimation: 0.01 ± 0.04 [SD] mm, overall overestimation of 2.43 %). Intravestibular prosthesis protrusion was of 0.5 ± 0.43 [SD] mm (range: 0-1) and 0.49 ± 0.44 [SD] mm (range: 0-1.1) for readers 1 and 2, respectively, and did not correlate with ABGs (r = 0.25 and 0.22; P = 0.39 and 0.47 for readers 1 and 2, respectively). Intra and interobserver agreements were excellent.
    Conclusion: UHR-CT provides 99.6 % and 97.6 % accuracy for prosthesis length and diameter measurements, respectively.
    Language English
    Publishing date 2024-04-13
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 138815-0
    ISSN 1872-7727 ; 0720-048X
    ISSN (online) 1872-7727
    ISSN 0720-048X
    DOI 10.1016/j.ejrad.2024.111467
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    Zs.A 1630: Show issues Location:
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  8. Article ; Online: Imaging of endolymphatic hydrops: A comprehensive update in primary and secondary hydropic ear disease.

    Eliezer, Michael / Attyé, Arnaud / Toupet, Michel / Hautefort, Charlotte

    Journal of vestibular research : equilibrium & orientation

    2021  Volume 31, Issue 4, Page(s) 261–268

    Abstract: Background: Since the first description by Hallpike and Cairns, the excess of endolymphatic fluid, also known as endolymphatic hydrops (EH), has been established as being the main biomarker in patients with Menière's disease. Recently, the concept of ... ...

    Abstract Background: Since the first description by Hallpike and Cairns, the excess of endolymphatic fluid, also known as endolymphatic hydrops (EH), has been established as being the main biomarker in patients with Menière's disease. Recently, the concept of primary (PHED) and secondary hydropic ear disease (SHED) has been introduced. PHED corresponded to Menière's disease while SHED was defined as the presence of EH in patients with pre-existing inner ear disease.
    Objective: In this article, we would like to summarize the methodology of hydrops exploration using MRI and the previously published radiological findings in patients with PHED and SHED.
    Results: Before the emergence of delayed inner ear MRI, the presence of EH was assumed based on clinical symptoms. However, because of the recent technical developments, inner ear MRI became an important tool in clinical settings for identifying EH in vivo, in patients with PHED and SHED. The presence of EH on MRI is related with the degree of sensorineural hearing loss whether in patients with PHED or SHED. By contrast, in PHED or SHED patients without sensorineural hearing loss, MRI showed no sign of EH.
    Conclusions: Thanks to the recent technical developments, inner ear MRI became an important tool in clinical settings for identifying EH in vivo, in patients with PHED and SHED.
    MeSH term(s) Ear Diseases ; Ear, Inner/diagnostic imaging ; Edema ; Endolymphatic Hydrops/diagnostic imaging ; Humans ; Magnetic Resonance Imaging ; Meniere Disease/diagnostic imaging
    Language English
    Publishing date 2021-02-26
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1051840-x
    ISSN 1878-6464 ; 0957-4271
    ISSN (online) 1878-6464
    ISSN 0957-4271
    DOI 10.3233/VES-200786
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    Zs.A 3072: Show issues Location:
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  9. Article ; Online: MRI IDENTIFICATION OF THE SACCULE? DO IT YOURSELF!

    Attyé, Arnaud / Eliezer, Michael

    Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology

    2018  Volume 39, Issue 8, Page(s) 1070–1071

    MeSH term(s) Ear Diseases ; Friends ; Humans ; Magnetic Resonance Imaging ; Saccule and Utricle
    Language English
    Publishing date 2018-07-16
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2036790-9
    ISSN 1537-4505 ; 1531-7129
    ISSN (online) 1537-4505
    ISSN 1531-7129
    DOI 10.1097/MAO.0000000000001894
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    Zs.A 1554: Show issues Location:
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  10. Article ; Online: Endolymphatic Hydrops: A Warning About the Interpretation of Magnetic Resonance Images Without Refreshed Knowledge of Inner Ear Endolymphatic Structure Anatomy.

    Attyé, Arnaud / Eliezer, Michael

    Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology

    2018  Volume 39, Issue 5, Page(s) 654–655

    MeSH term(s) Ear, Inner ; Endolymphatic Hydrops ; Friends ; Humans ; Magnetic Resonance Spectroscopy
    Language English
    Publishing date 2018-03-15
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2036790-9
    ISSN 1537-4505 ; 1531-7129
    ISSN (online) 1537-4505
    ISSN 1531-7129
    DOI 10.1097/MAO.0000000000001769
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