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Article: Ankyrin-B is lipid-modified by

Gupta, Julie P / Jenkins, Paul M

2023 Volume 14, Page(s) 959660

Abstract: Neuronal ankyrin-B is an intracellular scaffolding protein that plays multiple roles in the axon. By contrast, relatively little is known about the function of ankyrin-B in dendrites, where ankyrin-B is also localized in mature neurons. Recently, we ... ...

Abstract	Neuronal ankyrin-B is an intracellular scaffolding protein that plays multiple roles in the axon. By contrast, relatively little is known about the function of ankyrin-B in dendrites, where ankyrin-B is also localized in mature neurons. Recently, we showed that ankyrin-B acts as a scaffold for the voltage-gated sodium channel, Na
Language	English
Publishing date	2023-03-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564217-0
ISSN	1664-042X
ISSN	1664-042X
DOI	10.3389/fphys.2023.959660
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Article ; Online: Inhibitory synaptic transmission is impaired in the Kölliker-Fuse of male, but not female, Rett syndrome mice.

Whitaker-Fornek, Jessica R / Jenkins, Paul M / Levitt, Erica S

Journal of neurophysiology

2023 Volume 130, Issue 6, Page(s) 1578–1587

Abstract: Rett syndrome (RTT) is a severe neurodevelopmental disorder that mainly affects females due to silencing mutations in the X- ... ...

Abstract	Rett syndrome (RTT) is a severe neurodevelopmental disorder that mainly affects females due to silencing mutations in the X-linked
MeSH term(s)	Humans ; Male ; Mice ; Animals ; Female ; Rett Syndrome/genetics ; Methyl-CpG-Binding Protein 2/genetics ; Methyl-CpG-Binding Protein 2/metabolism ; Synaptic Transmission/physiology ; Neurons/physiology ; Respiration ; Pons ; Disease Models, Animal
Chemical Substances	Methyl-CpG-Binding Protein 2
Language	English
Publishing date	2023-11-15
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	80161-6
ISSN	1522-1598 ; 0022-3077
ISSN (online)	1522-1598
ISSN	0022-3077
DOI	10.1152/jn.00327.2023
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Article ; Online: Spatial organization of palmitoyl acyl transferases governs substrate localization and function.

Philippe, Julie M / Jenkins, Paul M

Molecular membrane biology

2020 Volume 35, Issue 1, Page(s) 60–75

Abstract: Protein palmitoylation is a critical posttranslational modification that regulates protein trafficking, localization, stability, sorting and function. In mammals, addition of this lipid modification onto proteins is mediated by a family of 23 palmitoyl ... ...

Abstract	Protein palmitoylation is a critical posttranslational modification that regulates protein trafficking, localization, stability, sorting and function. In mammals, addition of this lipid modification onto proteins is mediated by a family of 23 palmitoyl acyl transferases (PATs). PATs often palmitoylate substrates in a promiscuous manner, precluding our understanding of how these enzymes achieve specificity for their substrates. Despite generous efforts to identify consensus motifs defining PAT-substrate specificity, it remains to be determined whether additional factors beyond interaction motifs, such as local palmitoylation, participate in PAT-substrate selection. In this review, we emphasize the role of local palmitoylation, in which substrates are palmitoylated and trapped in the same subcellular compartments as their PATs, as a mechanism of enzyme-substrate specificity. We focus here on non-Golgi-localized PATs, as physical proximity to their substrates enables them to engage in local palmitoylation, compared to Golgi PATs, which often direct trafficking of their substrates elsewhere. PAT subcellular localization may be an under-recognized, yet important determinant of PAT-substrate specificity that may work in conjunction or completely independently of interaction motifs. We also discuss some current hypotheses about protein motifs that contribute to localization of non-Golgi-localized PATs, important for the downstream targeting of their substrates.
MeSH term(s)	Acyltransferases/metabolism ; Animals ; Humans ; Lipoylation ; Membrane Proteins/metabolism ; Protein Processing, Post-Translational ; Protein Transport ; Substrate Specificity
Chemical Substances	Membrane Proteins ; Acyltransferases (EC 2.3.-)
Language	English
Publishing date	2020-01-22
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1186324-9
ISSN	1464-5203 ; 0968-7688
ISSN (online)	1464-5203
ISSN	0968-7688
DOI	10.1080/09687688.2019.1710274
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Article: Effects of chronic lithium treatment on neuronal excitability and GABAergic transmission in an

Caballero-Florán, René N / Nelson, Andrew D / Min, Lia / Jenkins, Paul M

bioRxiv : the preprint server for biology

2023

Abstract: Bipolar disorder (BD) is a common psychiatric disease that can lead to psychosocial disability, decreased quality of life, and high risk for suicide. Genome-wide association studies have shown that ... ...

Abstract	Bipolar disorder (BD) is a common psychiatric disease that can lead to psychosocial disability, decreased quality of life, and high risk for suicide. Genome-wide association studies have shown that the
Language	English
Publishing date	2023-10-30
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.10.26.564203
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Article ; Online: A Novel Approach to Study Coherent γ-Band Oscillations in Hippocampal Brain Sections.

Rodríguez Díaz, Jean C / Jenkins, Paul M / Pritchett, Dominique L / Jones, Kevin S

eNeuro

2023 Volume 10, Issue 7

Abstract: γ-Band oscillations (GBOs) are generated by fast-spiking interneurons (FSIs) and are critical for cognitive functions. Abnormalities in GBOs are frequently observed in schizophrenia and bipolar disorder and are strongly correlated with cognitive ... ...

Abstract	γ-Band oscillations (GBOs) are generated by fast-spiking interneurons (FSIs) and are critical for cognitive functions. Abnormalities in GBOs are frequently observed in schizophrenia and bipolar disorder and are strongly correlated with cognitive impairment. However, the underlying mechanisms are poorly understood. Studying GBOs in
MeSH term(s)	Mice ; Animals ; Hippocampus/physiology ; Interneurons/physiology ; Schaffer Collaterals ; Oxygen
Chemical Substances	Oxygen (S88TT14065)
Language	English
Publishing date	2023-07-24
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2800598-3
ISSN	2373-2822 ; 2373-2822
ISSN (online)	2373-2822
ISSN	2373-2822
DOI	10.1523/ENEURO.0167-23.2023
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Article ; Online: Cross-linked phosphorylated RS4 wheat starch reduces glucose and insulin responses after 3 days of pre-feeding in healthy adults: an acute, double-blind, randomized controlled clinical trial.

Wolever, Thomas M S / Maningat, Clodualdo C / Seib, Paul A / Campbell, Janice E / Jenkins, Alexandra L

International journal of food sciences and nutrition

2023 Volume 74, Issue 5, Page(s) 621–629

Abstract: When this project was designed, there was no evidence that adding resistant starch to available carbohydrate (avCHO) reduced glycaemic and insulinaemic responses (GIR). We compared GIR elicited by a cookie containing cross-linked phosphorylated RS4 wheat ...

Abstract	When this project was designed, there was no evidence that adding resistant starch to available carbohydrate (avCHO) reduced glycaemic and insulinaemic responses (GIR). We compared GIR elicited by a cookie containing cross-linked phosphorylated RS4 wheat starch (Fibersym®) (RS4
MeSH term(s)	Humans ; Adult ; Insulin ; Starch ; Glucose ; Triticum ; Blood Glucose ; Glycemic Index ; Dietary Carbohydrates ; Postprandial Period ; Cross-Over Studies
Chemical Substances	Insulin ; Starch (9005-25-8) ; Glucose (IY9XDZ35W2) ; Blood Glucose ; Dietary Carbohydrates
Language	English
Publishing date	2023-07-20
Publishing country	England
Document type	Randomized Controlled Trial ; Journal Article
ZDB-ID	1121877-0
ISSN	1465-3478 ; 0963-7486
ISSN (online)	1465-3478
ISSN	0963-7486
DOI	10.1080/09637486.2023.2236809
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Article ; Online: Lentiviral Vector Preparation for Efficient Gene and MicroRNA Modulation of Peritoneal Cavity Tissue-Resident Macrophages In Vivo in Mice.

Gurney, Mark / Davies, Luke C / Jones, Ruth E / Bart, Valentina M / Jenkins, Robert H / Brennan, Paul / Taylor, Philip R / Czubala, Magdalena A

Journal of visualized experiments : JoVE

2024 , Issue 204

Abstract: Peritoneal tissue-resident macrophages have broad functions in the maintenance of homeostasis and are involved in pathologies within local and neighboring tissues. Their functions are dictated by microenvironmental cues; thus, it is essential to ... ...

Abstract	Peritoneal tissue-resident macrophages have broad functions in the maintenance of homeostasis and are involved in pathologies within local and neighboring tissues. Their functions are dictated by microenvironmental cues; thus, it is essential to investigate their behavior in an in vivo physiological niche. Currently, specific peritoneal macrophage-targeting methodologies employ whole-mouse transgenic models. Here, a protocol for effective in vivo modulation of mRNA and small RNA species (e.g., microRNA) expression in peritoneal macrophages using lentivirus particles is described. Lentivirus preparations were made in HEK293T cells and purified on a single sucrose layer. In vivo validation of lentivirus effectivity following intraperitoneal injection revealed predominant infection of macrophages restricted to local tissue. Targeting of peritoneal macrophages was successful during homeostasis and thioglycolate-induced peritonitis. The limitations of the protocol, including low-level inflammation induced by intraperitoneal delivery of lentivirus and time restrictions for potential experiments, are discussed. Overall, this study presents a quick and accessible protocol for the rapid assessment of gene function in peritoneal macrophages in vivo.
MeSH term(s)	Humans ; Animals ; Mice ; MicroRNAs/genetics ; Peritoneal Cavity ; Lentivirus/genetics ; HEK293 Cells ; Macrophages ; Disease Models, Animal
Chemical Substances	MicroRNAs
Language	English
Publishing date	2024-02-16
Publishing country	United States
Document type	Journal Article ; Video-Audio Media
ZDB-ID	2259946-0
ISSN	1940-087X ; 1940-087X
ISSN (online)	1940-087X
ISSN	1940-087X
DOI	10.3791/64926
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Article ; Online: Functional outcome after nonoperative management of minimally displaced greater tuberosity fractures and predictors of poorer patient experience.

Makaram, Navnit S / Khan, L A K / Jenkins, Paul J / Robinson, C M

The bone & joint journal

2023 Volume 105-B, Issue 5, Page(s) 534–542

Abstract: The outcomes following nonoperative management of minimally displaced greater tuberosity (GT) fractures, and the factors which influence patient experience, remain poorly defined. We assessed the early patient-derived outcomes following these injuries ... ...

Abstract	The outcomes following nonoperative management of minimally displaced greater tuberosity (GT) fractures, and the factors which influence patient experience, remain poorly defined. We assessed the early patient-derived outcomes following these injuries and examined the effect of a range of demographic- and injury-related variables on these outcomes. In total, 101 patients (53 female, 48 male) with a mean age of 50.9 years (19 to 76) with minimally displaced GT fractures were recruited to a prospective observational cohort study. During the first year after injury, patients underwent experiential assessment using the Disabilities of the Arm, Shoulder and Hand (DASH) score and assessment of associated injuries using MRI performed within two weeks of injury. The primary outcome was the one-year DASH score. Multivariate analysis was used to assess the effect of patient demographic factors, complications, and associated injuries, on outcome. The mean DASH score improved from 42.3 (SD 9.6) at six weeks post-injury, to 19.5 (SD 14.3) at one-year follow-up (p < 0.001), but outcomes were mixed, with 30 patients having a DASH score > 30 at one year. MRI revealed a range of associated injuries, with a full-thickness rotator cuff tear present in 19 patients (19%). Overall, 11 patients (11%) developed complications requiring further operative intervention; 20 patients (21%) developed post-traumatic secondary shoulder stiffness. Multivariate analysis revealed a high-energy mechanism (p = 0.009), tobacco consumption (p = 0.033), use of mobility aids (p = 0.047), a full-thickness rotator cuff tear (p = 0.002), and the development of post-traumatic secondary shoulder stiffness (p = 0.035) were independent predictors of poorer outcome. The results of nonoperative management of minimally displaced GT fractures are heterogeneous. While many patients have satisfactory early outcomes, a substantial subgroup fare much worse. There is a high prevalence of rotator cuff injuries and post-traumatic shoulder stiffness, and their presence is associated with poorer patient experience. Furthermore, patients who have a high-energy injury, smoke, or use walking aids, have worse outcomes.
MeSH term(s)	Humans ; Male ; Female ; Middle Aged ; Rotator Cuff Injuries/diagnostic imaging ; Rotator Cuff Injuries/therapy ; Prospective Studies ; Treatment Outcome ; Shoulder Fractures/diagnostic imaging ; Shoulder Fractures/therapy ; Joint Diseases ; Patient Outcome Assessment
Language	English
Publishing date	2023-05-01
Publishing country	England
Document type	Observational Study ; Journal Article
ZDB-ID	2697156-2
ISSN	2049-4408 ; 2049-4394
ISSN (online)	2049-4408
ISSN	2049-4394
DOI	10.1302/0301-620X.105B5.BJJ-2022-1142.R1
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Zs.A 6989: Show issues

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Book ; Online: Sampling probabilities, diffusions, ancestral graphs, and duality under strong selection

Favero, Martina / Jenkins, Paul A.

2023

Abstract: Wright-Fisher diffusions and their dual ancestral graphs occupy a central role in the study of allele frequency change and genealogical structure, and they provide expressions, explicit in some special cases but generally implicit, for the sampling ... ...

Abstract	Wright-Fisher diffusions and their dual ancestral graphs occupy a central role in the study of allele frequency change and genealogical structure, and they provide expressions, explicit in some special cases but generally implicit, for the sampling probability, a crucial quantity in inference. Under a finite-allele mutation model, with possibly parent-dependent mutation, we consider the asymptotic regime where the selective advantage of one allele grows to infinity, while the other parameters remain fixed. In this regime, we show that the Wright-Fisher diffusion can be approximated either by a Gaussian process or by a process whose components are independent continuous-state branching processes with immigration, aligning with analogous results for Wright-Fisher models but employing different methods. While the first process becomes degenerate at stationarity, the latter does not and provides a simple, analytic approximation for the leading term of the sampling probability. Furthermore, using another approach based on a recursion formula, we characterise all remaining terms to provide a full asymptotic expansion for the sampling probability. Finally, we study the asymptotic behaviour of the rates of the block-counting process of the conditional ancestral selection graph and establish an asymptotic duality relationship between this and the diffusion. Comment: 41 pages
Keywords	Mathematics - Probability ; Quantitative Biology - Populations and Evolution
Subject code	519
Publishing date	2023-12-28
Publishing country	us
Document type	Book ; Online
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Article ; Online: Physical and functional convergence of the autism risk genes Scn2a and Ank2 in neocortical pyramidal cell dendrites.

Nelson, Andrew D / Catalfio, Amanda M / Gupta, Julie P / Min, Lia / Caballero-Florán, René N / Dean, Kendall P / Elvira, Carina C / Derderian, Kimberly D / Kyoung, Henry / Sahagun, Atehsa / Sanders, Stephan J / Bender, Kevin J / Jenkins, Paul M

Neuron

2024 Volume 112, Issue 7, Page(s) 1133–1149.e6

Abstract: Dysfunction in sodium channels and their ankyrin scaffolding partners have both been implicated in neurodevelopmental disorders, including autism spectrum disorder (ASD). In particular, the genes SCN2A, which encodes the sodium channel ... ...

Abstract	Dysfunction in sodium channels and their ankyrin scaffolding partners have both been implicated in neurodevelopmental disorders, including autism spectrum disorder (ASD). In particular, the genes SCN2A, which encodes the sodium channel Na
MeSH term(s)	Animals ; Mice ; Ankyrins/genetics ; Ankyrins/metabolism ; Autism Spectrum Disorder/genetics ; Autism Spectrum Disorder/metabolism ; Autistic Disorder/metabolism ; Dendrites/physiology ; NAV1.2 Voltage-Gated Sodium Channel/genetics ; Neocortex/metabolism ; Pyramidal Cells/physiology
Chemical Substances	Ankyrins ; NAV1.2 Voltage-Gated Sodium Channel ; Scn2a protein, mouse ; Ank2 protein, mouse
Language	English
Publishing date	2024-01-29
Publishing country	United States
Document type	Journal Article
ZDB-ID	808167-0
ISSN	1097-4199 ; 0896-6273
ISSN (online)	1097-4199
ISSN	0896-6273
DOI	10.1016/j.neuron.2024.01.003
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