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Article ; Online: Efficacy of a new nutraceutical formulation: L-tryptophan, probiotics, charcoal, chamomile, mint, and licorice (COLONIR®) in the improvement of gastrointestinal symptoms in subjects with irritable bowel syndrome.

Fiorini, Giulia / Saracino, Ilaria M / Pavoni, Matteo / Nipote, Bruno / Colucci, Raffaele / Capone, Pietro / Sannino, Angela / Forte, Fabrizio / DE Vergori, Emiliano / Brancaccio, Mario / Cesareo, Maurizio / Casella, Giovanni / Morreale, Gaetano C / Bonfrate, Leonilde / Portincasa, Piero / Vincenzi, Massimo / Cottone, Carmelo / Ormando, Vittorio M / Scalise, Natale /

Lawson, Paulin F / Burattini, Osvaldo / Montale, Amedeo / Luzza, Francesco / Rossi, Mauro / Vanni, Riccardo / Bozzi, Rosamaria / Vincoli, Giuseppina / Stefani, Nicoletta / Borghi, Claudio / Vaira, Dino

Minerva gastroenterology

2023 Volume 69, Issue 1, Page(s) 123–127

Abstract: Background: Irritable bowel syndrome (IBS) is one of the most common functional gastrointestinal disorders. IBS is characterized by recurrent chronic abdominal pain and altered bowel habits in the absence of organic damage. Although there are reviews ... ...

Abstract	Background: Irritable bowel syndrome (IBS) is one of the most common functional gastrointestinal disorders. IBS is characterized by recurrent chronic abdominal pain and altered bowel habits in the absence of organic damage. Although there are reviews and guidelines for treating IBS, the complexity and diversity of IBS presentation make treatment difficult. Treatment of IBS focuses on relieving symptoms as mild signs and symptoms can often be controlled by managing stress and by making changes in diet and lifestyle. The use of nutraceutical compounds has been advocated as a possible alternative treatment in patients with IBS. COLONIR Methods: An initial cohort of 1004 consecutive patients referred to 25 different Units of Internal Medicine a/o Gastroenterology in Italy to perform colonoscopy for intestinal symptoms was asked to participate. Patients were treated for 2 months with two doses of nutraceuticals/day during meals namely COLONIR Results: After 2 months, 899 patients completed the follow-up. COLONIR Conclusions: These promising results, here reported, need to be confirmed, valuating the efficacy of COLONIR
MeSH term(s)	Humans ; Irritable Bowel Syndrome/complications ; Irritable Bowel Syndrome/drug therapy ; Charcoal ; Tryptophan ; Chamomile ; Glycyrrhiza ; Mentha ; Dietary Supplements ; Gastrointestinal Diseases ; Probiotics ; Abdominal Pain/drug therapy ; Abdominal Pain/etiology ; Flower Essences ; Chronic Pain
Chemical Substances	Charcoal (16291-96-6) ; Tryptophan (8DUH1N11BX) ; Flower Essences
Language	English
Publishing date	2023-03-01
Publishing country	Italy
Document type	Journal Article
ZDB-ID	3062713-8
ISSN	2724-5365
ISSN (online)	2724-5365
DOI	10.23736/S2724-5985.22.03282-X
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Article: Obstacles à la guérison de l’infection par le VIH. Partie 1 : les réservoirs latents.

Fombellida-Lopez, C / Chaslain, A / Susin, F / Vaira, D / Moutschen, M / Darcis, G

Revue medicale de Liege

2020 Volume 75, Issue 9, Page(s) 573–577

Abstract: The human immunodeficiency virus (HIV), responsible for acquired immunodeficiency syndrome or AIDS, is a major public health problem. In Belgium, 2 to 3 new cases are diagnosed every day. Since the advent of combined antiretroviral treatments in 1996, ... ...

Title translation	Hurdles to HIV cure. Part 1 : the latent reservoirs.
Abstract	The human immunodeficiency virus (HIV), responsible for acquired immunodeficiency syndrome or AIDS, is a major public health problem. In Belgium, 2 to 3 new cases are diagnosed every day. Since the advent of combined antiretroviral treatments in 1996, the life expectancy and quality of life of infected patients have greatly improved. However, to date there is no cure for HIV. Individuals infected with HIV must remain on antiretroviral treatment for life. One of the reasons for the difficulty in finding a cure for HIV is that the virus can remain in a latent form, i.e. dormant, in some of the cells it infects. These latent reservoirs are not recognized by the immune system and can reactivate and thus restart the infection if the patient stops the treatment. These latent reservoirs are therefore a major obstacle to cure HIV and a great deal of research is being conducted by the scientific community to find an eradication strategy. In this article, we will present the different characteristics of these latent reservoirs and the different strategies put in place to identify and eliminate them.
MeSH term(s)	Acquired Immunodeficiency Syndrome ; Belgium ; HIV Infections ; Humans ; Quality of Life ; Virus Latency
Language	French
Publishing date	2020-09-09
Publishing country	Belgium
Document type	Journal Article
ZDB-ID	414001-1
ISSN	0370-629X ; 0035-3663
ISSN	0370-629X ; 0035-3663
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Article: Obstacles à la guérison de l’infection par le VIH. Partie 2 : la réplication continue malgré le traitement.

Chaslain, A / Fombellida-Lopez, C / Susin, F / Vaira, D / Moutschen, M / Darcis, G

Revue medicale de Liege

2020 Volume 75, Issue 9, Page(s) 582–587

Abstract: The antiretroviral therapy (ART) has proven its effectiveness in improving the life expectancy of people infected with human immunodeficiency virus (HIV). Based on the inhibition of HIV replication, ART ensures the reduction of plasma viral load to ... ...

Title translation	Hurdles to HIV cure. Part 2 : ongoing HIV replication despite therapy.
Abstract	The antiretroviral therapy (ART) has proven its effectiveness in improving the life expectancy of people infected with human immunodeficiency virus (HIV). Based on the inhibition of HIV replication, ART ensures the reduction of plasma viral load to undetectable levels on long-term. Unfortunately, once ART is interrupted, the viral load rises up. Consequently, the therapy remains not curative. The reasons for this failure lie in the presence of latent reservoirs of the virus and/or the presence of ongoing replication, responsible for the persistence of the virus. This ongoing replication despite ongoing therapy has been demonstrated in sanctuary sites where the penetration of antiretroviral drugs is suboptimal. Moreover, some treatment intensification studies, mostly through addition of an integrase inhibitor, transiently resulted in increases in HIV replication by-products, highlighting that such strategies could reduce ongoing replication. Although the debate is still open, confirming the presence of this ongoing replication and finding strategies to eliminate it would be part of the key to a cure for HIV.
MeSH term(s)	Antiretroviral Therapy, Highly Active ; HIV Infections ; Humans ; Viral Load ; Virus Replication
Language	French
Publishing date	2020-09-09
Publishing country	Belgium
Document type	Journal Article
ZDB-ID	414001-1
ISSN	0370-629X ; 0035-3663
ISSN	0370-629X ; 0035-3663
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Article ; Online: Tablet and oral liquid L-thyroxine formulation in the treatment of naïve hypothyroid patients with Helicobacter pylori infection.

Ribichini, Danilo / Fiorini, Giulia / Repaci, Andrea / Castelli, Valentina / Gatta, Luigi / Vaira, Dino / Pasquali, Renato

Endocrine

2017 Volume 57, Issue 3, Page(s) 394–401

Abstract: To compare the clinical efficacy of tablet and oral liquid L-thyroxine (LT4) formulation in naïve ...

Abstract	To compare the clinical efficacy of tablet and oral liquid L-thyroxine (LT4) formulation in naïve hypothyroid subjects with Helicobacter pylori infection. Forty-seven adult naïve hypothyroid subjects with dyspeptic symptoms were investigated with upper endoscopy and divided into: 28 patients with Helicobacter pylori infection (Group A); 15 patients without gastric alterations (group B); 4 patients with autoimmune gastritis were excluded from the study. Subjects were randomly treated with a same dose of LT4 tablet (TAB) or oral liquid formulation (SOL), for 9 months on group A and 6 months on group B. Helicobacter pylori infection was eradicated after 3 months of LT4 treatment. On group A, after 3 months (before Helicobacter pylori eradication), subjects treated with SOL showed a greater thyroid-stimulating hormone reduction (ΔTSH
MeSH term(s)	Adult ; Anti-Bacterial Agents/therapeutic use ; Anti-Ulcer Agents/therapeutic use ; Drug Therapy, Combination ; Dyspepsia/etiology ; Dyspepsia/physiopathology ; Dyspepsia/prevention & control ; Female ; Gastritis/complications ; Gastritis/drug therapy ; Gastritis/microbiology ; Gastritis/physiopathology ; Helicobacter Infections/complications ; Helicobacter Infections/drug therapy ; Helicobacter Infections/microbiology ; Helicobacter Infections/physiopathology ; Helicobacter pylori/drug effects ; Helicobacter pylori/physiology ; Hormone Replacement Therapy/adverse effects ; Humans ; Hypothyroidism/blood ; Hypothyroidism/complications ; Hypothyroidism/drug therapy ; Hypothyroidism/microbiology ; Intestinal Absorption ; Male ; Middle Aged ; Pituitary Gland, Anterior/drug effects ; Pituitary Gland, Anterior/secretion ; Severity of Illness Index ; Tablets ; Thyroid Gland/drug effects ; Thyroid Gland/physiopathology ; Thyroid Gland/secretion ; Thyrotropin/blood ; Thyroxine/administration & dosage ; Thyroxine/adverse effects ; Thyroxine/chemistry ; Thyroxine/therapeutic use ; Young Adult
Chemical Substances	Anti-Bacterial Agents ; Anti-Ulcer Agents ; Tablets ; Thyrotropin (9002-71-5) ; Thyroxine (Q51BO43MG4)
Language	English
Publishing date	2017-09
Publishing country	United States
Document type	Journal Article ; Randomized Controlled Trial
ZDB-ID	1194484-5
ISSN	1559-0100 ; 1355-008X ; 0969-711X
ISSN (online)	1559-0100
ISSN	1355-008X ; 0969-711X
DOI	10.1007/s12020-016-1167-3
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Article ; Online: L’emergenza COVID-19 e la scuola. Una riflessione su alcune contraddizioni emergenti dalla crisi.

Romito, M / Vaira, M

2020

Keywords	Disuguaglianze ; Scuola ; Digital Divide ; Covid-19 ; Technologie ; SPS/08 - SOCIOLOGIA DEI PROCESSI CULTURALI E COMUNICATIVI ; covid19
Language	Italian
Publishing country	it
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: L-carnitine and isovaleryl L-carnitine fumarate positively affect human osteoblast proliferation and differentiation in vitro.

Colucci, S / Mori, G / Vaira, S / Brunetti, G / Greco, G / Mancini, L / Simone, G M / Sardelli, F / Koverech, A / Zallone, A / Grano, M

Calcified tissue international

2005 Volume 76, Issue 6, Page(s) 458–465

Abstract: ... with age; Therefore, two Carnitine derivatives, L-carnitine fumarate (LC) and isovaleryl L-carnitine ...

Abstract	Age-related bone loss is characterized by decreased osteoblast activity, possibly related to the reduction of energy production. Carnitine promotes energy availability and its concentration declines with age; Therefore, two Carnitine derivatives, L-carnitine fumarate (LC) and isovaleryl L-carnitine fumarate (Iso-V-LC), have been tested on several parameters of human osteoblasts in vitro. Both compounds significantly increased osteoblast activity, but the new compound Iso-V-LC was more efficient than LC at lower concentrations. They both significantly enhanced cell proliferation, [3H]-proline incorporation and the expression of collagen type I (COLLI), and the bone sialoproteins (BSPs) and osteopontin (OPN). The percentage of alkaline phosphatase (ALP)-positive cells and the secretion of osteocalcin were not modified by LC and Iso-V-LC. Both molecules increased the formation of mineralized nodules, but Iso-V-LC reached the maximum effect at a concentration 10-fold lower than that of LC. Furthermore, we showed that insulin-like growth factor (IGF)-I and IGF-II mRNA levels were not modified by the treatment. However, the two compounds induced an increase of insulin-like growth factor binding protein (IGFBP)-3 and a decrease of IGFBP-5 in both osteoblast lysates and the extracellular matrix (ECM). In conclusion these data suggest that carnitine and, in particular, its new derivative, Iso-V-LC supplementation in the elderly may stimulate osteoblast activity and decrease age-related bone loss.
MeSH term(s)	Alkaline Phosphatase/drug effects ; Alkaline Phosphatase/metabolism ; Blotting, Western ; Calcification, Physiologic/drug effects ; Carnitine/analogs & derivatives ; Carnitine/pharmacology ; Cell Differentiation/drug effects ; Cell Proliferation/drug effects ; Cells, Cultured ; Collagen Type I/drug effects ; Collagen Type I/metabolism ; Humans ; In Vitro Techniques ; Osteoblasts/cytology ; Osteoblasts/drug effects ; Osteocalcin/drug effects ; Osteocalcin/metabolism ; Osteopontin ; Receptors, Somatomedin/drug effects ; Receptors, Somatomedin/metabolism ; Reverse Transcriptase Polymerase Chain Reaction ; Sialoglycoproteins/drug effects ; Sialoglycoproteins/metabolism ; Somatomedins/drug effects ; Somatomedins/metabolism
Chemical Substances	Collagen Type I ; Receptors, Somatomedin ; SPP1 protein, human ; Sialoglycoproteins ; Somatomedins ; Osteocalcin (104982-03-8) ; Osteopontin (106441-73-0) ; Alkaline Phosphatase (EC 3.1.3.1) ; Carnitine (S7UI8SM58A)
Language	English
Publishing date	2005-06
Publishing country	United States
Document type	Comparative Study ; Journal Article
ZDB-ID	304266-2
ISSN	1432-0827 ; 0171-967X ; 0944-0747 ; 0008-0594
ISSN (online)	1432-0827
ISSN	0171-967X ; 0944-0747 ; 0008-0594
DOI	10.1007/s00223-004-0147-4
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Article: Molecular evaluation of the principal Ranunculus asiaticus L. viruses

Sacco, E / Borghi, C / Laura, M / Bobbio, V / Rabaglio, M / Kawka, M / Vaira, A. M / Ruffoni, B

Acta horticulturae. 2015 Feb. 20, , no. 1072

2015

Abstract: The buttercup (Ranunculus asiaticus L.) belongs to the family Ranunculaceae and is a popular ...

Abstract	The buttercup (Ranunculus asiaticus L.) belongs to the family Ranunculaceae and is a popular ornamental plant cultivated for the sale of cut flowers and for the production of pot or border plants. The hybrids of Ranunculus asiaticus are susceptible to infection by several viruses, very often present in mixed infection, and all associated with economically important diseases. In the present study the main viruses infecting Ranunculus hybrids (Tomato spotted wilt virus (TSWV), Ranunculus white mottle virus (RWMV), Ranunculus leaf distortion virus (RLDV) and others) were evaluated by double step RT-PCR assays and specific primers, using leaf tissues as starting material. Results showed the presence of some viral species in the samples analyzed, either in single or in mixed infection, and confirm that the molecular evaluation, due to versatility of use and reliability of results, can be easily used as a tool for viruses detection on large scale propagation materials in order to prevent the spread of the principal viruses and assure the production of virus-free Ranunculus plants.
Keywords	Ranunculus asiaticus ; Ranunculus leaf distortion virus ; Ranunculus white mottle virus ; Tomato spotted wilt virus ; biological resistance ; cut flowers ; hybrids ; leaves ; mixed infection ; ornamental plants ; propagation materials ; reliability ; reverse transcriptase polymerase chain reaction ; tissues ; viruses
Language	English
Dates of publication	2015-0220
Size	p. 165-171.
Publishing place	International Society for Horticultural Science.
Document type	Article
Note	Paper presented at the XIII International Symposium on Virus Diseases of Ornamental Plants held June 24-29, 2012, Ski and Grimstad (Norway)
ISSN	0567-7572
Database	NAL-Catalogue (AGRICOLA)

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Article: Taste and Smell Disorders: A Critical Look at Olfactory and Gustatory Dysfunction.

Maniaci, Antonino / Lechien, Jérome R / Vaira, Luigi Angelo / La Via, Luigi

Life (Basel, Switzerland)

2024 Volume 14, Issue 3

Abstract: In an era where modern medicine has made remarkable advances in managing diseases in the head and neck region, we present this Special Issue to provide a spotlight on the new research advances on olfactory and gustatory disorders [ ... ]. ...

Abstract	In an era where modern medicine has made remarkable advances in managing diseases in the head and neck region, we present this Special Issue to provide a spotlight on the new research advances on olfactory and gustatory disorders [...].
Language	English
Publishing date	2024-02-26
Publishing country	Switzerland
Document type	Editorial
ZDB-ID	2662250-6
ISSN	2075-1729
ISSN	2075-1729
DOI	10.3390/life14030301
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Article ; Online: Helicobacter pylori eradication and aspirin: a puzzle yet to be solved.

Gatta, Luigi / Zullo, Angelo / Vaira, Dino

Lancet (London, England)

2023 Volume 401, Issue 10384, Page(s) 1265–1266

MeSH term(s)	Humans ; Aspirin/therapeutic use ; Helicobacter pylori ; Anti-Inflammatory Agents, Non-Steroidal/therapeutic use ; Helicobacter Infections/drug therapy ; Anti-Bacterial Agents/therapeutic use
Chemical Substances	Aspirin (R16CO5Y76E) ; Anti-Inflammatory Agents, Non-Steroidal ; Anti-Bacterial Agents
Language	English
Publishing date	2023-04-13
Publishing country	England
Document type	Letter ; Comment
ZDB-ID	3306-6
ISSN	1474-547X ; 0023-7507 ; 0140-6736
ISSN (online)	1474-547X
ISSN	0023-7507 ; 0140-6736
DOI	10.1016/S0140-6736(23)00279-9
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Article ; Online: Implant-prosthetic rehabilitation of the atrophic posterior mandible with additively manufactured custom-made subperiosteal implants: a cohort study.

Vaira, L A / Biglio, A / Favro, A / Salzano, G / Abbate, V / Lechien, J R / De Riu, G

International journal of oral and maxillofacial surgery

2024

Abstract: The aim of this study was to retrospectively analyse a series of patients with posterior mandibular atrophy rehabilitated with custom-made subperiosteal implants. The study included patients with severe posterior mandibular atrophy who had undergone ... ...

Abstract	The aim of this study was to retrospectively analyse a series of patients with posterior mandibular atrophy rehabilitated with custom-made subperiosteal implants. The study included patients with severe posterior mandibular atrophy who had undergone rehabilitation with subperiosteal implants between September 2018 and August 2022 in the Maxillofacial Surgery Operative Unit of the University Hospital of Sassari. Complications and the success rate were reviewed. Data from 30 implants placed in 17 patients were included and analysed. There were no major complications during the surgeries. The main postoperative sequela was oedema, which was reported as moderate by most patients and had completely regressed within 10 days of surgery. No partial or complete exposures, infections, or loss of the implants were detected during follow-up (average follow-up 22.5 months). Control computed tomography scans, performed at 6 months and then annually in all cases, did not show significant bone loss below the abutments, displacement of the implants, or loss or loosening of the osteosynthesis screws. Subperiosteal implants may represent a safe and reliable technique for the rehabilitation of severe atrophy of the posterior mandible. Prospective studies with a long follow-up will be needed to establish the long-term results of this type of implant-prosthetic rehabilitation.
Language	English
Publishing date	2024-01-24
Publishing country	Denmark
Document type	Journal Article
ZDB-ID	353721-3
ISSN	1399-0020 ; 0901-5027
ISSN (online)	1399-0020
ISSN	0901-5027
DOI	10.1016/j.ijom.2024.01.003
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