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  1. Book ; Audio / Video ; Thesis: Der Einfluss von angeborener und spezifischer Immunität auf die Regeneration nach Verletzung von Rückenmark und Nerven bei Mäusen

    Jakovcevski, Igor

    2022  

    Author's details vorgelegt von Igor Jakovcevski
    Language German
    Size 1 CD-ROM, Illustrationen
    Publishing place Witten ; Herdecke
    Publishing country Germany
    Document type Book ; Audio / Video ; Thesis
    Thesis / German Habilitation thesis Dissertation, Universität Witten/Herdecke, 2022
    HBZ-ID HT030335157
    Database Catalogue ZB MED Medicine, Health

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    2023 MO 74 order for loan Magazin

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  2. Article: Editorial: Extracellular matrix in development and disorders of the nervous system.

    Jakovcevski, Igor / Andjus, Pavle R / Förster, Eckart

    Frontiers in cell and developmental biology

    2023  Volume 11, Page(s) 1153484

    Language English
    Publishing date 2023-02-13
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2023.1153484
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Impact of Depletion of Microglia/Macrophages on Regeneration after Spinal Cord Injury.

    Jakovčevski, Igor / Förster, Eckart / Reiss, Gebhard / Schachner, Melitta

    Neuroscience

    2021  Volume 459, Page(s) 129–141

    Abstract: Microglia/macrophages play important functional roles in regeneration after central nervous system injury. Infiltration of circulating macrophages and proliferation of resident microglia occur within minutes following spinal cord injury. Activated ... ...

    Abstract Microglia/macrophages play important functional roles in regeneration after central nervous system injury. Infiltration of circulating macrophages and proliferation of resident microglia occur within minutes following spinal cord injury. Activated microglia/macrophages clear tissue debris, but activation over time may hamper repair. To study the role of these cells in regeneration after spinal cord injury we used CD11b-herpes simplex virus thymidine kinase (HSVTK) (TK) transgenic mice, in which viral thymidine kinase activates ganciclovir toxicity in CD11b-expressing myeloid cells, including macrophages and microglia. A severe reduction in number of these cells was seen in TK versus wild-type littermate mice at 1 week and 5 weeks after injury, and numbers of Mac-2 expressing activated microglia/macrophages were almost completely reduced at these time points. One week after injury TK mice showed better locomotor recovery, but recovery was similar to wild-type mice as measured weekly up to 5 weeks thereafter. At 5 weeks after injury, numbers of axons at the lesion site and neurons in the lumbar spinal cord did not differ between groups. Also, catecholaminergic innervation of spinal motoneurons was similar. However, cholinergic innervation was lower and glial scarring was increased in TK mice compared to wild-type mice. We conclude that reducing numbers of CD11b-expressing cells improves locomotor recovery in the early phase after spinal cord injury, but does not affect recovery in the following 4 weeks. These observations point to differences in outcomes of astrocytic response and cholinergic innervation under CD11b cell ablation, which are, however, not reflected in the locomotor parameters analyzed at 5 weeks after injury.
    MeSH term(s) Animals ; Macrophages ; Mice ; Mice, Inbred C57BL ; Mice, Transgenic ; Microglia ; Recovery of Function ; Spinal Cord ; Spinal Cord Injuries
    Language English
    Publishing date 2021-02-13
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 196739-3
    ISSN 1873-7544 ; 0306-4522
    ISSN (online) 1873-7544
    ISSN 0306-4522
    DOI 10.1016/j.neuroscience.2021.02.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1215: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Editorial

    Igor Jakovcevski / Pavle R. Andjus / Eckart Förster

    Frontiers in Cell and Developmental Biology, Vol

    Extracellular matrix in development and disorders of the nervous system

    2023  Volume 11

    Keywords extracellular matrix (ECM) ; nervous system ; regeneration ; perineuronal nets (PNNs) ; synapses ; Biology (General) ; QH301-705.5
    Language English
    Publishing date 2023-02-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article: Pharmacology of repair after peripheral nerve injury.

    Divac, Nevena / Aksić, Milan / Rasulić, Lukas / Jakovčevski, Maja / Basailović, Miloš / Jakovčevski, Igor

    International journal of clinical pharmacology and therapeutics

    2021  Volume 59, Issue 6, Page(s) 447–462

    Abstract: Peripheral nerve injuries are common and present with a broad spectrum of symptoms, some of which may be the cause of life-long disabilities. The peripheral nerves show a far greater capacity for regeneration than those in the central nervous system, and ...

    Abstract Peripheral nerve injuries are common and present with a broad spectrum of symptoms, some of which may be the cause of life-long disabilities. The peripheral nerves show a far greater capacity for regeneration than those in the central nervous system, and the process of nerve regeneration resembles developmental processes to a certain degree. The regeneration of peripheral nerves does not always lead to a full functional recovery. That is why surgical methods are still the most reliable therapeutic options after injuries of peripheral nerves. However, there is an array of potential pharmacological options that could enhance the repair processes after surgery. This review gives a summary of the recent literature relevant to different classes of pharmacologically active substances that are used either as supplements or off-label as potential enhancers of peripheral nerve repair. Antioxidants, vitamins, calcium channel blockers, immunosuppressive drugs, growth factors, and neuroactive glycans are among the most researched in this field. More research is necessary to understand their mechanisms of action at the cellular and molecular level, and randomized clinical trials in order to establish their efficacy and safety, as well as possible synergistic or adverse interactions among them.
    MeSH term(s) Humans ; Immunosuppressive Agents ; Nerve Regeneration ; Peripheral Nerve Injuries/drug therapy ; Peripheral Nerves
    Chemical Substances Immunosuppressive Agents
    Language English
    Publishing date 2021-02-23
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 124384-6
    ISSN 0946-1965 ; 0340-0026 ; 0300-9718 ; 0174-4879
    ISSN 0946-1965 ; 0340-0026 ; 0300-9718 ; 0174-4879
    DOI 10.5414/CP203893
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 467: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Perforin affects regeneration in a mouse spinal cord injury model.

    Jakovcevski, Igor / Schachner, Melitta

    The International journal of neuroscience

    2020  Volume 132, Issue 1, Page(s) 1–12

    Abstract: Materials and methods: Locomotor outcomes in perforin-deficient (Pfp-/-) mice and wild-type littermate controls were measured after severe compression injury of the lower thoracic spinal cord up to six weeks after injury.: Results: According to both ... ...

    Abstract Materials and methods: Locomotor outcomes in perforin-deficient (Pfp-/-) mice and wild-type littermate controls were measured after severe compression injury of the lower thoracic spinal cord up to six weeks after injury.
    Results: According to both the Basso mouse scale score and single frame motion analysis, motor recovery of Pfp-/- mice was similar to wild-type controls. Interestingly, immunohistochemical analysis of cell types at six weeks after injury showed enhanced cholinergic reinnervation of spinal motor neurons caudal to the lesion site and neurofilament-positive structures at the injury site in Pfp-/- mice, whereas numbers of microglia/macrophages and astrocytes were decreased compared with controls.
    Conclusions: We conclude that, although, loss of perforin does not change the locomotor outcome after injury, it beneficially affects diverse cellular features, such as number of axons, cholinergic synapses, astrocytes and microglia/macrophages at or caudal to the lesion site. Perforin's ability to contribute to Rag2's influence on locomotion was observed in mice doubly deficient in perforin and Rag2 which recovered better than Rag2-/- or Pfp-/- mice, suggesting that natural killer cells can cooperate with T- and B-cells in spinal cord injury.
    MeSH term(s) Animals ; Behavior, Animal/physiology ; Disease Models, Animal ; Locomotion/physiology ; Male ; Mice ; Mice, Inbred C57BL ; Nerve Regeneration/physiology ; Pore Forming Cytotoxic Proteins/deficiency ; Pore Forming Cytotoxic Proteins/physiology ; Spinal Cord Injuries/enzymology ; Spinal Cord Injuries/immunology ; Spinal Cord Injuries/physiopathology
    Chemical Substances Pore Forming Cytotoxic Proteins ; perforin, mouse
    Language English
    Publishing date 2020-07-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 3061-2
    ISSN 1563-5279 ; 1543-5245 ; 0020-7454
    ISSN (online) 1563-5279 ; 1543-5245
    ISSN 0020-7454
    DOI 10.1080/00207454.2020.1796662
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 657: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Mice Mutated in the First Fibronectin Domain of Adhesion Molecule L1 Show Brain Malformations and Behavioral Abnormalities.

    Granato, Viviana / Congiu, Ludovica / Jakovcevski, Igor / Kleene, Ralf / Schwindenhammer, Benjamin / Fernandes, Luciana / Freitag, Sandra / Schachner, Melitta / Loers, Gabriele

    Biomolecules

    2024  Volume 14, Issue 4

    Abstract: The X-chromosome-linked cell adhesion molecule L1 (L1CAM), a glycoprotein mainly expressed by neurons in the central and peripheral nervous systems, has been implicated in many neural processes, including neuronal migration and survival, neuritogenesis, ... ...

    Abstract The X-chromosome-linked cell adhesion molecule L1 (L1CAM), a glycoprotein mainly expressed by neurons in the central and peripheral nervous systems, has been implicated in many neural processes, including neuronal migration and survival, neuritogenesis, synapse formation, synaptic plasticity and regeneration. L1 consists of extracellular, transmembrane and cytoplasmic domains. Proteolytic cleavage of L1's extracellular and transmembrane domains by different proteases generates several L1 fragments with different functions. We found that myelin basic protein (MBP) cleaves L1's extracellular domain, leading to enhanced neuritogenesis and neuronal survival in vitro. To investigate in vivo the importance of the MBP-generated 70 kDa fragment (L1-70), we generated mice with an arginine to alanine substitution at position 687 (L1/687), thereby disrupting L1's MBP cleavage site and obliterating L1-70. Young adult L1/687 males showed normal anxiety and circadian rhythm activities but enhanced locomotion, while females showed altered social interactions. Older L1/687 males were impaired in motor coordination. Furthermore, L1/687 male and female mice had a larger hippocampus, with more neurons in the dentate gyrus and more proliferating cells in the subgranular layer, while the thickness of the corpus callosum and the size of lateral ventricles were normal. In summary, subtle mutant morphological changes result in subtle behavioral changes.
    MeSH term(s) Animals ; Neural Cell Adhesion Molecule L1/genetics ; Neural Cell Adhesion Molecule L1/metabolism ; Mice ; Male ; Female ; Brain/metabolism ; Fibronectins/metabolism ; Fibronectins/genetics ; Mutation ; Behavior, Animal ; Protein Domains ; Neurons/metabolism ; Hippocampus/metabolism ; Mice, Inbred C57BL
    Chemical Substances Neural Cell Adhesion Molecule L1 ; Fibronectins
    Language English
    Publishing date 2024-04-11
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2701262-1
    ISSN 2218-273X ; 2218-273X
    ISSN (online) 2218-273X
    ISSN 2218-273X
    DOI 10.3390/biom14040468
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: The Role of Tenascin-C on the Structural Plasticity of Perineuronal Nets and Synaptic Expression in the Hippocampus of Male Mice.

    Jakovljević, Ana / Stamenković, Vera / Poleksić, Joko / Hamad, Mohammad I K / Reiss, Gebhard / Jakovcevski, Igor / Andjus, Pavle R

    Biomolecules

    2024  Volume 14, Issue 4

    Abstract: Neuronal plasticity is a crucial mechanism for an adapting nervous system to change. It is shown to be regulated by perineuronal nets (PNNs), the condensed forms of the extracellular matrix (ECM) around neuronal bodies. By assessing the changes in the ... ...

    Abstract Neuronal plasticity is a crucial mechanism for an adapting nervous system to change. It is shown to be regulated by perineuronal nets (PNNs), the condensed forms of the extracellular matrix (ECM) around neuronal bodies. By assessing the changes in the number, intensity, and structure of PNNs, the ultrastructure of the PNN mesh, and the expression of inhibitory and excitatory synaptic inputs on these neurons, we aimed to clarify the role of an ECM glycoprotein, tenascin-C (TnC), in the dorsal hippocampus. To enhance neuronal plasticity, TnC-deficient (TnC-/-) and wild-type (TnC+/+) young adult male mice were reared in an enriched environment (EE) for 8 weeks. Deletion of TnC in TnC-/- mice showed an ultrastructural reduction of the PNN mesh and an increased inhibitory input in the dentate gyrus (DG), and an increase in the number of PNNs with a rise in the inhibitory input in the CA2 region. EE induced an increased inhibitory input in the CA2, CA3, and DG regions; in DG, the change was also followed by an increased intensity of PNNs. No changes in PNNs or synaptic expression were found in the CA1 region. We conclude that the DG and CA2 regions emerged as focal points of alterations in PNNs and synaptogenesis with EE as mediated by TnC.
    MeSH term(s) Animals ; Tenascin/metabolism ; Tenascin/genetics ; Male ; Neuronal Plasticity ; Mice ; Hippocampus/metabolism ; Extracellular Matrix/metabolism ; Synapses/metabolism ; Mice, Knockout ; Neurons/metabolism ; Mice, Inbred C57BL ; Dentate Gyrus/metabolism
    Chemical Substances Tenascin ; Tnc protein, mouse
    Language English
    Publishing date 2024-04-22
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2701262-1
    ISSN 2218-273X ; 2218-273X
    ISSN (online) 2218-273X
    ISSN 2218-273X
    DOI 10.3390/biom14040508
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Tenascin-C fibronectin D domain is involved in the fine-tuning of glial response to CNS injury

    Bijelić, Dunja / Adžić, Marija / Perić, Mina / Reiss, Gebhard / Milošević, Milena / Andjus, Pavle R / Jakovčevski, Igor

    Frontiers in cell and developmental biology

    2022  Volume 10, Page(s) 952208

    Abstract: Understanding processes that occur after injuries to the central nervous system is essential in order to gain insight into how the restoration of function can be improved. Extracellular glycoprotein tenascin-C (TnC) has numerous functions in wound ... ...

    Abstract Understanding processes that occur after injuries to the central nervous system is essential in order to gain insight into how the restoration of function can be improved. Extracellular glycoprotein tenascin-C (TnC) has numerous functions in wound healing process depending on the expression time, location, isoform and binding partners which makes it interesting to study in this context. We used an
    Language English
    Publishing date 2022-08-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2022.952208
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Corrigendum: Different Functions of Recombinantly Expressed Domains of Tenascin-C in Glial Scar Formation.

    Bijelić, Dunja / Adžić, Marija / Perić, Mina / Jakovčevski, Igor / Förster, Eckart / Schachner, Melitta / Andjus, Pavle R

    Frontiers in immunology

    2021  Volume 12, Page(s) 672476

    Abstract: This corrects the article DOI: 10.3389/fimmu.2020.624612.]. ...

    Abstract [This corrects the article DOI: 10.3389/fimmu.2020.624612.].
    Language English
    Publishing date 2021-03-16
    Publishing country Switzerland
    Document type Published Erratum
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2021.672476
    Database MEDical Literature Analysis and Retrieval System OnLINE

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