Article ; Online: Lian-Mei-Yin formula alleviates diet-induced hepatic steatosis by suppressing Yap1/FOXM1 pathway-dependent lipid synthesis.
Acta biochimica et biophysica Sinica
2024 Volume 56, Issue 4, Page(s) 621–633
Abstract: ... therapeutic agents for NAFLD. Lian-Mei-Yin (LMY) is a traditional Chinese medicine formula used for decades ...
| Abstract | Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease, with a global prevalence of 25%. Patients with NAFLD are more likely to suffer from advanced liver disease, cardiovascular disease, or type II diabetes. However, unfortunately, there is still a shortage of FDA-approved therapeutic agents for NAFLD. Lian-Mei-Yin (LMY) is a traditional Chinese medicine formula used for decades to treat liver disorders. It has recently been applied to type II diabetes which is closely related to insulin resistance. Given that NAFLD is another disease involved in insulin resistance, we hypothesize that LMY might be a promising formula for NAFLD therapy. Herein, we verify that the LMY formula effectively reduces hepatic steatosis in diet-induced zebrafish and NAFLD model mice in a time- and dose-dependent manner. Mechanistically, LMY suppresses Yap1-mediated Foxm1 activation, which is crucial for the occurrence and development of NAFLD. Consequently, lipogenesis is ameliorated by LMY administration. In summary, the LMY formula alleviates diet-induced NAFLD in zebrafish and mice by inhibiting Yap1/Foxm1 signaling-mediated NAFLD pathology. |
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| MeSH term(s) | Humans ; Mice ; Animals ; Non-alcoholic Fatty Liver Disease/drug therapy ; Non-alcoholic Fatty Liver Disease/etiology ; Non-alcoholic Fatty Liver Disease/metabolism ; Lipogenesis ; Zebrafish ; Insulin Resistance ; Diabetes Mellitus, Type 2/metabolism ; Liver/metabolism ; Diet, High-Fat ; Transcription Factors/metabolism ; Adaptor Proteins, Signal Transducing/metabolism ; Lipids ; Mice, Inbred C57BL ; Forkhead Box Protein M1/metabolism |
| Chemical Substances | Transcription Factors ; Adaptor Proteins, Signal Transducing ; Lipids ; FOXM1 protein, human ; Forkhead Box Protein M1 |
| Language | English |
| Publishing date | 2024-03-21 |
| Publishing country | China |
| Document type | Journal Article |
| ZDB-ID | 2175256-4 |
| ISSN | 1745-7270 ; 0582-9879 ; 1672-9145 |
| ISSN (online) | 1745-7270 |
| ISSN | 0582-9879 ; 1672-9145 |
| DOI | 10.3724/abbs.2024025 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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