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  1. Article: Exploring neurosurgical oncology in medical school.

    Markosian, Christopher / Yan, Rachel E / Rallo, Michael S

    Surgical neurology international

    2023  Volume 14, Page(s) 418

    Language English
    Publishing date 2023-12-08
    Publishing country United States
    Document type Journal Article
    ISSN 2229-5097
    ISSN 2229-5097
    DOI 10.25259/SNI_757_2023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Generative artificial intelligence performs rudimentary structural biology modeling.

    Ille, Alexander M / Markosian, Christopher / Burley, Stephen K / Mathews, Michael B / Pasqualini, Renata / Arap, Wadih

    bioRxiv : the preprint server for biology

    2024  

    Abstract: Natural language-based generative artificial intelligence (AI) has become increasingly prevalent in scientific research. Intriguingly, capabilities of generative pre-trained transformer (GPT) language models beyond the scope of natural language tasks ... ...

    Abstract Natural language-based generative artificial intelligence (AI) has become increasingly prevalent in scientific research. Intriguingly, capabilities of generative pre-trained transformer (GPT) language models beyond the scope of natural language tasks have recently been identified. Here we explored how GPT-4 might be able to perform rudimentary structural biology modeling. We prompted GPT-4 to model 3D structures for the 20 standard amino acids and an α-helical polypeptide chain, with the latter incorporating Wolfram mathematical computation. We also used GPT-4 to perform structural interaction analysis between nirmatrelvir and its target, the SARS-CoV-2 main protease. Geometric parameters of the generated structures typically approximated close to experimental references. However, modeling was sporadically error-prone and molecular complexity was not well tolerated. Interaction analysis further revealed the ability of GPT-4 to identify specific amino acid residues involved in ligand binding along with corresponding bond distances. Despite current limitations, we show the capacity of natural language generative AI to perform basic structural biology modeling and interaction analysis with atomic-scale accuracy.
    Language English
    Publishing date 2024-03-04
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2024.01.10.575113
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Oligonucleotides and polyribonucleotides: a review of antiviral activity.

    Markosian, Michael / Hyde, Robyn M

    Antiviral chemistry & chemotherapy

    2005  Volume 16, Issue 2, Page(s) 91–102

    Abstract: Current antiviral therapies are insufficient for treating emerging, re-emerging and established viral diseases. In an effort to find new therapeutics, oligo- and polyribonucleotides are being studied for their antiviral capabilities. Studies have shown ... ...

    Abstract Current antiviral therapies are insufficient for treating emerging, re-emerging and established viral diseases. In an effort to find new therapeutics, oligo- and polyribonucleotides are being studied for their antiviral capabilities. Studies have shown that uniquely modified single- and double-stranded nucleic acid constructs are effective in inhibiting viral proliferation by various mechanisms. This review gives a brief history and highlights the development of oligo- and polyribonucleotides as antiviral agents primarily in the fields of interferon induction, mRNA complementation and reverse transcriptase inhibition.
    MeSH term(s) Animals ; Antiviral Agents/chemistry ; Antiviral Agents/pharmacology ; Humans ; Molecular Structure ; Oligonucleotides/pharmacology ; Polyribonucleotides/pharmacology ; Virus Diseases/drug therapy
    Chemical Substances Antiviral Agents ; Oligonucleotides ; Polyribonucleotides
    Language English
    Publishing date 2005
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1033586-9
    ISSN 2040-2066 ; 0956-3202
    ISSN (online) 2040-2066
    ISSN 0956-3202
    DOI 10.1177/095632020501600202
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2950: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: The Co-Pilot Project: An International Neurosurgical Collaboration in Ukraine.

    Tomycz, Luke D / Markosian, Christopher / Kurilets, Igor / Lovha, Mykhailo / Kashyrina, Oleksandra / Netliukh, Andrii / Kostiuk, Kostiantyn / Cheburakhin, Valeriy / Polishchuk, Andriy / Forbes, Jonathan / Cohen, Michael / Miley, Jefferson / Geck, Matthew / Siryk, Hanna / Mykytyn, Taras / Diakiv, Volodymyr / Salo, Viktor / Yushchak, Igor / Soroka, Mariya

    World neurosurgery

    2020  Volume 147, Page(s) e491–e515

    Abstract: Objective: We aim to provide a thorough description of the efforts and outcomes of the Co-Pilot Project in Ukraine, which facilitates neurosurgical collaboration between American and Ukrainian physicians.: Methods: The Co-Pilot Project, which ... ...

    Abstract Objective: We aim to provide a thorough description of the efforts and outcomes of the Co-Pilot Project in Ukraine, which facilitates neurosurgical collaboration between American and Ukrainian physicians.
    Methods: The Co-Pilot Project, which operates under its parent nonprofit organization, Razom, organized multiple trips for American physicians to Ukraine. Activities included consulting in clinic, assisting with neurosurgical operations, and providing didactic lectures. Further efforts have included coordinating training opportunities for Ukrainian surgeons. We retrospectively reviewed all operations performed by Ukrainian partner physicians alongside American co-pilot physicians across Ukraine since August 2016.
    Results: Teams of Ukrainian and American physicians operated on 78 patients (24 children and 54 adults) for a total of 84 procedures in 5 different cities (Kyiv, Lutsk, Lviv, Odessa, and Stryi) of Ukraine. Operations were classified into the following categories: adult brain tumors (n = 39), adult spine tumors (n = 1), epilepsy (n = 9), pain (n = 2), pediatric brain tumors (n = 11), vascular/endovascular (n = 10), and miscellaneous (n = 12). Four illustrative cases are described in detail. Of the patients with brain tumors, 43.5% (20/46) had giant tumors, and gross total resection or near-total resection was achieved in 78.3% (36/46).
    Conclusions: Profound disparities in neurosurgical care exist globally, which has led to the formation of collaborative relationships between physicians from various countries. We hope that the work of the Co-Pilot Project in Ukraine can serve as a template for effective international neurosurgical collaboration in other low-to-middle-income countries.
    Language English
    Publishing date 2020-12-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2534351-8
    ISSN 1878-8769 ; 1878-8750
    ISSN (online) 1878-8769
    ISSN 1878-8750
    DOI 10.1016/j.wneu.2020.12.100
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1159: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Intravenous ascorbic acid to prevent and treat cancer-associated sepsis?

    Ichim, Thomas E / Minev, Boris / Braciak, Todd / Luna, Brandon / Hunninghake, Ron / Mikirova, Nina A / Jackson, James A / Gonzalez, Michael J / Miranda-Massari, Jorge R / Alexandrescu, Doru T / Dasanu, Constantin A / Bogin, Vladimir / Ancans, Janis / Stevens, R Brian / Markosian, Boris / Koropatnick, James / Chen, Chien-Shing / Riordan, Neil H

    Journal of translational medicine

    2011  Volume 9, Page(s) 25

    Abstract: The history of ascorbic acid (AA) and cancer has been marked with controversy. Clinical studies evaluating AA in cancer outcome continue to the present day. However, the wealth of data suggesting that AA may be highly beneficial in addressing cancer- ... ...

    Abstract The history of ascorbic acid (AA) and cancer has been marked with controversy. Clinical studies evaluating AA in cancer outcome continue to the present day. However, the wealth of data suggesting that AA may be highly beneficial in addressing cancer-associated inflammation, particularly progression to systemic inflammatory response syndrome (SIRS) and multi organ failure (MOF), has been largely overlooked. Patients with advanced cancer are generally deficient in AA. Once these patients develop septic symptoms, a further decrease in ascorbic acid levels occurs. Given the known role of ascorbate in: a) maintaining endothelial and suppression of inflammatory markers; b) protection from sepsis in animal models; and c) direct antineoplastic effects, we propose the use of ascorbate as an adjuvant to existing modalities in the treatment and prevention of cancer-associated sepsis.
    MeSH term(s) Ascorbic Acid/administration & dosage ; Ascorbic Acid/pharmacology ; Ascorbic Acid/therapeutic use ; Ascorbic Acid Deficiency/complications ; Endothelium/drug effects ; Endothelium/physiopathology ; Humans ; Immunity/drug effects ; Injections, Intravenous ; Neoplasms/complications ; Sepsis/drug therapy ; Sepsis/etiology ; Sepsis/physiopathology ; Sepsis/prevention & control
    Chemical Substances Ascorbic Acid (PQ6CK8PD0R)
    Language English
    Publishing date 2011-03-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 2118570-0
    ISSN 1479-5876 ; 1479-5876
    ISSN (online) 1479-5876
    ISSN 1479-5876
    DOI 10.1186/1479-5876-9-25
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Intravenous ascorbic acid to prevent and treat cancer-associated sepsis?

    Bogin Vladimir / Ancans Janis / Dasanu Constantin A / Alexandrescu Doru T / Miranda-Massari Jorge R / Gonzalez Michael J / Jackson James A / Mikirova Nina A / Hunninghake Ron / Luna Brandon / Braciak Todd / Minev Boris / Ichim Thomas E / Stevens R Brian / Markosian Boris / Koropatnick James / Chen Chien-Shing / Riordan Neil H

    Journal of Translational Medicine, Vol 9, Iss 1, p

    2011  Volume 25

    Abstract: Abstract The history of ascorbic acid (AA) and cancer has been marked with controversy. Clinical studies evaluating AA in cancer outcome continue to the present day. However, the wealth of data suggesting that AA may be highly beneficial in addressing ... ...

    Abstract Abstract The history of ascorbic acid (AA) and cancer has been marked with controversy. Clinical studies evaluating AA in cancer outcome continue to the present day. However, the wealth of data suggesting that AA may be highly beneficial in addressing cancer-associated inflammation, particularly progression to systemic inflammatory response syndrome (SIRS) and multi organ failure (MOF), has been largely overlooked. Patients with advanced cancer are generally deficient in AA. Once these patients develop septic symptoms, a further decrease in ascorbic acid levels occurs. Given the known role of ascorbate in: a) maintaining endothelial and suppression of inflammatory markers; b) protection from sepsis in animal models; and c) direct antineoplastic effects, we propose the use of ascorbate as an adjuvant to existing modalities in the treatment and prevention of cancer-associated sepsis.
    Keywords Medicine ; R
    Language English
    Publishing date 2011-03-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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