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  1. Article: Omalizumab has a place in therapy for asthma disease management.

    Pesko, Lawrence J

    Journal of managed care pharmacy : JMCP

    2009  Volume 15, Issue 3, Page(s) 284–288

    MeSH term(s) Adolescent ; Adult ; Anti-Asthmatic Agents/therapeutic use ; Antibodies, Anti-Idiotypic ; Antibodies, Monoclonal/therapeutic use ; Antibodies, Monoclonal, Humanized ; Asthma/drug therapy ; Humans ; Injections, Subcutaneous ; Omalizumab ; Practice Guidelines as Topic
    Chemical Substances Anti-Asthmatic Agents ; Antibodies, Anti-Idiotypic ; Antibodies, Monoclonal ; Antibodies, Monoclonal, Humanized ; Omalizumab (2P471X1Z11)
    Language English
    Publishing date 2009-04-15
    Publishing country United States
    Document type Comment ; Journal Article
    ZDB-ID 2022394-8
    ISSN 1944-706X ; 1083-4087
    ISSN (online) 1944-706X
    ISSN 1083-4087
    DOI 10.18553/jmcp.2009.15.3.284
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5450: Show issues Location:
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  2. Article ; Online: Association Between Patients' Self-Reported Gaps in Care Coordination and Preventable Adverse Outcomes: a Cross-Sectional Survey.

    Kern, Lisa M / Reshetnyak, Evgeniya / Colantonio, Lisandro D / Muntner, Paul M / Rhodes, J David / Casalino, Lawrence P / Rajan, Mangala / Pesko, Michael / Pinheiro, Laura C / Safford, Monika M

    Journal of general internal medicine

    2020  Volume 35, Issue 12, Page(s) 3517–3524

    Abstract: Background: Whether patients' reports of gaps in care coordination reflect clinically significant problems is unclear.: Objective: To determine any association between patient-reported gaps in care coordination and patient-reported preventable ... ...

    Abstract Background: Whether patients' reports of gaps in care coordination reflect clinically significant problems is unclear.
    Objective: To determine any association between patient-reported gaps in care coordination and patient-reported preventable adverse outcomes.
    Design and participants: We administered a cross-sectional survey on experiences with healthcare to participants in the national Reasons for Geographic and Racial Differences in Stroke (REGARDS) study who were ≥ 65 years old. Of the 15,817 participants in REGARDS at the time of our survey (August 2017-November 2018), 11,138 completed the survey. We restricted the sample to participants who reported ≥ 2 ambulatory visits and ≥ 2 ambulatory providers in the past year (N = 7568).
    Main measures: We considered 7 gaps in ambulatory care coordination, elicited with previously validated questions. We considered 4 outcomes: (1) a test that was repeated because the doctor did not have the result of the first test, (2) a drug-drug interaction that occurred due to multiple prescribers, (3) an emergency department visit that could have been prevented by better communication among providers, and (4) a hospital admission that could have been prevented by better communication among providers. We used logistic regression to determine the association between ≥ 1 gap in care coordination and ≥ 1 preventable outcome, adjusting for potential confounders.
    Key results: The average age of the sample was 77.0 years; 55% were female, and 34% were African-American. More than one-third of participants (38.1%) reported ≥ 1 gap in care coordination and nearly one-tenth (9.8%) reported ≥ 1 preventable outcome. Having ≥ 1 gap in care coordination was associated with an increased odds of ≥ 1 preventable outcome (adjusted odds ratio 1.55; 95% confidence interval 1.33, 1.81).
    Conclusions: Participants' reports of gaps in care coordination were associated with an increased odds of preventable adverse outcomes. Future interventions should leverage patients' observations to detect and resolve gaps in care coordination.
    MeSH term(s) Aged ; Ambulatory Care ; Cross-Sectional Studies ; Emergency Service, Hospital ; Female ; Hospitalization ; Humans ; Male ; Self Report
    Language English
    Publishing date 2020-07-27
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 639008-0
    ISSN 1525-1497 ; 0884-8734
    ISSN (online) 1525-1497
    ISSN 0884-8734
    DOI 10.1007/s11606-020-06047-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2205: Show issues Location:
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  3. Article ; Online: Physician Networks and Ambulatory Care-sensitive Admissions.

    Casalino, Lawrence P / Pesko, Michael F / Ryan, Andrew M / Nyweide, David J / Iwashyna, Theodore J / Sun, Xuming / Mendelsohn, Jayme / Moody, James

    Medical care

    2015  Volume 53, Issue 6, Page(s) 534–541

    Abstract: Background: Research on the quality and cost of care traditionally focuses on individual physicians or medical groups. Social network theory suggests that the care a patient receives also depends on the network of physicians with whom a patient's ... ...

    Abstract Background: Research on the quality and cost of care traditionally focuses on individual physicians or medical groups. Social network theory suggests that the care a patient receives also depends on the network of physicians with whom a patient's physician is connected.
    Objectives: The objectives of the study are: (1) identify physician networks; (2) determine whether the rate of ambulatory care-sensitive hospital admissions (ACSAs) varies across networks--even different networks at the same hospital; and (3) determine the relationship between ACSA rates and network characteristics.
    Research design: We identified networks by applying network detection algorithms to Medicare 2008 claims for 987,000 beneficiaries in 5 states. We estimated a fixed-effects model to determine the relationship between networks and ACSAs and a multivariable model to determine the relationship between network characteristics and ACSAs.
    Results: We identified 417 networks. Mean size: 129 physicians; range, 26-963. In the fixed-effects model, ACSA rates varied significantly across networks: there was a 46% difference in rates between networks at the 25th and 75th performance percentiles. At 95% of hospitals with admissions from 2 networks, the networks had significantly different ACSA rates; the mean difference was 36% of the mean ACSA rate. Networks with a higher percentage of primary-care physicians and networks in which patients received care from a larger number of physicians had higher ACSA rates.
    Conclusions: Physician networks have a relationship with ACSAs that is independent of the physicians in the network. Physician networks could be an important focus for understanding variations in medical care and for intervening to improve care.
    MeSH term(s) Aged ; Aged, 80 and over ; Ambulatory Care/organization & administration ; Community Networks/organization & administration ; Continental Population Groups ; Female ; Hospitals/statistics & numerical data ; Humans ; Male ; Medicare/statistics & numerical data ; Physicians, Primary Care/statistics & numerical data ; Referral and Consultation/statistics & numerical data ; United States
    Language English
    Publishing date 2015-06
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 411646-x
    ISSN 1537-1948 ; 0025-7079
    ISSN (online) 1537-1948
    ISSN 0025-7079
    DOI 10.1097/MLR.0000000000000365
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 518: Show issues Location:
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    Zs.MO 63: Show issues

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  4. Article ; Online: Postdischarge Communication Between Home Health Nurses and Physicians: Measurement, Quality, and Outcomes.

    Press, Matthew J / Gerber, Linda M / Peng, Timothy R / Pesko, Michael F / Feldman, Penny H / Ouchida, Karin / Sridharan, Sridevi / Bao, Yuhua / Barron, Yolanda / Casalino, Lawrence P

    Journal of the American Geriatrics Society

    2015  Volume 63, Issue 7, Page(s) 1299–1305

    Abstract: Objectives: To use natural language processing (NLP) of text from electronic medical records (EMRs) to identify failed communication attempts between home health nurses and physicians, to identify predictors of communication failure, and to assess the ... ...

    Abstract Objectives: To use natural language processing (NLP) of text from electronic medical records (EMRs) to identify failed communication attempts between home health nurses and physicians, to identify predictors of communication failure, and to assess the association between communication failure and hospital readmission.
    Design: Retrospective cohort study.
    Setting: Visiting Nurse Service of New York (VNSNY), the nation's largest freestanding home health agency.
    Participants: Medicare beneficiaries with congestive heart failure who received home health care from VNSNY after hospital discharge in 2008-09 (N = 5,698).
    Measurements: Patient-level measures of communication failure and risk-adjusted 30-day all-cause readmission.
    Results: Identification of failed communication attempts using NLP had high external validity (kappa = 0.850, P < .001). A mean of 8% of communication attempts failed per episode of home care; failure rates were higher for black patients and lower for patients from higher median income ZIP codes. The association between communication failure and readmission was not significant with adjustment for patient, nurse, physician, and hospital factors.
    Conclusion: NLP of EMRs can be used to identify failed communication attempts between home health nurses and physicians, but other variables mostly explained the association between communication failure and readmission. Communication failures may contribute to readmissions in more-serious clinical situations, an association that this study may have been underpowered to detect.
    MeSH term(s) Aged, 80 and over ; Algorithms ; Electronic Health Records ; Female ; Heart Failure/nursing ; Humans ; Interdisciplinary Communication ; Male ; Medicare ; Natural Language Processing ; New York ; Nurses, Community Health ; Physicians ; Quality Assurance, Health Care ; Retrospective Studies ; Treatment Outcome ; United States
    Language English
    Publishing date 2015-07
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80363-7
    ISSN 1532-5415 ; 0002-8614
    ISSN (online) 1532-5415
    ISSN 0002-8614
    DOI 10.1111/jgs.13491
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Targeting BCL-2 with venetoclax and dexamethasone in patients with relapsed/refractory t(11;14) multiple myeloma.

    Kaufman, Jonathan L / Gasparetto, Cristina / Schjesvold, Fredrik H / Moreau, Philippe / Touzeau, Cyrille / Facon, Thierry / Boise, Lawrence H / Jiang, Yanwen / Yang, Xiaoqing / Dunbar, Fengjiao / Vishwamitra, Deeksha / Unger, Stefanie / Macartney, Tammy / Pesko, John / Yu, Yao / Salem, Ahmed Hamed / Ross, Jeremy A / Hong, Wan-Jen / Maciag, Paulo C /
    Pauff, James M / Kumar, Shaji

    American journal of hematology

    2021  Volume 96, Issue 4, Page(s) 418–427

    Abstract: Venetoclax (Ven) is a selective small-molecule inhibitor of BCL-2 that exhibits antitumoral activity against MM cells with t(11;14) translocation. We evaluated the safety and efficacy of Ven and dexamethasone (VenDex) combination in patients with t(11;14) ...

    Abstract Venetoclax (Ven) is a selective small-molecule inhibitor of BCL-2 that exhibits antitumoral activity against MM cells with t(11;14) translocation. We evaluated the safety and efficacy of Ven and dexamethasone (VenDex) combination in patients with t(11;14) positive relapsed/refractory (R/R) multiple myeloma (MM). This open-label, multicenter study had two distinct phases (phase one [P1], phase two [P2]). Patients in both phases received VenDex (oral Ven 800 mg/day + oral Dex 40 mg [20 mg for patients ≥75 years] on days 1, 8, and 15, per 21-day cycle). The primary objective of the P1 VenDex cohort was to assess safety and pharmacokinetics. Phase two further evaluated efficacy with objective response rate (ORR) and very good partial response or better. Correlative studies explored baseline BCL2 (BCL-2) and BCL2L1 (BCL-X
    MeSH term(s) Aged ; Antibodies, Monoclonal/pharmacology ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Antineoplastic Combined Chemotherapy Protocols/pharmacokinetics ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Bone Marrow/pathology ; Bridged Bicyclo Compounds, Heterocyclic/administration & dosage ; Bridged Bicyclo Compounds, Heterocyclic/adverse effects ; Bridged Bicyclo Compounds, Heterocyclic/pharmacokinetics ; Bridged Bicyclo Compounds, Heterocyclic/pharmacology ; Chromosomes, Human, Pair 11/genetics ; Chromosomes, Human, Pair 14/genetics ; Combined Modality Therapy ; Dexamethasone/administration & dosage ; Female ; Follow-Up Studies ; Genes, bcl-2 ; Hematologic Diseases/chemically induced ; Hematopoietic Stem Cell Transplantation ; Humans ; Infections/etiology ; Kaplan-Meier Estimate ; Male ; Middle Aged ; Multiple Myeloma/drug therapy ; Multiple Myeloma/genetics ; Multiple Myeloma/therapy ; Neoplasm Proteins/antagonists & inhibitors ; Proto-Oncogene Proteins c-bcl-2/antagonists & inhibitors ; Recurrence ; Salvage Therapy ; Signal Transduction ; Sulfonamides/administration & dosage ; Sulfonamides/adverse effects ; Sulfonamides/pharmacokinetics ; Sulfonamides/pharmacology ; Translocation, Genetic ; bcl-X Protein
    Chemical Substances Antibodies, Monoclonal ; BCL2L1 protein, human ; Bridged Bicyclo Compounds, Heterocyclic ; Neoplasm Proteins ; Proto-Oncogene Proteins c-bcl-2 ; Sulfonamides ; bcl-X Protein ; daratumumab (4Z63YK6E0E) ; Dexamethasone (7S5I7G3JQL) ; venetoclax (N54AIC43PW)
    Language English
    Publishing date 2021-01-19
    Publishing country United States
    Document type Clinical Trial, Phase I ; Clinical Trial, Phase II ; Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 196767-8
    ISSN 1096-8652 ; 0361-8609
    ISSN (online) 1096-8652
    ISSN 0361-8609
    DOI 10.1002/ajh.26083
    Database MEDical Literature Analysis and Retrieval System OnLINE

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