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  1. Article ; Online: Re: Herjan J.T. Coelingh Bennink, Jean-Michel Foidart, Frans M.J. Debruyne. Treatment of Serious COVID-19 with Testosterone Suppression and High-dose Estrogen Therapy. Eur Urol. In press. https://doi.org/10.1016/j.eururo.2021.06.024.

    Kazybay, Bexultan / Xie, Yingqiu

    European urology

    2021  Volume 80, Issue 5, Page(s) e115–e116

    MeSH term(s) COVID-19 ; Estrogens ; Humans ; Male ; Prostatic Neoplasms ; SARS-CoV-2 ; Testosterone
    Chemical Substances Estrogens ; Testosterone (3XMK78S47O)
    Language English
    Publishing date 2021-08-17
    Publishing country Switzerland
    Document type Letter ; Comment
    ZDB-ID 193790-x
    ISSN 1873-7560 ; 1421-993X ; 0302-2838
    ISSN (online) 1873-7560 ; 1421-993X
    ISSN 0302-2838
    DOI 10.1016/j.eururo.2021.08.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1247: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 294: Show issues

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  2. Article ; Online: Urgency of COVID-19 vaccination in adolescents: Androgen and estrogen receptors view.

    Kazybay, Bexultan / Ahmad, Ashfaq / Xie, Yingqiu

    Travel medicine and infectious disease

    2022  Volume 47, Page(s) 102306

    MeSH term(s) Adolescent ; Androgens ; COVID-19/prevention & control ; COVID-19 Vaccines ; Humans ; Receptors, Estrogen ; Vaccination
    Chemical Substances Androgens ; COVID-19 Vaccines ; Receptors, Estrogen
    Language English
    Publishing date 2022-03-05
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 2170891-5
    ISSN 1873-0442 ; 1477-8939
    ISSN (online) 1873-0442
    ISSN 1477-8939
    DOI 10.1016/j.tmaid.2022.102306
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6236: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Recent advances to enhance the immunomodulatory potential of mesenchymal stem cells.

    Sarsenova, Madina / Kim, Yevgeniy / Raziyeva, Kamila / Kazybay, Bexultan / Ogay, Vyacheslav / Saparov, Arman

    Frontiers in immunology

    2022  Volume 13, Page(s) 1010399

    Abstract: Considering the unique therapeutic potential of mesenchymal stem cells (MSCs), including their immunosuppressive and immunomodulatory properties as well as their ability to improve tissue regeneration, these cells have attracted the attention of ... ...

    Abstract Considering the unique therapeutic potential of mesenchymal stem cells (MSCs), including their immunosuppressive and immunomodulatory properties as well as their ability to improve tissue regeneration, these cells have attracted the attention of scientists and clinicians for the treatment of different inflammatory and immune system mediated disorders. However, various clinical trials using MSCs for the therapeutic purpose are conflicting and differ from the results of promising preclinical studies. This inconsistency is caused by several factors such as poor migration and homing capacities, low survival rate, low level of proliferation and differentiation, and donor-dependent variation of the cells. Enhancement and retention of persistent therapeutic effects of the cells remain a challenge to overcome in MSC-based therapy. In this review, we summarized various approaches to enhance the clinical outcomes of MSC-based therapy as well as revised current and future perspectives for the creation of cellular products with improved potential for diverse clinical applications.
    MeSH term(s) Cell Differentiation ; Immunomodulation ; Mesenchymal Stem Cells
    Language English
    Publishing date 2022-09-23
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2022.1010399
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Omicron N501Y mutation among SARS-CoV-2 lineages: Insilico analysis of potent binding to tyrosine kinase and hypothetical repurposed medicine.

    Kazybay, Bexultan / Ahmad, Ashfaq / Mu, Chenglin / Mengdesh, Diana / Xie, Yingqiu

    Travel medicine and infectious disease

    2021  Volume 45, Page(s) 102242

    Abstract: Variants of SARS-CoV-2 lineages including the most recently circulated Omicron, and previous pandemic B.1.351, B.1.1.7, which have been public concerns, contain a N501Y mutation located in the spike receptor binding domain. However, the potential ... ...

    Abstract Variants of SARS-CoV-2 lineages including the most recently circulated Omicron, and previous pandemic B.1.351, B.1.1.7, which have been public concerns, contain a N501Y mutation located in the spike receptor binding domain. However, the potential interactions with host cells linking N501Y mutation to pathogenic relevance remain elusive. Recently, we and others report that kinases such as PI3K/AKT signaling are essential in SARS-CoV-2 entry. Here we analyzed the predicted potential kinases interacting with the mutation. Bioinformatics tools including structure-prediction based molecular docking analysis were applied. We found kinases such as EGFR might potentially act as new factors involving the N501Y mutation binding through possible phosphorylation at Y501 and enhanced affinity in certain variants. To our surprise, the Omicron receptor binding domain harboring N501Y mutation did not enhance binding to EGFR which might be due to the mutations of charged polar to uncharged polar side chains located on the interaction interfaces. Similarly, potent gains of phosphorylation in B.1.351 and B.1.1.7 by mutations were predicted and interaction networks were analyzed with enrichment of pathways. Given kinases might be elevated in cancer patients, the N501Y mutation containing lineages may be possibly much more infectious and additional care for cancer management might be taken into consideration by precision prevention, therapy or recovery.
    MeSH term(s) COVID-19 ; Humans ; Molecular Docking Simulation ; Mutation ; Phosphatidylinositol 3-Kinases ; Protein-Tyrosine Kinases ; SARS-CoV-2 ; Spike Glycoprotein, Coronavirus
    Chemical Substances Spike Glycoprotein, Coronavirus ; Protein-Tyrosine Kinases (EC 2.7.10.1)
    Language English
    Publishing date 2021-12-17
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2170891-5
    ISSN 1873-0442 ; 1477-8939
    ISSN (online) 1873-0442
    ISSN 1477-8939
    DOI 10.1016/j.tmaid.2021.102242
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6236: Show issues Location:
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  5. Article ; Online: Network Pharmacology with Experimental Investigation of the Mechanisms of

    Kazybay, Bexultan / Sun, Qinglei / Dukenbayev, Kanat / Nurkesh, Ayan Amantaiuly / Xu, Na / Kutzhanova, Aidana / Razbekova, Madina / Kabylda, Anar / Yang, Qing / Wang, Qian / Ma, Cuiping / Xie, Yingqiu

    ACS omega

    2022  Volume 7, Issue 17, Page(s) 14465–14477

    Abstract: A combination therapy ... ...

    Abstract A combination therapy of
    Language English
    Publishing date 2022-04-18
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.1c03018
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Nano-evolution and protein-based enzymatic evolution predicts novel types of natural product nanozymes of traditional Chinese medicine: cases of herbzymes of Taishan-Huangjing (

    Nazarbek, Guldan / Kutzhanova, Aidana / Nurtay, Lazzat / Mu, Chenglin / Kazybay, Bexultan / Li, Xugang / Ma, Cuiping / Amin, Amr / Xie, Yingqiu

    Nanoscale advances

    2021  Volume 3, Issue 23, Page(s) 6728–6738

    Abstract: Nanozymes and natural product-derived herbzymes have been identified in different types of enzymes simulating the natural protein-based enzyme function. How to explore and predict enzyme types of novel nanozymes when synthesized remains elusive. An ... ...

    Abstract Nanozymes and natural product-derived herbzymes have been identified in different types of enzymes simulating the natural protein-based enzyme function. How to explore and predict enzyme types of novel nanozymes when synthesized remains elusive. An informed analysis might be useful for the prediction. Here, we applied a protein-evolution analysis method to predict novel types of enzymes with experimental validation. First, reported nanozymes were analyzed by chemical classification and nano-evolution. We found that nanozymes are predominantly classified as protein-based EC1 oxidoreductase. In comparison, we analyzed the evolution of protein-based natural enzymes by a phylogenetic tree and the most conserved enzymes were found to be peroxidase and lyase. Therefore, the natural products of
    Language English
    Publishing date 2021-08-12
    Publishing country England
    Document type Journal Article
    ISSN 2516-0230
    ISSN (online) 2516-0230
    DOI 10.1039/d1na00475a
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Network pharmacology and experimental investigation of

    Xie, Yingqiu / Mu, Chengling / Kazybay, Bexultan / Sun, Qinglei / Kutzhanova, Aidana / Nazarbek, Guldan / Xu, Na / Nurtay, Lazzat / Wang, Qian / Amin, Amr / Li, Xugang

    Drug delivery

    2021  Volume 28, Issue 1, Page(s) 2187–2197

    Abstract: ... Rhizoma ... ...

    Abstract Rhizoma polygonati
    MeSH term(s) Cell Enlargement/drug effects ; Cell Line, Tumor ; Drugs, Chinese Herbal/pharmacology ; Humans ; Network Pharmacology/methods ; Plant Extracts/pharmacology ; Polygonatum ; Protein Interaction Maps ; Proto-Oncogene Proteins c-akt/drug effects ; TOR Serine-Threonine Kinases/drug effects
    Chemical Substances Drugs, Chinese Herbal ; Plant Extracts ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; TOR Serine-Threonine Kinases (EC 2.7.11.1)
    Language English
    Publishing date 2021-10-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 1213261-5
    ISSN 1521-0464 ; 1071-7544
    ISSN (online) 1521-0464
    ISSN 1071-7544
    DOI 10.1080/10717544.2021.1977422
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4252: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Network pharmacology and experimental investigation of Rhizoma polygonati extract targeted kinase with herbzyme activity for potent drug delivery

    Yingqiu Xie / Chengling Mu / Bexultan Kazybay / Qinglei Sun / Aidana Kutzhanova / Guldan Nazarbek / Na Xu / Lazzat Nurtay / Qian Wang / Amr Amin / Xugang Li

    Drug Delivery, Vol 28, Iss 1, Pp 2187-

    2021  Volume 2197

    Abstract: Rhizoma polygonati (Huangjing, RP) has been used for a long history with many chemical components in inducing anti-cancer, anti-aging, anti-diabetes, anti-fatigue, and more prevention of diseases or acts as nutrition sources in food. Here we investigated ...

    Abstract Rhizoma polygonati (Huangjing, RP) has been used for a long history with many chemical components in inducing anti-cancer, anti-aging, anti-diabetes, anti-fatigue, and more prevention of diseases or acts as nutrition sources in food. Here we investigated RP extract combination with kinase inhibitors in anti-cell growth and blockade in pathways targeting kinases. Experimental investigation and network pharmacology analysis were applied to test the potent kinase-mediated signaling. Herbzyme activity was determined by substrate with optical density measurement. Extract of processed RP inhibits cell growth in a much greater manner than alone when applied in combination with inhibitors of mTOR or EGFR. Moreover, processing methods of RP from Mount Tai (RP-Mount Tai) play essential roles in herbzyme activity of phosphatase suggesting the interface is also essential, in addition to the chemical component. The network pharmacology analysis showed the chemical component and target networks involving AKT and mTOR, which is consistent with experimental validation. Finally, EGFR inhibitor could be associated with nano-extract of RP-Mount Tai but not significantly affects the phosphatase herbzyme activity in vitro. Thus the processed extract of RP-Mount Tai may play a dual role in the inhibition of cell proliferation signaling by both chemical component and nanoscale herbzyme of phosphatase activity to inhibit kinases including mTOR/AKT in potent drug delivery of kinase inhibitors.
    Keywords huangjing ; herbzyme ; traditional chinese medicine ; Therapeutics. Pharmacology ; RM1-950
    Subject code 500
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher Taylor & Francis Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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