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  1. Article: Broad Anti-Viral Capacities of Lian-Hua-Qing-Wen Capsule and Jin-Hua-Qing-Gan Granule and Rational use Against COVID-19 Based on Literature Mining.

    Shi, Mingfei / Peng, Bo / Li, An / Li, Ziyun / Song, Ping / Li, Jing / Xu, Ruodan / Li, Ning

    Frontiers in pharmacology

    2021  Volume 12, Page(s) 640782

    Abstract: ... relatively better clinical outcomes. Both Lian-Hua-Qing-Wen Capsule (LHQWC) and Jin-Hua-Qing-Gan Granule ...

    Abstract The novel coronavirus disease 2019 (COVID-19) has become a matter of international concern as the disease is spreading exponentially. Statistics showed that infected patients in China who received combined treatment of Traditional Chinese Medicine and modern medicine exhibited lower fatality rate and relatively better clinical outcomes. Both Lian-Hua-Qing-Wen Capsule (LHQWC) and Jin-Hua-Qing-Gan Granule (JHQGG) have been recommended by China Food and Drug Administration for the treatment of COVID-19 and have played a vital role in the prevention of a variety of viral infections. Here, we desired to analyze the broad-spectrum anti-viral capacities of LHQWC and JHQGG, and to compare their pharmacological functions for rational clinical applications. Based on literature mining, we found that both LHQWC and JHQGG were endowed with multiple antiviral activities by both targeting viral life cycle and regulating host immune responses and inflammation. In addition, from literature analyzed, JHQGG is more potent in modulating viral life cycle, whereas LHQWC exhibits better efficacies in regulating host anti-viral responses. When translating into clinical applications, oral administration of LHQWC could be more beneficial for patients with insufficient immune functions or for patients with alleviated symptoms after treatment with JHQGG.
    Language English
    Publishing date 2021-05-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2021.640782
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Safety and immunogenicity of COVID-19 vaccination in immunocompromised patients.

    Song, Jin-Wen / Hu, Wei / Shen, Lili / Wang, Fu-Sheng

    Chinese medical journal

    2022  Volume 135, Issue 22, Page(s) 2656–2666

    Abstract: Abstract: The coronavirus disease 2019 (COVID-19) pandemic poses a great threat to public health. Individuals who are immunocompromised because of the progression of the primary disease or receiving immunosuppressive medications are prone to severe ... ...

    Abstract Abstract: The coronavirus disease 2019 (COVID-19) pandemic poses a great threat to public health. Individuals who are immunocompromised because of the progression of the primary disease or receiving immunosuppressive medications are prone to severe COVID-19 complications and poor outcomes. Abundant data have shown that many COVID-19 vaccines are safe and effective in large-scale populations; however, these clinical trials have excluded immunocompromised populations. Available evidence indicates that immunocompromised populations have a blunted immune response to other vaccines, raising concerns regarding the efficacy of COVID-19 vaccination in these populations. Thus, there is an urgent need to delineate the efficacy of COVID-19 vaccines in these vulnerable populations. Here, we review the characteristics of specific humoral and cellular responses to COVID-19 vaccination in immunocompromised populations, including HIV-infected patients and those receiving immunosuppressive treatment, especially solid organ transplant recipients and those undergoing anti-CD20 treatment. We also addressed the challenges that immunocompromised populations will face in the future pandemic and the need for basic and clinical translational studies to highlight the best vaccination strategies for these populations.
    MeSH term(s) Humans ; COVID-19/prevention & control ; COVID-19 Vaccines/adverse effects ; Immunocompromised Host ; Immunosuppressive Agents/adverse effects ; Vaccination
    Chemical Substances COVID-19 Vaccines ; Immunosuppressive Agents
    Language English
    Publishing date 2022-11-20
    Publishing country China
    Document type Review ; Journal Article
    ZDB-ID 127089-8
    ISSN 2542-5641 ; 0366-6999 ; 1002-0187
    ISSN (online) 2542-5641
    ISSN 0366-6999 ; 1002-0187
    DOI 10.1097/CM9.0000000000002505
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 1207: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Ua VI Zs.425: Show issues Location:
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  3. Article: A Meta-Analysis of Growth Differentiation Factor-15 and Prognosis in Chronic Heart Failure.

    Luo, Jin-Wen / Duan, Wen-Hui / Song, Lei / Yu, Yan-Qiao / Shi, Da-Zhuo

    Frontiers in cardiovascular medicine

    2021  Volume 8, Page(s) 630818

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2021-11-05
    Publishing country Switzerland
    Document type Systematic Review
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2021.630818
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Prognostic Significance of Triglyceride-Glucose Index for Adverse Cardiovascular Events in Patients With Coronary Artery Disease: A Systematic Review and Meta-Analysis.

    Luo, Jin-Wen / Duan, Wen-Hui / Yu, Yan-Qiao / Song, Lei / Shi, Da-Zhuo

    Frontiers in cardiovascular medicine

    2021  Volume 8, Page(s) 774781

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2021-12-02
    Publishing country Switzerland
    Document type Systematic Review
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2021.774781
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: 

    Jin, Guang-Zhao / Sheludyakova, Mariya / Li, Wen-Jun / Song, Feng / Wen, Zhi-Bin / Feng, Ying

    PhytoKeys

    2023  Volume 229, Page(s) 229–239

    Abstract: ... ...

    Abstract Artemisiaqingheensis
    Language English
    Publishing date 2023-08-02
    Publishing country Bulgaria
    Document type Journal Article
    ZDB-ID 2579891-1
    ISSN 1314-2003 ; 1314-2011
    ISSN (online) 1314-2003
    ISSN 1314-2011
    DOI 10.3897/phytokeys.229.101689
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Safety and immunogenicity of COVID-19 vaccination in immunocompromised patients

    Jin-Wen Song / Wei Hu / Lili Shen / Fu-Sheng Wang / Yanjie Yin

    Chinese Medical Journal, Vol 135, Iss 22, Pp 2656-

    2022  Volume 2666

    Abstract: Abstract. The coronavirus disease 2019 (COVID-19) pandemic poses a great threat to public health. Individuals who are immunocompromised because of the progression of the primary disease or receiving immunosuppressive medications are prone to severe COVID- ...

    Abstract Abstract. The coronavirus disease 2019 (COVID-19) pandemic poses a great threat to public health. Individuals who are immunocompromised because of the progression of the primary disease or receiving immunosuppressive medications are prone to severe COVID-19 complications and poor outcomes. Abundant data have shown that many COVID-19 vaccines are safe and effective in large-scale populations; however, these clinical trials have excluded immunocompromised populations. Available evidence indicates that immunocompromised populations have a blunted immune response to other vaccines, raising concerns regarding the efficacy of COVID-19 vaccination in these populations. Thus, there is an urgent need to delineate the efficacy of COVID-19 vaccines in these vulnerable populations. Here, we review the characteristics of specific humoral and cellular responses to COVID-19 vaccination in immunocompromised populations, including HIV-infected patients and those receiving immunosuppressive treatment, especially solid organ transplant recipients and those undergoing anti-CD20 treatment. We also addressed the challenges that immunocompromised populations will face in the future pandemic and the need for basic and clinical translational studies to highlight the best vaccination strategies for these populations.
    Keywords Medicine ; R
    Subject code 610
    Language English
    Publishing date 2022-11-01T00:00:00Z
    Publisher Wolters Kluwer
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  7. Article ; Online: Aberrant activated Notch1 promotes prostate enlargement driven by androgen signaling via disrupting mitochondrial function in mouse.

    Kang, Jin-Wen / He, Jia-Peng / Liu, Ying-Nan / Zhang, Yu / Song, Shan-Shan / Xu, Qi-Xin / Wei, Shu-Wen / Lu, Lei / Meng, Xiang-Qi / Xu, Lin / Guo, Bin / Su, Ren-Wei

    Cellular and molecular life sciences : CMLS

    2024  Volume 81, Issue 1, Page(s) 155

    Abstract: The prostate is a vital accessory gonad in the mammalian male reproductive system. With the ever-increasing proportion of the population over 60 years of age worldwide, the incidence of prostate diseases, such as benign prostatic hyperplasia (BPH) and ... ...

    Abstract The prostate is a vital accessory gonad in the mammalian male reproductive system. With the ever-increasing proportion of the population over 60 years of age worldwide, the incidence of prostate diseases, such as benign prostatic hyperplasia (BPH) and prostate cancer (PCa), is on the rise and is gradually becoming a significant medical problem globally. The notch signaling pathway is essential in regulating prostate early development. However, the potential regulatory mechanism of Notch signaling in prostatic enlargement and hyperplasia remains unclear. In this study, we proved that overactivation of Notch1 signaling in mouse prostatic epithelial cells (OEx) led to prostatic enlargement via enhancing proliferation and inhibiting apoptosis of prostatic epithelial cells. Further study showed that N1ICD/RBPJ directly up-regulated the androgen receptor (AR) and enhanced prostatic sensitivity to androgens. Hyper-proliferation was not found in orchidectomized OEx mice without androgen supply but was observed after Dihydrotestosterone (DHT) supplementation. Our data showed that the number of mitochondrion in prostatic epithelial cells of OEx mice was increased, but the mitochondrial function was impaired, and the essential activity of the mitochondrial respiratory electron transport chain was significantly weakened. Disordered mitochondrial number and metabolic function further resulted in excessive accumulation of reactive oxygen species (ROS). Importantly, anti-oxidant N-Acetyl-L-Cysteine (NAC) therapy could alleviate prostatic hyperplasia caused by the over-activation of Notch1 signaling. Furthermore, we observed the incremental Notch signaling activity in progenitor-like club cells in the scRNA-seq data set of human BPH patients. Moreover, the increased number of TROP2
    MeSH term(s) Animals ; Humans ; Male ; Mice ; Androgens/metabolism ; Mammals/metabolism ; Mitochondria/metabolism ; Prostate/metabolism ; Prostatic Hyperplasia/metabolism ; Reactive Oxygen Species/metabolism ; Receptors, Androgen/genetics ; Receptors, Androgen/metabolism ; Signal Transduction
    Chemical Substances Androgens ; Reactive Oxygen Species ; Receptors, Androgen ; Notch1 protein, mouse
    Language English
    Publishing date 2024-03-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1358415-7
    ISSN 1420-9071 ; 1420-682X
    ISSN (online) 1420-9071
    ISSN 1420-682X
    DOI 10.1007/s00018-024-05143-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 195: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article: Potential co-infection of influenza A, influenza B, respiratory syncytial virus, and

    Feng, Yuanyuan / Wen, Shengzhu / Xue, Song / Hou, Meigui / Jin, Ying

    Frontiers in medicine

    2024  Volume 10, Page(s) 1325482

    Abstract: The occurrence of a co-infection involving four distinct respiratory pathogens could be underestimated. Here, we report the case of a 72-year-old woman who presented to a community hospital with a cough productive of sputum as her main clinical ... ...

    Abstract The occurrence of a co-infection involving four distinct respiratory pathogens could be underestimated. Here, we report the case of a 72-year-old woman who presented to a community hospital with a cough productive of sputum as her main clinical manifestation. Antibody detection of common respiratory pathogens revealed potential co-infection with influenza A, influenza B, respiratory syncytial virus, and
    Language English
    Publishing date 2024-01-08
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2023.1325482
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: The complete chloroplast genome of an endangered plant

    Jin, Guang-Zhao / Wen, Zhi-Bin / Song, Feng / Feng, Ying

    Mitochondrial DNA. Part B, Resources

    2023  Volume 8, Issue 1, Page(s) 145–148

    Abstract: Artemisia ... ...

    Abstract Artemisia borotalensis
    Language English
    Publishing date 2023-01-15
    Publishing country England
    Document type Journal Article
    ISSN 2380-2359
    ISSN (online) 2380-2359
    DOI 10.1080/23802359.2022.2163599
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Impact of Conventional Cardiovascular Risk Factors on Left Internal Mammary Artery Graft Disease.

    Zuo, Hui-Juan / Nan, Nan / Yang, Hong-Xia / Wang, Jin-Wen / Song, Xian-Tao

    Frontiers in cardiovascular medicine

    2022  Volume 8, Page(s) 705765

    Abstract: Background: The development of atherosclerosis was considered as the common cause of the stenosis of coronary artery grafts. Left internal mammary artery (LIMA) was the best artery graft for further effectiveness of coronary artery bypass grafting (CABG) ...

    Abstract Background: The development of atherosclerosis was considered as the common cause of the stenosis of coronary artery grafts. Left internal mammary artery (LIMA) was the best artery graft for further effectiveness of coronary artery bypass grafting (CABG). We sought to assess the impact of known conventional cardiovascular risk factors (RFs) on LIMA graft stenosis.
    Methods: A retrospective study including 618 participants, who had recurrence of chest pain after CABG, aged ≥18 years, hospitalized for coronary angiography in Beijing Anzhen hospital between 2010 and 2017 was performed. All the participants were confirmed to have LIMA graft. Multivariate analysis was conducted to determine the relationship between conventional RFs and LIMA graft stenosis.
    Results: Of the study, 220 (35.6%) participants continued to smoke, 504 (81.6%) were overweight or obese, and 411 (66.5%) and 242 (39.2%) reported concomitant hypertension and diabetes, respectively. LIMA graft stenosis occurred in 161 participants (26.1%). Postoperative smoking, a CABG duration of ≥10 years and hyperglycemia without diabetes had an increased risk of LIMA graft stenosis, the odds ratio (OR) was 1.86 [95% confidence interval (CI): 1.26-2.78], 2.24 (95%CI:1.33-3.478), and 2.44(95% CI:1.39-4.32), respectively. Statin use (OR, 0.28; 95% CI: 0.25-0.5) and low-density lipoprotein cholesterol (LDL-C) < 1.8 mmol/L (OR, 0.27; 95% CI: 0.14-0.53) had a significantly decreased risk of LIMA graft stenosis. While, only 15.4% (95/618) achieved the target LDL-C level.
    Conclusions: Postoperative smoking and hyperglycemia without diabetes had an increased risk of LIMA graft stenosis. Statin use and LDL-C <1.8 mmol/L decreased the risk.
    Language English
    Publishing date 2022-01-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2021.705765
    Database MEDical Literature Analysis and Retrieval System OnLINE

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