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  1. Article: On Determining the Age Distribution of COVID-19 Pandemic.

    Cortis, Dominic

    Frontiers in public health

    2020  Volume 8, Page(s) 202

    Abstract: Pandemics tend to have higher occurrence (morbidity) in younger individuals but higher mortality for the elderly. The higher rate of mortality of COVID-19 in elderly individuals has been discussed in many reports. However, this pandemic is a double-edged ...

    Abstract Pandemics tend to have higher occurrence (morbidity) in younger individuals but higher mortality for the elderly. The higher rate of mortality of COVID-19 in elderly individuals has been discussed in many reports. However, this pandemic is a double-edged sword as this comment shows higher morbidity rates in elderly as well. This is shown by comparing the age distribution of cases in China and South Korea to the relative populations. In every case, the relative number of elderly contracting the virus is far higher than the proportion of elderly in the population. This is unlike past pandemics and shows that aging populations are at an even higher risk than the perceived age dependent rates may imply.
    MeSH term(s) Adolescent ; Adult ; Age Distribution ; Aged ; COVID-19/epidemiology ; COVID-19/mortality ; Child ; Child, Preschool ; China/epidemiology ; Female ; Humans ; Middle Aged ; Republic of Korea/epidemiology ; Risk Factors ; Young Adult
    Keywords covid19
    Language English
    Publishing date 2020-05-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2711781-9
    ISSN 2296-2565
    ISSN 2296-2565
    DOI 10.3389/fpubh.2020.00202
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: On Determining the Age Distribution of COVID-19 Pandemic

    Dominic Cortis

    Frontiers in Public Health, Vol

    2020  Volume 8

    Abstract: Pandemics tend to have higher occurrence (morbidity) in younger individuals but higher mortality for the elderly. The higher rate of mortality of COVID-19 in elderly individuals has been discussed in many reports. However, this pandemic is a double-edged ...

    Abstract Pandemics tend to have higher occurrence (morbidity) in younger individuals but higher mortality for the elderly. The higher rate of mortality of COVID-19 in elderly individuals has been discussed in many reports. However, this pandemic is a double-edged sword as this comment shows higher morbidity rates in elderly as well. This is shown by comparing the age distribution of cases in China and South Korea to the relative populations. In every case, the relative number of elderly contracting the virus is far higher than the proportion of elderly in the population. This is unlike past pandemics and shows that aging populations are at an even higher risk than the perceived age dependent rates may imply.
    Keywords crude death rates ; COVID-19 ; age distribution ; South Korea ; China ; 2019 pandemic ; Public aspects of medicine ; RA1-1270 ; covid19
    Language English
    Publishing date 2020-05-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: On Determining the Age Distribution of COVID-19 Pandemic

    Cortis, Dominic

    Frontiers in Public Health

    2020  Volume 8

    Keywords covid19
    Publisher Frontiers Media SA
    Publishing country ch
    Document type Article ; Online
    ZDB-ID 2711781-9
    ISSN 2296-2565
    ISSN 2296-2565
    DOI 10.3389/fpubh.2020.00202
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article: Back to basics: measuring the impact of interventions to limit the spread of COVID-19 in Europe.

    Cortis, Dominic / Vella King, Fiona

    Archives of public health = Archives belges de sante publique

    2022  Volume 80, Issue 1, Page(s) 76

    Abstract: Background: Following the emergence of the COVID-19 pandemic in Europe at the start of 2020, most countries had implemented various measures in an attempt to control the spread of the virus. This study analyses the main non-pharmaceutical interventions ... ...

    Abstract Background: Following the emergence of the COVID-19 pandemic in Europe at the start of 2020, most countries had implemented various measures in an attempt to control the spread of the virus. This study analyses the main non-pharmaceutical interventions and their impact on the rate by which cumulative cases and deaths were growing in Europe during the first wave of this pandemic.
    Methods: The interventions analysed are the school closures, restrictions on travel, cancellation of events, restrictions on gatherings, partial and full lockdowns. Data was collected on the implementation date of these interventions, and the number of daily cases and deaths during the first wave of the pandemic for every country and territory geographically located in Europe. The study uses growth rates to calculate the increase in cumulative cases and deaths in Europe before, during, and after these interventions were implemented.
    Results: The results show that decisions to close schools, cancel events, and restrict travel were taken during the same time period, whereas the decisions for the other interventions were taken when the growth rates were similar. The most effective interventions at lowering the rate by which cumulative cases were increasing were the travel restrictions, school closures, and the partial lockdown, while most effective against cumulative deaths were the partial lockdown, travel restrictions, and full lockdown.
    Conclusion: All the interventions reduced the rate by which cumulative cases and deaths were increasing with the partial lockdowns being the most effective from the other interventions, during the first wave of the pandemic in Europe.
    Language English
    Publishing date 2022-03-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 1117688-x
    ISSN 2049-3258 ; 0778-7367 ; 0003-9578
    ISSN (online) 2049-3258
    ISSN 0778-7367 ; 0003-9578
    DOI 10.1186/s13690-022-00830-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: On Determining the Age Distribution of COVID-19 Pandemic

    Cortis, Dominic

    Front. Public Health

    Abstract: Pandemics tend to have higher occurrence (morbidity) in younger individuals but higher mortality for the elderly. The higher rate of mortality of COVID-19 in elderly individuals has been discussed in many reports. However, this pandemic is a double-edged ...

    Abstract Pandemics tend to have higher occurrence (morbidity) in younger individuals but higher mortality for the elderly. The higher rate of mortality of COVID-19 in elderly individuals has been discussed in many reports. However, this pandemic is a double-edged sword as this comment shows higher morbidity rates in elderly as well. This is shown by comparing the age distribution of cases in China and South Korea to the relative populations. In every case, the relative number of elderly contracting the virus is far higher than the proportion of elderly in the population. This is unlike past pandemics and shows that aging populations are at an even higher risk than the perceived age dependent rates may imply.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #609569
    Database COVID19

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  6. Article ; Online: Back to basics

    Dominic Cortis / Fiona Vella King

    Archives of Public Health, Vol 80, Iss 1, Pp 1-

    measuring the impact of interventions to limit the spread of COVID-19 in Europe

    2022  Volume 13

    Abstract: Abstract Background Following the emergence of the COVID-19 pandemic in Europe at the start of 2020, most countries had implemented various measures in an attempt to control the spread of the virus. This study analyses the main non-pharmaceutical ... ...

    Abstract Abstract Background Following the emergence of the COVID-19 pandemic in Europe at the start of 2020, most countries had implemented various measures in an attempt to control the spread of the virus. This study analyses the main non-pharmaceutical interventions and their impact on the rate by which cumulative cases and deaths were growing in Europe during the first wave of this pandemic. Methods The interventions analysed are the school closures, restrictions on travel, cancellation of events, restrictions on gatherings, partial and full lockdowns. Data was collected on the implementation date of these interventions, and the number of daily cases and deaths during the first wave of the pandemic for every country and territory geographically located in Europe. The study uses growth rates to calculate the increase in cumulative cases and deaths in Europe before, during, and after these interventions were implemented. Results The results show that decisions to close schools, cancel events, and restrict travel were taken during the same time period, whereas the decisions for the other interventions were taken when the growth rates were similar. The most effective interventions at lowering the rate by which cumulative cases were increasing were the travel restrictions, school closures, and the partial lockdown, while most effective against cumulative deaths were the partial lockdown, travel restrictions, and full lockdown. Conclusion All the interventions reduced the rate by which cumulative cases and deaths were increasing with the partial lockdowns being the most effective from the other interventions, during the first wave of the pandemic in Europe.
    Keywords Non-pharmaceutical interventions ; COVID-19 ; Europe ; Lockdown effectiveness ; Public aspects of medicine ; RA1-1270
    Subject code 940
    Language English
    Publishing date 2022-03-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article: Expected values and variances in bookmaker payouts

    Cortis, Dominic

    The journal of prediction markets Vol. 9, No. 1 , p. 1-14

    a theoretical approach towards setting limits on odds

    2015  Volume 9, Issue 1, Page(s) 1–14

    Author's details Dominic Cortis
    Keywords betting markets ; odds ; arbitrage ; multiples ; accumulators ; bookmakers
    Language English
    Size Ill.
    Publisher Univ. of Buckingham Press
    Publishing place Buckingham
    Document type Article
    ZDB-ID 2388613-4 ; 2272820-X
    ISSN 1750-676X ; 1750-6751
    ISSN (online) 1750-676X
    ISSN 1750-6751
    Database ECONomics Information System

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  8. Article ; Online: High-stakes hedges are misunderstood too. A commentary on

    Philip W. S. Newall / Dominic Cortis

    Judgment and Decision Making, Vol 14, Iss 5, Pp 605-

    “Valuing bets and hedges: Implications for the construct of risk preference”

    2019  Volume 607

    Abstract: Frederick, Levis, Malliaris and Meyer (2018) report a package of laboratory studies where participants underestimate the value of “hedges”: Risky bets which cancel out the risk of another presently-held bet. However, it might be questioned to what extent ...

    Abstract Frederick, Levis, Malliaris and Meyer (2018) report a package of laboratory studies where participants underestimate the value of “hedges”: Risky bets which cancel out the risk of another presently-held bet. However, it might be questioned to what extent laboratory findings predict field behavior. People might better understand hedges when more money is at stake, or when they have more time to reflect. We discuss three gamblers who, instead of hedging, used a costly “cash-out” option to eliminate the risk of their bets on Leicester FC’s improbable victory in the 2015/2016 English Premier League soccer season. The decision to cash-out rather than to hedge led to individual losses of up to £8,000, and did not seem plausibly explained by rational economic factors. High-stakes hedges are misunderstood too.
    Keywords gambling ; sports betting ; hedging ; cash-out ; soccerNAKeywords ; Social Sciences ; H ; Psychology ; BF1-990
    Subject code 910
    Language English
    Publishing date 2019-09-01T00:00:00Z
    Publisher Society for Judgment and Decision Making
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article: Intravitreal aflibercept (A-IVI) for the treatment of neovascular age-related macular degeneration (nv-AMD): one year experience.

    Papavasileiou, Evangelia / Zygoura, Vasiliki / Richardson, Theresa / Cortis, Dominic / Eleftheriadis, Haralabos / Jackson, Timothy L

    Hellenic journal of nuclear medicine

    2015  Volume 18 Suppl 1, Page(s) 29–32

    Abstract: Objective: To report the anatomical and functional results of intravitreal injections of aflibercept (Eylea) (A-IVI) for the treatment of naïve eyes with neovascular age-related macular degeneration (nv-AMD).: Subjects and methods: This retrospective, ...

    Abstract Objective: To report the anatomical and functional results of intravitreal injections of aflibercept (Eylea) (A-IVI) for the treatment of naïve eyes with neovascular age-related macular degeneration (nv-AMD).
    Subjects and methods: This retrospective, one-center, non-comparative chart review included 26 treatment naïve eyes with nv-AMD of 26 patients (14 male) with a mean age of 80.5 (range 63-91) who had a complete follow-up of 14 months. The morphological analysis included spectral domain optical coherence tomography and fundus fluorescein angiography, while the functional assessment included logarithm of the minimum angle of resolution (LogMAR) best correct visual acuity (BCVA). The timing of the follow-up was: baseline, 3, 6, and 14 months. All patients received 8 A-IVI according to the protocol (first 3 consecutive monthly A-IVI, followed by bi-monthly retreatment for the first year, regardless of disease activity as per local guidelines). Statistical analysis was performed using ANOVA. Improvement of visual acuity more than 15 letters was considered as "improvement", less than 5 letters as "stable" and any letter loss as "worsening".
    Results: Mean±standard deviation LogMAR visual acuity improved from 0.26±0.15 at presentation to 0.14±0.20 at the final follow-up of 14 months (P=0.02). BCVA was stable in 23.1%, improved in 61.5% (16 eyes) worsened in 15.4%. A mean pretreatment central macular thickness of 409μm reduced significantly to 229μm at month 14 (P<0.02). The OCT of eyes with worsened BCVA showed resolution of retinal fluid but presence of subretinal fibrosis. No adverse events were attributed to aflibercept.
    Conclusions: Patients who had a worsening in visual acuity were found to have longer duration of symptoms prior to treatment and presence of geographic atrophy, and/or subretinal haemorrhage and/or subretinal fibrosis at baseline. From our experience, with 14 months follow-up, A-IVI is an effective treatment for treatment naïve patients with nv-AMD. Our real world results were similar to pivotal trials.
    Language English
    Publishing date 2015-09
    Publishing country Greece
    Document type Journal Article
    ZDB-ID 2186026-9
    ISSN 1790-5427 ; 1108-1430
    ISSN 1790-5427 ; 1108-1430
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Real-world treatment of diabetic macular oedema: a comparison of combined ranibizumab plus macular LASER with macular LASER monotherapy.

    Zygoura, Vasiliki / Papavasileiou, Evangelia / Vavvas, Demetrios G / Cortis, Dominic / Eleftheriadis, Haralabos / Jackson, Timothy L

    Hellenic journal of nuclear medicine

    2015  Volume 18 Suppl 1, Page(s) 33–41

    Abstract: Objective: To study real world outcomes of ranibizumab (Lucentis) intravitreal injection in diabetic macular oedema (DMO).: Subjects and methods: We included 100 patients with DMO. Those who had optical coherence tomography central retinal thickness ( ...

    Abstract Objective: To study real world outcomes of ranibizumab (Lucentis) intravitreal injection in diabetic macular oedema (DMO).
    Subjects and methods: We included 100 patients with DMO. Those who had optical coherence tomography central retinal thickness (CRT) of 400μm or more (Group 1) underwent combination treatment with ranibizumab and macular LASER, while those with CRT less than 400μm (Group 2) had LASER monotherapy. The primary outcome measure was change in best corrected visual acuity (BCVA) from baseline. Secondary outcomes were change of CRT from baseline, the number of intravitreal injections in group one during the first and second year of follow-up and the proportion of LASER sessions in both groups at 2 years follow-up. Patients' lipid profile was compared to the presence and extent of macular hard exudates, quantified using masked readers and image analysis software.
    Results: Group 1 showed better outcomes in terms of BCVA and CRT compared to Group 2 during the two-year follow-up period. The mean number of ranibizumab intravitreal injections in Group 1 was reduced from 3.86 (standard deviation±1.37) in the first year to 2.02 in the second year. At 2 years, Group 1 had a higher proportion of individuals that had undergone 3 macular LASER treatments (4% Group 1, 28% Group 2). The presence of hard exudates was associated with higher total cholesterol (P=0.004 and P=0.041 group 1 and 2 respectively) and with higher low density lipoprotein (LDL) cholesterol (P=0.01 and P=0.045 respectively). The size of hard exudates was associated with higher total cholesterol (P=0.02 and P=0.03 respectively) and with higher LDL cholesterol (P=0.003 and P=0.01 respectively). Neither high density lipoprotein (HDL) cholesterol, nor triglycerides were related to the presence or size of hard exudates. No serious adverse events were attributed to either LASER or ranibizumab.
    Conclusions: Combination treatment of intravitreal ranibizumab injections and macular LASER appears safe and effective over two years. The need for injection declines over time. There is an association between higher levels of serum total and LDL cholesterol and the presence and the extent of hard exudates.
    Language English
    Publishing date 2015-09
    Publishing country Greece
    Document type Journal Article
    ZDB-ID 2186026-9
    ISSN 1790-5427 ; 1108-1430
    ISSN 1790-5427 ; 1108-1430
    Database MEDical Literature Analysis and Retrieval System OnLINE

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