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Article ; Online: Role of nanotechnology in facing SARS-CoV-2 pandemic: Solving crux of the matter with a hopeful arrow in the quiver.

Sivasankarapillai, Vishnu Sankar / Madaswamy, Suba Lakshmi / Dhanusuraman, Ragupathy

Sensors international

2021 Volume 2, Page(s) 100096

Abstract: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a positive-sense single-stranded RNA virus species with a zoonotic origin and responsible for the coronavirus disease 2019(COVID-19). This novel virus has an extremely high infectious rate, ... ...

Abstract	Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a positive-sense single-stranded RNA virus species with a zoonotic origin and responsible for the coronavirus disease 2019(COVID-19). This novel virus has an extremely high infectious rate, which occurs through the contact of contaminated surfaces and also by cough, sneeze, hand-to-mouth-to-eye contact with an affected person. The progression of infection, which goes beyond complications of pneumonia to affecting other physiological functions which cause gastrointestinal, Renal, and neurological complication makes this a life threatening condition. Intense efforts are going across the scientific community in elucidating various aspects of this virus, such as understanding the pathophysiology of the disease, molecular biology, and cellular pathways of viral replication. We hope that nanotechnology and material science can provide a significant contribution to tackle this problem through both diagnostic and therapeutic strategies. But the area is still in the budding phase, which needs urgent and significant attention. This review provides a brief idea regarding the various nanotechnological approaches reported for managing COVID-19 infection. The nanomaterials recently said to have good antiviral activities like Carbon nanotubes (CNTs) and quantum dots (QDs) were also discussed since they are also in the emerging stage of attaining research interest regarding antiviral applications.
Language	English
Publishing date	2021-04-25
Publishing country	Netherlands
Document type	Journal Article ; Review
ISSN	2666-3511
ISSN (online)	2666-3511
DOI	10.1016/j.sintl.2021.100096
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: One-pot green synthesis of ZnO nanoparticles using

Sivasankarapillai, Vishnu Sankar / Krishnamoorthy, Nishkala / Eldesoky, Gaber E / Wabaidur, Saikh Mohammad / Islam, Md Ataul / Dhanusuraman, Ragupathy / Ponnusamy, Vinoth Kumar

Applied nanoscience

2022 , Page(s) 1–11

Abstract: Nanostructured Zinc oxide (ZnO) materials have attained exciting research interests among various metal oxide nanoparticles due to their unique features. Thus, the scope of applications for ZnO nanoparticles (ZnO NPs) is vast and efficient. The current ... ...

Abstract	Nanostructured Zinc oxide (ZnO) materials have attained exciting research interests among various metal oxide nanoparticles due to their unique features. Thus, the scope of applications for ZnO nanoparticles (ZnO NPs) is vast and efficient. The current study demonstrates a simple and environmental-friendly approach for the synthesis of ZnO NPs using the extract of the
Language	English
Publishing date	2022-09-13
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2607723-1
ISSN	2190-5517 ; 2190-5509
ISSN (online)	2190-5517
ISSN	2190-5509
DOI	10.1007/s13204-022-02610-7
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Article ; Online: Recent advancements in the applications of carbon nanodots: exploring the rising star of nanotechnology.

Sivasankarapillai, Vishnu Sankar / Vishnu Kirthi, Arivarasan / Akksadha, Murugesan / Indu, Somasundaram / Dhiviya Dharshini, Udhayakumar / Pushpamalar, Janarthanan / Karthik, Loganathan

Nanoscale advances

2020 Volume 2, Issue 5, Page(s) 1760–1773

Abstract: Nanoparticles possess fascinating properties and applications, and there has been increasing critical consideration of their use. Because carbon is a component with immaterial cytotoxicity and extensive biocompatibility with different components, carbon ... ...

Abstract	Nanoparticles possess fascinating properties and applications, and there has been increasing critical consideration of their use. Because carbon is a component with immaterial cytotoxicity and extensive biocompatibility with different components, carbon nanomaterials have a wide scope of potential uses. Carbon nanodots are a type of carbon nanoparticle that is increasingly being researched because of their astounding properties such as extraordinary luminescence, simplicity of amalgamation and surface functionalization, and biocompatibility. Because of these properties, carbon nanodots can be used as material sensors, as indicators in fluorescent tests, and as nanomaterials for biomedical applications. In this review, we report on the ongoing and noteworthy utilization of carbon quantum dots such as bioimaging tests and photocatalytic applications. In addition, the extension and future components of these materials, which can be investigated for new potential applications, are discussed.
Language	English
Publishing date	2020-03-30
Publishing country	England
Document type	Journal Article ; Review
ISSN	2516-0230
ISSN (online)	2516-0230
DOI	10.1039/c9na00794f
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Article: Revisiting the cytotoxicity of quantum dots: an in-depth overview.

Nikazar, Sohrab / Sivasankarapillai, Vishnu Sankar / Rahdar, Abbas / Gasmi, Salim / Anumol, P S / Shanavas, Muhammad Salman

Biophysical reviews

2020 Volume 12, Issue 3, Page(s) 703–718

Abstract: Recently, medical research has been shifting its focus to nanomedicine and nanotherapeutics in the pursuit of drug development research. Quantum dots (QDs) are a critical class of nanomaterials due to their unique properties, which include optical, ... ...

Abstract	Recently, medical research has been shifting its focus to nanomedicine and nanotherapeutics in the pursuit of drug development research. Quantum dots (QDs) are a critical class of nanomaterials due to their unique properties, which include optical, electronic, and engineered biocompatibility in physiological environments. These properties have made QDs an attractive biomedical resource such that they have found application as both in vitro labeling and in vivo theranostic (therapy-diagnostic) agents. Considerable research has been conducted exploring the suitability of QDs in theranostic applications, but the cytotoxicity of QDs remains an obstacle. Several types of QDs have been investigated over the past decades, which may be suitable for use in biomedical applications if the barrier of cytotoxicity can be resolved. This review attempts to report and analyze the cytotoxicity of the major QDs along with relevant related aspects.
Language	English
Publishing date	2020-03-05
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	2486483-3
ISSN	1867-2469 ; 1867-2450
ISSN (online)	1867-2469
ISSN	1867-2450
DOI	10.1007/s12551-020-00653-0
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Article ; Online: Silicon Quantum Dots: Promising Theranostic Probes for the Future.

Sivasankarapillai, Vishnu Sankar / Jose, Jobin / Shanavas, Muhammad Salman / Marathakam, Akash / Uddin, Md Sahab / Mathew, Bijo

Current drug targets

2019 Volume 20, Issue 12, Page(s) 1255–1263

Abstract: Nanotechnology has emerged as one of the leading research areas involving nanoscale manipulation of atoms and molecules. During the past decade, the growth of nanotechnology has been one of the most important developments that have taken place in the ... ...

Abstract	Nanotechnology has emerged as one of the leading research areas involving nanoscale manipulation of atoms and molecules. During the past decade, the growth of nanotechnology has been one of the most important developments that have taken place in the biomedical field. The new generation nanomaterials like Quantum dots are gaining much importance. Also, there is a growing interest in the development of nano-theranostics platforms in medical diagnostics, biomedical imaging, drug delivery, etc. Quantum dots are also known as nanoscale semiconductor crystals, with unique electronic and optical properties. Recently, silicon quantum dots are being studied extensively due to their less-toxic, inert nature and ease of surface modification. The silicon quantum dots (2-10nm) are comparatively stable, having optical properties of silicon nanocrystals. This review focuses on silicon quantum dots and their various biomedical applications like drug delivery regenerative medicine and tissue engineering. Also, the processes involved in their modification for various biomedical applications along with future aspects are discussed.
MeSH term(s)	Drug Delivery Systems ; Humans ; Quantum Dots/chemistry ; Regenerative Medicine ; Silicon/chemistry ; Theranostic Nanomedicine ; Tissue Engineering
Chemical Substances	Silicon (Z4152N8IUI)
Language	English
Publishing date	2019-05-15
Publishing country	United Arab Emirates
Document type	Journal Article ; Review
ZDB-ID	2064859-5
ISSN	1873-5592 ; 1389-4501
ISSN (online)	1873-5592
ISSN	1389-4501
DOI	10.2174/1389450120666190405152315
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Article: On Facing the SARS-CoV-2 (COVID-19) with Combination of Nanomaterials and Medicine: Possible Strategies and First Challenges.

Sivasankarapillai, Vishnu Sankar / Pillai, Akhilash M / Rahdar, Abbas / Sobha, Anumol P / Das, Sabya Sachi / Mitropoulos, Athanasios C / Mokarrar, Mahboobeh Heidari / Kyzas, George Z

Nanomaterials (Basel, Switzerland)

2020 Volume 10, Issue 5

Abstract: Global health is facing the most dangerous situation regarding the novel severe acute respiratory syndrome called coronavirus 2 (SARS-CoV-2), which is widely known as the abbreviated COVID-19 pandemic. This is due to the highly infectious nature of the ... ...

Abstract	Global health is facing the most dangerous situation regarding the novel severe acute respiratory syndrome called coronavirus 2 (SARS-CoV-2), which is widely known as the abbreviated COVID-19 pandemic. This is due to the highly infectious nature of the disease and its possibility to cause pneumonia induced death in approximately 6.89% of infected individuals (data until 27 April 2020). The pathogen causing COVID-19 is called severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), which is believed to be originated from the Wuhan Province in China. Unfortunately, an effective and approved vaccine for SARS-CoV-2 virus is still not available, making the situation more dangerous and currently available medical care futile. This unmet medical need thus requires significant and very urgent research attention to develop an effective vaccine to address the SARS-CoV-2 virus. In this review, the state-of-the-art drug design strategies against the virus are critically summarized including exploitations of novel drugs and potentials of repurposed drugs. The applications of nanochemistry and general nanotechnology was also discussed to give the status of nanodiagnostic systems for COVID-19.
Keywords	covid19
Language	English
Publishing date	2020-04-28
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662255-5
ISSN	2079-4991
ISSN	2079-4991
DOI	10.3390/nano10050852
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Article ; Online: Borophene and Boron Fullerene Materials in Hydrogen Storage: Opportunities and Challenges.

Joseph, Jithu / Sivasankarapillai, Vishnu Sankar / Nikazar, Sohrab / Shanawaz, Muhammad Salman / Rahdar, Abbas / Lin, Han / Kyzas, George Z

ChemSusChem

2020 Volume 13, Issue 15, Page(s) 3754–3765

Abstract: Two-dimensional materials have led to a leap forward in materials science research, especially in the fields of energy conversion and storage. Borophene and its spherical counterpart boron fullerene represent emerging materials that have attracted much ... ...

Abstract	Two-dimensional materials have led to a leap forward in materials science research, especially in the fields of energy conversion and storage. Borophene and its spherical counterpart boron fullerene represent emerging materials that have attracted much attention in the whole area of advanced energy materials and technologies. Owing to their prominent features, such as electronic environment and geometry, borophene and boron fullerene have been used in versatile applications, such as supercapacitors, superconductors, anode materials for photochemical water splitting, and biosensors. Herein, one of the most promising applications/areas of hydrogen storage is discussed. Boron fullerenes have been considered and discussed for hydrogen-storage applications, and recently borophene was also included in the list of materials with promising hydrogen-storage properties. Studies focus mainly on doped borophene systems over pristine borophene due to enhanced features available upon decoration with metal atoms. This Review introduces very recent progress and novel paradigms with respect to both borophene derivatives and boron fullerene based systems reported for hydrogen storage, with a focus on the synthesis, physiochemical properties, hydrogen-storage mechanism, and practical applications.
Language	English
Publishing date	2020-06-15
Publishing country	Germany
Document type	Journal Article ; Review
ISSN	1864-564X
ISSN (online)	1864-564X
DOI	10.1002/cssc.202000782
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Article ; Online: Overview of the anticancer activity of withaferin A, an active constituent of the Indian ginseng Withania somnifera.

Sivasankarapillai, Vishnu Sankar / Madhu Kumar Nair, Reshmi / Rahdar, Abbas / Bungau, Simona / Zaha, Dana Carmen / Aleya, Lotfi / Tit, Delia Mirela

Environmental science and pollution research international

2020 Volume 27, Issue 21, Page(s) 26025–26035

Abstract: Cancer is still considered a "hopeless case", besides all of the advancements in oncology research. On the other hand, the natural products, as effective lead molecules, have gained significant interest for research due to the absence of toxic and ... ...

Abstract	Cancer is still considered a "hopeless case", besides all of the advancements in oncology research. On the other hand, the natural products, as effective lead molecules, have gained significant interest for research due to the absence of toxic and harmful side effects usually associated with conventional treatment methods. Medicinal properties of herbal plants are strongly evidenced in traditional medicine from ancient times. In the context above, withaferin A (WA) was identified as the active principle of the plant Withania somnifera, its molecule being reported to have excellent anticancer and tumour inhibition activities in various cell lines. Furthermore, the in silico approaches in the medicinal chemistry of WA revealed the biological targets and gave momentum for the research that leads to many amazing pharmacological activities of WA which are not yet explored. This includes a broad spectrum of anticancer actions manifested in different organs (breast, pancreas, colon), melanoma and B cell lymphoma, etc. This review is an extensive survey of the most recent anticancer studies reported for WA, along with its mechanism of action and details about its in vitro and/or in vivo behaviour.
MeSH term(s)	Panax ; Plant Extracts ; Withania ; Withanolides
Chemical Substances	Plant Extracts ; Withanolides ; withaferin A (L6DO3QW4K5)
Language	English
Publishing date	2020-05-13
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-020-09028-0
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Article: Overview of the anticancer activity of withaferin A, an active constituent of the Indian ginseng Withania somnifera

Sivasankarapillai, Vishnu Sankar / Madhu Kumar Nair, Reshmi / Rahdar, Abbas / Bungau, Simona / Zaha, Dana Carmen / Aleya, Lotfi / Tit, Delia Mirela

Environmental science and pollution research. 2020 July, v. 27, no. 21

2020

Abstract: Cancer is still considered a “hopeless case”, besides all of the advancements in oncology research. On the other hand, the natural products, as effective lead molecules, have gained significant interest for research due to the absence of toxic and ... ...

Abstract	Cancer is still considered a “hopeless case”, besides all of the advancements in oncology research. On the other hand, the natural products, as effective lead molecules, have gained significant interest for research due to the absence of toxic and harmful side effects usually associated with conventional treatment methods. Medicinal properties of herbal plants are strongly evidenced in traditional medicine from ancient times. In the context above, withaferin A (WA) was identified as the active principle of the plant Withania somnifera, its molecule being reported to have excellent anticancer and tumour inhibition activities in various cell lines. Furthermore, the in silico approaches in the medicinal chemistry of WA revealed the biological targets and gave momentum for the research that leads to many amazing pharmacological activities of WA which are not yet explored. This includes a broad spectrum of anticancer actions manifested in different organs (breast, pancreas, colon), melanoma and B cell lymphoma, etc. This review is an extensive survey of the most recent anticancer studies reported for WA, along with its mechanism of action and details about its in vitro and/or in vivo behaviour.
Keywords	B-cell lymphoma ; Withania somnifera ; antineoplastic activity ; breasts ; colon ; computer simulation ; mechanism of action ; melanoma ; momentum ; pancreas ; pollution ; research ; surveys ; toxicity ; traditional medicine
Language	English
Dates of publication	2020-07
Size	p. 26025-26035.
Publishing place	Springer Berlin Heidelberg
Document type	Article
Note	NAL-AP-2-clean ; Review
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-020-09028-0
Database	NAL-Catalogue (AGRICOLA)

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Article: On facing the SARS-cov-2 (COVID-19) with combination of nanomaterials and medicine: Possible strategies and first challenges

Sivasankarapillai, Vishnu Sankar / Pillai, Akhilash M. / Rahdar, Abbas / Sobha, Anumol P. / Das, Sabya Sachi / Mitropoulos, Athanasios C. / Mokarrar, Mahboobeh Heidari / Kyzas, George Z.

Nanomaterials

Abstract	Global health is facing the most dangerous situation regarding the novel severe acute respiratory syndrome called coronavirus 2 (SARS-CoV-2), which is widely known as the abbreviated COVID-19 pandemic. This is due to the highly infectious nature of the disease and its possibility to cause pneumonia induced death in approximately 6.89% of infected individuals (data until 27 April 2020). The pathogen causing COVID-19 is called severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), which is believed to be originated from the Wuhan Province in China. Unfortunately, an effective and approved vaccine for SARS-CoV-2 virus is still not available, making the situation more dangerous and currently available medical care futile. This unmet medical need thus requires significant and very urgent research attention to develop an effective vaccine to address the SARS-CoV-2 virus. In this review, the state-of-the-art drug design strategies against the virus are critically summarized including exploitations of novel drugs and potentials of repurposed drugs. The applications of nanochemistry and general nanotechnology was also discussed to give the status of nanodiagnostic systems for COVID-19.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #133536
Database	COVID19

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