Result 1 - 10 of total 66
Journal of anatomy and physiology
2007 Volume 36, Issue Pt 3, Page(s) 209–252
| Language | English |
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| Publishing date | 2007-01-17 |
| Publishing country | England |
| Document type | Journal Article |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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Journal of anatomy and physiology
2007 Volume 37, Issue Pt 1, Page(s) 73–88
| Language | English |
|---|---|
| Publishing date | 2007-01-17 |
| Publishing country | England |
| Document type | Journal Article |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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Journal of anatomy and physiology
2007 Volume 34, Issue Pt 1, Page(s) 113–150.25
| Language | English |
|---|---|
| Publishing date | 2007-01-17 |
| Publishing country | England |
| Document type | Journal Article |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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2006 Volume 13, Issue 3-4, Page(s) 260–271
| Language | English |
|---|---|
| Publishing date | 2006-09-21 |
| Publishing country | England |
| Document type | Journal Article |
| ZDB-ID | 3115-x |
| ISSN | 1469-7793 ; 0022-3751 |
| ISSN (online) | 1469-7793 |
| ISSN | 0022-3751 |
| DOI | 10.1113/jphysiol.1892.sp000407 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Uc I Zs.65: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG) |
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2023 Volume 79, Issue 1, Page(s) 75–82
Abstract: Background: Invasive pulmonary aspergillosis is a complication of severe COVID-19, with regional variation in reported incidence and mortality. We describe the incidence, risk factors and mortality associated with COVID-19-associated pulmonary ... ...
| Abstract | Background: Invasive pulmonary aspergillosis is a complication of severe COVID-19, with regional variation in reported incidence and mortality. We describe the incidence, risk factors and mortality associated with COVID-19-associated pulmonary aspergillosis (CAPA) in a prospective, multicentre UK cohort. Methods: From March 2020 to March 2021, 266 mechanically ventilated adults with COVID-19 were enrolled across 5 UK hospital intensive care units (ICUs). CAPA was defined using European Confederation for Medical Mycology and the International Society for Human and Animal Mycology criteria and fungal diagnostics performed on respiratory and serum samples. Results: Twenty-nine of 266 patients (10.9%) had probable CAPA, 14 (5.2%) possible CAPA and none proven CAPA. Probable CAPA was diagnosed a median of 9 (IQR 7-16) days after ICU admission. Factors associated with probable CAPA after multivariable logistic regression were cumulative steroid dose given within 28 days prior to ICU admission (adjusted OR (aOR) 1.16; 95% CI 1.01 to 1.43 per 100 mg prednisolone-equivalent), receipt of an interleukin (IL)-6 inhibitor (aOR 2.79; 95% CI 1.22 to 6.48) and chronic obstructive pulmonary disease (COPD) (aOR 4.78; 95% CI 1.13 to 18.13). Mortality in patients with probable CAPA was 55%, vs 46% in those without. After adjustment for immortal time bias, CAPA was associated with an increased risk of 90-day mortality (HR 1.85; 95% CI 1.07 to 3.19); however, this association did not remain statistically significant after further adjustment for confounders (adjusted HR 1.57; 95% CI 0.88 to 2.80). There was no difference in mortality between patients with CAPA prescribed antifungals (9 of 17; 53%) and those who were not (7 of 12; 58%) (p=0.77). Interpretation: In this first prospective UK study, probable CAPA was associated with corticosteroid use, receipt of IL-6 inhibitors and pre-existing COPD. CAPA did not impact mortality following adjustment for prognostic variables. |
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| MeSH term(s) | Adult ; Animals ; Humans ; COVID-19/complications ; Prospective Studies ; Respiration, Artificial/adverse effects ; Pulmonary Aspergillosis/epidemiology ; Pulmonary Disease, Chronic Obstructive ; United Kingdom/epidemiology |
| Language | English |
| Publishing date | 2023-12-15 |
| Publishing country | England |
| Document type | Multicenter Study ; Journal Article |
| ZDB-ID | 204353-1 |
| ISSN | 1468-3296 ; 0040-6376 |
| ISSN (online) | 1468-3296 |
| ISSN | 0040-6376 |
| DOI | 10.1136/thorax-2023-220002 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Ui III Zs.83: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG) |
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2022 Volume 28, Issue 8, Page(s) 1149.e1–1149.e9
Abstract: Objectives: This study aimed to investigate whether neutropenia influenced mortality and long-term outcomes of Staphylococcus aureus bloodstream (SAB) infection.: Methods: Data from two prospective, multicentre cohort studies (INSTINCT and ISAC) ... ...
| Abstract | Objectives: This study aimed to investigate whether neutropenia influenced mortality and long-term outcomes of Staphylococcus aureus bloodstream (SAB) infection. Methods: Data from two prospective, multicentre cohort studies (INSTINCT and ISAC) conducted at 20 tertiary care hospitals in six countries between 2006 and 2015 were analyzed. Neutropenic and severely neutropenic patients (defined by proxy of total white blood cell count <1000/μl and <500/μl, respectively, at onset of SAB infection) were compared with a control group using a propensity score model and overlapping weights to adjust for baseline characteristics. Overall survival and time to SAB infection-related late complications (SAB infection recurrence, infective endocarditis, osteomyelitis, or other deep-seated manifestations) were analyzed with Cox regression and competing risk analyses, respectively. Results: Of the 3187 included patients, 102 were neutropenic and 70 severely neutropenic at the time of SAB infection onset. Applying overlap weights yielded two groups of 83 neutropenic and 220 nonneutropenic patients, respectively. The baseline characteristics of these groups were exactly balanced. In the Cox regression analysis, we observed no significant difference in survival between the two groups (death during follow up: 36.1% in neutropenic vs. 30.6% in nonneutropenic patients; hazard ratio (HR): 1.21; 95% CI, 0.79-1.83). This finding remained unchanged when we considered severely neutropenic patients (HR: 1.08; 95% CI, 0.60-1.94). A competing risk analysis showed a cause-specific HR of 0.39 (95% CI, 0.11-1.39) for SAB infection-related late complications in neutropenic patients. Discussion: Neutropenia was not associated with a higher survival rate during follow up. The lower rate of SAB infection-related late complications in neutropenic patients should be validated in other cohorts. |
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| MeSH term(s) | Anti-Bacterial Agents/therapeutic use ; Bacteremia/microbiology ; Humans ; Neutropenia/complications ; Propensity Score ; Prospective Studies ; Staphylococcal Infections/microbiology ; Staphylococcus aureus |
| Chemical Substances | Anti-Bacterial Agents |
| Language | English |
| Publishing date | 2022-03-24 |
| Publishing country | England |
| Document type | Journal Article |
| ZDB-ID | 1328418-6 |
| ISSN | 1469-0691 ; 1470-9465 ; 1198-743X |
| ISSN (online) | 1469-0691 |
| ISSN | 1470-9465 ; 1198-743X |
| DOI | 10.1016/j.cmi.2022.03.018 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.A 4541: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG) |
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| Zs.MO 284: Show issues |
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The Lancet. Microbe
2021 Volume 2, Issue 9, Page(s) e461–e471
Abstract: Background: Lateral flow devices (LFDs) for rapid antigen testing are set to become a cornerstone of SARS-CoV-2 mass community testing, although their reduced sensitivity compared with PCR has raised questions of how well they identify infectious cases. ...
| Abstract | Background: Lateral flow devices (LFDs) for rapid antigen testing are set to become a cornerstone of SARS-CoV-2 mass community testing, although their reduced sensitivity compared with PCR has raised questions of how well they identify infectious cases. Understanding their capabilities and limitations is, therefore, essential for successful implementation. We evaluated six commercial LFDs and assessed their correlation with infectious virus culture and PCR cycle threshold (Ct) values. Methods: In a single-centre, laboratory evaluation study, we did a head-to-head comparison of six LFDs commercially available in the UK: Innova Rapid SARS-CoV-2 Antigen Test, Spring Healthcare SARS-CoV-2 Antigen Rapid Test Cassette, E25Bio Rapid Diagnostic Test, Encode SARS-CoV-2 Antigen Rapid Test Device, SureScreen COVID-19 Rapid Antigen Test Cassette, and SureScreen COVID-19 Rapid Fluorescence Antigen Test. We estimated the specificities and sensitivities of the LFDs using stored naso-oropharyngeal swabs collected at St Thomas' Hospital (London, UK) for routine diagnostic SARS-CoV-2 testing by real-time RT-PCR (RT-rtPCR). Swabs were from inpatients and outpatients from all departments of St Thomas' Hospital, and from health-care staff (all departments) and their household contacts. SARS-CoV-2-negative swabs from the same population (confirmed by RT-rtPCR) were used for comparative specificity determinations. All samples were collected between March 23 and Oct 27, 2020. We determined the limit of detection (LOD) for each test using viral plaque-forming units (PFUs) and viral RNA copy numbers of laboratory-grown SARS-CoV-2. Additionally, LFDs were selected to assess the correlation of antigen test result with RT-rtPCR Ct values and positive viral culture in Vero E6 cells. This analysis included longitudinal swabs from five infected inpatients with varying disease severities. Furthermore, the sensitivities of available LFDs were assessed in swabs (n=23; collected from Dec 4, 2020, to Jan 12, 2021) confirmed to be positive (RT-rtPCR and whole-genome sequencing) for the B.1.1.7 variant, which was the dominant genotype in the UK at the time of study completion. Findings: All LFDs showed high specificity (≥98·0%), except for the E25Bio test (86·0% [95% CI 77·9-99·9]), and most tests reliably detected 50 PFU/test (equivalent SARS-CoV-2 N gene Ct value of 23·7, or RNA copy number of 3 × 10 Interpretation: In this comprehensive comparison of antigen LFDs and virus infectivity, we found a clear relationship between Ct values, quantitative culture of infectious virus, and antigen LFD positivity in clinical samples. Our data support regular testing of target groups with LFDs to supplement the current PCR testing capacity, which would help to rapidly identify infected individuals in situations in which they would otherwise go undetected. Funding: King's Together Rapid COVID-19, Medical Research Council, Wellcome Trust, Huo Family Foundation, UK Department of Health, National Institute for Health Research Comprehensive Biomedical Research Centre. |
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| MeSH term(s) | COVID-19/diagnosis ; COVID-19 Testing ; Humans ; RNA, Viral/genetics ; SARS-CoV-2 |
| Chemical Substances | RNA, Viral |
| Language | English |
| Publishing date | 2021-06-30 |
| Publishing country | England |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't |
| ISSN | 2666-5247 |
| ISSN (online) | 2666-5247 |
| DOI | 10.1016/S2666-5247(21)00143-9 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
2021 Volume 73, Issue 7, Page(s) 1239–1247
Abstract: Background: Staphylococcus aureus bloodstream infection (SAB) is a common, life-threatening infection. The impact of immunosuppressive agents on the outcome of patients with SAB is incompletely understood.: Methods: Data from 2 large prospective, ... ...
| Abstract | Background: Staphylococcus aureus bloodstream infection (SAB) is a common, life-threatening infection. The impact of immunosuppressive agents on the outcome of patients with SAB is incompletely understood. Methods: Data from 2 large prospective, international, multicenter cohort studies (Invasive Staphylococcus aureus Infections Cohort [INSTINCT] and International Staphylococcus aureus Collaboration [ISAC]) between 2006 and 2015 were analyzed. Patients receiving immunosuppressive agents were identified and a 1:1 propensity score-matched analysis was performed to adjust for baseline characteristics of patients. Overall survival and time to SAB-related late complications (SAB relapse, infective endocarditis, osteomyelitis, or other deep-seated manifestations) were analyzed by Cox regression and competing risk analyses, respectively. This approach was then repeated for specific immunosuppressive agents (corticosteroid monotherapy and immunosuppressive agents other than steroids [IMOTS]). Results: Of 3188 analyzed patients, 309 were receiving immunosuppressive treatment according to our definitions and were matched to 309 nonimmunosuppressed patients. After propensity score matching, baseline characteristics were well balanced. In the Cox regression analysis, we observed no significant difference in survival between the 2 groups (death during follow-up: 105/309 [33.9%] immunosuppressed vs 94/309 [30.4%] nonimmunosuppressed; hazard ratio [HR], 1.20 [95% confidence interval {CI}, .84-1.71]). Competing risk analysis showed a cause-specific HR of 1.81 (95% CI, .85-3.87) for SAB-related late complications in patients receiving immunosuppressive agents. The cause-specific HR was higher in patients taking IMOTS (3.69 [95% CI, 1.41-9.68]). Conclusions: Immunosuppressive agents were not associated with an overall higher mortality. The risk for SAB-related late complications in patients receiving specific immunosuppressive agents such as IMOTS warrants further investigations. |
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| MeSH term(s) | Anti-Bacterial Agents/therapeutic use ; Bacteremia/drug therapy ; Humans ; Immunosuppressive Agents/adverse effects ; Propensity Score ; Prospective Studies ; Staphylococcal Infections/drug therapy ; Staphylococcal Infections/epidemiology ; Staphylococcus aureus |
| Chemical Substances | Anti-Bacterial Agents ; Immunosuppressive Agents |
| Language | English |
| Publishing date | 2021-04-28 |
| Publishing country | United States |
| Document type | Journal Article ; Multicenter Study |
| ZDB-ID | 1099781-7 |
| ISSN | 1537-6591 ; 1058-4838 |
| ISSN (online) | 1537-6591 |
| ISSN | 1058-4838 |
| DOI | 10.1093/cid/ciab385 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.A 1505: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG) |
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| Zs.MO 480: Show issues |
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2022 Volume 29, Issue 4, Page(s) 498–505
Abstract: Objectives: To analyse the adherence and impact of quality-of-care indicators (QCIs) in the management of Staphylococcus aureus bloodstream infection in a prospective and multicentre cohort.: Methods: Analysis of the prospective, multicentre ... ...
| Abstract | Objectives: To analyse the adherence and impact of quality-of-care indicators (QCIs) in the management of Staphylococcus aureus bloodstream infection in a prospective and multicentre cohort. Methods: Analysis of the prospective, multicentre international S. Aureus Collaboration cohort of S. Aureus bloodstream infection cases observed between January 2013 and April 2015. Multivariable analysis was performed to evaluate the impact of adherence to QCIs on 90-day mortality. Results: A total of 1784 cases were included. Overall, 90-day mortality was 29.9% and mean follow-up period was 118 days. Adherence was 67% (n = 1180/1762) for follow-up blood cultures, 31% (n = 416/1342) for early focus control, 77.6% (n = 546/704) for performance of echocardiography, 75.5% (n = 1348/1784) for adequacy of targeted antimicrobial therapy, 88.6% (n = 851/960) for adequacy of treatment duration in non-complicated bloodstream infections and 61.2% (n = 366/598) in complicated bloodstream infections. Full bundle adherence was 18.4% (n = 328/1784). After controlling for immortal time bias and potential confounders, focus control (adjusted hazard ratio = 0.76; 95% CI, 0.59-0.99; p 0.038) and adequate targeted antimicrobial therapy (adjusted hazard ratio = 0.75; 95% CI, 0.61-0.91; p 0.004) were associated with low 90-day mortality. Discussion: Adherence to QCIs in S. Aureus bloodstream infection did not reach expected rates. Apart from the benefits of application as a bundle, focus control and adequate targeted therapy were independently associated with low mortality. |
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| MeSH term(s) | Humans ; Staphylococcus aureus ; Prospective Studies ; Anti-Bacterial Agents/therapeutic use ; Bacteremia/diagnosis ; Bacteremia/drug therapy ; Bacteremia/microbiology ; Staphylococcal Infections/diagnosis ; Staphylococcal Infections/drug therapy ; Staphylococcal Infections/microbiology ; Sepsis/drug therapy ; Prognosis |
| Chemical Substances | Anti-Bacterial Agents |
| Language | English |
| Publishing date | 2022-10-23 |
| Publishing country | England |
| Document type | Observational Study ; Multicenter Study ; Journal Article |
| ZDB-ID | 1328418-6 |
| ISSN | 1469-0691 ; 1470-9465 ; 1198-743X |
| ISSN (online) | 1469-0691 |
| ISSN | 1470-9465 ; 1198-743X |
| DOI | 10.1016/j.cmi.2022.10.019 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.A 4541: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG) |
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| Zs.MO 284: Show issues |
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Rapid communications in mass spectrometry : RCM
2014 Volume 28, Issue 18, Page(s) 2008–2018
Abstract: ... as the corresponding spectra of the intact glycans (as released by PNGase F) in providing structural information on N ...
| Abstract | Rationale: Negative ion collision-induced dissociation (CID) spectra of N-glycans contain many diagnostic ions that provide more structural information than positive ion spectra. EndoH or endoS release of glycans from glycoproteins, as used by many investigators, cleaves glycans between the GlcNAc residues of the chitobiose core leaving the glycan without the reducing-terminal GlcNAc residue. However, their negative ion CID spectra do not appear to have been studied in detail. This paper examines the CID and ion mobility properties of these endoH-released glycans to determine if the missing GlcNAc influences the production of diagnostic fragment ions. Methods: N-Glycans were released from ribonuclease B, ovalbumin and gp120 with endoH to give high-mannose and hybrid glycans, and from IgG with endoS to produce biantennary complex glycans, all missing the reducing-terminal GlcNAc residue. Negative ion CID and travelling wave ion mobility spectra were recorded with a Waters Synapt G2 mass spectrometer using nanospray sample introduction. Results: The majority of glycans yielded CID spectra exhibiting the same diagnostic fragments, which were equivalently informative, as the fully released structures. However, the ability of ion mobility to separate isomers was generally found to be inferior to its use with the full glycans despite the smaller nature of the compounds. The exception was the partial resolution of a pair of biantennary monogalactosylated glycans from IgG where, as chloride adducts, slight separation of the isomers was observed. Conclusions: The results show that the CID spectra of endoH- and endoS-released glycans are as useful as the corresponding spectra of the intact glycans (as released by PNGase F) in providing structural information on N-glycans. |
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| MeSH term(s) | Acetylglucosamine/chemistry ; Anions/chemistry ; Carbohydrate Conformation ; Mannose/chemistry ; Spectrometry, Mass, Electrospray Ionization/methods |
| Chemical Substances | Anions ; Mannose (PHA4727WTP) ; Acetylglucosamine (V956696549) |
| Language | English |
| Publishing date | 2014-09-30 |
| Publishing country | England |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 58731-x |
| ISSN | 1097-0231 ; 0951-4198 |
| ISSN (online) | 1097-0231 |
| ISSN | 0951-4198 |
| DOI | 10.1002/rcm.6980 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.A 3461: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG) |
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