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  1. Article: Estimating the Clinical and Economic Impact of Switching from the 13-Valent Pneumococcal Conjugate Vaccine (PCV13) to Higher-Valent Options in Greek Infants.

    Warren, Sophie / Barmpouni, Myrto / Kossyvaki, Vasiliki / Gourzoulidis, George / Perdrizet, Johnna

    Vaccines

    2023  Volume 11, Issue 8

    Abstract: In June 2010, Greece introduced the 13-valent pneumococcal conjugate vaccine (PCV13) for pediatric vaccination and has since observed a large decrease in pneumococcal disease caused by these vaccine serotypes, yet the disease prevalence of non-vaccine ... ...

    Abstract In June 2010, Greece introduced the 13-valent pneumococcal conjugate vaccine (PCV13) for pediatric vaccination and has since observed a large decrease in pneumococcal disease caused by these vaccine serotypes, yet the disease prevalence of non-vaccine serotypes has increased. Two higher-valent conjugate vaccines, a 15-valent (PCV15) and a 20-valent (PCV20), were developed to improve serotype coverage and combat serotype replacement. A decision-analytic model was adapted to the Greek setting using historical pneumococcal disease trends from PCV13 to forecast future clinical and economic outcomes of higher-valent PCVs over a 10-year period (2023-2033). The model estimated outcomes related to invasive pneumococcal disease (IPD), hospitalized and non-hospitalized pneumonia, and otitis media (OM) resulting from a switch in vaccination programs to PCV15 in 2023 or switching to PCV20 in 2024. Cost-effectiveness was evaluated from the third-party payer's perspective in the Greek healthcare system. Compared to implementing PCV15 one year earlier, switching from PCV13 to PCV20 in 2024 was estimated to be a cost-saving strategy by saving the Greek health system over EUR 50 million in direct medical costs and averting over 250 IPD cases, 54,800 OM cases, 8450 pneumonia cases, and 255 deaths across all ages over a 10-year period.
    Language English
    Publishing date 2023-08-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2703319-3
    ISSN 2076-393X
    ISSN 2076-393X
    DOI 10.3390/vaccines11081369
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: On barring the vascular gateway against severe COVID-19 disease.

    Perdrizet, George / Hightower, Lawrence E

    Cell stress & chaperones

    2020  Volume 25, Issue 5, Page(s) 721–723

    MeSH term(s) Animals ; COVID-19 ; Coronavirus Infections/immunology ; Coronavirus Infections/therapy ; HSP70 Heat-Shock Proteins/immunology ; Humans ; Hyperbaric Oxygenation/methods ; Pandemics ; Pneumonia, Viral/immunology ; Pneumonia, Viral/therapy ; Rats, Wistar ; Tin Compounds/therapeutic use
    Chemical Substances HSP70 Heat-Shock Proteins ; HSPA1A protein, human ; Tin Compounds ; stannous chloride (1BQV3749L5)
    Keywords covid19
    Language English
    Publishing date 2020-05-26
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 1362749-1
    ISSN 1466-1268 ; 1355-8145
    ISSN (online) 1466-1268
    ISSN 1355-8145
    DOI 10.1007/s12192-020-01122-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4797: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Book: Heat shock response and organ preservation

    Perdrizet, George Alfred

    models of stress conditioning

    (Medical intelligence unit)

    1997  

    Author's details George A. Perdrizet
    Series title Medical intelligence unit
    Keywords Organ Preservation ; Heat ; Heat-Shock Proteins / physiology ; Stress / physiopathology ; Hitzestress ; Cytoprotektion ; Hitzeresistenz ; Hitzeschock-Proteine
    Subject Zytoprotektion ; Zellschutz ; Heat-shock proteins ; hsp 70 ; hsp 25 ; hsp 10 ; hsp 90 ; hsp 68 ; hsp 60 ; hsp 72 ; Hitzestress-Proteine ; Hitzeschock ; Hitzeschockantwort ; Heat-shock-response
    Language English
    Size 241 S. : Ill., graph. Darst.
    Publisher Springer u.a.
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT007559073
    ISBN 1-57059-229-2 ; 0-412-10831-3 ; 3-540-61430-3 ; 978-1-57059-229-4 ; 978-0-412-10831-0 ; 978-3-540-61430-2
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    1997 A 6100 order for loan Magazin

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  5. Article ; Online: On barring the vascular gateway against severe COVID-19 disease

    Perdrizet, George / Hightower, Lawrence E.

    Cell Stress and Chaperones

    2020  Volume 25, Issue 5, Page(s) 721–723

    Keywords Cell Biology ; Biochemistry ; covid19
    Language English
    Publisher Springer Science and Business Media LLC
    Publishing country us
    Document type Article ; Online
    ZDB-ID 1362749-1
    ISSN 1466-1268 ; 1355-8145
    ISSN (online) 1466-1268
    ISSN 1355-8145
    DOI 10.1007/s12192-020-01122-z
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4797: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: Principles and practice of hyperbaric medicine: a medical practitioner's primer, part I.

    Perdrizet, George A

    Connecticut medicine

    2014  Volume 78, Issue 6, Page(s) 325–332

    Abstract: The purpose of this monograph is to narrow the knowledge gap between current medical practice and hyperbaric oxygen therapy. Graduate medical education has not kept pace with the expanding science and practice of hyperbaric medicine. The number of ... ...

    Abstract The purpose of this monograph is to narrow the knowledge gap between current medical practice and hyperbaric oxygen therapy. Graduate medical education has not kept pace with the expanding science and practice of hyperbaric medicine. The number of hyperbaric chambers in the state of Connecticut has increased by >400% during the past five years. A brief overview of the science and practice of hyperbaric oxygen therapy is presented, with additional resources identified where more in-depth coverage can be found. The reader will find the basics of hyperbaric medical practice reviewed and be able to recognize diagnoses that are appropriate for referral to a hyperbaric medical center. The intended audience is practitioners who have had no formal exposure to hyperbaric medicine or chronic wound care.
    MeSH term(s) Chronic Disease ; Humans ; Hyperbaric Oxygenation/methods ; Hyperbaric Oxygenation/standards ; Oximetry ; Oxygen/metabolism ; Oxygen/pharmacology ; Patient Selection ; Wound Healing/physiology ; Wounds and Injuries/metabolism ; Wounds and Injuries/physiopathology ; Wounds and Injuries/therapy
    Chemical Substances Oxygen (S88TT14065)
    Language English
    Publishing date 2014-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 412600-2
    ISSN 0010-6178
    ISSN 0010-6178
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 288: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    ab Jg. 2022: Lesesaal (EG)

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  7. Article: Principles and practice of hyperbaric medicine: a medical practitioner's primer, part II.

    Perdrizet, George A

    Connecticut medicine

    2014  Volume 78, Issue 7, Page(s) 389–402

    Abstract: Advances in the treatment of chronic wounds* have steadily occurred over the past decade and include the specialized use of dynamic compression therapy, implementation of moist wound care techniques, chronic lymphedema therapy, negative pressure wound ... ...

    Abstract Advances in the treatment of chronic wounds* have steadily occurred over the past decade and include the specialized use of dynamic compression therapy, implementation of moist wound care techniques, chronic lymphedema therapy, negative pressure wound therapy, arterial compression therapy and application of off-loading devices. General medical practitioners should recognize when timely patient referral to a comprehensive wound care center is indicated. The clinical practice of HBOT and its scientific basis has also advanced significantly during this same time period. HBOT is a therapeutic tool with many qualities that are unique to medical care and enable difficult and otherwise untreatable conditions to be safely and effectively managed. Level 1 evidence exists for HBOT and the therapeutic indications are growing. It is the responsibility of all practitioners to become informed about the modern principles and practice of HBOT. Clinicians should take the advice of Mark Twain: "Supposing is good but finding out is better." It is the responsibility of educational institutions and medical societies to become informed and actively engaged in hyperbaric medical care, education and research. This will benefit our patients as well as our systems of medical care. There is now ample access to hyperbaric oxygen facilities and expertise with the state. There is a growing need for HBOT services due to the rising incidence of obesity and diabetes combined with an aging demographic. Appropriate networks and patterns of referral have lagged behind this demand due to a generalized lack of understanding of the true risks, benefits and indications for HBOT. This review will hopefully begin to address this problem. Hyperbaric medicine is in an early phase of development. The current and future demand for clinical services will drive development of research and educational programs. Only through continued efforts for perform high quality research and education will the full potential of HBOT be realized. Much remains to be done. As systems for the delivery of healthcare enter an era of population management, the regenerative potential of hyperbaric therapies should improve quality of and reduce costs and enable us to meet the challenge of providing care for the growing population of chronic wound patients.
    MeSH term(s) Connecticut ; Contraindications ; Humans ; Hyperbaric Oxygenation/trends ; Hyperbaric Oxygenation/utilization ; Practice Guidelines as Topic ; Wound Healing
    Language English
    Publishing date 2014-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 412600-2
    ISSN 0010-6178
    ISSN 0010-6178
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 288: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  8. Article: Type II DCS in an inside hyperbaric attendant: commentary.

    Perdrizet, George A

    Undersea & hyperbaric medicine : journal of the Undersea and Hyperbaric Medical Society, Inc

    2012  Volume 39, Issue 5, Page(s) 869

    MeSH term(s) Atmosphere Exposure Chambers ; Decompression Sickness/etiology ; Humans ; Hyperbaric Oxygenation/adverse effects ; Male
    Language English
    Publishing date 2012-09
    Publishing country United States
    Document type Comment ; Editorial
    ZDB-ID 1154414-4
    ISSN 1066-2936
    ISSN 1066-2936
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1069: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  9. Article ; Online: The effect of hyperbaric oxygen on mitochondrial and glycolytic energy metabolism: the caloristasis concept.

    Tezgin, Didem / Giardina, Charles / Perdrizet, George A / Hightower, Lawrence E

    Cell stress & chaperones

    2020  Volume 25, Issue 4, Page(s) 667–677

    Abstract: We present new data on the effects of HBOT on human kidney (HK-2) cell metabolism using a SeaHorse XF Analyzer to evaluate separately the state of mitochondrial and glycolytic energy metabolism. The data are discussed in the context of the concept of ... ...

    Abstract We present new data on the effects of HBOT on human kidney (HK-2) cell metabolism using a SeaHorse XF Analyzer to evaluate separately the state of mitochondrial and glycolytic energy metabolism. The data are discussed in the context of the concept of cellular caloristasis networks. The information on the changes in cellular energy metabolism stimulated by HBOT presented here provides new insights into the cellular energy state and mitochondrial environment in which sHSPs function. These data will be useful in forming testable hypotheses about the functions of translocated sHSPs in human mitochondria responding to stressors.
    MeSH term(s) Cell Line ; Energy Metabolism ; Glycolysis ; Humans ; Hyperbaric Oxygenation ; Mitochondria/metabolism ; Oxidative Stress ; Oxygen/metabolism
    Chemical Substances Oxygen (S88TT14065)
    Language English
    Publishing date 2020-04-06
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1362749-1
    ISSN 1466-1268 ; 1355-8145
    ISSN (online) 1466-1268
    ISSN 1355-8145
    DOI 10.1007/s12192-020-01100-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4797: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article: Wound Healing Devices Brief Vignettes.

    Anderson, Caesar A / Hare, Marc A / Perdrizet, George A

    Advances in wound care

    2016  Volume 5, Issue 4, Page(s) 185–190

    Abstract: Significance: ...

    Abstract Significance:
    Language English
    Publishing date 2016-04-01
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 2650541-1
    ISSN 2162-1934 ; 2162-1918
    ISSN (online) 2162-1934
    ISSN 2162-1918
    DOI 10.1089/wound.2015.0651
    Database MEDical Literature Analysis and Retrieval System OnLINE

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