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  1. Article: A systematic review and meta-regression of exogenous ketone infusion rates and resulting ketosis-A tool for clinicians and researchers.

    Storoschuk, Kristi L / Wood, Thomas R / Stubbs, Brianna J

    Frontiers in physiology

    2023  Volume 14, Page(s) 1202186

    Abstract: Introduction: ...

    Abstract Introduction:
    Language English
    Publishing date 2023-06-28
    Publishing country Switzerland
    Document type Systematic Review
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2023.1202186
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: A Novel Powder Formulation of the Ketone Ester, Bis Hexanoyl (R)-1,3-Butanediol, Rapidly Increases Circulating ß-Hydroxybutyrate Concentrations in Healthy Adults.

    Nieman, Kristin M / Anthony, Joshua C / Stubbs, Brianna J

    Journal of the American Nutrition Association

    2022  Volume 42, Issue 7, Page(s) 635–642

    Abstract: Objective: ...

    Abstract Objective:
    Language English
    Publishing date 2022-10-24
    Publishing country United States
    Document type Journal Article
    ISSN 2769-707X
    ISSN (online) 2769-707X
    DOI 10.1080/27697061.2022.2117743
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Ketogenic diet and adipose tissue inflammation-a simple story? Fat chance!

    Stubbs, Brianna J / Newman, John C

    Nature metabolism

    2020  Volume 2, Issue 1, Page(s) 3–4

    Language English
    Publishing date 2020-07-21
    Publishing country Germany
    Document type Journal Article
    ISSN 2522-5812
    ISSN (online) 2522-5812
    DOI 10.1038/s42255-019-0164-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: A randomized, open-label, parallel pilot study investigating metabolic product kinetics of the novel ketone ester, bis-hexanoyl (R)-1,3-butanediol, over one week of ingestion in healthy adults.

    Mah, Eunice / Blonquist, Traci M / Kaden, Valerie N / Beckman, Dawn / Boileau, Amy C / Anthony, Joshua C / Stubbs, Brianna J

    Frontiers in physiology

    2023  Volume 14, Page(s) 1196535

    Abstract: Introduction: ...

    Abstract Introduction:
    Language English
    Publishing date 2023-06-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2023.1196535
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  5. Article: Editorial: Emerging aspects of ketone metabolism in health & disease.

    Stubbs, Brianna Jane / Ford, Kenneth M / Volek, Jeff

    Frontiers in physiology

    2024  Volume 15, Page(s) 1404454

    Language English
    Publishing date 2024-04-03
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2564217-0
    ISSN 1664-042X
    ISSN 1664-042X
    DOI 10.3389/fphys.2024.1404454
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  6. Article ; Online: Exogenous Ketone Bodies as Promising Neuroprotective Agents for Developmental Brain Injury.

    Wood, Thomas R / Stubbs, Brianna J / Juul, Sandra E

    Developmental neuroscience

    2019  Volume 40, Issue 5-6, Page(s) 451–462

    Abstract: Ketone bodies are a promising area of neuroprotection research that may be ideally suited to the injured newborn. During normal development, the human infant is in significant ketosis for at least the first week of life. Ketone uptake and metabolism is ... ...

    Abstract Ketone bodies are a promising area of neuroprotection research that may be ideally suited to the injured newborn. During normal development, the human infant is in significant ketosis for at least the first week of life. Ketone uptake and metabolism is upregulated in the both the fetus and neonate, with ketone bodies providing at least 10% of cerebral metabolic energy requirements, as well as being the preferred precursors for the synthesis of fatty acids and cholesterol. At the same time, ketone bodies have been shown to have multiple neuroprotective effects, including being anticonvulsant, decreasing oxidative stress and inflammation, and epigenetically upregulating the production of neurotrophic factors. While ketogenic diets and exogenous ketosis are largely being investigated in the setting of adult brain injury, the adaptation of the neonate to ketosis suggests that developmental brain injury may be the area most suited to the use of ketones for neuroprotection. Here, we describe the mechanisms by which ketone bodies exert their neuroprotective effects, and how these may translate to benefits within each of the phases of neonatal asphyxial brain injury.
    Language English
    Publishing date 2019-05-14
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 556887-0
    ISSN 1421-9859 ; 0378-5866
    ISSN (online) 1421-9859
    ISSN 0378-5866
    DOI 10.1159/000499563
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    Zs.A 1438: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  7. Article: Case Report: Ketogenic Diet Is Associated With Improvements in Chronic Obstructive Pulmonary Disease.

    Norwitz, Nicholas G / Winwood, Russell / Stubbs, Brianna J / D'Agostino, Dominic P / Barnes, Peter J

    Frontiers in medicine

    2021  Volume 8, Page(s) 699427

    Abstract: Chronic Obstructive Pulmonary Disease (COPD) is a debilitating inflammatory respiratory condition that presents with worsening breathing difficulties and it is assumed to be progressive and incurable. As an inflammatory disease, COPD is associated with ... ...

    Abstract Chronic Obstructive Pulmonary Disease (COPD) is a debilitating inflammatory respiratory condition that presents with worsening breathing difficulties and it is assumed to be progressive and incurable. As an inflammatory disease, COPD is associated with recruitment of immune cells to lung tissue and increased levels of pro-inflammatory cytokines, including TNF-α, IL-1β, IL-6, IL-8, and GM-CSF. Low-carbohydrate ketogenic diets have anti-inflammatory properties that could, in theory, improve COPD symptoms and progression. Herein, we report on a 54-year-old patient (C.A.) with COPD who adopted a ketogenic diet (70% calories from fat). Subsequently, C.A. experienced a reduction in inflammatory markers in association with a meaningful improvement in lung function. His inflammatory markers decreased into the normal range and his forced expiratory volume increased by 37.5% relative to its pre-ketogenic diet value. Future research should explore nutritional ketosis and ketogenic diets as possible therapeutic options for individuals with COPD.
    Language English
    Publishing date 2021-07-29
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2021.699427
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  8. Article ; Online: From bedside to battlefield: intersection of ketone body mechanisms in geroscience with military resilience.

    Stubbs, Brianna J / Koutnik, Andrew P / Volek, Jeff S / Newman, John C

    GeroScience

    2020  Volume 43, Issue 3, Page(s) 1071–1081

    Abstract: Ketone bodies are endogenous metabolites that are linked to multiple mechanisms of aging and resilience. They are produced by the body when glucose availability is low, including during fasting and dietary carbohydrate restriction, but also can be ... ...

    Abstract Ketone bodies are endogenous metabolites that are linked to multiple mechanisms of aging and resilience. They are produced by the body when glucose availability is low, including during fasting and dietary carbohydrate restriction, but also can be consumed as exogenous ketone compounds. Along with supplying energy to peripheral tissues such as brain, heart, and skeletal muscle, they increasingly are understood to have drug-like protein binding activities that regulate inflammation, epigenetics, and other cellular processes. While these energy and signaling mechanisms of ketone bodies are currently being studied in a variety of aging-related diseases such as Alzheimer's disease and type 2 diabetes mellitus, they may also be relevant to military service members undergoing stressors that mimic or accelerate aging pathways, particularly traumatic brain injury and muscle rehabilitation and recovery. Here we summarize the biology of ketone bodies relevant to resilience and rehabilitation, strategies for translational use of ketone bodies, and current clinical investigations in this area.
    MeSH term(s) Aging ; Alzheimer Disease ; Diabetes Mellitus, Type 2 ; Humans ; Ketone Bodies ; Military Personnel
    Chemical Substances Ketone Bodies
    Language English
    Publishing date 2020-10-02
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2886586-8
    ISSN 2509-2723 ; 2509-2715
    ISSN (online) 2509-2723
    ISSN 2509-2715
    DOI 10.1007/s11357-020-00277-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1502: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  9. Article ; Online: Lactate Utilization Enables Metabolic Escape to Confer Resistance to BET Inhibition in Acute Myeloid Leukemia.

    Monteith, Andrew J / Ramsey, Haley E / Silver, Alexander J / Brown, Donovan / Greenwood, Dalton / Smith, Brianna N / Wise, Ashley D / Liu, Juan / Olmstead, Sarah D / Watke, Jackson / Arrate, Maria P / Gorska, Agnieszka E / Fuller, Londa / Locasale, Jason W / Stubbs, Matthew C / Rathmell, Jeffrey C / Savona, Michael R

    Cancer research

    2024  Volume 84, Issue 7, Page(s) 1101–1114

    Abstract: Impairing the BET family coactivator BRD4 with small-molecule inhibitors (BETi) showed encouraging preclinical activity in treating acute myeloid leukemia (AML). However, dose-limiting toxicities and limited clinical activity dampened the enthusiasm for ... ...

    Abstract Impairing the BET family coactivator BRD4 with small-molecule inhibitors (BETi) showed encouraging preclinical activity in treating acute myeloid leukemia (AML). However, dose-limiting toxicities and limited clinical activity dampened the enthusiasm for BETi as a single agent. BETi resistance in AML myeloblasts was found to correlate with maintaining mitochondrial respiration, suggesting that identifying the metabolic pathway sustaining mitochondrial integrity could help develop approaches to improve BETi efficacy. Herein, we demonstrated that mitochondria-associated lactate dehydrogenase allows AML myeloblasts to utilize lactate as a metabolic bypass to fuel mitochondrial respiration and maintain cellular viability. Pharmacologically and genetically impairing lactate utilization rendered resistant myeloblasts susceptible to BET inhibition. Low-dose combinations of BETi and oxamate, a lactate dehydrogenase inhibitor, reduced in vivo expansion of BETi-resistant AML in cell line and patient-derived murine models. These results elucidate how AML myeloblasts metabolically adapt to BETi by consuming lactate and demonstrate that combining BETi with inhibitors of lactate utilization may be useful in AML treatment.
    Significance: Lactate utilization allows AML myeloblasts to maintain metabolic integrity and circumvent antileukemic therapy, which supports testing of lactate utilization inhibitors in clinical settings to overcome BET inhibitor resistance in AML. See related commentary by Boët and Sarry, p. 950.
    MeSH term(s) Humans ; Animals ; Mice ; Nuclear Proteins/metabolism ; Transcription Factors/metabolism ; Lactic Acid ; Cell Line, Tumor ; Leukemia, Myeloid, Acute/drug therapy ; Leukemia, Myeloid, Acute/metabolism ; Lactate Dehydrogenases ; Bromodomain Containing Proteins ; Cell Cycle Proteins
    Chemical Substances Nuclear Proteins ; Transcription Factors ; Lactic Acid (33X04XA5AT) ; Lactate Dehydrogenases (EC 1.1.-) ; BRD4 protein, human ; Bromodomain Containing Proteins ; Cell Cycle Proteins
    Language English
    Publishing date 2024-02-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1432-1
    ISSN 1538-7445 ; 0008-5472
    ISSN (online) 1538-7445
    ISSN 0008-5472
    DOI 10.1158/0008-5472.CAN-23-0291
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uh III Zs.135/5: Show issues Location:
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  10. Article ; Online: On the interdependence of ketone body oxidation, glycogen content, glycolysis and energy metabolism in the heart.

    Kadir, Azrul Abdul / Stubbs, Brianna J / Chong, Cher-Rin / Lee, Henry / Cole, Mark / Carr, Carolyn / Hauton, David / McCullagh, James / Evans, Rhys D / Clarke, Kieran

    The Journal of physiology

    2023  Volume 601, Issue 7, Page(s) 1207–1224

    Abstract: In heart, glucose and glycolysis are important for anaplerosis and potentially therefore for d-β-hydroxybutyrate (βHB) oxidation. As a glucose store, glycogen may also furnish anaplerosis. We determined the effects of glycogen content on βHB oxidation ... ...

    Abstract In heart, glucose and glycolysis are important for anaplerosis and potentially therefore for d-β-hydroxybutyrate (βHB) oxidation. As a glucose store, glycogen may also furnish anaplerosis. We determined the effects of glycogen content on βHB oxidation and glycolytic rates, and their downstream effects on energetics, in the isolated rat heart. High glycogen (HG) and low glycogen (LG) containing hearts were perfused with 11 mM [5-
    MeSH term(s) Rats ; Animals ; NAD/metabolism ; Glycogen/metabolism ; 3-Hydroxybutyric Acid/metabolism ; Energy Metabolism ; Glycolysis ; Oxidation-Reduction ; Myocardium/metabolism ; Ketone Bodies/metabolism ; Glucose/metabolism ; Adenosine Triphosphate/metabolism
    Chemical Substances NAD (0U46U6E8UK) ; Glycogen (9005-79-2) ; 3-Hydroxybutyric Acid (TZP1275679) ; Ketone Bodies ; Glucose (IY9XDZ35W2) ; Adenosine Triphosphate (8L70Q75FXE)
    Language English
    Publishing date 2023-03-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 3115-x
    ISSN 1469-7793 ; 0022-3751
    ISSN (online) 1469-7793
    ISSN 0022-3751
    DOI 10.1113/JP284270
    Database MEDical Literature Analysis and Retrieval System OnLINE

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