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  1. Article ; Online: Mesenchymal stromal cells extracellular vesicles; unlocking the potential.

    Yarani, Reza / Lim, Sai Kiang / Giebel, Bernd

    Cytotherapy

    2023  Volume 25, Issue 8, Page(s) 808–809

    MeSH term(s) Extracellular Vesicles ; Mesenchymal Stem Cells
    Language English
    Publishing date 2023-06-08
    Publishing country England
    Document type Editorial
    ZDB-ID 2039821-9
    ISSN 1477-2566 ; 1465-3249
    ISSN (online) 1477-2566
    ISSN 1465-3249
    DOI 10.1016/j.jcyt.2023.05.008
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5601: Show issues Location:
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  2. Article: Portrait GSEV

    Giebel, Bernd

    Trillium extracellular vesicles

    2019  Volume 1, Issue 1, Page(s) 6

    Language English
    Document type Article
    ZDB-ID 2988015-4
    ISSN 2698-8739
    Database Current Contents Medicine

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  3. Article: On the function and heterogeneity of extracellular vesicles.

    Giebel, Bernd

    Annals of translational medicine

    2017  Volume 5, Issue 6, Page(s) 150

    Language English
    Publishing date 2017-03-01
    Publishing country China
    Document type Editorial ; Comment
    ZDB-ID 2893931-1
    ISSN 2305-5847 ; 2305-5839
    ISSN (online) 2305-5847
    ISSN 2305-5839
    DOI 10.21037/atm.2017.02.14
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: EV products obtained from iPSC-derived MSCs show batch-to-batch variations in their ability to modulate allogeneic immune responses

    Tertel, Tobias / Dittrich, Robin / Arsène, Pierre / Jensen, Arne / Giebel, Bernd

    Frontiers in cell and developmental biology

    2023  Volume 11, Page(s) 1282860

    Abstract: Mesenchymal stromal cells (MSCs) have demonstrated therapeutic potential in diverse clinical settings, largely due to their ability to produce extracellular vesicles (EVs). These EVs play a pivotal role in modulating immune responses, transforming pro- ... ...

    Abstract Mesenchymal stromal cells (MSCs) have demonstrated therapeutic potential in diverse clinical settings, largely due to their ability to produce extracellular vesicles (EVs). These EVs play a pivotal role in modulating immune responses, transforming pro-inflammatory cues into regulatory signals that foster a pro-regenerative milieu. Our previous studies identified the variability in the immunomodulatory effects of EVs sourced from primary human bone marrow MSCs as a consistent challenge. Given the limited proliferation of primary MSCs, protocols were advanced to derive MSCs from GMP-compliant induced pluripotent stem cells (iPSCs), producing iPSC-derived MSCs (iMSCs) that satisfied rigorous MSC criteria and exhibited enhanced expansion potential. Intriguingly, even though obtained iMSCs contained the potential to release immunomodulatory active EVs, the iMSC-EV products displayed batch-to-batch functional inconsistencies, mirroring those from bone marrow counterparts. We also discerned variances in EV-specific protein profiles among independent iMSC-EV preparations. Our results underscore that while iMSCs present an expansive growth advantage, they do not overcome the persistent challenge of functional variability of resulting MSC-EV products. Once more, our findings accentuate the crucial need for batch-to-batch functional testing, ensuring discrimination of effective and ineffective MSC-EV products for considered downstream applications.
    Language English
    Publishing date 2023-10-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2023.1282860
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  5. Article ; Online: Extracellular vesicles set the stage for brain plasticity and recovery by multimodal signalling.

    Hermann, Dirk M / Peruzzotti-Jametti, Luca / Giebel, Bernd / Pluchino, Stefano

    Brain : a journal of neurology

    2023  Volume 147, Issue 2, Page(s) 372–389

    Abstract: Extracellular vesicles (EVs) are extremely versatile naturally occurring membrane particles that convey complex signals between cells. EVs of different cellular sources are capable of inducing striking therapeutic responses in neurological disease models. ...

    Abstract Extracellular vesicles (EVs) are extremely versatile naturally occurring membrane particles that convey complex signals between cells. EVs of different cellular sources are capable of inducing striking therapeutic responses in neurological disease models. Differently from pharmacological compounds that act by modulating defined signalling pathways, EV-based therapeutics possess multiple abilities via a variety of effectors, thus allowing the modulation of complex disease processes that may have very potent effects on brain tissue recovery. When applied in vivo in experimental models of neurological diseases, EV-based therapeutics have revealed remarkable effects on immune responses, cell metabolism and neuronal plasticity. This multimodal modulation of neuroimmune networks by EVs profoundly influences disease processes in a highly synergistic and context-dependent way. Ultimately, the EV-mediated restoration of cellular functions helps to set the stage for neurological recovery. With this review we first outline the current understanding of the mechanisms of action of EVs, describing how EVs released from various cellular sources identify their cellular targets and convey signals to recipient cells. Then, mechanisms of action applicable to key neurological conditions such as stroke, multiple sclerosis and neurodegenerative diseases are presented. Pathways that deserve attention in specific disease contexts are discussed. We subsequently showcase considerations about EV biodistribution and delineate genetic engineering strategies aiming at enhancing brain uptake and signalling. By sketching a broad view of EV-orchestrated brain plasticity and recovery, we finally define possible future clinical EV applications and propose necessary information to be provided ahead of clinical trials. Our goal is to provide a steppingstone that can be used to critically discuss EVs as next generation therapeutics for brain diseases.
    MeSH term(s) Humans ; Tissue Distribution ; Extracellular Vesicles/metabolism ; Biological Transport ; Brain ; Neuronal Plasticity
    Language English
    Publishing date 2023-09-28
    Publishing country England
    Document type Review ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80072-7
    ISSN 1460-2156 ; 0006-8950
    ISSN (online) 1460-2156
    ISSN 0006-8950
    DOI 10.1093/brain/awad332
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    Ui II Zs.26: Show issues Location:
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  6. Book ; Online ; Thesis: Extracellular Vesicles in Hepatobiliary Cancer Management

    Urban, Sabine Katharina [Verfasser] / Lukacs-Kornek, Veronika [Akademischer Betreuer] / Giebel, Bernd [Gutachter]

    2023  

    Author's details Sabine Katharina Urban ; Gutachter: Bernd Giebel ; Betreuer: Veronika Lukacs-Kornek
    Keywords Biowissenschaften, Biologie ; Life Science, Biology
    Subject code sg570
    Language English
    Publisher Universitäts- und Landesbibliothek Bonn
    Publishing place Bonn
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  7. Article ; Online: EV products obtained from iPSC-derived MSCs show batch-to-batch variations in their ability to modulate allogeneic immune responses in vitro

    Tobias Tertel / Robin Dittrich / Pierre Arsène / Arne Jensen / Bernd Giebel

    Frontiers in Cell and Developmental Biology, Vol

    2023  Volume 11

    Abstract: Mesenchymal stromal cells (MSCs) have demonstrated therapeutic potential in diverse clinical settings, largely due to their ability to produce extracellular vesicles (EVs). These EVs play a pivotal role in modulating immune responses, transforming pro- ... ...

    Abstract Mesenchymal stromal cells (MSCs) have demonstrated therapeutic potential in diverse clinical settings, largely due to their ability to produce extracellular vesicles (EVs). These EVs play a pivotal role in modulating immune responses, transforming pro-inflammatory cues into regulatory signals that foster a pro-regenerative milieu. Our previous studies identified the variability in the immunomodulatory effects of EVs sourced from primary human bone marrow MSCs as a consistent challenge. Given the limited proliferation of primary MSCs, protocols were advanced to derive MSCs from GMP-compliant induced pluripotent stem cells (iPSCs), producing iPSC-derived MSCs (iMSCs) that satisfied rigorous MSC criteria and exhibited enhanced expansion potential. Intriguingly, even though obtained iMSCs contained the potential to release immunomodulatory active EVs, the iMSC-EV products displayed batch-to-batch functional inconsistencies, mirroring those from bone marrow counterparts. We also discerned variances in EV-specific protein profiles among independent iMSC-EV preparations. Our results underscore that while iMSCs present an expansive growth advantage, they do not overcome the persistent challenge of functional variability of resulting MSC-EV products. Once more, our findings accentuate the crucial need for batch-to-batch functional testing, ensuring discrimination of effective and ineffective MSC-EV products for considered downstream applications.
    Keywords exosomes ; EV products ; iPSC-derived MSCs ; heterogeneity ; immune modulation ; quality control ; Biology (General) ; QH301-705.5
    Subject code 570
    Language English
    Publishing date 2023-10-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: New Light on the Horizon: Extracellular Vesicles as Diagnostic Tool in Transient Ischemic Attack and Ischemic Stroke.

    Hermann, Dirk M / Doeppner, Thorsten R / Giebel, Bernd

    Stroke

    2021  Volume 52, Issue 10, Page(s) 3348–3350

    MeSH term(s) Brain Ischemia/diagnosis ; Extracellular Vesicles ; Humans ; Ischemic Attack, Transient/diagnosis ; Ischemic Stroke ; Stroke/diagnosis
    Language English
    Publishing date 2021-08-04
    Publishing country United States
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 80381-9
    ISSN 1524-4628 ; 0039-2499 ; 0749-7954
    ISSN (online) 1524-4628
    ISSN 0039-2499 ; 0749-7954
    DOI 10.1161/STROKEAHA.121.036150
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Circulating MicroRNAs: Posttranscriptional Regulators and Disease Markers Holding Promise in Stroke Prediction.

    Hermann, Dirk M / Doeppner, Thorsten R / Giebel, Bernd

    Stroke

    2021  Volume 52, Issue 3, Page(s) 954–956

    MeSH term(s) Circulating MicroRNA ; Humans ; MicroRNAs/genetics ; Stroke/diagnosis ; Stroke/genetics
    Chemical Substances Circulating MicroRNA ; MicroRNAs
    Language English
    Publishing date 2021-02-10
    Publishing country United States
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 80381-9
    ISSN 1524-4628 ; 0039-2499 ; 0749-7954
    ISSN (online) 1524-4628
    ISSN 0039-2499 ; 0749-7954
    DOI 10.1161/STROKEAHA.120.033688
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Identification of the right cell sources for the production of therapeutically active extracellular vesicles in ischemic stroke.

    Giebel, Bernd / Hermann, Dirk M

    Annals of translational medicine

    2019  Volume 7, Issue 9, Page(s) 188

    Language English
    Publishing date 2019-05-03
    Publishing country China
    Document type Editorial ; Comment
    ZDB-ID 2893931-1
    ISSN 2305-5847 ; 2305-5839
    ISSN (online) 2305-5847
    ISSN 2305-5839
    DOI 10.21037/atm.2019.03.49
    Database MEDical Literature Analysis and Retrieval System OnLINE

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