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  1. Article ; Online: Evaluation of health-related quality of life in patients receiving outpatient parenteral antimicrobial therapy (OPAT) in a UK setting.

    Durojaiye, Oyewole Christopher / Kritsotakis, Evangelos I

    Expert review of anti-infective therapy

    2024  , Page(s) 1–9

    Abstract: Background: Studies assessing the benefits of outpatient parenteral antimicrobial therapy (OPAT) have paid less attention to patient-centered factors such as patients' experiences and their health-related quality of life (HRQoL).: Research design and ... ...

    Abstract Background: Studies assessing the benefits of outpatient parenteral antimicrobial therapy (OPAT) have paid less attention to patient-centered factors such as patients' experiences and their health-related quality of life (HRQoL).
    Research design and methods: Prospective before-and-after quasi-experimental study enrolled adult patients receiving OPAT at a tertiary hospital in Derbyshire, UK, between October 2022 and October 2023. Consenting patients completed paired EQ-5D-3 L questionnaires before OPAT initiation and upon completion of therapy or 30 days after its commencement (whichever occurred first). Changes and predictors of change in HRQoL indicators and associations with clinical outcomes (treatment failure, adverse events, and 30-day unplanned readmission) were examined.
    Results: Health state index and visual analogue scale (EQ VAS) scores of 162 enrolled patients at baseline were significantly lower than the UK population averages, but the patients experienced significant improvements in both scores and in four EQ-5D dimensions (mobility, self-care, usual activities, and pain/discomfort). Baseline health index and EQ VAS scores were significant independent predictors of positive changes in HRQoL scores.
    Conclusions: OPAT is associated with improved patient-reported quality of life and facilitates early return to work or school. Nevertheless, it is crucial to closely monitor patients with a lower baseline quality of life to optimize their overall OPAT experience.
    Language English
    Publishing date 2024-03-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 2181279-2
    ISSN 1744-8336 ; 1478-7210
    ISSN (online) 1744-8336
    ISSN 1478-7210
    DOI 10.1080/14787210.2024.2334059
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: On the importance of population-based serological surveys of SARS-CoV-2 without overlooking their inherent uncertainties.

    Kritsotakis, Evangelos I

    Public health in practice (Oxford, England)

    2020  Volume 1, Page(s) 100013

    Abstract: The SARS-CoV-2 epidemic has caused an unprecedented public health situation and more than ever it is important to be well informed on methods to monitor and analyse the progression of the epidemic. This brief note aims to explain the scope in conducting ... ...

    Abstract The SARS-CoV-2 epidemic has caused an unprecedented public health situation and more than ever it is important to be well informed on methods to monitor and analyse the progression of the epidemic. This brief note aims to explain the scope in conducting large-scale serological surveys of SARS-CoV-2 to define the landscape of population immunity, without overlooking the inherent uncertainty steaming from sampling design and diagnostic validity. The note completes with a succinct appendix of simple statistical methods for estimating prevalence from random population samples using imperfect diagnostic tests.
    Language English
    Publishing date 2020-12-22
    Publishing country England
    Document type Journal Article
    ISSN 2666-5352
    ISSN (online) 2666-5352
    DOI 10.1016/j.puhip.2020.100013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Editorial for the Special Issue: "Epidemiology, Prognosis and Antimicrobial Treatment of Extensively Antibiotic-Resistant Bacterial Infections".

    Karakonstantis, Stamatis / Kritsotakis, Evangelos I

    Antibiotics (Basel, Switzerland)

    2022  Volume 11, Issue 6

    Abstract: The increasing consumption of broad-spectrum antimicrobials is fuelling a vicious cycle leading to extensively drug-resistant (XDR) and pandrug-resistant (PDR) bacteria [ ... ]. ...

    Abstract The increasing consumption of broad-spectrum antimicrobials is fuelling a vicious cycle leading to extensively drug-resistant (XDR) and pandrug-resistant (PDR) bacteria [...].
    Language English
    Publishing date 2022-06-15
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2681345-2
    ISSN 2079-6382
    ISSN 2079-6382
    DOI 10.3390/antibiotics11060804
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Artificial Intelligence in Surgical Risk Prediction.

    Kokkinakis, Stamatios / Kritsotakis, Evangelos I / Lasithiotakis, Konstantinos

    Journal of clinical medicine

    2023  Volume 12, Issue 12

    Abstract: Risk prediction and stratification of short-term and long-term postoperative outcomes are growing in importance and scope of application in everyday clinical practice [ ... ]. ...

    Abstract Risk prediction and stratification of short-term and long-term postoperative outcomes are growing in importance and scope of application in everyday clinical practice [...].
    Language English
    Publishing date 2023-06-13
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12124016
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  5. Article ; Online: Effectiveness and safety of a disposable elastomeric continuous infusion pump for outpatient parenteral antimicrobial therapy (OPAT) in a UK setting.

    Durojaiye, Oyewole Christopher / Cole, Joby / Kritsotakis, Evangelos I

    Journal of chemotherapy (Florence, Italy)

    2023  Volume 36, Issue 2, Page(s) 119–126

    Abstract: We evaluated the effectiveness and safety of continuous antimicrobial infusion using a disposable elastomeric device in an outpatient parenteral antimicrobial therapy (OPAT) setting. We conducted a retrospective analysis of all patients who received ... ...

    Abstract We evaluated the effectiveness and safety of continuous antimicrobial infusion using a disposable elastomeric device in an outpatient parenteral antimicrobial therapy (OPAT) setting. We conducted a retrospective analysis of all patients who received either flucloxacillin (
    MeSH term(s) Humans ; Anti-Bacterial Agents/therapeutic use ; Outpatients ; Retrospective Studies ; Anti-Infective Agents ; Infusion Pumps ; United Kingdom ; Ambulatory Care ; Infusions, Parenteral
    Chemical Substances Anti-Bacterial Agents ; Anti-Infective Agents
    Language English
    Publishing date 2023-11-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 1036294-0
    ISSN 1973-9478 ; 1120-009X
    ISSN (online) 1973-9478
    ISSN 1120-009X
    DOI 10.1080/1120009X.2023.2277507
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2701: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 387: Show issues

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  6. Article ; Online: Risk of venous thromboembolism in outpatient parenteral antimicrobial therapy (OPAT): A systematic review and meta-analysis.

    Durojaiye, Oyewole Christopher / Cole, Joby / Kritsotakis, Evangelos I

    International journal of antimicrobial agents

    2023  Volume 62, Issue 3, Page(s) 106911

    Abstract: The risk of venous thromboembolism (VTE) in outpatient parenteral antimicrobial therapy (OPAT) is not fully understood and the optimal strategy for thromboprophylaxis remains unclear. This systematic review investigated the incidence of VTE in OPAT ... ...

    Abstract The risk of venous thromboembolism (VTE) in outpatient parenteral antimicrobial therapy (OPAT) is not fully understood and the optimal strategy for thromboprophylaxis remains unclear. This systematic review investigated the incidence of VTE in OPAT settings (PROSPERO CRD42022381523). MEDLINE, CINAHL, Emcare, Embase, Cochrane Library and grey literature were searched from earliest records to 18 January 2023. Primary studies reporting non-catheter-related VTE or catheter-related thromboembolism (CRT) events in adults who received parenteral antibiotics in home or outpatient settings were eligible. In total, 43 studies involving 23 432 patient episodes were reviewed, of which 4 studies reported non-catheter-related VTE and 39 included CRT. Based on generalised linear mixed-effects models, pooled risk estimates of non-catheter-related VTE and CRT were 0.2% [95% confidence interval (CI) 0.0-0.7%] and 1.1% [95% CI 0.8-1.5%; prediction interval (PI) 0.2-5.4%]. Heterogeneity was largely attributed to risk of bias by meta-regression (R
    MeSH term(s) Adult ; Humans ; Venous Thromboembolism/drug therapy ; Venous Thromboembolism/prevention & control ; Venous Thromboembolism/epidemiology ; Anticoagulants/therapeutic use ; Outpatients ; Risk Factors ; Anti-Infective Agents/adverse effects
    Chemical Substances Anticoagulants ; Anti-Infective Agents
    Language English
    Publishing date 2023-07-06
    Publishing country Netherlands
    Document type Meta-Analysis ; Systematic Review ; Journal Article ; Review
    ZDB-ID 1093977-5
    ISSN 1872-7913 ; 0924-8579
    ISSN (online) 1872-7913
    ISSN 0924-8579
    DOI 10.1016/j.ijantimicag.2023.106911
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3368: Show issues Location:
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    Zs.MO 500: Show issues

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  7. Article ; Online: On the importance of population-based serological surveys of SARS-CoV-2 without overlooking their inherent uncertainties

    Kritsotakis, Evangelos I.

    Public Health in Practice

    2020  Volume 1, Page(s) 100013

    Keywords covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ISSN 2666-5352
    DOI 10.1016/j.puhip.2020.100013
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Artificial Intelligence in Surgical Risk Prediction

    Stamatios Kokkinakis / Evangelos I. Kritsotakis / Konstantinos Lasithiotakis

    Journal of Clinical Medicine, Vol 12, Iss 4016, p

    2023  Volume 4016

    Abstract: Risk prediction and stratification of short-term and long-term postoperative outcomes are growing in importance and scope of application in everyday clinical practice [.] ...

    Abstract Risk prediction and stratification of short-term and long-term postoperative outcomes are growing in importance and scope of application in everyday clinical practice [.]
    Keywords n/a ; Medicine ; R
    Language English
    Publishing date 2023-06-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Co-isolates of

    Karakonstantis, Stamatis / Ioannou, Petros / Kritsotakis, Evangelos I

    Access microbiology

    2022  Volume 4, Issue 5, Page(s) acmi000348

    Abstract: Background.: Results: Twenty-eight eligible studies were analysed reporting 575 polymicrobial bloodstream and 290 polymicrobial pulmonary infections. Common co-isolates in pulmonary infections were : Conclusion: The common co-isolation of certain ... ...

    Abstract Background.
    Results: Twenty-eight eligible studies were analysed reporting 575 polymicrobial bloodstream and 290 polymicrobial pulmonary infections. Common co-isolates in pulmonary infections were
    Conclusion: The common co-isolation of certain pathogens (especially
    Language English
    Publishing date 2022-05-09
    Publishing country England
    Document type Journal Article
    ISSN 2516-8290
    ISSN (online) 2516-8290
    DOI 10.1099/acmi.0.000348
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Systematic review and meta-analysis of the proportion and associated mortality of polymicrobial (vs monomicrobial) pulmonary and bloodstream infections by Acinetobacter baumannii complex.

    Karakonstantis, Stamatis / Kritsotakis, Evangelos I

    Infection

    2021  Volume 49, Issue 6, Page(s) 1149–1161

    Abstract: Background: Differentiating Acinetobacter baumannii complex (ABC) infection from colonization remains difficult and further complicated in polymicrobial infections.: Purpose: To assess the frequency of polymicrobial ABC infections and associated ... ...

    Abstract Background: Differentiating Acinetobacter baumannii complex (ABC) infection from colonization remains difficult and further complicated in polymicrobial infections.
    Purpose: To assess the frequency of polymicrobial ABC infections and associated mortality. We hypothesized a lower mortality in polymicrobial infections if ABC isolation reflects colonization in some polymicrobial infections.
    Methods: A systematic review was conducted in PubMed, Scopus and CENTRAL for studies reporting ABC pulmonary and bloodstream infections. The proportion of infections that were polymicrobial and the magnitude of the association between polymicrobial (vs monomicrobial) infection and mortality were estimated with meta-analyses.
    Results: Based on 80 studies (9759 infections) from 23 countries, the pooled proportion of polymicrobial infection was 27% (95% CI 22-31%) and was similarly high for bloodstream and pulmonary infections. Polymicrobial infection was variably and insufficiently defined in most (95%) studies. Considerable heterogeneity (I
    Conclusion: Polymicrobial ABC infections are common and may be associated with lower 28-day mortality. Considering the heterogeneity of polymicrobial infections and limitations of the available literature, more research is required to clarify the clinical impact of polymicrobial (vs monomicrobial) ABC infection.
    MeSH term(s) Acinetobacter baumannii ; Bacteremia/epidemiology ; Coinfection/epidemiology ; Humans ; Retrospective Studies ; Sepsis
    Language English
    Publishing date 2021-07-14
    Publishing country Germany
    Document type Journal Article ; Meta-Analysis ; Review ; Systematic Review
    ZDB-ID 185104-4
    ISSN 1439-0973 ; 0300-8126 ; 0173-2129
    ISSN (online) 1439-0973
    ISSN 0300-8126 ; 0173-2129
    DOI 10.1007/s15010-021-01663-0
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    Zs.MO 528: Show issues

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