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Article ; Online: Reply To the Editor.

Dasanu, Constantin A / Alexandrescu, Doru T

Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners

2016 Volume 22, Issue 3, Page(s) 575–576

Language	English
Publishing date	2016-06
Publishing country	England
Document type	Editorial
ZDB-ID	1330764-2
ISSN	1477-092X ; 1078-1552
ISSN (online)	1477-092X
ISSN	1078-1552
DOI	10.1177/1078155215611070
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Article ; Online: New frontiers in laser surgery.

Alexandrescu, Doru T / Ross, Edward V

Seminars in cutaneous medicine and surgery

2012 Volume 31, Issue 2, Page(s) 88–97

Abstract: The simultaneous advances in engineering, medicine, and molecular biology have accelerated the pace of introductions of new light-based technologies in dermatology. In this review, the authors examine recent advances in laser surgery as well as peer into ...

Abstract	The simultaneous advances in engineering, medicine, and molecular biology have accelerated the pace of introductions of new light-based technologies in dermatology. In this review, the authors examine recent advances in laser surgery as well as peer into the future of energy-based cutaneous medicine. The future landscape of dermatology will almost undoubtedly include (1) noninvasive imaging technologies and (2) improved "destructive" modalities based on real-time feedback from the skin surface.
MeSH term(s)	Acne Vulgaris/therapy ; Dermatology/instrumentation ; Dermatology/methods ; Dermatology/trends ; Forecasting ; Humans ; Laser Therapy/instrumentation ; Laser Therapy/methods ; Laser Therapy/trends ; Photochemotherapy/methods ; Photochemotherapy/trends ; Port-Wine Stain/surgery ; Skin Neoplasms/surgery ; Skin Pigmentation
Language	English
Publishing date	2012-06
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1355511-x
ISSN	1558-0768 ; 1085-5629
ISSN (online)	1558-0768
ISSN	1085-5629
DOI	10.1016/j.sder.2012.04.002
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Zs.A 1754: Show issues

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Article ; Online: Pyoderma gangrenosum due to lenalidomide use for multiple myeloma.

Dasanu, Constantin A / Bockorny, Bruno / Alexandrescu, Doru T

Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners

2015 Volume 21, Issue 6, Page(s) 471–473

Abstract: Pyoderma gangrenosum has been described in association with multiple myeloma and usually affects patients with active/untreated disease. This dermatologic condition was shown to resolve after successful anti-myeloma therapy. We report herein occurrence ... ...

Abstract	Pyoderma gangrenosum has been described in association with multiple myeloma and usually affects patients with active/untreated disease. This dermatologic condition was shown to resolve after successful anti-myeloma therapy. We report herein occurrence of pyoderma gangrenosum involving bilateral knees in a patient with multiple myeloma responding to lenalidomide therapy. Previous papers claimed usefulness of thalidomide and its newer derivatives for the therapy of this neutrophilic dermatosis. Occurrence of pyoderma gangrenosum in a myeloma patient responding to lenalidomide would argue against its effectiveness in treating this skin condition. Moreover, the clinical setting suggested that lenalidomide either induced or contributed to the occurrence of pyoderma gangrenosum in our patient. If our hypothesis is correct, we expect more reports of pyoderma gangrenosum with the use of this class of pharmaceuticals.
MeSH term(s)	Aged, 80 and over ; Angiogenesis Inhibitors/adverse effects ; Angiogenesis Inhibitors/therapeutic use ; Blood Cell Count ; Fatal Outcome ; Humans ; Knee/pathology ; Male ; Multiple Myeloma/complications ; Multiple Myeloma/drug therapy ; Pyoderma Gangrenosum/chemically induced ; Pyoderma Gangrenosum/pathology ; Skin/pathology ; Thalidomide/adverse effects ; Thalidomide/analogs & derivatives ; Thalidomide/therapeutic use
Chemical Substances	Angiogenesis Inhibitors ; Thalidomide (4Z8R6ORS6L) ; lenalidomide (F0P408N6V4)
Language	English
Publishing date	2015-12
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	1330764-2
ISSN	1477-092X ; 1078-1552
ISSN (online)	1477-092X
ISSN	1078-1552
DOI	10.1177/1078155214541975
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Article ; Online: Risk of additional cancers in untreated and treated hairy cell leukemia patients.

Dasanu, Constantin A / Alexandrescu, Doru T

Expert opinion on pharmacotherapy

2010 Volume 11, Issue 1, Page(s) 41–50

Abstract: ... suppression of the CD4(+) T-lymphocyte counts, often in excess of 2 - 3 years. And while there is no clear-cut ...

Abstract	Importance of the field: One of the feared events encountered in hairy cell leukemia (HCL) survivors is the subsequent development of a malignant neoplasm. The increased incidence of second cancers in HCL has been documented in large epidemiologic studies conducted in various locations on the globe. Areas covered in this review: The authors explore the current clinico-epidemiologic evidence, as well as the immune alterations, that link HCL and its therapies to the development of second cancers. Most relevant publications have been identified through the PubMed/Medline database search. What the reader will gain: Although HCL patients could develop both HCL and secondary malignancies because of a shared genetic predisposition, a common environmental carcinogen, or not yet identified infectious agents, multiple immune defects documented in HCL might play an important role in second carcinogenesis. Furthermore, the 'gold standards' of HCL therapy - cladribine and pentostatin - are associated with profound and prolonged suppression of the CD4(+) T-lymphocyte counts, often in excess of 2 - 3 years. And while there is no clear-cut evidence that pentostatin or interferon-alpha play an established role in generation of an excess of second cancers in HCL, the safety of cladribine, the preferred agent by a majority of clinicians worldwide, in this regard is a still largely unsettled issue. Take-home message: Therefore, it remains to be seen if the immune deficiencies induced by the HCL therapies and their consequences can be offset by the benefit conferred by controlling the leukemic process.
MeSH term(s)	Antineoplastic Combined Chemotherapy Protocols ; Cladribine/therapeutic use ; Female ; Humans ; Incidence ; Leukemia, Hairy Cell/drug therapy ; Leukemia, Hairy Cell/pathology ; Male ; Neoplasm Recurrence, Local ; Neoplasms, Second Primary/complications ; Neoplasms, Second Primary/epidemiology ; Pentostatin/therapeutic use
Chemical Substances	Pentostatin (395575MZO7) ; Cladribine (47M74X9YT5)
Language	English
Publishing date	2010-01
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2001535-5
ISSN	1744-7666 ; 1465-6566
ISSN (online)	1744-7666
ISSN	1465-6566
DOI	10.1517/14656560903405647
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Zs.A 5130: Show issues

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Article ; Online: Prophylactic antivirals may be helpful in prevention of varicella-zoster virus reactivation in myeloma, but are they safe?

Dasanu, Constantin A / Alexandrescu, Doru T

Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners

2010 Volume 16, Issue 4, Page(s) 266–268

Abstract: Purpose: Retrospective analysis of two recent multiple myeloma (MM) clinical trials suggested that the use of bortezomib may be associated with an increased incidence of herpes zoster infections. Therefore, prophylactic use of antivirals has been ... ...

Abstract	Purpose: Retrospective analysis of two recent multiple myeloma (MM) clinical trials suggested that the use of bortezomib may be associated with an increased incidence of herpes zoster infections. Therefore, prophylactic use of antivirals has been advocated by some authors. This article explores the potential risks and pitfalls linked to routine acyclovir prophylaxis in bortezomib-treated MM. Summary: use of antivirals can be associated with important nephro- and neurotoxicity. The nephrotoxicity induced by MM itself and its supportive therapies, superimposed to aging and inherent immunosuppression in myeloma, makes the development of renal impairment even more likely. On the other hand, sensory neuropathy is known to occur both during myeloma progression and in the setting of bortezomib therapy. Furthermore, preexisting nephropathy in MM patients can contribute to the occurrence of serious neurologic toxicity with acyclovir. Conclusions: long-term acyclovir prophylaxis in MM patients treated with bortezomib may cause severe renal and neurological toxicity. Prevention of these complications can be achieved through either withholding of the antivirals or a very close monitoring of both neurologic status and renal function in this patient population. This highlights the importance of both clinician's and pharmacist's involvement in optimization of myeloma patient care.
MeSH term(s)	Acyclovir/adverse effects ; Acyclovir/therapeutic use ; Antineoplastic Agents/therapeutic use ; Antiviral Agents/adverse effects ; Antiviral Agents/therapeutic use ; Boronic Acids/therapeutic use ; Bortezomib ; Drug Monitoring ; Herpes Zoster/complications ; Herpes Zoster/epidemiology ; Herpes Zoster/prevention & control ; Herpesvirus 3, Human/drug effects ; Herpesvirus 3, Human/physiology ; Humans ; Incidence ; Multiple Myeloma/complications ; Multiple Myeloma/drug therapy ; Neurotoxicity Syndromes ; Pyrazines/therapeutic use ; Renal Insufficiency/chemically induced ; Virus Activation/drug effects
Chemical Substances	Antineoplastic Agents ; Antiviral Agents ; Boronic Acids ; Pyrazines ; Bortezomib (69G8BD63PP) ; Acyclovir (X4HES1O11F)
Language	English
Publishing date	2010-12
Publishing country	England
Document type	Journal Article
ZDB-ID	1330764-2
ISSN	1477-092X ; 1078-1552
ISSN (online)	1477-092X
ISSN	1078-1552
DOI	10.1177/1078155209350374
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Article ; Online: Muehrcke's lines (Leukonychia striata) due to transretinoic acid therapy for acute promyelocytic leukemia.

Dasanu, Constantin A / Ichim, Thomas E / Alexandrescu, Doru T

Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners

2013 Volume 19, Issue 4, Page(s) 377–379

Abstract: Transverse leukonychia (Leukonychia striata or Muehrcke's lines) has been described with the use of several drugs in oncology, mainly chemotherapeutic agents. This condition is thought to represent an abnormality of the vascular nail bed. As the ... ...

Abstract	Transverse leukonychia (Leukonychia striata or Muehrcke's lines) has been described with the use of several drugs in oncology, mainly chemotherapeutic agents. This condition is thought to represent an abnormality of the vascular nail bed. As the diagnosis is clinical and the condition is self-limited, referral to other specialists is usually not required. We report the first case of transverse leukonychia related to the use of transretinoic acid for acute promyelocytic leukemia. Physician awareness of transverse leukonychia is important in order to reassure the patients and avoid unnecessary (and often not inexpensive) diagnostic work-up.
MeSH term(s)	Aged ; Antineoplastic Agents/adverse effects ; Antineoplastic Agents/therapeutic use ; Female ; Humans ; Leukemia, Promyelocytic, Acute/drug therapy ; Nail Diseases/chemically induced ; Nail Diseases/diagnosis ; Nail Diseases/pathology ; Tretinoin/adverse effects ; Tretinoin/therapeutic use
Chemical Substances	Antineoplastic Agents ; Tretinoin (5688UTC01R)
Language	English
Publishing date	2013-12
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	1330764-2
ISSN	1477-092X ; 1078-1552
ISSN (online)	1477-092X
ISSN	1078-1552
DOI	10.1177/1078155212468923
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Article ; Online: Does bortezomib induce de facto varicella zoster virus reactivation in patients with multiple myeloma?

Dasanu, Constantin A / Alexandrescu, Doru T

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

2009 Volume 27, Issue 13, Page(s) 2293–4; author reply 2294–6

MeSH term(s)	Antineoplastic Agents/adverse effects ; Boronic Acids/adverse effects ; Bortezomib ; Herpesvirus 3, Human/drug effects ; Herpesvirus 3, Human/physiology ; Humans ; Killer Cells, Natural/drug effects ; Killer Cells, Natural/immunology ; Leukocyte Common Antigens/analysis ; Multiple Myeloma/drug therapy ; Pyrazines/adverse effects ; Virus Activation/drug effects
Chemical Substances	Antineoplastic Agents ; Boronic Acids ; Pyrazines ; Bortezomib (69G8BD63PP) ; Leukocyte Common Antigens (EC 3.1.3.48)
Language	English
Publishing date	2009-05-01
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	604914-x
ISSN	1527-7755 ; 0732-183X
ISSN (online)	1527-7755
ISSN	0732-183X
DOI	10.1200/JCO.2008.21.0138
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Zs.A 1847: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 650: Show issues

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Article ; Online: Bilateral Leser-Trélat sign mirroring lung adenocarcinoma with early metastases to the contralateral lung.

Dasanu, Constantin A / Alexandrescu, Doru T

Southern medical journal

2009 Volume 102, Issue 2, Page(s) 216–218

Abstract: We present a case featuring a unique overlap between the body areas involved by lung adenocarcinoma and the cutaneous paraneoplastic sign of Leser-Trélat. In our patient, the Leser-Trélat sign consisted of explosive multiple seborrheic keratoses in ... ...

Abstract	We present a case featuring a unique overlap between the body areas involved by lung adenocarcinoma and the cutaneous paraneoplastic sign of Leser-Trélat. In our patient, the Leser-Trélat sign consisted of explosive multiple seborrheic keratoses in combination with acanthosis nigricans, representing a remarkable geometric skin projection of lung cancer which involved both the upper lobes. Our case suggests a unique interrelation between the paraneoplastic sign of Leser-Trélat and the tumor itself. The recognition of this phenomenon may contribute to an early diagnosis and prompt surgical treatment of occult cancers.
MeSH term(s)	Acanthosis Nigricans/diagnosis ; Acanthosis Nigricans/pathology ; Adenocarcinoma/diagnosis ; Adenocarcinoma/drug therapy ; Adenocarcinoma/pathology ; Aged, 80 and over ; Female ; Humans ; Lung Neoplasms/diagnosis ; Lung Neoplasms/drug therapy ; Lung Neoplasms/pathology ; Neoplasm Metastasis ; Paraneoplastic Syndromes/diagnosis ; Paraneoplastic Syndromes/pathology
Language	English
Publishing date	2009-01-13
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	185329-6
ISSN	1541-8243 ; 0038-4348
ISSN (online)	1541-8243
ISSN	0038-4348
DOI	10.1097/smj.0b013e31818f604d
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Ua VI Zs.117: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 336: Show issues

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Article ; Online: A case of prekallikrein deficiency resulting in severe recurrent mucosal hemorrhage.

Dasanu, Constantin A / Alexandrescu, Doru T

The American journal of the medical sciences

2009 Volume 338, Issue 5, Page(s) 429–430

Abstract: Although most cases of prekallikrein deficiency are asymptomatic, a few reports link severe prekallikrein deficiency with thrombotic phenomena and recurrent pregnancy loss. Here, we present a case of a Jamaican female patient with prekallikrein ... ...

Abstract	Although most cases of prekallikrein deficiency are asymptomatic, a few reports link severe prekallikrein deficiency with thrombotic phenomena and recurrent pregnancy loss. Here, we present a case of a Jamaican female patient with prekallikrein deficiency, associated with a severe bleeding diathesis. A low level of plasma prekallikrein activity, along with the presence of C529Y mutation, confirmed the diagnosis in our patient. Some animals with prekallikrein deficiency were shown to have moderate bleeding tendencies. Furthermore, the first patient with prekallikrein deficiency from the African continent was a young child who presented with severe, hemophilia-like bleeding, featuring recurrent hemarthrosis and subcutaneous hematomas. We find it intriguing that our patient is of African heritage and presented with a moderate nasal bleeding tendency in her youth, followed by severe recurrent mucosal bleeding later in life.
MeSH term(s)	Aged ; Blood Coagulation ; Epistaxis/blood ; Epistaxis/etiology ; Epistaxis/genetics ; Female ; Humans ; Partial Thromboplastin Time ; Point Mutation ; Prekallikrein/deficiency ; Prekallikrein/genetics ; Recurrence ; Severity of Illness Index
Chemical Substances	Prekallikrein (9055-02-1)
Language	English
Publishing date	2009-11
Publishing country	United States
Document type	Case Reports ; Journal Article
ZDB-ID	82078-7
ISSN	1538-2990 ; 0002-9629
ISSN (online)	1538-2990
ISSN	0002-9629
DOI	10.1097/MAJ.0b013e3181b270bb
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Article: Acute retinal pigment epithelial detachment secondary to pamidronate administration.

Dasanu, Constantin A / Alexandrescu, Doru T

Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners

2009 Volume 15, Issue 2, Page(s) 119–121

Abstract: Bisphosphonates are associated with an important number of inflammatory ocular side-effects including but not limited to conjunctivitis, episcleritis, scleritis, uveitis, and optic neuritis. The intravenous bisphosphonates appear to be linked with more ... ...

Abstract	Bisphosphonates are associated with an important number of inflammatory ocular side-effects including but not limited to conjunctivitis, episcleritis, scleritis, uveitis, and optic neuritis. The intravenous bisphosphonates appear to be linked with more severe ocular inflammation than the orally administered ones. These eye complications tend to resolve with the bisphosphonate discontinuation and can re-occur with its re-challenge. We present here the first case of an acute retinal pigment epithelial detachment associated with pamidronate infusion in a 59-year-old patient with metastatic prostate cancer.
MeSH term(s)	Bone Density Conservation Agents/adverse effects ; Bone Neoplasms/drug therapy ; Bone Neoplasms/secondary ; Diphosphonates/adverse effects ; Fluorescein Angiography ; Humans ; Injections, Intravenous ; Male ; Middle Aged ; Prostatic Neoplasms/drug therapy ; Prostatic Neoplasms/pathology ; Radiography ; Retinal Detachment/chemically induced ; Retinal Detachment/diagnostic imaging
Chemical Substances	Bone Density Conservation Agents ; Diphosphonates ; pamidronate (OYY3447OMC)
Language	English
Publishing date	2009-06
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	1330764-2
ISSN	1477-092X ; 1078-1552
ISSN (online)	1477-092X
ISSN	1078-1552
DOI	10.1177/1078155208097632
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