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  1. Article ; Online: On the Pentapeptide as the Measurement Unit in Immunology.

    Kanduc, Darja

    Global medical genetics

    2024  Volume 11, Issue 1, Page(s) 34–35

    Abstract: This communication concerns a crucial query in immunology, that is, the dimension of an epitope. The issue has essential implications in vaccine formulations. ...

    Abstract This communication concerns a crucial query in immunology, that is, the dimension of an epitope. The issue has essential implications in vaccine formulations.
    Language English
    Publishing date 2024-01-18
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 3009997-3
    ISSN 2699-9404 ; 2699-9404
    ISSN (online) 2699-9404
    ISSN 2699-9404
    DOI 10.1055/s-0044-1779041
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Exposure to SARS-CoV-2 and Infantile Diseases.

    Kanduc, Darja

    Global medical genetics

    2023  Volume 10, Issue 2, Page(s) 72–78

    Abstract: Background and ... ...

    Abstract Background and Aim
    Language English
    Publishing date 2023-05-02
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 3009997-3
    ISSN 2699-9404 ; 2699-9404
    ISSN (online) 2699-9404
    ISSN 2699-9404
    DOI 10.1055/s-0043-1768699
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Molecular Mimicry between Meningococcal B Factor H-Binding Protein and Human Proteins.

    Kanduc, Darja

    Global medical genetics

    2023  Volume 10, Issue 4, Page(s) 311–314

    Abstract: This study calls attention on molecular mimicry and the consequent autoimmune cross reactivity as the molecular mechanism that can cause adverse events following meningococcal B vaccination and warns against active immunizations based on entire antigen. ...

    Abstract This study calls attention on molecular mimicry and the consequent autoimmune cross reactivity as the molecular mechanism that can cause adverse events following meningococcal B vaccination and warns against active immunizations based on entire antigen.
    Language English
    Publishing date 2023-11-16
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 3009997-3
    ISSN 2699-9404 ; 2699-9404
    ISSN (online) 2699-9404
    ISSN 2699-9404
    DOI 10.1055/s-0043-1776985
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Molecular Mimicry between Respiratory Syncytial Virus F Antigen and the Human Proteome.

    Kanduc, Darja

    Global medical genetics

    2023  Volume 10, Issue 1, Page(s) 19–21

    Abstract: This study examined respiratory syncytial virus (RSV) F glycoprotein (gp) antigen for molecular mimicry with the human proteome. It was found that the viral antigen presents an impressive number of pentapeptides (namely, 525 out of 570) in common with ... ...

    Abstract This study examined respiratory syncytial virus (RSV) F glycoprotein (gp) antigen for molecular mimicry with the human proteome. It was found that the viral antigen presents an impressive number of pentapeptides (namely, 525 out of 570) in common with the human proteome, with viral sequences widely and repeatedly distributed among 3,762 human proteins implicated in crucial fundamental cellular functions. The data can have implications for anti-RSV vaccines. Indeed, the high level of molecular mimicry can lead to cross-reactivity and autoimmunity, and invites to follow safer vaccinal protocols based on pentapeptide sequences uniquely present in the viral antigen.
    Language English
    Publishing date 2023-01-30
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 3009997-3
    ISSN 2699-9404 ; 2699-9404
    ISSN (online) 2699-9404
    ISSN 2699-9404
    DOI 10.1055/s-0043-1761489
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Epigenetics of Hypogonadotropic Hypogonadism: Molecular Mimicry between Severe Acute Respiratory Syndrome Coronavirus 2 and KISSR.

    Kanduc, Darja

    Global medical genetics

    2023  Volume 10, Issue 2, Page(s) 129–132

    Abstract: This study analyzed KISS1 and its receptor KISSR for peptide sharing with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It was found that SARS-CoV-2 shares numerous minimal immune pentapeptide determinants with KISSR only. The peptide ... ...

    Abstract This study analyzed KISS1 and its receptor KISSR for peptide sharing with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It was found that SARS-CoV-2 shares numerous minimal immune pentapeptide determinants with KISSR only. The peptide sharing has a high immunologic potential since almost all the common peptides are present in 101 SARS-CoV-2-derived immunoreactive epitopes. Data are in favor of configuring molecular mimicry as an epigenetic factor that can alter KISSR thus causing the hypogonadotropic hypogonadism syndrome with which altered KISSR associates.
    Language English
    Publishing date 2023-06-23
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 3009997-3
    ISSN 2699-9404 ; 2699-9404
    ISSN (online) 2699-9404
    ISSN 2699-9404
    DOI 10.1055/s-0043-1770767
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: On the Pentapeptide as the Measurement Unit in Immunology

    Kanduc, Darja

    Global Medical Genetics

    2024  Volume 11, Issue 01, Page(s) 34–35

    Abstract: This communication concerns a crucial query in immunology, that is, the dimension of an epitope. The issue has essential implications in vaccine formulations. ...

    Abstract This communication concerns a crucial query in immunology, that is, the dimension of an epitope. The issue has essential implications in vaccine formulations.
    Keywords epitope dimensions ; pentapeptides ; vaccines
    Language English
    Publishing date 2024-01-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 3009997-3
    ISSN 2699-9404 ; 2699-9404
    ISSN (online) 2699-9404
    ISSN 2699-9404
    DOI 10.1055/s-0044-1779041
    Database Thieme publisher's database

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  7. Article ; Online: SARS-CoV-2-Induced Immunosuppression: A Molecular Mimicry Syndrome.

    Kanduc, Darja

    Global medical genetics

    2022  Volume 9, Issue 3, Page(s) 191–199

    Abstract: ... ...

    Abstract Background
    Language English
    Publishing date 2022-07-14
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 3009997-3
    ISSN 2699-9404 ; 2699-9404
    ISSN (online) 2699-9404
    ISSN 2699-9404
    DOI 10.1055/s-0042-1748170
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: SARS-CoV-2: The Self-Nonself Issue and Diagnostic Tests.

    Kanduc, Darja

    Journal of laboratory physicians

    2022  Volume 15, Issue 1, Page(s) 56–61

    Abstract: ... ...

    Abstract Objective
    Language English
    Publishing date 2022-07-26
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 2461120-7
    ISSN 0974-7826 ; 0974-2727
    ISSN (online) 0974-7826
    ISSN 0974-2727
    DOI 10.1055/s-0042-1750078
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: SARS-CoV-2

    Darja Kanduc

    Journal of Laboratory Physicians, Vol 15, Iss 01, Pp 056-

    The Self-Nonself Issue and Diagnostic Tests

    2023  Volume 061

    Abstract: Objective At present, false negatives/positives have been reported in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) diagnostics. Searching for the molecular basis of such tests' unreliability, this study aimed at defining how specific are ... ...

    Abstract Objective At present, false negatives/positives have been reported in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) diagnostics. Searching for the molecular basis of such tests' unreliability, this study aimed at defining how specific are the sequences used in serological and polymerase chain reaction (PCR) tests to detect SARS-CoV-2. Materials and Methods Analyses were performed on the leading SARS-CoV-2 biomarker spike glycoprotein (gp). Sharing of peptide sequences between the spike antigen and the human host was analyzed using the Peptide Search program from Uniprot database. Sharing of oligonucleotide sequences was investigated using the nucleotide Basic Local Alignment Search Tool (BLASTn) from National Center for Biotechnology Information (NCBI). Results Two main points stand out: (1) a massive pentapeptide sharing exists between the spike gp and the human proteome, and only a limited number of pentapeptides (namely 107) identify SARS-CoV-2 spike gp as nonself when compared with the human proteome, and (2) the small phenetic difference practically disappears at the genetic level. Indeed, almost all of the 107 pentadecameric nucleotide sequences coding for the pentapeptides unique to SARS-CoV-2 spike gp are present in human nucleic acids too. Conclusion The data are of immunological significance for defining the issue of the viral versus human specificity and likely explain the fact that false positives can occur in serological and PCR tests for SARS-CoV-2 detection.
    Keywords sars-cov-2 spike gp ; self-nonself ; serological tests ; pcr tests ; false positives ; Medicine ; R
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher Thieme Medical and Scientific Publishers Pvt. Ltd.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: The Role of Codon Usage, tRNA Availability, and Cell Proliferation in EBV Latency and (Re)Activation.

    Kanduc, Darja

    Global medical genetics

    2022  Volume 9, Issue 3, Page(s) 219–225

    Abstract: Epstein-Barr nuclear antigen 1 (EBNA1) protein synthesis is inhibited during Epstein-Barr virus (EBV) latency and is resumed in EBV (re)activation. In analyzing the molecular mechanisms underpinning the translation ... ...

    Abstract Epstein-Barr nuclear antigen 1 (EBNA1) protein synthesis is inhibited during Epstein-Barr virus (EBV) latency and is resumed in EBV (re)activation. In analyzing the molecular mechanisms underpinning the translation of
    Language English
    Publishing date 2022-09-15
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 3009997-3
    ISSN 2699-9404 ; 2699-9404
    ISSN (online) 2699-9404
    ISSN 2699-9404
    DOI 10.1055/s-0042-1751301
    Database MEDical Literature Analysis and Retrieval System OnLINE

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