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Book ; Online ; E-Book: Elderly Health Services and Remote Health Monitoring

Chen, Lumin / Li, Yihao / Han, Lina / Yuan, Liang / Sun, Yuxiang / Tang, Xiaolu

(SpringerBriefs in Applied Sciences and Technology,)

2020

Abstract: This book focuses on typical health services and remote monitoring methods, such as visual recognition and deep learning. Chiefly addressing the design and simulation of rehabilitation devices, and the evaluation of their effects on various diseases, it ... ...

Author's details	by Lumin Chen, Yihao Li, Lina Han, Liang Yuan, Yuxiang Sun, Xiaolu Tang
Series title	SpringerBriefs in Applied Sciences and Technology,
Abstract	This book focuses on typical health services and remote monitoring methods, such as visual recognition and deep learning. Chiefly addressing the design and simulation of rehabilitation devices, and the evaluation of their effects on various diseases, it offers a valuable resource for professional researchers and graduate students in the fields of elderly medicine, signal processing, and rehabilitation.
Keywords	System theory ; Mathematical models ; Computer science—Mathematics ; Computer mathematics ; Algorithms ; Systems Theory, Control ; Mathematical Modeling and Industrial Mathematics ; Mathematical Applications in Computer Science ; Mathematics of Algorithmic Complexity
Subject code	617.03
Language	English
Size	1 online resource (X, 81 p. 73 illus., 59 illus. in color.)
Edition	1st ed. 2020.
Publisher	Springer Singapore ; Imprint: Springer
Publishing place	Singapore
Document type	Book ; Online ; E-Book
Remark	Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
ISBN	981-15-7154-6 ; 981-15-7153-8 ; 978-981-15-7154-1 ; 978-981-15-7153-4
DOI	10.1007/978-981-15-7154-1
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Heterogeneity of mesencephalic dopaminergic neurons: From molecular classifications, electrophysiological properties to functional connectivity.

Lu, Xiaying / Xue, Jinhua / Lai, Yudong / Tang, Xiaolu

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

2024 Volume 38, Issue 3, Page(s) e23465

Abstract: The mesencephalic dopamine (DA) system is composed of neuronal subtypes that are molecularly and functionally distinct, are responsible for specific behaviors, and are closely associated with numerous brain disorders. Existing research has made ... ...

Abstract	The mesencephalic dopamine (DA) system is composed of neuronal subtypes that are molecularly and functionally distinct, are responsible for specific behaviors, and are closely associated with numerous brain disorders. Existing research has made significant advances in identifying the heterogeneity of mesencephalic DA neurons, which is necessary for understanding their diverse physiological functions and disease susceptibility. Moreover, there is a conflict regarding the electrophysiological properties of the distinct subsets of midbrain DA neurons. This review aimed to elucidate recent developments in the heterogeneity of midbrain DA neurons, including subpopulation categorization, electrophysiological characteristics, and functional connectivity to provide new strategies for accurately identifying distinct subtypes of midbrain DA neurons and investigating the underlying mechanisms of these neurons in various diseases.
MeSH term(s)	Dopaminergic Neurons/physiology ; Mesencephalon/physiology
Language	English
Publishing date	2024-02-05
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	639186-2
ISSN	1530-6860 ; 0892-6638
ISSN (online)	1530-6860
ISSN	0892-6638
DOI	10.1096/fj.202302031R
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Article ; Online: Performance optimization for Pb(II) -containing wastewater treatment in constructed wetland-microbial fuel cell triggered by biomass dosage and Pb(II) level.

Tang, Xiaolu / Wang, Lu / Zhang, Qingyun / Xu, Dayong / Tao, Zhengkai

Environmental science and pollution research international

2024 Volume 31, Issue 10, Page(s) 15039–15049

Abstract: Three identical sets of constructed wetland-microbial fuel cells (CW-MFCs) fabricated with biomass carbon source addition were constructed and underwent the short- and long-term experiments. For this, the efficacy of biomass dosage and Pb(II) ... ...

Abstract	Three identical sets of constructed wetland-microbial fuel cells (CW-MFCs) fabricated with biomass carbon source addition were constructed and underwent the short- and long-term experiments. For this, the efficacy of biomass dosage and Pb(II) concentration towards Pb(II) removal and concurrent bioelectricity production of CW-MFCs were systematically explored. From the perspective of integrated capabilities and economic benefits, the solid biomass carbon sources equivalent to 500 mg/L COD was regarded as the optimal dosage, and the corresponding device was labeled as CW-MFC-2. For the short-term experiment, the closed-circuit CW-MFC-2 produced maximum output voltages and power densities in a range of 386-657 mV and 1.55 × 10
MeSH term(s)	Bioelectric Energy Sources ; Electricity ; Lead ; Wetlands ; Biomass ; Water Purification ; Electrodes ; Carbon
Chemical Substances	Lead (2P299V784P) ; Carbon (7440-44-0)
Language	English
Publishing date	2024-01-29
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1178791-0
ISSN	1614-7499 ; 0944-1344
ISSN (online)	1614-7499
ISSN	0944-1344
DOI	10.1007/s11356-024-32137-z
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Article ; Online: Molecular insights into the adaptive evolution of SARS-CoV-2 spike protein.

Yao, Zhuocheng / Zhang, Lin / Duan, Yuange / Tang, Xiaolu / Lu, Jian

The Journal of infection

2024 Volume 88, Issue 3, Page(s) 106121

Abstract: The COVID-19 pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has substantially damaged the global economy and human health. The spike (S) protein of coronaviruses plays a pivotal role in viral entry by binding to ... ...

Abstract	The COVID-19 pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has substantially damaged the global economy and human health. The spike (S) protein of coronaviruses plays a pivotal role in viral entry by binding to host cell receptors. Additionally, it acts as the primary target for neutralizing antibodies in those infected and is the central focus for currently utilized or researched vaccines. During the virus's adaptation to the human host, the S protein of SARS-CoV-2 has undergone significant evolution. As the COVID-19 pandemic has unfolded, new mutations have arisen and vanished, giving rise to distinctive amino acid profiles within variant of concern strains of SARS-CoV-2. Notably, many of these changes in the S protein have been positively selected, leading to substantial alterations in viral characteristics, such as heightened transmissibility and immune evasion capabilities. This review aims to provide an overview of our current understanding of the structural implications associated with key amino acid changes in the S protein of SARS-CoV-2. These research findings shed light on the intricate and dynamic nature of viral evolution, underscoring the importance of continuous monitoring and analysis of viral genomes. Through these molecular-level investigations, we can attain deeper insights into the virus's adaptive evolution, offering valuable guidance for designing vaccines and developing antiviral drugs to combat the ever-evolving viral threats.
MeSH term(s)	Humans ; COVID-19 ; Spike Glycoprotein, Coronavirus ; SARS-CoV-2/genetics ; Pandemics/prevention & control ; Vaccines ; Amino Acids
Chemical Substances	spike protein, SARS-CoV-2 ; Spike Glycoprotein, Coronavirus ; Vaccines ; Amino Acids
Language	English
Publishing date	2024-02-16
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	424417-5
ISSN	1532-2742 ; 0163-4453
ISSN (online)	1532-2742
ISSN	0163-4453
DOI	10.1016/j.jinf.2024.106121
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Article ; Online: Microplastics enhance the invasion of exotic submerged macrophytes by mediating plant functional traits, sediment properties, and microbial communities.

Li, Xiaowei / Qin, Hongjie / Tang, Na / Li, Xiaolu / Xing, Wei

Journal of hazardous materials

2024 Volume 469, Page(s) 134032

Abstract: Plant invasions and microplastics (MPs) have significantly altered the structure and function of aquatic habitats worldwide, resulting in severe damage to aquatic ecosystem health. However, the effects of MPs on plant invasion and the underlying ... ...

Abstract	Plant invasions and microplastics (MPs) have significantly altered the structure and function of aquatic habitats worldwide, resulting in severe damage to aquatic ecosystem health. However, the effects of MPs on plant invasion and the underlying mechanisms remain largely unknown. In this study, we conducted mesocosm experiments over a 90-day period to assess the effects of polystyrene microplastics on the invasion of exotic submerged macrophytes, sediment physicochemical properties, and sediment bacterial communities. Our results showed that PS-MPs significantly promoted the performance of functional traits and the invasive ability of exotic submerged macrophytes, while native plants remained unaffected. Moreover, PS-MPs addition significantly decreased sediment pH while increasing sediment carbon and nitrogen content. Additionally, MPs increased the diversity of sediment bacterial community but inhibited its structural stability, thereby impacting sediment bacterial multifunctionality to varying degrees. Importantly, we identified sediment properties, bacterial composition, and bacterial multifunctionality as key mediators that greatly enhance the invasion of exotic submerged macrophytes. These findings provide compelling evidence that the increase in MPs may exacerbate the invasion risk of exotic submerged macrophytes through multiple pathways. Overall, this study enhances our understanding of the ecological impacts of MPs on aquatic plant invasion and the health of aquatic ecosystems.
MeSH term(s)	Microplastics/toxicity ; Ecosystem ; Plastics ; Polystyrenes ; Bacteria ; Microbiota
Chemical Substances	Microplastics ; Plastics ; Polystyrenes
Language	English
Publishing date	2024-03-13
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	1491302-1
ISSN	1873-3336 ; 0304-3894
ISSN (online)	1873-3336
ISSN	0304-3894
DOI	10.1016/j.jhazmat.2024.134032
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Article ; Online: Adaptive Evolution of the Spike Protein in Coronaviruses.

Tang, Xiaolu / Qian, Zhaohui / Lu, Xuemei / Lu, Jian

Molecular biology and evolution

2023 Volume 40, Issue 4

Abstract: Coronaviruses are single-stranded, positive-sense RNA viruses that can infect many mammal and avian species. The Spike (S) protein of coronaviruses binds to a receptor on the host cell surface to promote viral entry. The interactions between the S ... ...

Abstract	Coronaviruses are single-stranded, positive-sense RNA viruses that can infect many mammal and avian species. The Spike (S) protein of coronaviruses binds to a receptor on the host cell surface to promote viral entry. The interactions between the S proteins of coronaviruses and receptors of host cells are extraordinarily complex, with coronaviruses from different genera being able to recognize the same receptor and coronaviruses from the same genus able to bind distinct receptors. As the coronavirus disease 2019 pandemic has developed, many changes in the S protein have been under positive selection by altering the receptor-binding affinity, reducing antibody neutralization activities, or affecting T-cell responses. It is intriguing to determine whether the selection pressure on the S gene differs between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and other coronaviruses due to the host shift from nonhuman animals to humans. Here, we show that the S gene, particularly the S1 region, has experienced positive selection in both SARS-CoV-2 and other coronaviruses. Although the S1 N-terminal domain exhibits signals of positive selection in the pairwise comparisons in all four coronavirus genera, positive selection is primarily detected in the S1 C-terminal domain (the receptor-binding domain) in the ongoing evolution of SARS-CoV-2, possibly owing to the change in host settings and the widespread natural infection and SARS-CoV-2 vaccination in humans.
MeSH term(s)	Animals ; Humans ; COVID-19 ; SARS-CoV-2/genetics ; SARS-CoV-2/metabolism ; Spike Glycoprotein, Coronavirus/chemistry ; COVID-19 Vaccines ; Mammals/metabolism
Chemical Substances	spike protein, SARS-CoV-2 ; Spike Glycoprotein, Coronavirus ; COVID-19 Vaccines
Language	English
Publishing date	2023-05-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	998579-7
ISSN	1537-1719 ; 0737-4038
ISSN (online)	1537-1719
ISSN	0737-4038
DOI	10.1093/molbev/msad089
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Article ; Online: Clinicopathological characteristics and prognosis of metaplastic breast cancer versus triple-negative invasive ductal carcinoma: a retrospective analysis.

Yang, Xiaolu / Tang, Tiantian / Zhou, Tao

World journal of surgical oncology

2023 Volume 21, Issue 1, Page(s) 364

Abstract: Background: Metaplastic breast cancer(MBC) is a specific pathological type of invasive breast cancer. There are few studies related to MBC due to its rarity. This study aimed to analyse the differences in clinicopathological characteristics and ... ...

Abstract	Background: Metaplastic breast cancer(MBC) is a specific pathological type of invasive breast cancer. There are few studies related to MBC due to its rarity. This study aimed to analyse the differences in clinicopathological characteristics and prognosis between Metaplastic breast cancer and triple-negative invasive ductal carcinoma (TN-IDC). Methods: We retrospectively compared the clinicopathological characteristics of patients diagnosed with MBC and TN-IDC at the Fourth Hospital of Hebei Medical University between 2011 and 2020 in a 1:2 ratio. The log-rank test was used to compare the two groups' disease-free survival (DFS) and overall survival (OS). For MBCs, we performed univariate and multivariate analyses using the Cox proportional hazards model to determine the characteristics that impacted OS and DFS. Results: A total of 81 patients with MBC and 162 patients with TN-IDC were included in this study. At initial diagnosis, MBC patients had larger tumour diameters(P = 0.03) and fewer positive lymph nodes (P = 0.04). Patients with MBC were more likely to have organ metastases after surgery (P = 0.03). Despite receiving the same treatment, MBC patients had worse DFS (HR = 1.66, 95%CI 0.90-3.08, P = 0.11) and OS (HR = 1.98, 95% CI 1.03-3.81, P = 0.04), and OS was statistically significant. Positive lymph nodes at initial diagnosis were associated with worse DFS (HR = 3.98, 95%CI 1.05-15.12, P = 0.04) and OS (HR = 3.70, 95%CI 1.03-13.34, P = 0.04) for patients with MBC. The efficacy of platinum-based agents is insensitive for MBC patients receiving chemotherapy. In addition, patients treated with preoperative chemotherapy had worse DFS compared to patients treated with postoperative chemotherapy (HR = 3.51, 95%CI 1.05-11.75, P = 0.04). Conclusions: The clinicopathological characteristics and prognosis of MBC and TN-IDC differ in many ways. Further studies are required to determine suitable treatment guidelines for patients with MBC.
MeSH term(s)	Humans ; Female ; Breast Neoplasms ; Retrospective Studies ; Carcinoma, Ductal, Breast/therapy ; Prognosis ; Disease-Free Survival
Language	English
Publishing date	2023-11-24
Publishing country	England
Document type	Journal Article
ZDB-ID	2118383-1
ISSN	1477-7819 ; 1477-7819
ISSN (online)	1477-7819
ISSN	1477-7819
DOI	10.1186/s12957-023-03261-w
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Article ; Online: Convergent and divergent evolution of microRNA-mediated regulation in metazoans.

Wang, Yirong / Tang, Xiaolu / Lu, Jian

Biological reviews of the Cambridge Philosophical Society

2023 Volume 99, Issue 2, Page(s) 525–545

Abstract: The evolution of microRNAs (miRNAs) has been studied extensively to understand their roles in gene regulation and evolutionary processes. This review focuses on how miRNA-mediated regulation has evolved in bilaterian animals, highlighting both convergent ...

Abstract	The evolution of microRNAs (miRNAs) has been studied extensively to understand their roles in gene regulation and evolutionary processes. This review focuses on how miRNA-mediated regulation has evolved in bilaterian animals, highlighting both convergent and divergent evolution. Since animals and plants display significant differences in miRNA biogenesis and target recognition, the 'independent origin' hypothesis proposes that miRNA pathways in these groups independently evolved from the RNA interference (RNAi) pathway, leading to modern miRNA repertoires through convergent evolution. However, recent evidence raises the alternative possibility that the miRNA pathway might have already existed in the last common ancestor of eukaryotes, and that the differences in miRNA pathway and miRNA repertoires among animal and plant lineages arise from lineage-specific innovations and losses of miRNA pathways, miRNA acquisition, and loss of miRNAs after eukaryotic divergence. The repertoire of miRNAs has considerably expanded during bilaterian evolution, primarily through de novo creation and duplication processes, generating new miRNAs. Although ancient functionally established miRNAs are rarely lost, many newly emerged miRNAs are transient and lineage specific, following a birth-death evolutionary pattern aligning with the 'out-of-the-testis' and 'transcriptional control' hypotheses. Our focus then shifts to the convergent molecular evolution of miRNAs. We summarize how miRNA clustering and seed mimicry contribute to this phenomenon, and we review how miRNAs from different sources converge to degrade maternal messenger RNAs (mRNAs) during animal development. Additionally, we describe how miRNAs evolve across species due to changes in sequence, seed shifting, arm switching, and spatiotemporal expression patterns, which can result in variations in target sites among orthologous miRNAs across distant strains or species. We also provide a summary of the current understanding regarding how the target sites of orthologous miRNAs can vary across strains or distantly related species. Although many paralogous miRNAs retain their seed or mature sequences after duplication, alterations can occur in the seed or mature sequences or expression patterns of paralogous miRNAs, leading to functional diversification. We discuss our current understanding of the functional divergence between duplicated miRNAs, and illustrate how the functional diversification of duplicated miRNAs impacts target site evolution. By investigating these topics, we aim to enhance our current understanding of the functions and evolutionary dynamics of miRNAs. Additionally, we shed light on the existing challenges in miRNA evolutionary studies, particularly the complexity of deciphering the role of miRNA-mediated regulatory network evolution in shaping gene expression divergence and phenotypic differences among species.
MeSH term(s)	Male ; Animals ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Gene Expression Regulation ; Evolution, Molecular ; Plants/genetics ; Plants/metabolism ; Seeds
Chemical Substances	MicroRNAs
Language	English
Publishing date	2023-11-21
Publishing country	England
Document type	Review ; Journal Article
ZDB-ID	1423558-4
ISSN	1469-185X ; 0006-3231 ; 1464-7931
ISSN (online)	1469-185X
ISSN	0006-3231 ; 1464-7931
DOI	10.1111/brv.13033
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Article ; Online: Changes in Qinghai Lake Area and Their Interactions with Climatic Factors

Xiaolu Ling / Zeyu Tang / Jian Gao / Chenggang Li / Wenhao Liu

Remote Sensing, Vol 16, Iss 1, p

2023 Volume 129

Abstract: Lakes play a crucial role in the global water cycle and significantly contribute to enhancing regional ecological environments and simulating economic growth. In this study, based on the data from the Landsat TM 4-5, Landsat 7 ETM SLC-off, and Landsat 8- ... ...

Abstract	Lakes play a crucial role in the global water cycle and significantly contribute to enhancing regional ecological environments and simulating economic growth. In this study, based on the data from the Landsat TM 4-5, Landsat 7 ETM SLC-off, and Landsat 8-9 OLI/TIRS C2 L2 satellites, the surface area of Qinghai Lake is obtained by using the Normalized Difference Water Index (NDWI) method. Additionally, leveraging the European Centre for Medium-Range Weather Forecasts (ECMWF) fifth-generation land surface reanalysis dataset (ERA5-Land), we analyzed the interplay between lake area and related climate factors by using the Noise Assisted–Multivariate Empirical Mode Decomposition (NA-MEMD) and wavelet coherence analysis method. The surface area of Qinghai Lake showed an overall expansion trend from 1986 to 2022, with an expansion rate of 2.89 km 2 /a. Precipitation, temperature, and evapotranspiration (ET) also showed an increasing trend, with the largest increasing trend in autumn, summer, and summer, respectively. The area of Qinghai Lake did not demonstrate distinct periodic patterns from 1986 to 2022, in contrast to the marked 8–16 month oscillations observed in precipitation, temperature, and ET. In the phase of lake area expansion between 2008 and 2016, changes in the lake’s surface area were observed to trail behind variations in precipitation and temperature by approximately three months. Furthermore, the shift in ET was found to lag behind alterations in the lake area, displaying a delay of 3–6 months.
Keywords	Qinghai Lake ; climatic factors ; NA-MEMD ; wavelet analysis ; evapotranspiration ; Science ; Q
Subject code	333
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article ; Online: Spatiotemporal Impact on Vegetation by Tunnel Discharging in the Jinping II Hydropower Station

Ci Song / Runqiu Huang / Xiaolu Tang

Frontiers in Earth Science, Vol

Evidence From the NDVI and GPP Monitoring Dataset of 2001–2019

2022 Volume 10

Abstract: An impact on vegetation by tunnel discharging has been a critical point for underground constructions around the world. The Jinping II hydropower station in China possesses the world’s largest karst diversion tunnel group and discharged massive ... ...

Abstract	An impact on vegetation by tunnel discharging has been a critical point for underground constructions around the world. The Jinping II hydropower station in China possesses the world’s largest karst diversion tunnel group and discharged massive groundwater during the construction period. This study assessed the effects on vegetation in the karst and non-karst areas at different stages before construction (2001–2003, BC), during construction (2004–2014, DC), and after construction (2015–2019, AC) based on the Normalized Difference Vegetation Index (NDVI) and the gross primary productivity (GPP) dataset of the moderate resolution-imaging spectroradiometer (MODIS). The regional median results of the NDVI and GPP showed that the whole vegetation was little changed by massive tunnel drainage throughout BC, DC, and AC. The NDVI and GPP were locally decreased in the first 3 years, and then recovered to the original level within next several years. Notably, the NDVI and GPP of the karst area (20 and 50% in the total area) were decreased more significantly than those of the non-karst area (8 and 20% in the total area). The factors controlling vegetation change are the development of karst and fractures, which are the conduits of groundwater flow. Therefore, massive groundwater discharge is the primary influence leading to the vegetation deterioration in the Jinping II hydropower station. The research would provide a vital reference for vegetation protection of large-scale underground construction in the world.
Keywords	groundwater discharging ; karst ; fracture ; vegetation ; spatiotemporal impact ; Jinping II hydropower station ; Science ; Q
Subject code	910
Language	English
Publishing date	2022-05-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
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