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  1. Article ; Online: Geometrically frustrated interactions drive structural complexity in amorphous calcium carbonate.

    Nicholas, Thomas C / Stones, Adam Edward / Patel, Adam / Michel, F Marc / Reeder, Richard J / Aarts, Dirk G A L / Deringer, Volker L / Goodwin, Andrew L

    Nature chemistry

    2023  Volume 16, Issue 1, Page(s) 36–41

    Abstract: Amorphous calcium carbonate is an important precursor for biomineralization in marine organisms. Key outstanding problems include understanding the structure of amorphous calcium carbonate and rationalizing its metastability as an amorphous phase. Here ... ...

    Abstract Amorphous calcium carbonate is an important precursor for biomineralization in marine organisms. Key outstanding problems include understanding the structure of amorphous calcium carbonate and rationalizing its metastability as an amorphous phase. Here we report high-quality atomistic models of amorphous calcium carbonate generated using state-of-the-art interatomic potentials to help guide fits to X-ray total scattering data. Exploiting a recently developed inversion approach, we extract from these models the effective Ca⋯Ca interaction potential governing the structure. This potential contains minima at two competing distances, corresponding to the two different ways that carbonate ions bridge Ca
    Language English
    Publishing date 2023-09-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 2464596-5
    ISSN 1755-4349 ; 1755-4330
    ISSN (online) 1755-4349
    ISSN 1755-4330
    DOI 10.1038/s41557-023-01339-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: How disability can win England the World Cup.

    Stones, Richard / Ahmed, Osman Hassan / Weiler, Richard

    The British journal of general practice : the journal of the Royal College of General Practitioners

    2014  Volume 64, Issue 623, Page(s) 298

    MeSH term(s) Adult ; Athletic Performance ; Disability Evaluation ; Disabled Persons/statistics & numerical data ; Female ; Forecasting ; Humans ; Male ; Soccer ; Sports for Persons with Disabilities/statistics & numerical data ; Sports for Persons with Disabilities/trends ; United Kingdom ; Young Adult
    Language English
    Publishing date 2014-05-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 1043148-2
    ISSN 1478-5242 ; 0035-8797 ; 0960-1643
    ISSN (online) 1478-5242
    ISSN 0035-8797 ; 0960-1643
    DOI 10.3399/bjgp14X680209
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 576: Show issues Location:
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    Zs.MO 100: Show issues

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  3. Article ; Online: Tissue optimization strategies for high-quality ex vivo diffusion imaging.

    Barrett, Rachel L C / Cash, Diana / Simmons, Camilla / Kim, Eugene / Wood, Tobias C / Stones, Richard / Vernon, Anthony C / Catani, Marco / Dell'Acqua, Flavio

    NMR in biomedicine

    2022  Volume 36, Issue 3, Page(s) e4866

    Abstract: Ex vivo diffusion imaging can be used to study healthy and pathological tissue microstructure in the rodent brain with high resolution, providing a link between in vivo MRI and ex vivo microscopy techniques. Major challenges for the successful ... ...

    Abstract Ex vivo diffusion imaging can be used to study healthy and pathological tissue microstructure in the rodent brain with high resolution, providing a link between in vivo MRI and ex vivo microscopy techniques. Major challenges for the successful acquisition of ex vivo diffusion imaging data however are changes in the relaxivity and diffusivity of brain tissue following perfusion fixation. In this study we address this question by examining the combined effects of tissue preparation factors that influence signal-to-noise ratio (SNR) and consequently image quality, including fixative concentration, contrast agent concentration and tissue rehydration time. We present an optimization strategy combining these factors to manipulate the
    MeSH term(s) Fixatives ; Diffusion Magnetic Resonance Imaging/methods ; Brain/diagnostic imaging ; Magnetic Resonance Imaging ; Gray Matter
    Chemical Substances Fixatives
    Language English
    Publishing date 2022-12-04
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1000976-0
    ISSN 1099-1492 ; 0952-3480
    ISSN (online) 1099-1492
    ISSN 0952-3480
    DOI 10.1002/nbm.4866
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2869: Show issues Location:
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  4. Book ; Online: Geometrically-frustrated interactions drive structural complexity in amorphous calcium carbonate

    Nicholas, Thomas C. / Stones, Adam E. / Patel, Adam / Michel, F. Marc / Reeder, Richard J. / Aarts, Dirk G. A. L. / Deringer, Volker L. / Goodwin, Andrew L.

    2023  

    Abstract: Amorphous calcium carbonate (ACC) is an important precursor for biomineralisation in marine organisms. Among the key outstanding problems regarding ACC are how best to understand its structure and how to rationalise its metastability as an amorphous ... ...

    Abstract Amorphous calcium carbonate (ACC) is an important precursor for biomineralisation in marine organisms. Among the key outstanding problems regarding ACC are how best to understand its structure and how to rationalise its metastability as an amorphous phase. Here, we report high-quality atomistic models of ACC generated by using state-of-the-art interatomic potentials to help guide fits to X-ray total scattering data. Exploiting a recently-developed inversion approach, we extract from these models the effective Ca$\boldsymbol\cdots$Ca interaction potential governing ACC formation. This potential contains minima at two competing distances, corresponding to the two different ways in which carbonate ions bridge Ca$^{2+}$-ion pairs. We reveal an unexpected mapping to the Lennard-Jones--Gauss (LJG) model normally studied in the context of computational soft-matter, with the empirical LJG parameters for ACC taking values known to promote structural complexity. In this way we show that both the complex structure of ACC and its resilience to crystallisation are actually encoded in the geometrically-frustrated effective interactions between Ca$^{\boldsymbol 2+}$ ions.
    Keywords Condensed Matter - Materials Science
    Subject code 541
    Publishing date 2023-03-10
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article: On the performance of a photosystem II reaction centre-based photocell.

    Stones, Richard / Hossein-Nejad, Hoda / van Grondelle, Rienk / Olaya-Castro, Alexandra

    Chemical science

    2017  Volume 8, Issue 10, Page(s) 6871–6880

    Abstract: The photosystem II reaction centre is the photosynthetic complex responsible for oxygen production on Earth. Its water splitting function is particularly favoured by the formation of a stable charge separated ... ...

    Abstract The photosystem II reaction centre is the photosynthetic complex responsible for oxygen production on Earth. Its water splitting function is particularly favoured by the formation of a stable charge separated state
    Language English
    Publishing date 2017-08-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 2559110-1
    ISSN 2041-6539 ; 2041-6520
    ISSN (online) 2041-6539
    ISSN 2041-6520
    DOI 10.1039/c7sc02983g
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  6. Article ; Online: One world is not enough: the structured phenomenology of lifestyle migrants in East Asia.

    Stones, Rob / Botterill, Kate / Lee, Maggy / O'Reilly, Karen

    The British journal of sociology

    2018  Volume 70, Issue 1, Page(s) 44–69

    Abstract: ... to the interplay between social structures and the lived experience of migrants. The approach enables a rich ...

    Abstract The paper is based on original empirical research into the lifestyle migration of European migrants, primarily British, to Thailand and Malaysia, and of Hong Kong Chinese migrants to Mainland China. We combine strong structuration theory (SST) with Heideggerian phenomenology to develop a distinctive approach to the interplay between social structures and the lived experience of migrants. The approach enables a rich engagement with the subjectivities of migrants, an engagement that is powerfully enhanced by close attention to how these inner lives are deeply interwoven with relevant structural contexts. The approach is presented as one that could be fruitfully adopted to explore parallel issues within all types of migration. As is intrinsic to lifestyle migration, commitment to a better quality of life is central to the East Asian migrants, but they seek an uncomplicated, physically enhanced texture of life, framed more by a phenomenology of prosaic well-being than of self-realization or transcendence. In spite of possessing economic and status privileges due to their relatively elite position within global structures the reality for a good number of the lifestyle migrants falls short of their prior expectations. They are subject to particular kinds of socio-structural marginaliszation as a consequence of the character of their migration, and they find themselves relatively isolated and facing a distinct range of challenges. A comparison with research into various groups of migrants to the USA brings into relief the specificities of the socio-structural positioning of the lifestyle migrants of the study. Those East Asian migrants who express the greatest sense of ease and contentment seem to be those who have responded creatively to the specific challenges of their socio-structural situation. Often, this appears to have been achieved through understated but active involvements with their new settings and through sustaining focused transnational connections and relationships.
    MeSH term(s) Acculturation ; Anthropology, Cultural ; Cultural Characteristics ; England ; Far East ; Female ; Humans ; Interviews as Topic ; Life Style ; Male ; Quality of Life ; Residence Characteristics ; Social Environment ; Social Isolation ; Sociological Factors ; Transients and Migrants/psychology
    Language English
    Publishing date 2018-02-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 1491378-1
    ISSN 1468-4446 ; 0007-1315
    ISSN (online) 1468-4446
    ISSN 0007-1315
    DOI 10.1111/1468-4446.12357
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  7. Article ; Online: Preventing deaths from complications of labour and delivery.

    Buchmann, Eckhart J / Stones, William / Thomas, Niranjan

    Best practice & research. Clinical obstetrics & gynaecology

    2016  Volume 36, Page(s) 103–115

    Abstract: ... are large disparities between rich and poor countries, and sub-Saharan Africa has not seen the scale ...

    Abstract The process of labour and delivery remains an unnecessary and preventable cause of death of women and babies around the world. Although the rates of maternal and perinatal death are declining, there are large disparities between rich and poor countries, and sub-Saharan Africa has not seen the scale of decline as seen elsewhere. In many areas, maternity services remain sparse and under-equipped, with insufficient and poorly trained staff. Priorities for reducing the mortality burden are provision of safe caesarean section, prevention of sepsis and appropriate care of women in labour in line with the current best practices, appropriately and affordably delivered. A concern is that large-scale recourse to caesarean delivery has its own dangers and may present new dominant causes for maternal mortality. An area of current neglect is newborn care. However, innovative training methods and appropriate technologies offer opportunities for affordable and effective newborn resuscitation and follow-up management in low-income settings.
    MeSH term(s) Birth Injuries/complications ; Birth Injuries/prevention & control ; Birth Injuries/therapy ; Cesarean Section ; Delivery, Obstetric ; Dystocia/therapy ; Emergencies ; Female ; Fetal Hypoxia/complications ; Fetal Hypoxia/prevention & control ; Fetal Hypoxia/therapy ; Health Services Accessibility ; Humans ; Infant Care ; Infant, Newborn ; Inservice Training ; Labor, Obstetric ; Maternal Death/etiology ; Maternal Death/prevention & control ; Obstetric Labor Complications/therapy ; Perinatal Death/etiology ; Perinatal Death/prevention & control ; Postpartum Hemorrhage/therapy ; Pregnancy ; Sepsis/complications ; Sepsis/therapy ; Simulation Training ; Uterine Hemorrhage/complications ; Uterine Hemorrhage/therapy
    Language English
    Publishing date 2016-10
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 2050090-7
    ISSN 1532-1932 ; 1521-6934
    ISSN (online) 1532-1932
    ISSN 1521-6934
    DOI 10.1016/j.bpobgyn.2016.05.012
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    In stock of ZB MED Cologne/Königswinter

    Se 1040: Show issues Location:
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  8. Article ; Online: SARS-CoV-2 vaccine responses following CD20-depletion treatment in patients with haematological and rheumatological disease: a West Midlands Research Consortium study.

    Shields, Adrian M / Venkatachalam, Srinivasan / Shafeek, Salim / Paneesha, Shankara / Ford, Mark / Sheeran, Tom / Kelly, Melanie / Qureshi, Iman / Salhan, Beena / Karim, Farheen / De Silva, Neelakshi / Stones, Jacqueline / Lee, Sophie / Khawaja, Jahanzeb / Kaudlay, Praveen Kumar / Whitmill, Richard / Kakepoto, Ghulam Nabi / Parry, Helen M / Moss, Paul /
    Faustini, Sian E / Richter, Alex G / Drayson, Mark T / Basu, Supratik

    Clinical and experimental immunology

    2022  Volume 207, Issue 1, Page(s) 3–10

    Abstract: B-cell-depleting agents are among the most commonly used drugs to treat haemato-oncological and autoimmune diseases. They rapidly induce a state of peripheral B-cell aplasia with the potential to interfere with nascent vaccine responses, particularly to ... ...

    Abstract B-cell-depleting agents are among the most commonly used drugs to treat haemato-oncological and autoimmune diseases. They rapidly induce a state of peripheral B-cell aplasia with the potential to interfere with nascent vaccine responses, particularly to novel antigens. We have examined the relationship between B-cell reconstitution and SARS-CoV-2 vaccine responses in two cohorts of patients previously exposed to B-cell-depleting agents: a cohort of patients treated for haematological B-cell malignancy and another treated for rheumatological disease. B-cell depletion severely impairs vaccine responsiveness in the first 6 months after administration: SARS-CoV-2 antibody seroprevalence was 42.2% and 33.3% in the haemato-oncological patients and rheumatology patients, respectively and 22.7% in patients vaccinated while actively receiving anti-lymphoma chemotherapy. After the first 6 months, vaccine responsiveness significantly improved during early B-cell reconstitution; however, the kinetics of reconstitution was significantly faster in haemato-oncology patients. The AstraZeneca ChAdOx1 nCoV-19 vaccine and the Pfizer BioNTech 162b vaccine induced equivalent vaccine responses; however, shorter intervals between vaccine doses (<1 m) improved the magnitude of the antibody response in haeamto-oncology patients. In a subgroup of haemato-oncology patients, with historic exposure to B-cell-depleting agents (>36 m previously), vaccine non-responsiveness was independent of peripheral B-cell reconstitution. The findings have important implications for primary vaccination and booster vaccination strategies in individuals clinically vulnerable to SARS-CoV-2.
    MeSH term(s) COVID-19 ; COVID-19 Vaccines ; ChAdOx1 nCoV-19 ; Humans ; Rheumatic Diseases/drug therapy ; SARS-CoV-2 ; Seroepidemiologic Studies
    Chemical Substances COVID-19 Vaccines ; ChAdOx1 nCoV-19 (B5S3K2V0G8)
    Language English
    Publishing date 2022-01-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 218531-3
    ISSN 1365-2249 ; 0009-9104 ; 0964-2536
    ISSN (online) 1365-2249
    ISSN 0009-9104 ; 0964-2536
    DOI 10.1093/cei/uxab018
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 337: Show issues Location:
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  9. Article ; Online: Autism Is Associated With Interindividual Variations of Gray and White Matter Morphology.

    Mei, Ting / Forde, Natalie J / Floris, Dorothea L / Dell'Acqua, Flavio / Stones, Richard / Ilioska, Iva / Durston, Sarah / Moessnang, Carolin / Banaschewski, Tobias / Holt, Rosemary J / Baron-Cohen, Simon / Rausch, Annika / Loth, Eva / Oakley, Bethany / Charman, Tony / Ecker, Christine / Murphy, Declan G M / Beckmann, Christian F / Llera, Alberto /
    Buitelaar, Jan K

    Biological psychiatry. Cognitive neuroscience and neuroimaging

    2022  Volume 8, Issue 11, Page(s) 1084–1093

    Abstract: Background: Although many studies have explored atypicalities in gray matter (GM) and white matter (WM) morphology of autism, most of them relied on unimodal analyses that did not benefit from the likelihood that different imaging modalities may reflect ...

    Abstract Background: Although many studies have explored atypicalities in gray matter (GM) and white matter (WM) morphology of autism, most of them relied on unimodal analyses that did not benefit from the likelihood that different imaging modalities may reflect common neurobiology. We aimed to establish brain patterns of modalities that differentiate between individuals with and without autism and explore associations between these brain patterns and clinical measures in the autism group.
    Methods: We studied 183 individuals with autism and 157 nonautistic individuals (age range, 6-30 years) in a large, deeply phenotyped autism dataset (EU-AIMS LEAP [European Autism Interventions-A Multicentre Study for Developing New Medications Longitudinal European Autism Project]). Linked independent component analysis was used to link all participants' GM volume and WM diffusion tensor images, and group comparisons of modality shared variances were examined. Subsequently, we performed univariate and multivariate brain-behavior correlation analyses to separately explore the relationships between brain patterns and clinical profiles.
    Results: One multimodal pattern was significantly related to autism. This pattern was primarily associated with GM volume in bilateral insula and frontal, precentral and postcentral, cingulate, and caudate areas and co-occurred with altered WM features in the superior longitudinal fasciculus. The brain-behavior correlation analyses showed a significant multivariate association primarily between brain patterns that involved variation of WM and symptoms of restricted and repetitive behavior in the autism group.
    Conclusions: Our findings demonstrate the assets of integrated analyses of GM and WM alterations to study the brain mechanisms that underpin autism and show that the complex clinical autism phenotype can be interpreted by brain covariation patterns that are spread across the brain involving both cortical and subcortical areas.
    MeSH term(s) Humans ; Child ; Adolescent ; Young Adult ; Adult ; White Matter/diagnostic imaging ; Autistic Disorder ; Magnetic Resonance Imaging/methods ; Brain ; Gray Matter/diagnostic imaging
    Language English
    Publishing date 2022-09-06
    Publishing country United States
    Document type Multicenter Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2879089-3
    ISSN 2451-9030 ; 2451-9022
    ISSN (online) 2451-9030
    ISSN 2451-9022
    DOI 10.1016/j.bpsc.2022.08.011
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  10. Article: Identification and verification under the money laundering regulations

    Stones, Richard

    Journal of financial regulation and compliance : an international journal 5 ,2, S. 146-153

    problems with compliance

    1997  

    Author's details Richard Stones
    Keywords Geldwäsche ; Großbritannien
    Language English
    Publisher Emerald
    Publishing place Bingley
    Document type Article
    ZDB-ID 1400767-8 ; 2093796-9
    ISSN 1358-1988
    ISSN 1358-1988
    Database ECONomics Information System

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