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  1. Article ; Online: Cancer risk and pesticide use in agricultural settings

    Pierluigi Cocco

    Safety and Health at Work, Vol 13, Iss , Pp S50- (2022)

    2022  

    Keywords Public aspects of medicine ; RA1-1270
    Language English
    Publishing date 2022-01-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Time for Re-Evaluating the Human Carcinogenicity of Ethylenedithiocarbamate Fungicides? A Systematic Review.

    Cocco, Pierluigi

    International journal of environmental research and public health

    2022  Volume 19, Issue 5

    Abstract: Background: In January 2021, the European Union ended the license of Mancozeb, the bestselling ethylenedithiocarbamate (EBDC) fungicide, because of some properties typical of human carcinogens. This decision contrasts the IARC classification of EBDC ... ...

    Abstract Background: In January 2021, the European Union ended the license of Mancozeb, the bestselling ethylenedithiocarbamate (EBDC) fungicide, because of some properties typical of human carcinogens. This decision contrasts the IARC classification of EBDC fungicides (Group 3, not classifiable as to human carcinogenicity). A systematic review of the scientific literature was conducted to explore the current evidence.
    Methods: Human and experimental studies of cancer and exposure to EBDC fungicides (Mancozeb, Maneb, Zineb, and others) and ethylene thiourea (ETU), their major metabolite, published in English as of December 2021, were retrieved using PubMed, the list of references of the relevant reports, and grey literature.
    Results: The epidemiological evidence of EBDC carcinogenicity is inadequate, with two studies each suggesting an association with melanoma and brain cancer and inconsistent findings for thyroid cancer. Experimental animal studies point at thyroid cancer in rats and liver cancer in mice, while multiple organs were affected following the long-term oral administration of Mancozeb. The mechanism of thyroid carcinogenesis in rats has also been shown to occur in humans. Genotoxic effects have been reported.
    Conclusions: The results of this systematic review suggest inadequate evidence for the carcinogenicity of EBDC fungicides from human studies and sufficient evidence from animal studies, with positive results on three out of ten key characteristics of carcinogens applying to humans as well. An IARC re-evaluation of the human carcinogenicity of EBDC fungicides is warranted.
    MeSH term(s) Animals ; Carcinogens/toxicity ; Fungicides, Industrial/toxicity ; Humans ; Maneb/toxicity ; Mice ; Rats ; Thyroid Neoplasms
    Chemical Substances Carcinogens ; Fungicides, Industrial ; Maneb (12427-38-2)
    Language English
    Publishing date 2022-02-24
    Publishing country Switzerland
    Document type Journal Article ; Review ; Systematic Review
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph19052632
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  3. Article: Cancer incidence among the NATO peacekeeping forces in Bosnia and Kosovo: a systematic review and metanalysis.

    Cocco, Pierluigi

    La Medicina del lavoro

    2022  Volume 113, Issue 1, Page(s) e2022011

    Abstract: Background: A few cohort studies of the NATO peacekeepers in the Bosnia and Kosovo war reported inconclusive results on cancer risk. A systematic review and metanalysis of such studies might help to resolve the interpretative limitations.: Methods: ... ...

    Abstract Background: A few cohort studies of the NATO peacekeepers in the Bosnia and Kosovo war reported inconclusive results on cancer risk. A systematic review and metanalysis of such studies might help to resolve the interpretative limitations.
    Methods: Relevant publications were retrieved through a PubMed search and from the list of references of the selected reports. Five epidemiological studies, one each from Denmark, Italy, the Netherlands, Norway, and Sweden, satisfied the selection criteria. Random and fixed effect estimators were calculated. Heterogeneity across studies was formally tested for all cancer outcomes.
    Results: Incidence of all cancers was below the expectation, as was the case for lung cancer and cancer at most other organs. The incidence of Hodgkin's lymphoma exceeded expectation in the first years after deployment in the Italian cohort but not in the subsequent years of follow-up. The risk of colorectal cancer and bone cancer was increased in the Danish cohort, and so was the risk of leukaemia in the Swedish cohort. Bladder cancer cases were non significantly more than expected in the three Scandinavian studies. The Cochrane's Q-test was indicative of significant heterogeneity across studies for total cancer, colorectal cancer, melanoma, and leukaemia. The meta-estimate of risk of bladder cancer was increased two-fold (fixed effect summary [FES] = 2.16 (95% CI 1.35 - 2.97), based on three studies.
    Discussion: Exposure to depleted uranium, metals, and ultrafine particles has been claimed as responsible for the cancer cases observed among peacekeepers. None of these would account for the excess of bladder cancer. The hypothesis of viral epidemics around the deployment area of the Italian military as contributing to the temporary excess of Hodgkin's Lymphoma cases would be worth exploring.
    MeSH term(s) Bosnia and Herzegovina ; Humans ; Incidence ; Kosovo ; Military Personnel ; Neoplasms/epidemiology ; Neoplasms/etiology
    Language English
    Publishing date 2022-02-22
    Publishing country Italy
    Document type Journal Article ; Meta-Analysis ; Systematic Review
    ZDB-ID 123678-7
    ISSN 0025-7818
    ISSN 0025-7818
    DOI 10.23749/mdl.v113i1.12600
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  4. Article ; Online: Time for Re-Evaluating the Human Carcinogenicity of Ethylenedithiocarbamate Fungicides? A Systematic Review

    Pierluigi Cocco

    International Journal of Environmental Research and Public Health, Vol 19, Iss 2632, p

    2022  Volume 2632

    Abstract: Background. In January 2021, the European Union ended the license of Mancozeb, the bestselling ethylenedithiocarbamate (EBDC) fungicide, because of some properties typical of human carcinogens. This decision contrasts the IARC classification of EBDC ... ...

    Abstract Background. In January 2021, the European Union ended the license of Mancozeb, the bestselling ethylenedithiocarbamate (EBDC) fungicide, because of some properties typical of human carcinogens. This decision contrasts the IARC classification of EBDC fungicides (Group 3, not classifiable as to human carcinogenicity). A systematic review of the scientific literature was conducted to explore the current evidence. Methods. Human and experimental studies of cancer and exposure to EBDC fungicides (Mancozeb, Maneb, Zineb, and others) and ethylene thiourea (ETU), their major metabolite, published in English as of December 2021, were retrieved using PubMed, the list of references of the relevant reports, and grey literature. Results. The epidemiological evidence of EBDC carcinogenicity is inadequate, with two studies each suggesting an association with melanoma and brain cancer and inconsistent findings for thyroid cancer. Experimental animal studies point at thyroid cancer in rats and liver cancer in mice, while multiple organs were affected following the long-term oral administration of Mancozeb. The mechanism of thyroid carcinogenesis in rats has also been shown to occur in humans. Genotoxic effects have been reported. Conclusions. The results of this systematic review suggest inadequate evidence for the carcinogenicity of EBDC fungicides from human studies and sufficient evidence from animal studies, with positive results on three out of ten key characteristics of carcinogens applying to humans as well. An IARC re-evaluation of the human carcinogenicity of EBDC fungicides is warranted.
    Keywords ethylenedithiocarbamates ; Mancozeb ; Maneb ; Zineb ; ethylenthiourea ; fungicides ; Medicine ; R
    Subject code 610
    Language English
    Publishing date 2022-02-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
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  5. Article ; Online: Hazardous Effects of Pesticides on Human Health.

    Ádám, Balázs / Cocco, Pierluigi / Godderis, Lode

    Toxics

    2024  Volume 12, Issue 3

    Abstract: Pesticides, a major group of biocides, are designed to control harmful and/or unwanted organisms [ ... ]. ...

    Abstract Pesticides, a major group of biocides, are designed to control harmful and/or unwanted organisms [...].
    Language English
    Publishing date 2024-02-28
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2733883-6
    ISSN 2305-6304 ; 2305-6304
    ISSN (online) 2305-6304
    ISSN 2305-6304
    DOI 10.3390/toxics12030186
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  6. Article ; Online: The determinants of the changing speed of spread of COVID-19 across Italy.

    Cocco, Pierluigi / De Matteis, Sara

    Epidemiology and infection

    2022  , Page(s) 1–26

    Language English
    Publishing date 2022-05-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 632982-2
    ISSN 1469-4409 ; 0950-2688
    ISSN (online) 1469-4409
    ISSN 0950-2688
    DOI 10.1017/S095026882200084X
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    Un I Zs.271: Show issues Location:
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  7. Book ; Conference proceedings: Abstracts / Sixteenth International Symposium on Epidemiology in Occupational Health ; Jack Pepys Symposium on Prevention of Occupational Asthma ; Third International Conference on Women's Health: Occupation, Cancer and Reproduction

    Cocco, Pierluigi

    [11 - 14 September 2002, Barcelona, Spain]

    (La medicina del lavoro ; 93,5)

    2002  

    Institution International Symposium on Epidemiology in Occupational Health
    Event/congress Jack Pepys Symposium on Prevention of Occupational Asthma (2002, Barcelona) ; International Conference on Women's Health: Occupation, Cancer and Reproduction (3, 2002, Barcelona)
    Author's details Guest eds.: Pierluigi Cocco
    Series title La medicina del lavoro ; 93,5
    Collection
    Language English
    Size S. 367 - 494
    Publisher Casa Editrice Mattioli
    Publishing place Fidenza
    Publishing country Italy
    Document type Book ; Conference proceedings
    HBZ-ID HT013458232
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
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  8. Article ; Online: COVID-19 and non-Hodgkin's lymphoma: A common susceptibility pattern?

    Sara, De Matteis / Minelli, Cosetta / Broccia, Giorgio / Vineis, Paolo / Cocco, Pierluigi

    PloS one

    2023  Volume 18, Issue 3, Page(s) e0277588

    Abstract: Objective: To explore the link between COVID-19 incidence, socio-economic covariates, and NHL incidence.: Design: Ecological study design.: Setting: Sardinia, Italy.: Participants: We used official reports on the total cases of COVID-19 in 2020, ...

    Abstract Objective: To explore the link between COVID-19 incidence, socio-economic covariates, and NHL incidence.
    Design: Ecological study design.
    Setting: Sardinia, Italy.
    Participants: We used official reports on the total cases of COVID-19 in 2020, published data on NHL incidence, and socio-economic indicators by administrative unit, covering the whole regional population.
    Main outcomes and measures: We used multivariable regression analysis to explore the association between the natural logarithm (ln) of the 2020 cumulative incidence of COVID-19 and the ln-transformed NHL incidence in 1974-2003, weighing by population size and adjusting by socioeconomic deprivation and other covariates.
    Results: The cumulative incidence of COVID-19 increased in relation to past incidence of NHL (p < 0.001), socioeconomic deprivation (p = 0.006), and proportion of elderly residents (p < 0.001) and decreased with urban residency (p = 0.001). Several sensitivity analyses confirmed the finding of an association between COVID-19 and NHL.
    Conclusion: This ecological study found an ecological association between NHL and COVID-19. If further investigation would confirm our findings, shared susceptibility factors should be investigated among the plausible underlying mechanisms.
    MeSH term(s) Humans ; Aged ; COVID-19/epidemiology ; Lymphoma, Non-Hodgkin/epidemiology ; Incidence ; Italy/epidemiology
    Language English
    Publishing date 2023-03-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0277588
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  9. Article ; Online: Epidemiology of Chronic Lymphocytic Leukemia in Sardinia, Italy (1974-2003).

    Broccia, Giorgio / Carter, Jonathan / Ozsin-Ozler, Cansu / De Matteis, Sara / Cocco, Pierluigi

    Experimental hematology

    2023  Volume 125-126, Page(s) 37–44

    Abstract: Several reports have described a worldwide increasing incidence of chronic lymphocytic leukemia (CLL) dating back seven to eight decades. Although genetic susceptibility would be an implausible explanation, the determinants of this upward trend and its ... ...

    Abstract Several reports have described a worldwide increasing incidence of chronic lymphocytic leukemia (CLL) dating back seven to eight decades. Although genetic susceptibility would be an implausible explanation, the determinants of this upward trend and its spatial coordinates are poorly understood. We explored CLL incidence in Sardinia, Italy, using a validated database including the 1700 CLL cases diagnosed during 1974-2003. We applied Bayesian methods to map the CLL probability by administrative unit and Poisson regression analysis to investigate socioeconomic and environmental determinants adjusting by possible confounders. The standardized (Standard European population) incidence rate for the Sardinian population over the study period was 5.1 per 100,000 (95% confidence interval [CI] 4.9-5.3), increased annually by 5.8% (95% CI 5.7-6.0) consistently by sex and age, and was more noticeable in urban areas. Five administrative units exceeded the 95% posterior probability of an elevated CLL incidence: these were rural areas spread over the regional territory, not suggestive of spatial clustering. The Poisson regression analysis showed that the risk was elevated in urban areas (RR = 1.11, 95% CI 1.05-1.17), among residents ≥ 30 km from the nearest hospital (RR = 1.09, 95% CI 1.06-1.12), and with the local prevalence of cork harvesting (RR = 1.62, 95% CI 1.12-2.34). Our results suggest that better access to health care facilities and improvements in diagnostic efficacy might have generated the observed upward trend in CLL incidence, along with contributing environmental factors.
    MeSH term(s) Humans ; Leukemia, Lymphocytic, Chronic, B-Cell/epidemiology ; Bayes Theorem ; Incidence ; Prevalence ; Italy/epidemiology
    Language English
    Publishing date 2023-08-09
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 185107-x
    ISSN 1873-2399 ; 0531-5573 ; 0301-472X
    ISSN (online) 1873-2399
    ISSN 0531-5573 ; 0301-472X
    DOI 10.1016/j.exphem.2023.08.002
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  10. Article ; Online: Corrigendum to "Lifetime occupational and recreational physical activity and risk of lymphoma subtypes. Results from the European Epilymph case-control study" [Cancer Epidemiol. 87 (2023) 102495].

    Meloni, Federico / Benavente, Yolanda / Becker, Nikolaus / Casabonne, Delphine / Foretova, Lenka / Maynadié, Marc / Nieters, Alexandra / Staines, Anthony / Trobbiani, Carlotta / Pilia, Ilaria / Zucca, Mariagrazia / Cocco, Pierluigi

    Cancer epidemiology

    2024  Volume 89, Page(s) 102542

    Language English
    Publishing date 2024-02-14
    Publishing country Netherlands
    Document type Published Erratum
    ZDB-ID 2508729-0
    ISSN 1877-783X ; 1877-7821
    ISSN (online) 1877-783X
    ISSN 1877-7821
    DOI 10.1016/j.canep.2024.102542
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    Zs.A 1427: Show issues Location:
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