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  1. Book: Centrosomes in development and disease

    Nigg, Erich A.

    2004  

    Author's details ed. by Erich A. Nigg
    Keywords Centrosom
    Subject Zentrosom
    Language English
    Size XLII, 431 S. : Ill., graph. Darst.
    Publisher Wiley-VCH
    Publishing place Weinheim
    Publishing country Germany
    Document type Book
    HBZ-ID HT014088542
    ISBN 3-527-30980-2 ; 978-3-527-30980-1
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

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    2004 A 3331 order for loan Magazin

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  2. Book: Genome instability in cancer development

    Nigg, Erich A.

    (Advances in experimental medicine and biology ; 570)

    2005  

    Author's details ed. by Erich A. Nigg
    Series title Advances in experimental medicine and biology ; 570
    Collection
    Keywords DNS-Reparatur ; DNS-Schädigung ; Carcinogenese
    Subject DNS ; DNA-Reparatur ; Krebs ; Krebsentstehung ; Karzinogenese ; Kanzerogenese ; Onkogenese ; DNA-Schädigung ; DNA-Schaden ; DNS-Schaden
    Language English
    Size XV, 511 S. : Ill.
    Publisher Springer
    Publishing place New York, NY
    Publishing country United States
    Document type Book
    HBZ-ID HT014624465
    ISBN 1-4020-3763-5 ; 978-1-4020-3763-4
    Database Catalogue ZB MED Medicine, Health

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  3. Article ; Online: New Editor-in-Chief-welcome to Simon Boulton!

    Nigg, Erich A / Boulton, Simon J

    Chromosoma

    2018  Volume 127, Issue 1, Page(s) 1

    Language English
    Publishing date 2018-01-29
    Publishing country Austria
    Document type Editorial
    ZDB-ID 203083-4
    ISSN 1432-0886 ; 0009-5915
    ISSN (online) 1432-0886
    ISSN 0009-5915
    DOI 10.1007/s00412-018-0661-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Seventy-five years of Chromosoma: Ivory Towers, citation metrics, and longevity of research.

    Nigg, Erich A

    Chromosoma

    2014  Volume 123, Issue 1-2, Page(s) 1–2

    MeSH term(s) Journal Impact Factor ; Peer Review, Research ; Periodicals as Topic ; Research ; Research Support as Topic
    Language English
    Publishing date 2014-03
    Publishing country Austria
    Document type Editorial
    ZDB-ID 203083-4
    ISSN 1432-0886 ; 0009-5915
    ISSN (online) 1432-0886
    ISSN 0009-5915
    DOI 10.1007/s00412-014-0453-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Once and only once: mechanisms of centriole duplication and their deregulation in disease.

    Nigg, Erich A / Holland, Andrew J

    Nature reviews. Molecular cell biology

    2018  Volume 19, Issue 5, Page(s) 297–312

    Abstract: Centrioles are conserved microtubule-based organelles that form the core of the centrosome and act as templates for the formation of cilia and flagella. Centrioles have important roles in most microtubule-related processes, including motility, cell ... ...

    Abstract Centrioles are conserved microtubule-based organelles that form the core of the centrosome and act as templates for the formation of cilia and flagella. Centrioles have important roles in most microtubule-related processes, including motility, cell division and cell signalling. To coordinate these diverse cellular processes, centriole number must be tightly controlled. In cycling cells, one new centriole is formed next to each pre-existing centriole in every cell cycle. Advances in imaging, proteomics, structural biology and genome editing have revealed new insights into centriole biogenesis, how centriole numbers are controlled and how alterations in these processes contribute to diseases such as cancer and neurodevelopmental disorders. Moreover, recent work has uncovered the existence of surveillance pathways that limit the proliferation of cells with numerical centriole aberrations. Owing to this progress, we now have a better understanding of the molecular mechanisms governing centriole biogenesis, opening up new possibilities for targeting these pathways in the context of human disease.
    MeSH term(s) Animals ; Cell Cycle/physiology ; Centrioles/physiology ; Centrosome/physiology ; Cilia/physiology ; Humans ; Microtubules/physiology ; Mitosis/physiology ; Signal Transduction/physiology
    Language English
    Publishing date 2018-01-24
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2031313-5
    ISSN 1471-0080 ; 1471-0072
    ISSN (online) 1471-0080
    ISSN 1471-0072
    DOI 10.1038/nrm.2017.127
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Jg. 1995 - 2021: Lesesall (2.OG)
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    Zs.MG 26: Show issues

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  6. Article ; Online: 21st International Chromosome Conference-Foz do Iguaçu, Brazil.

    Nigg, Erich A / Martins, Cesar

    Chromosoma

    2016  Volume 125, Issue 3, Page(s) 353

    MeSH term(s) Animals ; Brazil ; Chromosomes, Human ; Congresses as Topic ; Humans
    Language English
    Publishing date 2016-06
    Publishing country Austria
    Document type Editorial
    ZDB-ID 203083-4
    ISSN 1432-0886 ; 0009-5915
    ISSN (online) 1432-0886
    ISSN 0009-5915
    DOI 10.1007/s00412-016-0584-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Book ; Thesis: Messung der Rotationsbeweglichkeit von Membranproteinen unter Verwendung einer Flash-Photolyse-Technik

    Nigg, Erich A.

    Untersuchung von Protein-Protein- und Lipid-Protein-Wechselwirkungen in der Membran menschlicher Erythrozyten

    1980  

    Author's details von Erich A. Nigg
    Language German
    Size 117 S. : Ill., graph. Darst.
    Publishing country Switzerland
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Zürich, Techn. Hochsch., Diss. 1980
    HBZ-ID HT000293420
    Database Catalogue ZB MED Medicine, Health

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  8. Article ; Online: In memoriam--Walter J. Gehring.

    Affolter, Markus / Nigg, Erich A

    Chromosoma

    2015  Volume 124, Issue 3, Page(s) 291

    MeSH term(s) Developmental Biology ; Germany ; History, 20th Century ; History, 21st Century ; Molecular Biology
    Language English
    Publishing date 2015-09
    Publishing country Austria
    Document type Biography ; Editorial ; Historical Article
    ZDB-ID 203083-4
    ISSN 1432-0886 ; 0009-5915
    ISSN (online) 1432-0886
    ISSN 0009-5915
    DOI 10.1007/s00412-015-0523-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Editorial Note on Carlberg and Seuter (2010) Dynamics of nuclear receptor target gene regulation, Chromosoma (2010) 119: 479-484.

    Nigg, Erich A

    Chromosoma

    2011  Volume 120, Issue 6, Page(s) 531

    MeSH term(s) Chromatin/genetics ; DNA-Binding Proteins/metabolism ; Gene Expression Regulation ; Humans ; Receptors, Cytoplasmic and Nuclear/metabolism ; Regulatory Elements, Transcriptional ; Transcription Factors/metabolism ; Transcription, Genetic
    Chemical Substances Chromatin ; DNA-Binding Proteins ; Receptors, Cytoplasmic and Nuclear ; Transcription Factors
    Language English
    Publishing date 2011-12
    Publishing country Austria
    Document type Comment ; Editorial
    ZDB-ID 203083-4
    ISSN 1432-0886 ; 0009-5915
    ISSN (online) 1432-0886
    ISSN 0009-5915
    DOI 10.1007/s00412-011-0345-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: The PLK4-STIL-SAS-6 module at the core of centriole duplication.

    Arquint, Christian / Nigg, Erich A

    Biochemical Society transactions

    2016  Volume 44, Issue 5, Page(s) 1253–1263

    Abstract: Centrioles are microtubule-based core components of centrosomes and cilia. They are duplicated exactly once during S-phase progression. Central to formation of each new (daughter) centriole is the formation of a nine-fold symmetrical cartwheel structure ... ...

    Abstract Centrioles are microtubule-based core components of centrosomes and cilia. They are duplicated exactly once during S-phase progression. Central to formation of each new (daughter) centriole is the formation of a nine-fold symmetrical cartwheel structure onto which microtubule triplets are deposited. In recent years, a module comprising the protein kinase polo-like kinase 4 (PLK4) and the two proteins STIL and SAS-6 have been shown to stay at the core of centriole duplication. Depletion of any one of these three proteins blocks centriole duplication and, conversely, overexpression causes centriole amplification. In this short review article, we summarize recent insights into how PLK4, STIL and SAS-6 co-operate in space and time to form a new centriole. These advances begin to shed light on the very first steps of centriole biogenesis.
    MeSH term(s) Amino Acid Sequence ; Animals ; Cell Cycle Proteins/genetics ; Cell Cycle Proteins/metabolism ; Centrioles/metabolism ; Humans ; Intracellular Signaling Peptides and Proteins/genetics ; Intracellular Signaling Peptides and Proteins/metabolism ; Models, Biological ; Protein Binding ; Protein-Serine-Threonine Kinases/genetics ; Protein-Serine-Threonine Kinases/metabolism ; Sequence Homology, Amino Acid
    Chemical Substances Cell Cycle Proteins ; Intracellular Signaling Peptides and Proteins ; SASS6 protein, human ; STIL protein, human ; PLK4 protein, human (EC 2.7.1.-) ; Protein-Serine-Threonine Kinases (EC 2.7.11.1)
    Language English
    Publishing date 2016-10-15
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 184237-7
    ISSN 1470-8752 ; 0300-5127
    ISSN (online) 1470-8752
    ISSN 0300-5127
    DOI 10.1042/BST20160116
    Database MEDical Literature Analysis and Retrieval System OnLINE

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