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  1. Article ; Online: Double-headed molecule activates cell-death pathways in cancer cells.

    Phelan, James D / Staudt, Louis M

    Nature

    2023  Volume 620, Issue 7973, Page(s) 285–286

    Language English
    Publishing date 2023-07-07
    Publishing country England
    Document type News
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/d41586-023-02213-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Burkitt's Lymphoma.

    Roschewski, Mark / Staudt, Louis M / Wilson, Wyndham H

    The New England journal of medicine

    2022  Volume 387, Issue 12, Page(s) 1111–1122

    MeSH term(s) Burkitt Lymphoma/diagnosis ; Diagnosis, Differential ; Humans
    Language English
    Publishing date 2022-09-21
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMra2025746
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  3. Article ; Online: CRISPR-based technology to silence the expression of IncRNAs.

    Phelan, James D / Staudt, Louis M

    Proceedings of the National Academy of Sciences of the United States of America

    2020  Volume 117, Issue 15, Page(s) 8225–8227

    MeSH term(s) CRISPR-Cas Systems ; Cell Proliferation ; Clustered Regularly Interspaced Short Palindromic Repeats
    Language English
    Publishing date 2020-04-03
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2003702117
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  4. Book: Genomics & proteomics

    Shaffer, Arthur L. / Staudt, Louis M.

    (Immunological reviews ; 210)

    2006  

    Title variant Genomics and proteomics
    Author's details Arthur L. Shaffer & Louis M. Staudt
    Series title Immunological reviews ; 210
    Collection
    Language English
    Size 234 S. : Ill., graph. Darst.
    Publisher Blackwell Munksgaard
    Publishing place Oxford
    Publishing country Great Britain
    Document type Book
    HBZ-ID HT014701457
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    Se 160 -210- verfügbar in Königswinter Königswinter

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  5. Article ; Online: Structure of S1PR2-heterotrimeric G

    Chen, Hongwen / Chen, Kevin / Huang, Weijiao / Staudt, Louis M / Cyster, Jason G / Li, Xiaochun

    Science advances

    2022  Volume 8, Issue 13, Page(s) eabn0067

    Abstract: Sphingosine-1-phosphate (S1P) regulates immune cell trafficking, angiogenesis, and vascular function via its five receptors. Inherited mutations in S1P receptor 2 (S1PR2) occur in individuals with hearing loss, and acquired mutations in S1PR2 and ... ...

    Abstract Sphingosine-1-phosphate (S1P) regulates immune cell trafficking, angiogenesis, and vascular function via its five receptors. Inherited mutations in S1P receptor 2 (S1PR2) occur in individuals with hearing loss, and acquired mutations in S1PR2 and G
    Language English
    Publishing date 2022-03-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2810933-8
    ISSN 2375-2548 ; 2375-2548
    ISSN (online) 2375-2548
    ISSN 2375-2548
    DOI 10.1126/sciadv.abn0067
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  6. Article ; Online: II. Therapy of DLBCL based on genomics.

    Staudt, Louis M

    Hematological oncology

    2013  Volume 31 Suppl 1, Page(s) 26–28

    MeSH term(s) Genomics ; Humans ; Lymphoma, Large B-Cell, Diffuse/drug therapy ; Lymphoma, Large B-Cell, Diffuse/genetics
    Language English
    Publishing date 2013-06
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 604884-5
    ISSN 1099-1069 ; 0278-0232
    ISSN (online) 1099-1069
    ISSN 0278-0232
    DOI 10.1002/hon.2062
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  7. Article ; Online: Functional genomics identifies N-acetyllactosamine extension of complex N-glycans as a mechanism to evade lysis by natural killer cells.

    Zhuang, Xiaoxuan / Woods, James / Ji, Yanlong / Scheich, Sebastian / Mo, Fei / Rajagopalan, Sumati / Coulibaly, Zana A / Voss, Matthias / Urlaub, Henning / Staudt, Louis M / Pan, Kuan-Ting / Long, Eric O

    Cell reports

    2024  Volume 43, Issue 4, Page(s) 114105

    Abstract: Natural killer (NK) cells are primary defenders against cancer precursors, but cancer cells can persist by evading immune surveillance. To investigate the genetic mechanisms underlying this evasion, we perform a genome-wide CRISPR screen using B ... ...

    Abstract Natural killer (NK) cells are primary defenders against cancer precursors, but cancer cells can persist by evading immune surveillance. To investigate the genetic mechanisms underlying this evasion, we perform a genome-wide CRISPR screen using B lymphoblastoid cells. SPPL3, a peptidase that cleaves glycosyltransferases in the Golgi, emerges as a top hit facilitating evasion from NK cytotoxicity. SPPL3-deleted cells accumulate glycosyltransferases and complex N-glycans, disrupting not only binding of ligands to NK receptors but also binding of rituximab, a CD20 antibody approved for treating B cell cancers. Notably, inhibiting N-glycan maturation restores receptor binding and sensitivity to NK cells. A secondary CRISPR screen in SPPL3-deficient cells identifies B3GNT2, a transferase-mediating poly-LacNAc extension, as crucial for resistance. Mass spectrometry confirms enrichment of N-glycans bearing poly-LacNAc upon SPPL3 loss. Collectively, our study shows the essential role of SPPL3 and poly-LacNAc in cancer immune evasion, suggesting a promising target for cancer treatment.
    MeSH term(s) Humans ; Polysaccharides/metabolism ; Killer Cells, Natural/metabolism ; Killer Cells, Natural/immunology ; Amino Sugars/metabolism ; Genomics/methods ; Rituximab/pharmacology ; Rituximab/metabolism ; Cell Line, Tumor
    Chemical Substances Polysaccharides ; Amino Sugars ; N-acetyllactosamine (3Y5B2K5OOK) ; Rituximab (4F4X42SYQ6)
    Language English
    Publishing date 2024-04-14
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2649101-1
    ISSN 2211-1247 ; 2211-1247
    ISSN (online) 2211-1247
    ISSN 2211-1247
    DOI 10.1016/j.celrep.2024.114105
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Genetics of Diffuse Large B-Cell Lymphoma.

    Wright, George W / Wilson, Wyndham H / Staudt, Louis M

    The New England journal of medicine

    2018  Volume 379, Issue 5, Page(s) 493–494

    MeSH term(s) Humans ; Lymphoma, Large B-Cell, Diffuse/genetics
    Language English
    Publishing date 2018--02
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc1806191
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  9. Article ; Online: The next horizon in precision oncology: Proteogenomics to inform cancer diagnosis and treatment.

    Rodriguez, Henry / Zenklusen, Jean Claude / Staudt, Louis M / Doroshow, James H / Lowy, Douglas R

    Cell

    2021  Volume 184, Issue 7, Page(s) 1661–1670

    Abstract: When it comes to precision oncology, proteogenomics may provide better prospects to the clinical characterization of tumors, help make a more accurate diagnosis of cancer, and improve treatment for patients with cancer. This perspective describes the ... ...

    Abstract When it comes to precision oncology, proteogenomics may provide better prospects to the clinical characterization of tumors, help make a more accurate diagnosis of cancer, and improve treatment for patients with cancer. This perspective describes the significant contributions of The Cancer Genome Atlas and the Clinical Proteomic Tumor Analysis Consortium to precision oncology and makes the case that proteogenomics needs to be fully integrated into clinical trials and patient care in order for precision oncology to deliver the right cancer treatment to the right patient at the right dose and at the right time.
    MeSH term(s) Databases, Genetic ; Drug Discovery ; Genetic Association Studies ; Humans ; Neoplasms/diagnosis ; Neoplasms/genetics ; Neoplasms/therapy ; Precision Medicine ; Proteogenomics/methods
    Language English
    Publishing date 2021-04-02
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 187009-9
    ISSN 1097-4172 ; 0092-8674
    ISSN (online) 1097-4172
    ISSN 0092-8674
    DOI 10.1016/j.cell.2021.02.055
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  10. Article ; Online: Bill Paul: The heart of immunology.

    Lenardo, Michael J / Staudt, Louis M

    Proceedings of the National Academy of Sciences of the United States of America

    2015  Volume 112, Issue 46, Page(s) 14117–14118

    MeSH term(s) Allergy and Immunology/history ; Animals ; History, 20th Century ; History, 21st Century ; Humans ; Portraits as Topic
    Language English
    Publishing date 2015-11-17
    Publishing country United States
    Document type Biography ; Historical Article ; Journal Article
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.1519815112
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