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  1. Article: Prolonged generalized immune response on

    Sawant, Devendra A / Razmaria, Ali Aria / Pandit-Taskar, Neeta

    Radiology case reports

    2023  Volume 18, Issue 8, Page(s) 2552–2557

    Abstract: The Coronavirus disease 2019 (COVID-19) pandemic continues to be a major public health concern affecting millions of people globally. The COVID-19 vaccination has implications in medical assessment of cancer patients especially undergoing diagnostic ... ...

    Abstract The Coronavirus disease 2019 (COVID-19) pandemic continues to be a major public health concern affecting millions of people globally. The COVID-19 vaccination has implications in medical assessment of cancer patients especially undergoing diagnostic imaging such as
    Language English
    Publishing date 2023-05-23
    Publishing country Netherlands
    Document type Case Reports
    ZDB-ID 2406300-9
    ISSN 1930-0433
    ISSN 1930-0433
    DOI 10.1016/j.radcr.2023.04.046
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Molecular Imaging with PET-CT and PET-MRI in Pediatric Musculoskeletal Diseases.

    Guja, Kip E / Behr, Gerald / Bedmutha, Akshay / Kuhn, Marlena / Nadel, Helen R / Pandit-Taskar, Neeta

    Seminars in nuclear medicine

    2024  

    Abstract: Molecular imaging has emerged as an integral part of oncologic imaging. Given the physiologic changes that precede anatomic changes, molecular imaging can enable early detection of disease and monitoring of response. [18F] Fluorodeoxyglucose (FDG) ... ...

    Abstract Molecular imaging has emerged as an integral part of oncologic imaging. Given the physiologic changes that precede anatomic changes, molecular imaging can enable early detection of disease and monitoring of response. [18F] Fluorodeoxyglucose (FDG) Positron emission tomography (PET) is the predominant molecular imaging modality used in oncologic assessment and can be performed using PET/CT or PET/MR. In pediatric patients, PET/MRI imaging is generally preferred due to low radiation exposure and PET/MRI is particularly advantageous for imaging musculoskeletal (MSK) diseases, as MRI provides superior characterization of tissue changes as compared to CT. In this article, we provide an overview of the typical role of PET CT/MRI in assessment of some common pediatric malignancies and benign MSK diseases with case examples. We also discuss the relative advantages of PET/MRI compared to PET/CT, and review published data with a primary focus on the use of PET/MR.
    Language English
    Publishing date 2024-04-29
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 120248-0
    ISSN 1558-4623 ; 0001-2998
    ISSN (online) 1558-4623
    ISSN 0001-2998
    DOI 10.1053/j.semnuclmed.2024.03.003
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 763: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Targeted Radioimmunotherapy and Theranostics with Alpha Emitters.

    Pandit-Taskar, Neeta

    Journal of medical imaging and radiation sciences

    2019  Volume 50, Issue 4 Suppl 1, Page(s) S41–S44

    Abstract: Radiolabeled antibodies allow for selective targeting of the cancer cells within a tumor. Both beta- and alpha-emitting radioisotopes can be linked to the antibodies for delivery of radiation to the cells. The choice of the radionuclide would depend on ... ...

    Abstract Radiolabeled antibodies allow for selective targeting of the cancer cells within a tumor. Both beta- and alpha-emitting radioisotopes can be linked to the antibodies for delivery of radiation to the cells. The choice of the radionuclide would depend on the biological characteristics of the antibody including its biodistribution and biological half-life. Alpha-emitting isotopes deliver high energy to target sites within short range and therefore less radiation to adjacent normal tissues. Whole antibodies have long biological clearance times that may be limiting due to radiation levels to blood and marrow. Novel strategies, such as development of smaller antibody fragments such as minibodies and diabodies, which have faster biological clearance, engineered bispecific antibodies, and multistep targeting that uses pretargeting and bioorthogonal click chemistry methods, appear promising. Several novel targets are being investigated in early-phase studies. This review provides a brief summary and current status of radioimmunotargeted agents in oncology.
    MeSH term(s) Alpha Particles/therapeutic use ; Humans ; Neoplasms/radiotherapy ; Radioimmunotherapy/methods ; Radiometry/methods ; Radiotherapy/methods ; Theranostic Nanomedicine/methods
    Language English
    Publishing date 2019-08-23
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2426513-5
    ISSN 1876-7982 ; 1939-8654
    ISSN (online) 1876-7982
    ISSN 1939-8654
    DOI 10.1016/j.jmir.2019.07.006
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  4. Article ; Online: Molecular imaging of sarcomas with FDG PET.

    Mendoza, Humberto / Nosov, Anton / Pandit-Taskar, Neeta

    Skeletal radiology

    2022  

    Abstract: Sarcoma comprises a heterogenous entity of musculoskeletal malignancies arising from a mesenchymal origin. The diagnosis and management of pediatric sarcoma requires a multidisciplinary approach and the use of various imaging modalities including CT, MRI ...

    Abstract Sarcoma comprises a heterogenous entity of musculoskeletal malignancies arising from a mesenchymal origin. The diagnosis and management of pediatric sarcoma requires a multidisciplinary approach and the use of various imaging modalities including CT, MRI and FDG PET scans. FDG PET/CT (FDG PET), as a metabolic imaging, complements and provides superior diagnostic information as against other imaging modalities alone. Advantages of FDG PET in differentiating malignant sarcomatous lesions from benign lesions, and value in staging and restaging have been noted in several studies. The use of FDG PET in clinical management has increased over the years. The data on prognostication of outcomes or predicting responders to therapy with FDG PET in patients with sarcoma is somewhat limited. This review will focus on the pearls and pitfalls of FDG PET and role of FDG PET in initial extent of disease assessment, treatment response, and surveillance imaging pertaining to osteosarcoma, chondrosarcoma, Ewing's sarcoma, and rhabdomyosarcoma. We also discuss the limitations and unmet needs of FDG PET in the management of patients with sarcoma.
    Language English
    Publishing date 2022-09-29
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 527592-1
    ISSN 1432-2161 ; 0364-2348
    ISSN (online) 1432-2161
    ISSN 0364-2348
    DOI 10.1007/s00256-022-04182-7
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1304: Show issues Location:
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  5. Article ; Online: Functional Imaging Methods for Assessment of Minimal Residual Disease in Multiple Myeloma: Current Status and Novel ImmunoPET Based Methods.

    Pandit-Taskar, Neeta

    Seminars in hematology

    2018  Volume 55, Issue 1, Page(s) 22–32

    Abstract: Imaging plays a key role in assessment of myeloma. Osteolytic bone lesions are optimally assessed using structural imaging, however the structural changes lag the functional changes in the disease. Functional imaging with fluoro deoxy glucose (FDG) ... ...

    Abstract Imaging plays a key role in assessment of myeloma. Osteolytic bone lesions are optimally assessed using structural imaging, however the structural changes lag the functional changes in the disease. Functional imaging with fluoro deoxy glucose (FDG) positron emission tomography (PET) computerized tomography (CT) is useful in assessment of high-risk myeloma. FDG PET provides prognostic information and is helpful in monitoring response to therapy. However, it is nonspecific and may not be optimal in assessing treatment response to immunotherapeutic agents. Imaging with targeted agents may allow for better assessment of changes from therapy, that is based on the specific targeted mechanism. ImmunoPET imaging is a novel method to assess targeting of specific antigen by therapeutic antibodies. This review summarizes the role of functional imaging and development of novel immunoPET agents for assessment of treatment response and residual disease.
    MeSH term(s) Humans ; Multiple Myeloma/diagnostic imaging ; Multiple Myeloma/pathology ; Neoplasm, Residual/diagnostic imaging ; Neoplasm, Residual/pathology ; Positron-Emission Tomography/methods ; Prognosis
    Language English
    Publishing date 2018-03-05
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 206923-4
    ISSN 1532-8686 ; 0037-1963
    ISSN (online) 1532-8686
    ISSN 0037-1963
    DOI 10.1053/j.seminhematol.2018.02.009
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  6. Article: Feasibility of safe outpatient treatment in pediatric patients following intraventricular radioimmunotherapy with 131I-omburtamab for leptomeningeal disease.

    Prasad, Kavya / Serencsits, Brian E / Chu, Bae P / Dauer, Lawrence T / Donzelli, Maria / Basu, Ellen / Kramer, Kim / Pandit-Taskar, Neeta

    Research square

    2024  

    Abstract: Background: Radiolabeled antibody : Methods: Intraventricular radioimmunotherapy (RIT) with 925-1850 MBq (25-50 mCi) of : Results: Post-administration exposure rates for patients ranged from 0.16-0.46 μSv/hr/MBq at 1 ft and 0.03-0.08 μSv/hr/MBq at ...

    Abstract Background: Radiolabeled antibody
    Methods: Intraventricular radioimmunotherapy (RIT) with 925-1850 MBq (25-50 mCi) of
    Results: Post-administration exposure rates for patients ranged from 0.16-0.46 μSv/hr/MBq at 1 ft and 0.03-0.08 μSv/hr/MBq at 1 m. Radiation exposure duration ranged from 1-10 days after release for the four evaluated cohorts. Based on the highest measured exposure rates and slowest whole-body clearance, the longest precautions were approximately 78% lower than the regulatory guidance recommendations. Radiation exposure to staff associated with
    Conclusion: 131
    Language English
    Publishing date 2024-02-28
    Publishing country United States
    Document type Preprint
    DOI 10.21203/rs.3.rs-3969388/v1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: ImmunoPET: harnessing antibodies for imaging immune cells.

    Wu, Anna M / Pandit-Taskar, Neeta

    Molecular imaging and biology

    2021  Volume 24, Issue 2, Page(s) 181–197

    Abstract: Dramatic, but uneven, progress in the development of immunotherapies for cancer has created a need for better diagnostic technologies including innovative non-invasive imaging approaches. This review discusses challenges and opportunities for molecular ... ...

    Abstract Dramatic, but uneven, progress in the development of immunotherapies for cancer has created a need for better diagnostic technologies including innovative non-invasive imaging approaches. This review discusses challenges and opportunities for molecular imaging in immuno-oncology and focuses on the unique role that antibodies can fill. ImmunoPET has been implemented for detection of immune cell subsets, activation and inhibitory biomarkers, tracking adoptively transferred cellular therapeutics, and many additional applications in preclinical models. Parallel progress in radionuclide availability and infrastructure supporting biopharmaceutical manufacturing has accelerated clinical translation. ImmunoPET is poised to provide key information on prognosis, patient selection, and monitoring immune responses to therapy in cancer and beyond.
    MeSH term(s) Antibodies ; Humans ; Immunotherapy ; Neoplasms/diagnostic imaging ; Neoplasms/therapy ; Positron-Emission Tomography/methods ; Radioisotopes
    Chemical Substances Antibodies ; Radioisotopes
    Language English
    Publishing date 2021-09-22
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2079160-4
    ISSN 1860-2002 ; 1536-1632
    ISSN (online) 1860-2002
    ISSN 1536-1632
    DOI 10.1007/s11307-021-01652-7
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    Zs.A 6468: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Novel Agents and Future Perspectives on Theranostics.

    Solnes, Lilja B / Shokeen, Monica / Pandit-Taskar, Neeta

    Seminars in radiation oncology

    2020  Volume 31, Issue 1, Page(s) 83–92

    Abstract: In the current era of precision medicine, there is renewed interest in radiopharmaceutical therapy and theranostics. The approval of somatostatin receceptor directed therapy and norepinephrine transporter ... ...

    Abstract In the current era of precision medicine, there is renewed interest in radiopharmaceutical therapy and theranostics. The approval of somatostatin receceptor directed therapy and norepinephrine transporter targeted
    MeSH term(s) Humans ; Male ; Precision Medicine ; Prostatic Neoplasms/radiotherapy ; Radiopharmaceuticals/therapeutic use
    Chemical Substances Radiopharmaceuticals
    Language English
    Publishing date 2020-11-27
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 1146999-7
    ISSN 1532-9461 ; 1053-4296
    ISSN (online) 1532-9461
    ISSN 1053-4296
    DOI 10.1016/j.semradonc.2020.07.010
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3654: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  9. Article: Assessment of salivary gland function after 177Lu-PSMA radioligand therapy: Current concepts in imaging and management.

    Mahajan, Sonia / Grewal, Ravinder K / Friedman, Kent P / Schöder, Heiko / Pandit-Taskar, Neeta

    Translational oncology

    2022  Volume 21, Page(s) 101445

    Abstract: Prostate specific membrane antigen (PSMA) is a transmembrane protein that is highly expressed on prostate epithelial cells and is strongly upregulated in prostate cancer. Radioligand therapy using beta-emitting Lutetium-177 ( ...

    Abstract Prostate specific membrane antigen (PSMA) is a transmembrane protein that is highly expressed on prostate epithelial cells and is strongly upregulated in prostate cancer. Radioligand therapy using beta-emitting Lutetium-177 (
    Language English
    Publishing date 2022-05-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2443840-6
    ISSN 1936-5233
    ISSN 1936-5233
    DOI 10.1016/j.tranon.2022.101445
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  10. Article ; Online: Radioimmunoscintigraphy and Pretreatment Dosimetry of

    Pandit-Taskar, Neeta / Grkovski, Milan / Zanzonico, Pat B / Pentlow, Keith S / Modak, Shakeel / Kramer, Kim / Humm, John L

    Journal of nuclear medicine : official publication, Society of Nuclear Medicine

    2023  Volume 64, Issue 6, Page(s) 946–950

    Abstract: Radiolabeled antibody treatment ... ...

    Abstract Radiolabeled antibody treatment with
    MeSH term(s) Humans ; Kinetics ; Tissue Distribution ; Radioimmunodetection ; Radiometry/methods ; Antibodies, Monoclonal/therapeutic use
    Chemical Substances Iodine-131 ; Antibodies, Monoclonal
    Language English
    Publishing date 2023-02-09
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 80272-4
    ISSN 1535-5667 ; 0097-9058 ; 0161-5505 ; 0022-3123
    ISSN (online) 1535-5667
    ISSN 0097-9058 ; 0161-5505 ; 0022-3123
    DOI 10.2967/jnumed.122.265131
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    Zs.A 114: Show issues Location:
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