Result 1 - 10 of total 3168
1984
| Author's details | Xiao di fei |
|---|---|
| Language | Chinese |
| Size | 5, 2, 4, 325 S |
| Edition | Di yi ban |
| Publisher | Ren min wen xue chu ban she |
| Publishing place | Beijing |
| Document type | Book |
| Database | Former special subject collection: coastal and deep sea fishing |
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2024 Volume 14, Issue 5, Page(s) 2190–2209
Abstract: Here we explored the potential role of Gαi2 (G protein subunit alpha i2) in endothelial cell function and angiogenesis. ...
| Abstract | Here we explored the potential role of Gαi2 (G protein subunit alpha i2) in endothelial cell function and angiogenesis. |
|---|---|
| MeSH term(s) | Mice ; Animals ; Diabetic Retinopathy/drug therapy ; GTP-Binding Protein alpha Subunit, Gi2/metabolism ; GTP-Binding Protein alpha Subunit, Gi2/pharmacology ; Endothelial Cells/metabolism ; Angiogenesis ; Streptozocin/adverse effects ; Oxygen/metabolism ; RNA, Small Interfering/metabolism ; Cell Proliferation |
| Chemical Substances | GTP-Binding Protein alpha Subunit, Gi2 (EC 3.6.5.1) ; Streptozocin (5W494URQ81) ; Oxygen (S88TT14065) ; RNA, Small Interfering |
| Language | English |
| Publishing date | 2024-03-03 |
| Publishing country | Australia |
| Document type | Journal Article |
| ZDB-ID | 2592097-2 |
| ISSN | 1838-7640 ; 1838-7640 |
| ISSN (online) | 1838-7640 |
| ISSN | 1838-7640 |
| DOI | 10.7150/thno.92909 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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American journal of reproductive immunology (New York, N.Y. : 1989)
2024 Volume 91, Issue 1, Page(s) e13808
Abstract: Background: The recurrence rate of intrauterine adhesions (IUA) was high. At present, there are few studies on the relationship between proinflammatory factors IL-17A and IL-6 and IUA. The expression of serum IL-17A and IL-6 in IUA patients and their ... ...
| Abstract | Background: The recurrence rate of intrauterine adhesions (IUA) was high. At present, there are few studies on the relationship between proinflammatory factors IL-17A and IL-6 and IUA. The expression of serum IL-17A and IL-6 in IUA patients and their predictive value for postoperative recurrence were retrospectively analyzed. Methods: A total of 90 IUA patients who underwent hysteroscopic adhesion lysis in our hospital from January 2020 to January 2023 were selected as the IUA group. Patients were divided into mild, moderate, and severe IUA groups. At the same time, 60 cases of secondary infertility patients with normal endometrium were selected as the control group. The clinical baseline characteristics and serum levels of IL-17A and IL-6 were compared between control group and IUA group. To analyze the correlation and predictive value of IL-17A and IL-6 expression levels with the recurrence rate of IUA patients. Results: The preoperative levels of IL-17A and IL-6 in the IUA group were significantly higher than those in the control group. The higher the levels of inflammatory factors IL-17A and IL-6, the deeper the degree of IUA. Multivariate analysis showed that pregnancy, curettage history, IL-17A, and IL-6 levels were risk factors for IUA recurrence. In addition, the specificity and area under the curve of combining baseline data with postoperative serum IL-17A and IL-6 for predicting IUA were higher than those predicted separately. Conclusion: The expression levels of serum IL-17A and IL-6 can be used as a value index to evaluate postoperative recurrence in IUA patients. |
|---|---|
| MeSH term(s) | Pregnancy ; Female ; Humans ; Interleukin-6 ; Hysteroscopy/adverse effects ; Retrospective Studies ; Interleukin-17 ; Uterine Diseases/surgery ; Tissue Adhesions/surgery |
| Chemical Substances | Interleukin-6 ; Interleukin-17 |
| Language | English |
| Publishing date | 2024-01-29 |
| Publishing country | Denmark |
| Document type | Journal Article |
| ZDB-ID | 604542-x |
| ISSN | 1600-0897 ; 0271-7352 ; 8755-8920 ; 1046-7408 |
| ISSN (online) | 1600-0897 |
| ISSN | 0271-7352 ; 8755-8920 ; 1046-7408 |
| DOI | 10.1111/aji.13808 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.A 1653: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG) |
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International journal of biological macromolecules
2024 Volume 268, Issue Pt 2, Page(s) 131816
Abstract: Paeoniae Radix alba is used in Traditional Chinese Medicine for the treatment of gastrointestinal disorders, immunomodulatory, cancer, and other diseases. In the current study, the yield of Paeoniae Radix alba polysaccharide (PRP) was significantly ... ...
| Abstract | Paeoniae Radix alba is used in Traditional Chinese Medicine for the treatment of gastrointestinal disorders, immunomodulatory, cancer, and other diseases. In the current study, the yield of Paeoniae Radix alba polysaccharide (PRP) was significantly increased with optimal ultrasound-assisted extraction compared to hot water extraction. Further, an acidic polysaccharide (PRP-AP) was isolated from PRP after chromatographic separation and was characterized as a typical pectic polysaccharide with side chains of arabinogalactans types I and II. Moreover, it showed antioxidant effects on LPS-induced damage on IPEC-J2 cells determined by qRT-PCR and ELISA, including decreasing the pro-inflammatory factors' expressions and increasing the antioxidant enzymes activities, which was shown to be related to the Nrf2/Keap1 pathway modulated by PRP-AP. The metabolites change (such as itaconate, cholesterol sulfate, etc.) detected by untargeted metabolomic analysis in cells was also shown to be modulated by PRP-AP, and these metabolites were further utilized and protected cells damaged by LPS. These results revealed the cellular active mechanism of the macromolecular PRP-AP on protecting cells, and supported the hypothesis that PRP-AP has strong benefits as an alternative dietary supplement for the prevention of intestinal oxidative stress by modulating cellular metabolism. |
|---|---|
| Language | English |
| Publishing date | 2024-04-26 |
| Publishing country | Netherlands |
| Document type | Journal Article |
| ZDB-ID | 282732-3 |
| ISSN | 1879-0003 ; 0141-8130 |
| ISSN (online) | 1879-0003 |
| ISSN | 0141-8130 |
| DOI | 10.1016/j.ijbiomac.2024.131816 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.B 2374: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG) |
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Journal of physics. Condensed matter : an Institute of Physics journal
2024 Volume 36, Issue 22
Abstract: Based on first-principles calculation of density functional theory, this study investigates the structural stability, magnetic properties, and electronic properties of the three different phases (i.e. type 1, type 2, and type 3) of ... ...
| Abstract | Based on first-principles calculation of density functional theory, this study investigates the structural stability, magnetic properties, and electronic properties of the three different phases (i.e. type 1, type 2, and type 3) of Os |
|---|---|
| Language | English |
| Publishing date | 2024-03-07 |
| Publishing country | England |
| Document type | Journal Article |
| ZDB-ID | 1472968-4 |
| ISSN | 1361-648X ; 0953-8984 |
| ISSN (online) | 1361-648X |
| ISSN | 0953-8984 |
| DOI | 10.1088/1361-648X/ad2388 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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2020 Volume 99, Issue 26, Page(s) e20745
Abstract: Background: The potential benefits and safety of hepatic arterial infusion chemotherapy (HAIC) for the treatment of patients with hepatocellular carcinoma (HCC) remains inconsistent. Therefore, we conducted this meta-analysis of evaluate the efficacy ... ...
| Abstract | Background: The potential benefits and safety of hepatic arterial infusion chemotherapy (HAIC) for the treatment of patients with hepatocellular carcinoma (HCC) remains inconsistent. Therefore, we conducted this meta-analysis of evaluate the efficacy and safety of HAIC in the treatment of HCC. Methods: A comprehensive literature search was performed using PubMed, Embase, Web of Science, and the Cochrane library to identify eligible studies that compared HAIC with other therapies for patients with HCC. The main outcomes of our interest, including overall survival (OS), disease free survival (DFS), objective response rate (ORR), disease control rate (DCR), and adverse events, were calculated using the meta-analysis. The pooled estimates were expressed with hazard ratio (HR) with 95%confidence intervals (95%CIs) or risk ratio (RR) with 95%CIs. Results: A total of 13 studies met the inclusion criteria and were included in this meta-analysis. Pooled estimates showed that, HAIC was associated with significantly improved OS (HR = 0.61, 95%CI: 0.48, 0.77; P < .001) and DFS (HR = 0.66, 95%CI: 0.52, 0.84; P = .001) as compared with other therapies. The ORR (RR = 2.28, 95%CI: 1.77, 2.94; P < .001) and DCR (RR = 1.47, 95%CI: 1.23, 1.77; P < .001) were also significantly higher in HAIC group than in control group. Most of the common adverse events were comparably occurred in the 2 groups, except for nausea/vomiting, hypoalbuminemia, pain, anemia and hepatic toxicity. Subgroup analysis suggested that, the improved OS and DFS associated with HAIC were only observed in patients with colorectal liver metastases (CRLM), or advanced HCC, but not in those with unresectable HCC or pancreatic liver metastases. Conclusion: Based on the present data, HAIC showed benefit effect in HCC patients, with pronged OS and DFS, as well as increased ORR and DCR. These benefit effects were more obvious in CRLM or advanced HCC patients. However, considering the potential limitations, more large-scale, randomized trials are needed to verify our findings. |
|---|---|
| MeSH term(s) | Carcinoma, Hepatocellular/drug therapy ; Carcinoma, Hepatocellular/pathology ; Chemotherapy, Cancer, Regional Perfusion/adverse effects ; Chemotherapy, Cancer, Regional Perfusion/methods ; Humans ; Infusions, Intra-Arterial/adverse effects ; Infusions, Intra-Arterial/methods ; Liver Neoplasms/drug therapy ; Liver Neoplasms/pathology ; Neoplasm Staging ; Treatment Outcome |
| Language | English |
| Publishing date | 2020-07-06 |
| Publishing country | United States |
| Document type | Journal Article ; Meta-Analysis |
| ZDB-ID | 80184-7 |
| ISSN | 1536-5964 ; 0025-7974 |
| ISSN (online) | 1536-5964 |
| ISSN | 0025-7974 |
| DOI | 10.1097/MD.0000000000020745 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Ua VI Zs.171: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG) |
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2023
Abstract: Insects are the most diverse group of organisms in the animal kingdom, and some species exhibit complex social behaviors. Although research on insect object use is still in its early stages, insects have already been shown to display rich object-use ... ...
| Abstract | Insects are the most diverse group of organisms in the animal kingdom, and some species exhibit complex social behaviors. Although research on insect object use is still in its early stages, insects have already been shown to display rich object-use behaviors. This review focuses on patterns and behavioral flexibility in insect object-use behavior, and the role of cultural evolution in the development of object-use behaviors. Object use in insects is not widespread but has been documented in a diverse set of taxa. Some insects can use objects flexibly and display various object-use patterns. Like mammals and birds, insects use objects in diverse activities, including foraging, predator defense, courtship, and play. Intelligence, pre-existing manipulative behaviors, and anatomical structure affect innovations in object use. In addition, learning and imitation are the main mechanisms underlying the spread of object-use behaviors within populations. Given that insects are one of the major animal groups engaging in object use, studies of insect object use could provide general insights into object use in the animal kingdom. |
|---|---|
| Language | English |
| Publishing date | 2023-10-13 |
| Publishing country | Australia |
| Document type | Journal Article ; Review |
| ZDB-ID | 2179775-4 |
| ISSN | 1744-7917 ; 1672-9609 |
| ISSN (online) | 1744-7917 |
| ISSN | 1672-9609 |
| DOI | 10.1111/1744-7917.13275 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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2023 Volume 25, Issue 4, Page(s) 541–543
| MeSH term(s) | Humans ; Neoplasm Recurrence, Local ; Histiocytoma, Malignant Fibrous ; Sarcoma/surgery |
|---|---|
| Language | English |
| Publishing date | 2023-08-04 |
| Publishing country | China |
| Document type | Letter |
| ZDB-ID | 2075824-8 |
| ISSN | 1745-7262 ; 1008-682X |
| ISSN (online) | 1745-7262 |
| ISSN | 1008-682X |
| DOI | 10.4103/aja202291 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
| Zs.A 5739: Show issues | Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG) |
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Huan jing ke xue= Huanjing kexue
2024 Volume 45, Issue 2, Page(s) 668–677
Abstract: To explore the formation mechanism of the ozone （ ... ...
| Abstract | To explore the formation mechanism of the ozone （O |
|---|---|
| Language | Chinese |
| Publishing date | 2024-03-12 |
| Publishing country | China |
| Document type | English Abstract ; Journal Article |
| ISSN | 0250-3301 |
| ISSN | 0250-3301 |
| DOI | 10.13227/j.hjkx.202302191 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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2024 Volume 17, Page(s) 89–96
Abstract: Purpose: Eosinophils have pivotal roles in the development of allergic rhinitis (AR) through the release of cytotoxic substances. Apolipoprotein A-I (Apo-AI) exhibits a strong inhibitory effect on eosinophil infiltration in allergic diseases. ... ...
| Abstract | Purpose: Eosinophils have pivotal roles in the development of allergic rhinitis (AR) through the release of cytotoxic substances. Apolipoprotein A-I (Apo-AI) exhibits a strong inhibitory effect on eosinophil infiltration in allergic diseases. Nevertheless, the precise impact of Apolipoprotein A-I on eosinophils remains uncertain. Methods: Our study recruited a total of 15 AR children and 15 controls. The correlation between Apo-AI expression and the counts of blood eosinophils was examined. Flow cytometry was employed to assess the role of Apo-AI in eosinophil apoptosis and adhesion. The Transwell system was performed to conduct the migration assay. An animal model using AR mice was established to test the effect of Apo-AI on eosinophils. Results: Serum Apo-AI were negatively related to eosinophils counts and eosinophil chemotactic protein levels in AR. Apo-AI exerts a pro-apoptotic effect while also impeding the processes of adhesion, migration, and activation of eosinophils. The apoptosis triggered by Apo-AI was facilitated through the phosphoinositide 3-kinase (PI3K) pathway. The chemotaxis and activation of eosinophils, which are influenced by Apolipoprotein A-I, are regulated through the PI3K and MAPK signaling pathways. Apo-AI treated mice presented with decreased blood and nasal eosinophilic inflammation as well as down-regulated eosinophil related cytokines. Conclusion: Our findings provide confirmation that Apo-AI exhibits inhibitory effects on the function of eosinophils in allergic rhinitis. This suggests that Apo-AI holds potential as a therapeutic target for future treatment strategies. |
|---|---|
| Language | English |
| Publishing date | 2024-02-13 |
| Publishing country | New Zealand |
| Document type | Journal Article |
| ZDB-ID | 2494877-9 |
| ISSN | 1178-6965 |
| ISSN | 1178-6965 |
| DOI | 10.2147/JAA.S449948 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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