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Article: Quality attributes enhancement of ready-to-eat hairtail fish balls by high-pressure processing

Luo, H. / Sheng, Z. / Guo, C. / Jia, R. / Yang, W.

2021 Volume 147, Issue -, Page(s) 111658

Language	English
Document type	Article
ZDB-ID	2169058-3
ISSN	0023-6438
Database	Current Contents Nutrition, Environment, Agriculture

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Article ; Online: Dirac-Weyl semimetal in photonic metacrystals.

Long, Sheng / Yang, Jie / Wang, Hanyu / Yu, Zhide / Yang, Biao / Guo, Qinghua / Xiang, Yuanjiang / Xia, Lingbo / Zhang, Shuang

Optics letters

2023 Volume 48, Issue 9, Page(s) 2349–2352

Abstract: ... for the existence of Dirac points, whose Z ...

Abstract	Dirac-Weyl semimetal is a novel type of topological phase that features the coexistence of Dirac and Weyl points in momentum space. In this study, a photonic Dirac-Weyl semimetal is proposed by introducing screw rotation symmetries into a spatial inversion symmetry-lacking system. A realistic metacrystal structure is designed for experimental consideration. The screw rotation symmetries are crucial for the existence of Dirac points, whose Z
Language	English
Publishing date	2023-04-27
Publishing country	United States
Document type	Journal Article
ISSN	1539-4794
ISSN (online)	1539-4794
DOI	10.1364/OL.490001
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: A composite photocatalytic system based on spent alkaline Zn-Mn batteries for toluene removal under multiple conditions.

Zhao, Zhong / Du, Huan / Shen, Boxiong / Gao, Pei / Huang, Chao / Guo, Sheng-Qi

Environmental research

2022 Volume 212, Issue Pt B, Page(s) 113300

Abstract: ... used directly: construct a Z-scheme photocatalytic system by combining with commercial TiO ...

Abstract	The resource utilization of spent alkaline Zn-Mn batteries (S-AZMB) has always been a hot issue in the field of energy regeneration and environmental protection. The cumbersome and complicated purification process is the reason for their limited recycling. Not long ago, we proved that unpurified S-AZMB can be used directly: construct a Z-scheme photocatalytic system by combining with commercial TiO
Language	English
Publishing date	2022-04-12
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	205699-9
ISSN	1096-0953 ; 0013-9351
ISSN (online)	1096-0953
ISSN	0013-9351
DOI	10.1016/j.envres.2022.113300
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 726: Show issues

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Article ; Online: Association between serum lactate, lactate clearance rate, and 30-day mortality among patients undergoing mechanical ventilation: A retrospective cohort study of MIMIC-III database.

Sheng, Bo / Li, Shan / Wang, He / Guo, Zhe / Zhang, Zhenyu

Medicine

2024 Volume 103, Issue 4, Page(s) e35818

Abstract: Serum lactate has been used as a prognostic indicator in intensive care unit patients, and however, the single lactate value may not be enough to reflect changes during illness conditions. Herein, this study aims to explore the association between serum ... ...

Abstract	Serum lactate has been used as a prognostic indicator in intensive care unit patients, and however, the single lactate value may not be enough to reflect changes during illness conditions. Herein, this study aims to explore the association between serum lactate and lactate clearance rate and 30-day mortality in patients undergoing mechanical ventilation (MV). Demographic and clinical data of 2628 adults were extracted from the medical information mart for intensive care-III clinical database in this retrospective cohort study. The lactate clearance rate was calculated using the serum lactate at the beginning of MV (T0), and serum lactate at the12 hours after MV beginning (T1). Univariate and multivariate Cox regression analyses were used to screen covariates, and explore the association between serum lactate and lactate clearance rate and 30-day mortality. We also explored these associations in different T0 serum lactate level subgroups. The evaluation indexes were hazard ratios (HRs) and 95% CIs. In addition, receiver operator characteristic (ROC) curve with area under the curve (AUC) was used to reflect the predictive performance of serum lactate and lactate clearance rate on 30-day mortality. A total of 827 (31.47%) mechanically ventilated patients died within 30 days. After adjusting for covariates, elevated T0 (HR = 1.04, 95%CI: [1.02-1.07]) and T1 (HR = 1.07, 95%CI: [1.04-1.10]) serum lactate was both associated with an increased risk of 30-day mortality, while higher lactate clearance rate was negatively associated with the risk of 30-day mortality (HR = 0.64, 95%CI: [0.50-0.81]). Among patients with T0 lactate ≥2 mmol/L, T1 serum lactate ≥4 mmol/L was associated with an increased risk of 30-day mortality, while lactate clearance rate ≥50 was associated with a decreased risk (all P < .05). Moreover, T1 serum lactate had a potential predictive value on 30-day mortality with an AUC of 0.605. Serum lactate and lactate clearance rate were both associated with 30-day mortality in patients undergoing MV. Our results may provide some references for further studies to explore the roles of serum lactate and lactate clearance rate in prognoses of critical patients.
MeSH term(s)	Adult ; Humans ; Lactic Acid ; Respiration, Artificial ; Retrospective Studies ; Prognosis ; Critical Care ; Intensive Care Units ; ROC Curve
Chemical Substances	Lactic Acid (33X04XA5AT)
Language	English
Publishing date	2024-01-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000035818
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Ua VI Zs.171: Show issues

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Article ; Online: Coexistence of Dirac points and nodal chains in photonic metacrystal.

Yang, Jie / Long, Sheng / Wang, Hanyu / Yu, Zhide / Yang, Biao / Guo, Qinghua / Xiang, Yuanjiang / Xia, Lingbo / Zhang, Shuang

Optics express

2023 Volume 31, Issue 11, Page(s) 17943–17949

Abstract: ... located right at the intersection points of nodal chains. The nontrivial Z ...

Abstract	Gapless topological phases, i.e. topological semimetals, come in various forms such as Weyl/Dirac semimetals, nodal line/chain semimetals, and surface-node semimetals. However, the coexistence of two or more topological phases in a single system is still rare. Here, we propose the coexistence of Dirac points and nodal chain degeneracies in a judiciously designed photonic metacrystal. The designed metacrystal exhibits nodal line degeneracies lying in perpendicular planes, which are chained together at the Brillouin zone boundary. Interestingly, the Dirac points, which are protected by nonsymmorphic symmetries, are located right at the intersection points of nodal chains. The nontrivial Z
Language	English
Publishing date	2023-06-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	1491859-6
ISSN	1094-4087 ; 1094-4087
ISSN (online)	1094-4087
ISSN	1094-4087
DOI	10.1364/OE.489873
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: ATP-Responsive Manganese-Based Bacterial Materials Synergistically Activate the cGAS-STING Pathway for Tumor Immunotherapy.

Yang, Huang / Yang, Sisi / Guo, Quanshi / Sheng, Jifang / Mao, Zhengwei

Advanced materials (Deerfield Beach, Fla.)

2024 , Page(s) e2310189

Abstract: Stimulating the cyclic guanosine monophophate(GMP)-adenosine monophosphate (AMP) synthase (cGAS)-stimulator of interferon genes (STING) pathway is a crucial strategy by which bacteria activate the tumor immune system. However, the limited stimulation ... ...

Abstract	Stimulating the cyclic guanosine monophophate(GMP)-adenosine monophosphate (AMP) synthase (cGAS)-stimulator of interferon genes (STING) pathway is a crucial strategy by which bacteria activate the tumor immune system. However, the limited stimulation capability poses significant challenges in advancing bacterial immunotherapy. Here, an adenosine 5'-triphosphate (ATP)-responsive manganese (Mn)-based bacterial material (E. coli@PDMC-PEG (polyethylene glycol)) is engineered successfully, which exhibits an exceptional ability to synergistically activate the cGAS-STING pathway. In the tumor microenvironment, which is characterized by elevated ATP levels, this biohybrid material degrades, resulting in the release of divalent manganese ions (Mn
Language	English
Publishing date	2024-02-27
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1474949-X
ISSN	1521-4095 ; 0935-9648
ISSN (online)	1521-4095
ISSN	0935-9648
DOI	10.1002/adma.202310189
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Next-Generation Sequencing-Based Copy Number Variation Analysis in Chinese Patients with Primary Ciliary Dyskinesia Revealed Novel

Chen, Weicheng / Guo, Zhuoyao / Li, Mengru / Sheng, Wei / Huang, Guoying

Phenomics (Cham, Switzerland)

2024 Volume 4, Issue 1, Page(s) 24–33

Abstract: Primary ciliary dyskinesia (PCD) is a rare disorder characterized by extensive genetic heterogeneity. However, in the genetic pathogenesis of PCD, copy number variation (CNV) has not received sufficient attention and has rarely been reported, especially ... ...

Abstract	Primary ciliary dyskinesia (PCD) is a rare disorder characterized by extensive genetic heterogeneity. However, in the genetic pathogenesis of PCD, copy number variation (CNV) has not received sufficient attention and has rarely been reported, especially in China. Next-generation sequencing (NGS) followed by targeted CNV analysis was used in patients highly suspected to have PCD with negative results in routine whole-exome sequencing (WES) analysis. Quantitative real-time polymerase chain reaction (qPCR) and Sanger sequencing were used to confirm these CNVs. To further characterize the ciliary phenotypes, high-speed video microscopy analysis (HSVA), transmission electron microscopy (TEM), and immunofluorescence (IF) analysis were used. Patient 1 (F1: II-1), a 0.6-year-old girl, came from a nonconsanguineous family-I. She presented with situs inversus totalis, neonatal respiratory distress, and sinusitis. The nasal nitric oxide level was markedly reduced. The respiratory cilia beat with reduced amplitude. TEM revealed shortened outer dynein arms (ODA) of cilia. chr5:13717907-13722661del spanning exons 71-72 was identified by NGS-based CNV analysis. Patient 2 (F2: IV-4), a 37-year-old man, and his eldest brother Patient 3 (F2: IV-2) came from a consanguineous family-II. Both had sinusitis, bronchiectasis and situs inversus totalis. The respiratory cilia of Patient 2 and Patient 3 were found to be uniformly immotile, with ODA defects. Two novel homozygous deletions chr5:13720087_13733030delinsGTTTTC and chr5:13649539_1 3707643del, spanning exons 69-71 and exons 77-79 were identified by NGS-based CNV analysis. Abnormalities in DNA copy number were confirmed by qPCR amplification. IF showed that the respiratory cilia of Patient 1 and Patient 2 were deficient in dynein axonemal heavy chain 5 (DNAH5) protein expression. This report identified three novel Supplementary information: The online version contains supplementary material available at 10.1007/s43657-023-00130-0.
Language	English
Publishing date	2024-02-22
Publishing country	Switzerland
Document type	Journal Article
ISSN	2730-5848
ISSN (online)	2730-5848
DOI	10.1007/s43657-023-00130-0
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: [Preliminary effects of toripalimab combined with axitinib in the treatment of advanced renal cell carcinoma].

Zhou, L / Xu, H Y / Yan, X Q / Li, S M / Chi, Z H / Si, L / Cui, Z L / Li, J / Wu, X W / Guo, J / Sheng, X N

Zhonghua yi xue za zhi

2022 Volume 102, Issue 2, Page(s) 136–140

Abstract: Objective: ...

Abstract	Objective:
MeSH term(s)	Adult ; Aged ; Antibodies, Monoclonal, Humanized/therapeutic use ; Antineoplastic Agents/therapeutic use ; Axitinib/therapeutic use ; Carcinoma, Renal Cell/drug therapy ; Female ; Humans ; Kidney Neoplasms/drug therapy ; Male ; Middle Aged ; Retrospective Studies ; Treatment Outcome ; Young Adult
Chemical Substances	Antibodies, Monoclonal, Humanized ; Antineoplastic Agents ; toripalimab (8JXN261VVA) ; Axitinib (C9LVQ0YUXG)
Language	Chinese
Publishing date	2022-01-05
Publishing country	China
Document type	Journal Article
ZDB-ID	132513-9
ISSN	0376-2491
ISSN	0376-2491
DOI	10.3760/cma.j.cn112137-20210527-01225
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Phase II clinical trial of neoadjuvant anti-PD-1 (toripalimab) combined with axitinib in resectable mucosal melanoma.

Lian, B / Li, Z / Wu, N / Li, M / Chen, X / Zheng, H / Gao, M / Wang, D / Sheng, X / Tian, H / Si, L / Chi, Z / Wang, X / Lai, Y / Sun, T / Zhang, Q / Kong, Y / Long, G V / Guo, J /

Cui, C

Annals of oncology : official journal of the European Society for Medical Oncology

2023 Volume 35, Issue 2, Page(s) 211–220

Abstract: Background: The outcome of patients with resectable mucosal melanoma is poor. Toripalimab combined with axitinib has shown impressive results in metastatic mucosal melanoma with an objective response rate of 48.3% and a median progression-free survival ... ...

Abstract	Background: The outcome of patients with resectable mucosal melanoma is poor. Toripalimab combined with axitinib has shown impressive results in metastatic mucosal melanoma with an objective response rate of 48.3% and a median progression-free survival of 7.5 months in a phase Ib trial. It was hypothesized that this combination administered in the neoadjuvant setting might induce a pathologic response in resectable mucosal melanoma, so we conducted this trial. Patients and methods: This single-arm phase II trial enrolled patients with resectable mucosal melanoma. Patients received toripalimab 3 mg/kg once every 2 weeks (Q2W) plus axitinib 5 mg two times a day (b.i.d.) for 8 weeks as neoadjuvant therapy, then surgery and adjuvant toripalimab 3 mg/kg Q2W starting 2 ± 1weeks after surgery for 44 weeks. The primary endpoint was the pathologic response rate according to the International Neoadjuvant Melanoma Consortium recommendations. Results: Between August 2019 and October 2021, 29 patients were enrolled and received treatment, of whom 24 underwent resection. The median follow-up time was 34.2 months (95% confidence interval 20.4-48.0 months). The pathologic response rate was 33.3% (8/24; 4 pathological complete responses and 4 pathological partial responses). The median event-free survival for all patients was 11.1 months (95% confidence interval 5.3-16.9 months). The median overall survival was not reached. Neoadjuvant therapy was tolerable with 8 (27.5%) grade 3-4 treatment-related adverse events and no treatment-related deaths. Tissue samples of 17 patients at baseline and after surgery were collected (5 responders and 12 nonresponders). Multiplex immunohistochemistry demonstrated a significant increase in CD3+ (P = 0.0032) and CD3+CD8+ (P = 0.0038) tumor-infiltrating lymphocytes after neoadjuvant therapy, particularly in pathological responders. Conclusions: Neoadjuvant toripalimab combined with axitinib in resectable mucosal melanoma demonstrated a promising pathologic response rate with significantly increased infiltrating CD3+ and CD3+CD8+ T cells after therapy.
MeSH term(s)	Humans ; Antibodies, Monoclonal, Humanized ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Axitinib/adverse effects ; Axitinib/therapeutic use ; Melanoma/drug therapy ; Melanoma/surgery ; Neoadjuvant Therapy/methods ; Neoplasm Staging
Chemical Substances	Antibodies, Monoclonal, Humanized ; Axitinib (C9LVQ0YUXG) ; toripalimab (8JXN261VVA)
Language	English
Publishing date	2023-11-11
Publishing country	England
Document type	Clinical Trial, Phase II ; Journal Article
ZDB-ID	1025984-3
ISSN	1569-8041 ; 0923-7534
ISSN (online)	1569-8041
ISSN	0923-7534
DOI	10.1016/j.annonc.2023.10.793
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 2862: Show issues

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Article: A composite photocatalytic system based on spent alkaline Zn–Mn batteries for toluene removal under multiple conditions

Zhao, Zhong / Du, Huan / Shen, Boxiong / Gao, Pei / Huang, Chao / Guo, Sheng-Qi

Environmental research. 2022 Sept., v. 212

2022

Abstract: ... used directly: construct a Z-scheme photocatalytic system by combining with commercial TiO₂ ...

Abstract	The resource utilization of spent alkaline Zn–Mn batteries (S-AZMB) has always been a hot issue in the field of energy regeneration and environmental protection. The cumbersome and complicated purification process is the reason for their limited recycling. Not long ago, we proved that unpurified S-AZMB can be used directly: construct a Z-scheme photocatalytic system by combining with commercial TiO₂ through high-temperature calcination. In order for this finding to be truly adopted by the application market, the high energy consumption calcination process needs to be improved urgently. In this work, we explore the temperature dependence of performance for the composite photocatalyst (TiO₂@S-AZMB). A series of experimental results confirm that lowering the calcination temperature not only conducive to improving the separation efficiency of photogenerated electron-hole pairs, but also can significantly improve the environmental adaptability of the catalyst. Specifically, the catalyst synthesized by calcination temperature at 200 °C exhibits higher toluene removal efficiency than that at 500 °C under different initial concentration of pollutants, relative humidity, light intensity and oxygen content. This study not only further improves the photocatalytic performance of the composite catalyst, but also accords with the idea of energy saving and emission reduction, which provides more space for the possibility of recycling S-AZMB.
Keywords	energy ; environmental protection ; light intensity ; markets ; oxygen ; photocatalysis ; photocatalysts ; purification methods ; relative humidity ; research ; temperature ; toluene
Language	English
Dates of publication	2022-09
Publishing place	Elsevier Inc.
Document type	Article
ZDB-ID	205699-9
ISSN	1096-0953 ; 0013-9351
ISSN (online)	1096-0953
ISSN	0013-9351
DOI	10.1016/j.envres.2022.113300
Database	NAL-Catalogue (AGRICOLA)

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