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Article ; Online: Integration of next-generation sequencing based multi-omics approaches in toxicogenomics.

Jayapal, Manikandan

2012 Volume 3, Page(s) 88

Language	English
Publishing date	2012-05-21
Publishing country	Switzerland
Document type	Comment ; Journal Article
ZDB-ID	2606823-0
ISSN	1664-8021 ; 1664-8021
ISSN (online)	1664-8021
ISSN	1664-8021
DOI	10.3389/fgene.2012.00088
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Comparative Evaluation of Xerostomia among Diabetic and Nondiabetic Subjects Wearing Complete Denture.

Sundaram, Manikandan / Manikandan, Saranya / Satheesh, Balakrishnan / Srinivasan, Deenadayalan / Jayapal, Dinakaran / Kumar, Dhivya

Journal of pharmacy & bioallied sciences

2020 Volume 12, Issue Suppl 1, Page(s) S419–S422

Abstract: Background: Diabetes mellitus represents a group of metabolic diseases that are characterised by hyperglycaemia due to a total or relative lack of insulin secretion and insulin resistance or both. Diabetes mellitus patients present with a higher ... ...

Abstract	Background: Diabetes mellitus represents a group of metabolic diseases that are characterised by hyperglycaemia due to a total or relative lack of insulin secretion and insulin resistance or both. Diabetes mellitus patients present with a higher susceptibility to infections due to a deficiency in polymorphonuclear leukocytes, as a result of vascular alterations and neuropathies. An increased risk of infections has been observed in complete denture wearing subjects with xerostomia. The objective of this study was to compare diabetic and non-diabetic subjects wearing complete dentures regarding xerostomia of different age group. Materials and methods: A cross-sectional study was conducted among 50 subjects, 25 with and 25 without a diagnosis of diabetes, were matched for gender, race, and age. Results: In this study we intended to compare diabetic and non-diabetic subjects wearing complete dentures regarding xerostomia and we found that xerostomia was more associated with diabetic denture wearer group in comparison with the non-diabetic denture wearers with a significant Conclusion: These results indicate that xerostomia should be diagnosed and effectively managed before any complete denture therapy is initiated in diabetic denture wearing patients to improve the quality of life.
Language	English
Publishing date	2020-08-28
Publishing country	India
Document type	Journal Article
ZDB-ID	2573569-X
ISSN	0975-7406 ; 0976-4879
ISSN (online)	0975-7406
ISSN	0976-4879
DOI	10.4103/jpbs.JPBS_124_20
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Article: Corn protein isolate: Characteristic analysis, functional properties, and utilization in beverage formulation

Premkumar, Jayapal / Kumar, Manikandan Santhosh / RaghulPrashanth, Rajan / Eshwar, Guhan / Kumar, Arun

Journal of food processing and preservation. 2022 Feb., v. 46, no. 2

2022

Abstract: The study demonstrates the analysis of novel protein isolated from corn oil cake. The protein has been extracted from the industrial by‐product and was formulated to make out a supplement that could potentially solve the malnourished cases. The protein ... ...

Abstract	The study demonstrates the analysis of novel protein isolated from corn oil cake. The protein has been extracted from the industrial by‐product and was formulated to make out a supplement that could potentially solve the malnourished cases. The protein was extracted using isoelectric precipitation method. The functional properties of the extracted protein isolates that include its bulk density, flow properties, emulsifying properties, oil and water absorption capacity, and protein solubility were determined. Further instrumental analyses, including FTIR, SEM, XRD, and color analysis were performed to reveal the physical properties of proteins. After the study of proteins, the end product protein isolates were formulated into a protein‐based beverage drink. At the end of the research, we perceived the potential of corn oil cake protein isolates in the role of alternative nutrition source and in new product development. NOVELTY IMPACT STATEMENT: Since there is an increased awareness on protein intake and the prevalence of protein malnutrition in developing and under developed countries, this research focuses on identifying novel protein sources to meet the increasing demand. In the present study, functional properties and utilization of corn protein isolates for beverage formulation was conducted. The results obtained in the study showcases the novelty of the research and clearly concludes that corn protein isolates are good to be used as food additives like foaming, emulsifying, oil‐binding agent, and also it can be utilized as a protein supplement to prepare many protein enriched product.
Keywords	beverages ; bulk density ; chemical precipitation ; color ; corn oil ; corn protein ; industrial byproducts ; kwashiorkor ; product development ; protein intake ; protein isolates ; protein solubility ; protein supplements ; water binding capacity
Language	English
Dates of publication	2022-02
Publishing place	John Wiley & Sons, Ltd
Document type	Article
Note	JOURNAL ARTICLE
ZDB-ID	243448-9
ISSN	1745-4549 ; 0145-8892
ISSN (online)	1745-4549
ISSN	0145-8892
DOI	10.1111/jfpp.16257
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Comparative evaluation of xerostomia among diabetic and nondiabetic subjects wearing complete denture

Manikandan Sundaram / Saranya Manikandan / Balakrishnan Satheesh / Deenadayalan Srinivasan / Dinakaran Jayapal / Dhivya Kumar

Journal of Pharmacy and Bioallied Sciences, Vol 12, Iss 5, Pp 419-

2020 Volume 422

Abstract	Background: Diabetes mellitus represents a group of metabolic diseases that are characterised by hyperglycaemia due to a total or relative lack of insulin secretion and insulin resistance or both. Diabetes mellitus patients present with a higher susceptibility to infections due to a deficiency in polymorphonuclear leukocytes, as a result of vascular alterations and neuropathies. An increased risk of infections has been observed in complete denture wearing subjects with xerostomia. The objective of this study was to compare diabetic and non-diabetic subjects wearing complete dentures regarding xerostomia of different age group. Materials and Methods: A cross-sectional study was conducted among 50 subjects, 25 with and 25 without a diagnosis of diabetes, were matched for gender, race, and age. Results: In this study we intended to compare diabetic and non-diabetic subjects wearing complete dentures regarding xerostomia and we found that xerostomia was more associated with diabetic denture wearer group in comparison with the non-diabetic denture wearers with a significant P value of <0.05. Conclusion: These results indicate that xerostomia should be diagnosed and effectively managed before any complete denture therapy is initiated in diabetic denture wearing patients to improve the quality of life.
Keywords	diabetes mellitus ; salivary flow ; stimulated saliva ; xerostomia ; Pharmacy and materia medica ; RS1-441 ; Analytical chemistry ; QD71-142
Subject code	571
Language	English
Publishing date	2020-01-01T00:00:00Z
Publisher	Wolters Kluwer Medknow Publications
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Role of Xeroderma pigmentosum D (XPD) protein in genome maintenance in human cells under oxidative stress.

Low, Grace Kah Mun / Ting, Aloysius Poh Leong / Fok, Edwin Dan Zhihao / Gopalakrishnan, Kalpana / Zeegers, Dimphy / Khaw, Aik Kia / Jayapal, Manikandan / Martinez-Lopez, Wilner / Hande, M Prakash

Mutation research. Genetic toxicology and environmental mutagenesis

2022 Volume 876-877, Page(s) 503444

Abstract: Xeroderma pigmentosum D (XPD) protein plays a pivotal role in the nucleotide excision repair pathway. XPD unwinds the local area of the damaged DNA by virtue of constituting transcription factor II H (TFIIH) and is important not only for repair but also ... ...

Abstract	Xeroderma pigmentosum D (XPD) protein plays a pivotal role in the nucleotide excision repair pathway. XPD unwinds the local area of the damaged DNA by virtue of constituting transcription factor II H (TFIIH) and is important not only for repair but also for basal transcription. Although cells deficient in XPD have shown to be defective in oxidative base-lesion repair, the effects of the oxidative assault on primary fibroblasts from patients suffering from Xeroderma Pigmentosum D have not been fully explored. Therefore, we sought to investigate the role of XPD in oxidative DNA damage-repair by treating primary fibroblasts derived from a patient suffering from Xeroderma Pigmentosum D, with hydrogen peroxide. Our results show dose-dependent increase in genotoxicity with minimal effect on cytotoxicity with H
MeSH term(s)	DNA Repair ; Humans ; Hydrogen Peroxide/toxicity ; Oxidative Stress ; Xeroderma Pigmentosum/genetics ; Xeroderma Pigmentosum Group D Protein/genetics ; Xeroderma Pigmentosum Group D Protein/metabolism
Chemical Substances	Hydrogen Peroxide (BBX060AN9V) ; Xeroderma Pigmentosum Group D Protein (EC 3.6.4.12)
Language	English
Publishing date	2022-01-15
Publishing country	Netherlands
Document type	Journal Article
ISSN	1879-3592
ISSN (online)	1879-3592
DOI	10.1016/j.mrgentox.2022.503444
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Evaluation of aromatic plants and compounds used to fight multidrug resistant infections.

Perumal Samy, Ramar / Manikandan, Jayapal / Al Qahtani, Mohammed

Evidence-based complementary and alternative medicine : eCAM

2013 Volume 2013, Page(s) 525613

Abstract: Traditional medicine plays a vital role for primary health care in India, where it is widely practiced to treat various ailments. Among those obtained from the healers, 78 medicinal plants were scientifically evaluated for antibacterial activity. ... ...

Abstract	Traditional medicine plays a vital role for primary health care in India, where it is widely practiced to treat various ailments. Among those obtained from the healers, 78 medicinal plants were scientifically evaluated for antibacterial activity. Methanol extract of plants (100 μ g of residue) was tested against the multidrug resistant (MDR) Gram-negative and Gram-positive bacteria. Forty-seven plants showed strong activity against Burkholderia pseudomallei (strain TES and KHW) and Staphylococcus aureus, of which Tragia involucrata L., Citrus acida Roxb. Hook.f., and Aegle marmelos (L.) Correa ex Roxb. showed powerful inhibition of bacteria. Eighteen plants displayed only a moderate effect, while six plants failed to provide any evidence of inhibition against the tested bacteria. Purified compounds showed higher antimicrobial activity than crude extracts. The compounds showed less toxic effect to the human skin fibroblasts (HEPK) cells than their corresponding aromatic fractions. Phytochemical screening indicates that the presence of various secondary metabolites may be responsible for this activity. Most of the plant extracts contained high levels of phenolic or polyphenolic compounds and exhibited activity against MDR pathogens. In conclusion, plants are promising agents that deserve further exploration. Lead molecules available from such extracts may serve as potential antimicrobial agents for future drug development to combat diseases caused by the MDR bacterial strains as reported in this study.
Language	English
Publishing date	2013-10-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	2171158-6
ISSN	1741-4288 ; 1741-427X
ISSN (online)	1741-4288
ISSN	1741-427X
DOI	10.1155/2013/525613
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Article: DNA microarray technology for target identification and validation.

Jayapal, Manikandan / Melendez, Alirio J

Clinical and experimental pharmacology & physiology

2006 Volume 33, Issue 5-6, Page(s) 496–503

Abstract: 1. Microarrays, a recent development, provide a revolutionary platform to analyse thousands of genes at once. They have enormous potential in the study of biological processes in health and disease and, perhaps, microarrays have become crucial tools in ... ...

Abstract	1. Microarrays, a recent development, provide a revolutionary platform to analyse thousands of genes at once. They have enormous potential in the study of biological processes in health and disease and, perhaps, microarrays have become crucial tools in diagnostic applications and drug discovery. 2. Microarray based studies have provided the essential impetus for biomedical experiments, such as identification of disease-causing genes in malignancies and regulatory genes in the cell cycle mechanism. Microarrays can identify genes for new and unique potential drug targets, predict drug responsiveness for individual patients and, finally, initiate gene therapy and prevention strategies. 3. The present article reviews the principles and technological concerns, as well as the steps involved in obtaining and analysing of data. Furthermore, applications of microarray based experiments in drug target identifications and validation strategies are discussed. 4. To exemplify how this tool can be useful, in the present review we provide an overview of some of the past and potential future aspects of microarray technology and present a broad overview of this rapidly growing field.
MeSH term(s)	Animals ; Cells, Cultured ; Colorectal Neoplasms/genetics ; Colorectal Neoplasms/metabolism ; Databases, Genetic ; Gene Expression Profiling/methods ; Gene Expression Profiling/trends ; Gene Expression Regulation, Neoplastic ; Genotype ; Humans ; Mice ; Mice, Transgenic ; Oligonucleotide Array Sequence Analysis ; Polymorphism, Single Nucleotide ; RNA Interference ; RNA, Messenger/metabolism ; Reproducibility of Results
Chemical Substances	RNA, Messenger
Keywords	covid19
Language	English
Publishing date	2006-04-07
Publishing country	Australia
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	189277-0
ISSN	1440-1681 ; 0305-1870 ; 0143-9294
ISSN (online)	1440-1681
ISSN	0305-1870 ; 0143-9294
DOI	10.1111/j.1440-1681.2006.04398.x
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Article ; Online: Evaluation of Aromatic Plants and Compounds Used to Fight Multidrug Resistant Infections

Ramar Perumal Samy / Jayapal Manikandan / Mohammed Al Qahtani

Evidence-Based Complementary and Alternative Medicine, Vol

2013 Volume 2013

Abstract	Traditional medicine plays a vital role for primary health care in India, where it is widely practiced to treat various ailments. Among those obtained from the healers, 78 medicinal plants were scientifically evaluated for antibacterial activity. Methanol extract of plants (100 μg of residue) was tested against the multidrug resistant (MDR) Gram-negative and Gram-positive bacteria. Forty-seven plants showed strong activity against Burkholderia pseudomallei (strain TES and KHW) and Staphylococcus aureus, of which Tragia involucrata L., Citrus acida Roxb. Hook.f., and Aegle marmelos (L.) Correa ex Roxb. showed powerful inhibition of bacteria. Eighteen plants displayed only a moderate effect, while six plants failed to provide any evidence of inhibition against the tested bacteria. Purified compounds showed higher antimicrobial activity than crude extracts. The compounds showed less toxic effect to the human skin fibroblasts (HEPK) cells than their corresponding aromatic fractions. Phytochemical screening indicates that the presence of various secondary metabolites may be responsible for this activity. Most of the plant extracts contained high levels of phenolic or polyphenolic compounds and exhibited activity against MDR pathogens. In conclusion, plants are promising agents that deserve further exploration. Lead molecules available from such extracts may serve as potential antimicrobial agents for future drug development to combat diseases caused by the MDR bacterial strains as reported in this study.
Keywords	Other systems of medicine ; RZ201-999
Subject code	580
Language	English
Publishing date	2013-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Decoding the differential biomarkers of Rheumatoid arthritis and Osteoarthritis: A functional genomics paradigm to design disease specific therapeutics.

Biswas, Sreyasi / Manikandan, Jayapal / Pushparaj, Peter Natesan

Bioinformation

2011 Volume 6, Issue 4, Page(s) 153–157

Abstract: Rheumatoid arthritis (RA) is a chronic systemic inflammatory disease of unidentified aetiology, chiefly affecting the synovial membranes of joints, cartilage, bone, bursa and tendon sheath. Osteoarthritis (OA) is a degenerative disorder and encompass ... ...

Abstract	Rheumatoid arthritis (RA) is a chronic systemic inflammatory disease of unidentified aetiology, chiefly affecting the synovial membranes of joints, cartilage, bone, bursa and tendon sheath. Osteoarthritis (OA) is a degenerative disorder and encompass different sets of pathogenic pathways than RA; however, it shows a medley of clinical manifestations or symptoms resembling RA. Hence, we intend to identify more disease specific biomarkers through the meta-analysis of microarray datasets that can be crucial in the differential diagnosis, disease specific treatment as well as management of both RA and OA in a typical clinical setting.
Language	English
Publishing date	2011-05-07
Publishing country	Singapore
Document type	Journal Article
ZDB-ID	2203786-X
ISSN	0973-2063 ; 0973-2063
ISSN (online)	0973-2063
ISSN	0973-2063
DOI	10.6026/97320630006153
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Immunomagnetic-Enriched Subpopulations of Melanoma Circulating Tumour Cells (CTCs) Exhibit Distinct Transcriptome Profiles.

Aya-Bonilla, Carlos / Gray, Elin S / Manikandan, Jayapal / Freeman, James B / Zaenker, Pauline / Reid, Anna L / Khattak, Muhammad A / Frank, Markus H / Millward, Michael / Ziman, Mel

Cancers

2019 Volume 11, Issue 2

Abstract: Cutaneous melanoma circulating tumour cells (CTCs) are phenotypically and molecularly heterogeneous. We profiled the gene expression of CTC subpopulations immunomagnetic-captured by targeting either the melanoma-associated marker, MCSP, or the melanoma- ... ...

Abstract	Cutaneous melanoma circulating tumour cells (CTCs) are phenotypically and molecularly heterogeneous. We profiled the gene expression of CTC subpopulations immunomagnetic-captured by targeting either the melanoma-associated marker, MCSP, or the melanoma-initiating marker, ABCB5. Firstly, the expression of a subset of melanoma genes was investigated by RT-PCR in MCSP-enriched and ABCB5-enriched CTCs isolated from a total of 59 blood draws from 39 melanoma cases. Of these, 6 MCSP- and 6 ABCB5-enriched CTC fractions were further analysed using a genome-wide gene expression microarray. The transcriptional programs of both CTC subtypes included cell survival maintenance, cell proliferation, and migration pathways. ABCB5-enriched CTCs were specifically characterised by up-regulation of genes involved in epithelial to mesenchymal transition (EMT), suggesting an invasive phenotype. These findings underscore the presence of at least two distinct melanoma CTC subpopulations with distinct transcriptional programs, which may have distinct roles in disease progression and response to therapy.
Language	English
Publishing date	2019-01-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers11020157
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