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  1. Book: Controversies in Thyroid Nodules and Differentiated Thyroid Cancer

    Roman, Sanziana A. / Sosa, Julie Ann / Shen, Wen T.

    A Case-Based Approach

    2023  

    Author's details Sanziana A. Roman, MD Professor University of California, San Francisco Department of Surgery Wen T. Shen MD MA Professor University of California, San Francisco Department of Surgery Julie Ann Sosa, MD MA Professor and Chair University of California, San Francisco Department of Surgery§
    Keywords fine-needleaspiration ; Low-RiskDTC ; PreoperativeLaryngoscopy ; RadiofrequencyAblation ; FamilialDTC ; IntraoperativeNerveMonitoring ; Fine-Needle Aspiration ; Low-Risk DTC ; Preoperative Laryngoscopy ; Radiofrequency Ablation ; Familial DTC ; Intraoperative Nerve Monitoring
    Language English
    Size 224 p.
    Edition 1
    Publisher Springer International Publishing
    Document type Book
    Note PDA Manuell_23
    Format 160 x 241 x 17
    ISBN 9783031371349 ; 3031371348
    Database PDA

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  2. Article ; Online: Quantifying the Possible Consequences of Parathyroidectomy on Hypertension in Patients With Primary Hyperparathyroidism: Bones, Kidneys, Brain-and Heart?

    Shen, Wen T

    JAMA surgery

    2019  Volume 155, Issue 1, Page(s) 40

    MeSH term(s) Brain ; Humans ; Hyperparathyroidism, Primary/surgery ; Hypertension/etiology ; Kidney ; Parathyroidectomy
    Language English
    Publishing date 2019-10-06
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2701841-6
    ISSN 2168-6262 ; 2168-6254
    ISSN (online) 2168-6262
    ISSN 2168-6254
    DOI 10.1001/jamasurg.2019.3961
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Gratitude and Good Outcomes: Rediscovering Positivity and Perspective in an Uncertain Time.

    Shen, Wen T / Sosa, Julie Ann

    World journal of surgery

    2020  Volume 44, Issue 9, Page(s) 2848–2849

    Keywords covid19
    Language English
    Publishing date 2020-06-21
    Publishing country United States
    Document type Editorial
    ZDB-ID 224043-9
    ISSN 1432-2323 ; 0364-2313
    ISSN (online) 1432-2323
    ISSN 0364-2313
    DOI 10.1007/s00268-020-05649-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: [Correlation analysis between blood routine-derived inflammatory markers and respiratory function in pneumoconiosis patients].

    Hu, X X / Liu, S P / Zhou, R S / Hu, M N / Wen, J / Shen, T

    Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases

    2022  Volume 40, Issue 7, Page(s) 508–514

    Abstract: Objective: ...

    Abstract Objective:
    MeSH term(s) Forced Expiratory Volume ; Humans ; Male ; Pneumoconiosis ; Respiratory Function Tests ; Retrospective Studies ; Vital Capacity
    Language Chinese
    Publishing date 2022-08-01
    Publishing country China
    Document type Journal Article
    ZDB-ID 1050900-8
    ISSN 1001-9391
    ISSN 1001-9391
    DOI 10.3760/cma.j.cn121094-20210705-00321
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  5. Article: Heart-rate-based prediction of velocity at lactate threshold in ordinary adults.

    Shen, Tonghui / Wen, Xu

    Journal of exercise science and fitness

    2019  Volume 17, Issue 3, Page(s) 108–112

    Abstract: ... were established, in which 47%-65% of variance of VLT could be explained. The results of the paired t ...

    Abstract Background: Velocity lactate threshold (VLT) is commonly used as a standard for exercise intensity, although previous studies of VLT have focused mostly on well-trained athletes. Heart rate (HR) is an important physiological index which is easy to measure, the heart rate-workload relationship curve is the reported coincidence with lactate threshold (LT). This study aimed to develop valid, simple and economical velocity at lactate threshold prediction methods for general Chinese adults.
    Methods: Eighty-four Chinese adults (49 males and 35 females aged 27.1 ± 8.3 years) were recruited to perform a graded exercise test on a treadmill. A 20-s rest time for the blood sample collection was set between each 3-min successive stage. Blood lactate concentration and heart rate (HR) were determined using a blood lactate analyser and HR monitors. Multiple linear regressions were applied to develop VLT prediction models using velocity at different HR levels, genders, BMI and ages as dependent variables.
    Results: Eight VLT prediction models were established, in which 47%-65% of variance of VLT could be explained. The results of the paired t-tests showed no significant difference can be observed between estimated and measured VLTs.
    Conclusion: In conclusion, simple and convenient VLT prediction models were established, and the models are valid in predicting VLT for general population.
    Language English
    Publishing date 2019-06-26
    Publishing country Singapore
    Document type Journal Article
    ZDB-ID 2205204-5
    ISSN 1728-869X
    ISSN 1728-869X
    DOI 10.1016/j.jesf.2019.06.002
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  6. Article: RC48-ADC combined with tislelizumab as neoadjuvant treatment in patients with HER2-positive locally advanced muscle-invasive urothelial bladder cancer: a multi-center phase Ib/II study (HOPE-03).

    Wen, Feng / Lin, Tianhai / Zhang, Peng / Shen, Yali

    Frontiers in oncology

    2024  Volume 13, Page(s) 1233196

    Abstract: Background: Bladder cancer with high expression of human epidermal growth factor receptor-2 (HER2) is related to pathological malignancy and poor prognosis. The standard care for muscle-invasive urothelial bladder cancer (MIBC) is neoadjuvant ... ...

    Abstract Background: Bladder cancer with high expression of human epidermal growth factor receptor-2 (HER2) is related to pathological malignancy and poor prognosis. The standard care for muscle-invasive urothelial bladder cancer (MIBC) is neoadjuvant chemotherapy (NAC) followed by radical cystectomy (RC) with pelvic lymph node dissection. For HER2-positive MIBC, the efficacy of cisplatin-based NAC is unsatisfactory, and adverse reactions are inevitable or even intolerable. New regimens with higher efficiency and lower toxicity need to be explored in the neoadjuvant setting for this population.
    Methods: HOPE-03 is a multi-center, open-label, single-arm, phase Ib/II study aiming to evaluate the safety and efficacy of RC48-ADC (disitamab vedotin (DV)), a humanized anti-HER2 antibody conjugated with monomethyl auristatin E, and tislelizumab (PD-1 antibody) as a novel neoadjuvant treatment combination in patients with HER2-positive locally advanced urothelial MIBC. Fifty-one patients with cT2-4bN0-3M0-1a pathology- and imaging-diagnosed HER2 positive (immunohistochemistry status 3+ or 2+ or 1+) MIBC were recruited. Of these patients, six were enrolled in the dose-escalation phase (three patients in the RC48-ADC 1.5 mg/kg group and three patients in the 2.0 mg/kg group), and 45 patients were enrolled in the phase II study (the expected recommended phase II dose for RC48-ADC was 2.0 mg/kg). Patients without disease progression received radical cystectomy or bladder-sparing therapies as their preference after neoadjuvant treatment. The primary endpoints were clinical complete remission rate (cCR rate; T0/Ta/Tis), pathological complete remission rate (pCR rate), and safety. The secondary endpoints were overall survival (OS), local recurrence-free survival (LRFS), distant metastasis-free survival (DMFS), and quality of life.
    Discussion: The HOPE-03 trial provides a description of the safety profile of RC-48 and tislelizumab combination in the neoadjuvant treatment of HER2-positive locally advanced urothelial MIBC, and the efficacy is explored as well in this population.
    Clinical trial registration: https://www.chictr.org.cn/showproj.html?proj=137111, identifier ChiCTR2200060153.
    Language English
    Publishing date 2024-01-10
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2023.1233196
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  7. Article ; Online: Single-cell RNA sequencing reveals immune microenvironment of small cell lung cancer-associated malignant pleural effusion.

    Wang, Shuyan / An, Jing / Hu, Xueru / Zeng, Tingting / Li, Ping / Qin, Jiangyue / Shen, Yongchun / Chen, Mei / Wen, Fuqiang

    Thoracic cancer

    2023  Volume 15, Issue 1, Page(s) 98–103

    Abstract: ... divided into 10 cell clusters further identified as B cells, T cells, myeloid cells, NK cells, and ... expressed in different degrees during differentiation of T and B cells. Different ligands and receptors ... between T, B and tumor cells almost interact through MHC II, IL-16, galectin, and APP signaling pathway. ...

    Abstract We used 10 × genomics single-cell transcriptome sequencing technology to reveal the tumor immune microenvironment characteristics of small cell lung cancer (SCLC) in a patient with malignant pleural effusion (MPE). A total of 8008 high-quality cells were finally obtained for subsequent bioinformatic analysis, which were divided into 10 cell clusters further identified as B cells, T cells, myeloid cells, NK cells, and cancer cells. Such SCLC related genes as NOTCH1, MYC, TSC22D1, SOX4, BLNK, YBX3, VIM, CD8A, CD8B, and KLF6 were expressed in different degrees during differentiation of T and B cells. Different ligands and receptors between T, B and tumor cells almost interact through MHC II, IL-16, galectin, and APP signaling pathway.
    MeSH term(s) Humans ; Small Cell Lung Carcinoma/complications ; Small Cell Lung Carcinoma/genetics ; Lung Neoplasms/pathology ; Pleural Effusion, Malignant/genetics ; Pleural Effusion, Malignant/pathology ; Cell Differentiation ; Sequence Analysis, RNA ; Pleural Effusion ; Tumor Microenvironment/genetics ; SOXC Transcription Factors/genetics
    Chemical Substances SOX4 protein, human ; SOXC Transcription Factors
    Language English
    Publishing date 2023-11-27
    Publishing country Singapore
    Document type Case Reports
    ZDB-ID 2625856-0
    ISSN 1759-7714 ; 1759-7706
    ISSN (online) 1759-7714
    ISSN 1759-7706
    DOI 10.1111/1759-7714.15145
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    Zs.A 6921: Show issues Location:
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  8. Article ; Online: Deciphering Cholesterol's Role in PD-L2 Stability: A Distinct Regulatory Mechanism From PD-L1.

    Zhang, Yu / Xiao, Taoran / Wen, Maorong / Shen, Lijuan / Du, Lingyu / Wei, Shukun / Wu, Bin / Yu, Yang / Wang, Shuqing / OuYang, Bo

    Journal of molecular biology

    2024  Volume 436, Issue 8, Page(s) 168500

    Abstract: ... with programmed cell death 1 ligand 1 (PD-L1) in binding to the programmed cell death protein 1 (PD-1) on T cells, PD-L2 ...

    Abstract Programmed cell death 1 ligand 2 (PD-L2), a member of the B7 immune checkpoint protein family, emerges as a crucial player in immune modulation. Despite its functional overlap with programmed cell death 1 ligand 1 (PD-L1) in binding to the programmed cell death protein 1 (PD-1) on T cells, PD-L2 exhibits a divergent expression pattern and a higher affinity for PD-1. However, the regulatory mechanisms of PD-L2 remain under-explored. Here, our investigations illustrate the pivotal role of cholesterol in modulating PD-L2 stability. Using advanced nuclear magnetic resonance (NMR) and biochemical analyses, we demonstrate a direct and specific binding between cholesterol and PD-L2, mediated by an F-xxx-V-xx-LR motif in its transmembrane domain, distinct from that in PD-L1. This interaction stabilizes PD-L2 and prevents its downstream degradation. Disruption of this binding motif compromises PD-L2's cellular stability, underscoring its potential significance in cancer biology. These findings not only deepen our understanding of PD-L2 regulation in the context of tumors, but also open avenues for potential therapeutic interventions.
    MeSH term(s) B7-H1 Antigen/genetics ; B7-H1 Antigen/metabolism ; Programmed Cell Death 1 Receptor ; T-Lymphocytes/metabolism ; Protein Domains
    Chemical Substances B7-H1 Antigen ; Programmed Cell Death 1 Receptor
    Language English
    Publishing date 2024-02-22
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 80229-3
    ISSN 1089-8638 ; 0022-2836
    ISSN (online) 1089-8638
    ISSN 0022-2836
    DOI 10.1016/j.jmb.2024.168500
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  9. Article ; Online: Heat stress and excessive maturity of fruiting bodies suppress GABA accumulation by modulating GABA metabolism in Pleurotus ostreatus (Jacq. ex Fr.) P. Kumm

    Wen, Qing / Zhao, Haoyang / Shao, Yanhong / Li, J. T. / Hu, Yanru / Qi, Yuancheng / Wang, Fengqin / Shen, Jinwen

    Food Research International. 2023 Mar., v. 165 p.112549-

    2023  

    Abstract: GABA is a health-promoting bioactive substance. Here, the GABA biosynthetic pathways were investigated, and then the dynamic quantitative changes in GABA and the expression levels of genes related to GABA metabolism under heat stress or at different ... ...

    Abstract GABA is a health-promoting bioactive substance. Here, the GABA biosynthetic pathways were investigated, and then the dynamic quantitative changes in GABA and the expression levels of genes related to GABA metabolism under heat stress or at different developmental stages of fruiting bodies in Pleurotus ostreatus (Jacq. ex Fr.) P. Kumm were determined. We found that the polyamine degradation pathway was the main route of GABA production under growth normal condition. The accumulation of GABA and the expression of most genes related to GABA biosynthesis, including genes encoding glutamate decarboxylase (PoGAD-2), polyamine oxidase (PoPAO-1), diamine oxidase (PoDAO) and aminoaldehyde dehydrogenase (PoAMADH-1 and PoAMADH-2), were significantly suppressed by heat stress and the excessive maturity of fruiting bodies. Finally, the effects of GABA on the mycelial growth, heat tolerance and the morphogenesis and development of fruiting bodies were studied, the results showed that the deficiency of endogenous GABA inhibited the mycelial growth and primordial formation and aggravated heat damage, whereas exogenous application of GABA could improve thermotolerance and promote the development of fruiting bodies.
    Keywords Pleurotus ostreatus ; aminobutyraldehyde dehydrogenase ; bioactive compounds ; biosynthesis ; diamine oxidase ; food research ; glutamate decarboxylase ; health promotion ; heat ; heat stress ; heat tolerance ; morphogenesis ; mycelium ; polyamines ; GABA ; Fruiting body ; Biosynthetic pathway
    Language English
    Dates of publication 2023-03
    Publishing place Elsevier Ltd
    Document type Article ; Online
    ZDB-ID 1111695-x
    ISSN 1873-7145 ; 0963-9969
    ISSN (online) 1873-7145
    ISSN 0963-9969
    DOI 10.1016/j.foodres.2023.112549
    Database NAL-Catalogue (AGRICOLA)

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