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Article: High Risk of Heart Tumors after COVID-19.

Mitrofanova, Lubov / Makarov, Igor / Goncharova, Ekaterina / Makarova, Taiana / Starshinova, Anna / Kudlay, Dmitry / Shlaykhto, Evgeny

Life (Basel, Switzerland)

2023 Volume 13, Issue 10

Abstract: An emergence of evidence suggests that severe COVID-19 is associated with an increased risk of developing breast and gastrointestinal cancers. The aim of this research was to assess the risk of heart tumors development in patients who have had COVID-19.!# ...

Abstract	An emergence of evidence suggests that severe COVID-19 is associated with an increased risk of developing breast and gastrointestinal cancers. The aim of this research was to assess the risk of heart tumors development in patients who have had COVID-19. Methods: A comparative analysis of 173 heart tumors was conducted between 2016 and 2023. Immunohistochemical examination with antibodies against spike SARS-CoV-2 was performed on 21 heart tumors: 10 myxomas operated before 2020 (the control group), four cardiac myxomas, one proliferating myxoma, three papillary fibroelastomas, two myxofibrosarcomas, one chondrosarcoma resected in 2022-2023. Immunohistochemical analysis with antibodies against CD34 and CD68 was also conducted on the same 11 Post-COVID period heart tumors. Immunofluorescent examination with a cocktail of antibodies against spike SARS-CoV-2/CD34 and spike SARS-CoV-2/CD68 was performed in 2 cases out of 11 (proliferating myxoma and classic myxoma). Results: A 1.5-fold increase in the number of heart tumors by 2023 was observed, with a statistically significant increase in the number of myxomas. There was no correlation with vaccination, and no significant differences were found between patients from 2016-2019 and 2021-2023 in terms of gender, age, and cardiac rhythm dis-orders. Morphological examination revealed the expression of spike SARS-CoV-2 in tumor cells, endothelial cells, and macrophages in 10 out of 11 heart tumors. Conclusion: The detection of SARS-CoV-2 persistence in endothelium and macrophages as well as in tumor cells of benign and malignant cardiac neoplasms, the increase in the number of these tumors, especially cardiac myxomas, after the pandemic by 2023 may indicate a trend toward an increased risk of cardiac neoplasms in COVID-19 patients, which re-quires further research on this issue and a search for new evidence.
Language	English
Publishing date	2023-10-20
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662250-6
ISSN	2075-1729
ISSN	2075-1729
DOI	10.3390/life13102087
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Article ; Online: Novel Cytotoxic Sesquiterpene Coumarin Ethers and Sulfur-Containing Compounds from the Roots of

Eruçar, Fatma Memnune / Senadeera, Sarath P D / Wilson, Jennifer A / Goncharova, Ekaterina / Beutler, John A / Miski, Mahmut

Molecules (Basel, Switzerland)

2023 Volume 28, Issue 15

Abstract: Six new sesquiterpene coumarin ethers, namely turcicanol A ( ...

Abstract	Six new sesquiterpene coumarin ethers, namely turcicanol A (
MeSH term(s)	Ferula/chemistry ; Sulfur Compounds/analysis ; Molecular Structure ; Ethers ; Antineoplastic Agents, Phytogenic/pharmacology ; Antineoplastic Agents/analysis ; Anesthetics, General ; Coumarins/chemistry ; Sesquiterpenes/chemistry ; Sulfur/analysis ; Plant Roots/chemistry
Chemical Substances	Sulfur Compounds ; Ethers ; Antineoplastic Agents, Phytogenic ; Antineoplastic Agents ; Anesthetics, General ; Coumarins ; Sesquiterpenes ; Sulfur (70FD1KFU70)
Language	English
Publishing date	2023-07-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules28155733
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Article: Founding of the culture collection of antibiotic-resistant strains of zoonotic bacteria in the Russian Federation.

Ivanova, Olga / Blumenkrants, Dmitry / Krylova, Ekaterina / Soltynskaya, Irina / Goncharova, Anastasia / Chaikin, Evgeny / Akhmetzyanova, Anna / Panin, Alexander

Veterinary world

2023 Volume 16, Issue 7, Page(s) 1451–1460

Abstract: Background and aim: The main purpose of a national bioresource center is to standardize, centralize, preserve, and ensure accessibility of microbial bioresources that accumulate there because of state research programs. The establishment of national ... ...

Abstract	Background and aim: The main purpose of a national bioresource center is to standardize, centralize, preserve, and ensure accessibility of microbial bioresources that accumulate there because of state research programs. The establishment of national bioresource centers for antibiotic-resistant microorganisms allows to solve practical problems in the field of veterinary service, as well as to develop effective chemotherapeutic and disinfectant drugs to overcome the mechanisms of resistance. This study aimed to outline the process of forming a national culture collection of antibiotic-resistant strains of zoonotic bacteria in the Russian Federation using two microbial strains. Materials and methods: The object of research was isolates of Results: During monitoring studies, 1489 bacterial isolates were isolated. In total, 408 bacterial isolates were tested for sensitivity to antimicrobial agents, including Conclusion: Deposited isolates that underwent whole-genome analysis can be used as positive control samples both in the development and use of methods or test systems for the detection of various resistance genes in zoonotic bacteria. In addition, such isolates can also be used for microbiological studies related to determining the sensitivity of microorganisms to antibacterial drugs, for phenotypic studies in the diagnosis of various bacterial infections in animals and birds, and retrospective analysis of strains from numerous collections.
Language	English
Publishing date	2023-07-19
Publishing country	India
Document type	Journal Article
ZDB-ID	2456277-4
ISSN	2231-0916 ; 0972-8988
ISSN (online)	2231-0916
ISSN	0972-8988
DOI	10.14202/vetworld.2023.1451-1460
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Article ; Online: Comparative pharmacokinetics of florfenicol in heifers after intramuscular and subcutaneous administration.

Selimov, Renat / Goncharova, Elizaveta / Koriakovtsev, Pavel / Gabidullina, Diana / Karsakova, Julia / Kozlov, Sergey / Komarov, Alexander / Engasheva, Ekaterina / Engashev, Sergey

Journal of veterinary pharmacology and therapeutics

2023 Volume 46, Issue 3, Page(s) 177–184

Abstract: Florfenicol was administered to five heifers intramuscularly at a dose rate of 20 mg/kg bwt and following wash-out period, subcutaneously at a dose rate of 40 mg/kg bwt. Blood plasma samples were collected from heifers before injection of florfenicol and ...

Abstract	Florfenicol was administered to five heifers intramuscularly at a dose rate of 20 mg/kg bwt and following wash-out period, subcutaneously at a dose rate of 40 mg/kg bwt. Blood plasma samples were collected from heifers before injection of florfenicol and up to 120 h after intramuscular (IM) injection and up to 264 h after subcutaneous (SC) injection. Florfenicol concentrations in plasma were measured by high-performance liquid chromatography with mass-spectrometric detection. Pharmacokinetics of florfenicol was estimated using non-compartment analysis. Mean maximum plasma concentration, area under the concentration-time curve and elimination half-life for florfenicol were 3.2 μg/ml, 101.5 μg × h/ml and 24.5 h, respectively, after IM injection at 20 mg/kg bwt, and 2.7 μg/ml, 194.5 μg × h/ml and 103.8 h, respectively, after SC injection at 40 mg/kg bwt. The obtained results indicated that both administration routes provided comparable bioavailability, whereas SC route was attributed with lower peak levels and markedly slower absorption of florfenicol from injection site. Both administration routes provided plasma florfenicol levels which are expected to be effective against prevalent infectious agents of cattle.
MeSH term(s)	Cattle ; Animals ; Female ; Anti-Bacterial Agents/pharmacokinetics ; Thiamphenicol/pharmacokinetics ; Injections, Subcutaneous/veterinary ; Biological Availability ; Injections, Intramuscular/veterinary ; Half-Life ; Area Under Curve ; Injections, Intravenous/veterinary
Chemical Substances	florfenicol (9J97307Y1H) ; Anti-Bacterial Agents ; Thiamphenicol (FLQ7571NPM)
Language	English
Publishing date	2023-01-12
Publishing country	England
Document type	Journal Article
ZDB-ID	435216-6
ISSN	1365-2885 ; 0140-7783
ISSN (online)	1365-2885
ISSN	0140-7783
DOI	10.1111/jvp.13110
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Article ; Online: Novel Cytotoxic Sesquiterpene Coumarin Ethers and Sulfur-Containing Compounds from the Roots of Ferula turcica

Fatma Memnune Eruçar / Sarath P. D. Senadeera / Jennifer A. Wilson / Ekaterina Goncharova / John A. Beutler / Mahmut Miski

Molecules, Vol 28, Iss 5733, p

2023 Volume 5733

Abstract: Six new sesquiterpene coumarin ethers, namely turcicanol A ( 1 ), turcicanol A acetate ( 2 ), turcicanol B ( 3 ), turcica ketone ( 4 ), 11′-dehydrokaratavicinol ( 5 ), and galbanaldehyde ( 6 ), and one new sulfur-containing compound, namely ... ...

Abstract	Six new sesquiterpene coumarin ethers, namely turcicanol A ( 1 ), turcicanol A acetate ( 2 ), turcicanol B ( 3 ), turcica ketone ( 4 ), 11′-dehydrokaratavicinol ( 5 ), and galbanaldehyde ( 6 ), and one new sulfur-containing compound, namely turcicasulphide ( 7 ), along with thirty-two known secondary metabolites were isolated from the root of the endemic species Ferula turcica Akalın, Miski, & Tuncay through a bioassay-guided isolation approach. The structures of the new compounds were elucidated by spectroscopic analysis and comparison with the literature. Cell growth inhibition of colon cancer cell lines (COLO205 and HCT116) and kidney cancer cell lines (UO31 and A498) was used to guide isolation. Seventeen of the compounds showed significant activity against the cell lines.
Keywords	Apiaceae ; Ferula turcica ; sesquiterpene coumarin ethers ; sulfur-containing compounds ; cytotoxic activity ; colon cancer ; Organic chemistry ; QD241-441
Subject code	540
Language	English
Publishing date	2023-07-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article ; Online: Bifunctional RNA-Targeting Deoxyribozyme Nanodevice as a Potential Theranostic Agent.

Spelkov, Aleksandr A / Goncharova, Ekaterina A / Savin, Artemii M / Kolpashchikov, Dmitry M

Chemistry (Weinheim an der Bergstrasse, Germany)

2020 Volume 26, Issue 16, Page(s) 3489–3493

Abstract: Theranostic approaches rely on simultaneous diagnostic of a disease and its therapy. Here, we designed a DNA nanodevice, which can simultaneously report the presence of a specific RNA target through an increase in fluorescence and cleave it. High ... ...

Abstract	Theranostic approaches rely on simultaneous diagnostic of a disease and its therapy. Here, we designed a DNA nanodevice, which can simultaneously report the presence of a specific RNA target through an increase in fluorescence and cleave it. High selectivity of RNA target recognition under near physiological conditions was achieved. The proposed approach can become a basis for the design of DNA nanomachines and robots for diagnostics and therapy of viral infections, cancer, and genetic disorders.
MeSH term(s)	DNA, Catalytic/chemistry ; DNA, Catalytic/genetics ; DNA, Catalytic/metabolism ; Fluorescence ; Humans ; Neoplasms/chemistry ; Neoplasms/genetics ; RNA/chemistry ; RNA/metabolism ; Theranostic Nanomedicine ; Virus Diseases/diagnosis
Chemical Substances	DNA, Catalytic ; RNA (63231-63-0)
Language	English
Publishing date	2020-02-27
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1478547-X
ISSN	1521-3765 ; 0947-6539
ISSN (online)	1521-3765
ISSN	0947-6539
DOI	10.1002/chem.201905528
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Article ; Online: The influence of weight loss interventions on psycho-emotional state of young men with obesity

Nina A. Petunina / Milena Е. Теlnova / Ekaterina V. Goncharova / Olga A. Myrinova

Терапевтический архив, Vol 94, Iss 1, Pp 18-

2022 Volume 23

Abstract: Aim. To assess the relationship of psychoemotional changes with obesity in young men, depending on the age of manifestation of the disease and against the background of the program of weight loss. Materials and methods. The study included 48 young men ... ...

Abstract	Aim. To assess the relationship of psychoemotional changes with obesity in young men, depending on the age of manifestation of the disease and against the background of the program of weight loss. Materials and methods. The study included 48 young men with obesity, aged 17 to 24 years. The subjects were divided into two groups. Group A consisted of 26 men with manifestation of obesity since childhood, group B 22 patients with onset of the disease from puberty. Subsequently, the study patients were subdivided depending on the type of obesity treatment (complex and non-pharmacological). The psychological status and anthropometric parameters were assessed on screening and after 12 weeks of treatment. Results. Depressive disorders were initially observed in 40.9% of patients in group B and in 19.2% of patients in group A. In young men who underwent complex treatment of obesity, regardless of the time of manifestation of the disease, a clinically significant decrease in symptoms of depression was revealed. All types of eating behavior were revealed in the subjects, and these manifestations are more common in patients with manifestation of the disease since childhood. In group A, the restrained eating was in 50% of young men, external eating in 42.3%, and emotional eating in 30.7%. In group B, emotional eating in 9% of patients, external eating in 40.9%, and restrained eating in 31.8% of young obese men. Conclusion. In the group of patients with manifestation of obesity since puberty, the frequency of depressive disorders was higher than in the group of young men with onset of obesity since childhood.
Keywords	оbesity ; men ; depressive disorders ; eating behavior ; orlistat ; Medicine ; R
Subject code	796 ; 616
Language	Russian
Publishing date	2022-01-01T00:00:00Z
Publisher	"Consilium Medicum" Publishing house
Document type	Article ; Online
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Article ; Online: Electronic and steric effects controlling monomer-dimer self-assembly in 6

Tarakanov, Pavel A / Simakov, Anton O / Pushkarev, Victor E / Konev, Dmitry V / Goncharova, Olga A / Slesarenko, Nikita A / Tarakanova, Ekaterina N / Nefedov, Sergey E / Stuzhin, Pavel A

Dalton transactions (Cambridge, England : 2003)

2023 Volume 52, Issue 7, Page(s) 2124–2134

Abstract: A series of 5,7-disubstituted 1,4-diazepinoporphyrazinato magnesium(II) and nickel(II) complexes, including two novel compounds, were obtained by metal-templated macrocyclization. A combination of X-ray diffraction, ...

Abstract	A series of 5,7-disubstituted 1,4-diazepinoporphyrazinato magnesium(II) and nickel(II) complexes, including two novel compounds, were obtained by metal-templated macrocyclization. A combination of X-ray diffraction,
Language	English
Publishing date	2023-02-14
Publishing country	England
Document type	Journal Article
ZDB-ID	1472887-4
ISSN	1477-9234 ; 1364-5447 ; 0300-9246 ; 1477-9226
ISSN (online)	1477-9234 ; 1364-5447
ISSN	0300-9246 ; 1477-9226
DOI	10.1039/d2dt03371b
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Article ; Online: A DNA minimachine for selective and sensitive detection of DNA.

Lyalina, Tatiana A / Goncharova, Ekaterina A / Prokofeva, Nadezhda Y / Voroshilina, Ekaterina S / Kolpashchikov, Dmitry M

The Analyst

2019 Volume 144, Issue 2, Page(s) 416–420

Abstract: Synthetic molecular machines have been explored to manipulate matter at the molecular level. Here, we designed a multifunctional DNA nano-construct, dubbed a 'DNA minimachine' (DMM), which (i) tightly binds complementary DNA; (ii) recognizes specific ... ...

Abstract	Synthetic molecular machines have been explored to manipulate matter at the molecular level. Here, we designed a multifunctional DNA nano-construct, dubbed a 'DNA minimachine' (DMM), which (i) tightly binds complementary DNA; (ii) recognizes specific fragments with high selectivity and (iii) amplifies output signals. DMM1 detects lower concentrations of both single-stranded DNA and double-stranded DNA compared to a conventional probe. This study sets a direction towards the development of molecular machines for selective, sensitive and cost-efficient DNA analysis.
MeSH term(s)	Base Sequence ; Biosensing Techniques/methods ; DNA/analysis ; DNA/chemistry ; DNA/genetics ; Limit of Detection ; Nanostructures/chemistry ; Nanotechnology
Chemical Substances	DNA (9007-49-2)
Language	English
Publishing date	2019-01-02
Publishing country	England
Document type	Journal Article
ZDB-ID	210747-8
ISSN	1364-5528 ; 0003-2654
ISSN (online)	1364-5528
ISSN	0003-2654
DOI	10.1039/c8an02274g
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Zs.A 2423: Show issues

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Article ; Online: Discovery and Synthesis of a Naturally Derived Protein Kinase Inhibitor that Selectively Inhibits Distinct Classes of Serine/Threonine Kinases.

Du, Lin / Wilson, Brice A P / Li, Ning / Shah, Rohan / Dalilian, Masoumeh / Wang, Dongdong / Smith, Emily A / Wamiru, Antony / Goncharova, Ekaterina I / Zhang, Ping / O'Keefe, Barry R

Journal of natural products

2023 Volume 86, Issue 10, Page(s) 2283–2293

Abstract: ... ...

Abstract	The
MeSH term(s)	Humans ; Protein Kinase Inhibitors/pharmacology ; Protein Serine-Threonine Kinases ; Carcinoma, Hepatocellular/pathology ; Biological Products ; Serine ; HSP40 Heat-Shock Proteins/chemistry ; HSP40 Heat-Shock Proteins/genetics ; HSP40 Heat-Shock Proteins/metabolism
Chemical Substances	Protein Kinase Inhibitors ; Protein Serine-Threonine Kinases (EC 2.7.11.1) ; Biological Products ; Serine (452VLY9402) ; DNAJB1 protein, human ; HSP40 Heat-Shock Proteins
Language	English
Publishing date	2023-10-16
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Intramural ; Research Support, N.I.H., Extramural
ZDB-ID	304325-3
ISSN	1520-6025 ; 0163-3864
ISSN (online)	1520-6025
ISSN	0163-3864
DOI	10.1021/acs.jnatprod.3c00394
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