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Article ; Online: Where global crop yields may falter next.

Davis, Kyle Frankel / Abou Ali, Hanan / Kebede, Endalkachew / Khan, Bhoktear / Sarwar, Afia

Nature food

2024 Volume 5, Issue 2, Page(s) 98–99

MeSH term(s)	Agriculture ; Crops, Agricultural
Language	English
Publishing date	2024-01-26
Publishing country	England
Document type	Journal Article
ISSN	2662-1355
ISSN (online)	2662-1355
DOI	10.1038/s43016-023-00911-w
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Article: Giant Cell Tumor of the Distal Fibula Managed by an Autologous Proximal Fibula Graft.

Ali Muhammad, Soima / Salman, Afia / Sahito, Badaruddin / Ahmed, Jawad

Cureus

2023 Volume 15, Issue 7, Page(s) e42620

Abstract: A giant cell tumor of the bone is among the most common bone tumors encountered by orthopedic surgeons. These benign and aggressive tumors are most commonly present around the knee joint; however, rare cases may involve the distal fibula. An 18-year-old ... ...

Abstract	A giant cell tumor of the bone is among the most common bone tumors encountered by orthopedic surgeons. These benign and aggressive tumors are most commonly present around the knee joint; however, rare cases may involve the distal fibula. An 18-year-old man presented with a painless swelling of the lateral aspect of the left ankle. Clinical examination, radiologic evaluation, and biopsy confirmed the diagnosis of a giant cell tumor of the distal fibula. The patient was treated with resection of the distal fibula followed by reconstruction using an ipsilateral proximal fibula graft. The post-operative recovery was uneventful, and the patient was doing well on the last visit, one month after the intervention.
Language	English
Publishing date	2023-07-28
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.42620
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Article ; Online: The fate of interneurons, GABA

Ali, Afia B / Islam, Anam / Constanti, Andrew

Brain pathology (Zurich, Switzerland)

2022 Volume 33, Issue 1, Page(s) e13129

Abstract: Alzheimer's disease (AD) is the most common neurological disease, which is associated with gradual memory loss and correlated with synaptic hyperactivity and abnormal oscillatory rhythmic brain activity that precedes phenotypic alterations and is partly ... ...

Abstract	Alzheimer's disease (AD) is the most common neurological disease, which is associated with gradual memory loss and correlated with synaptic hyperactivity and abnormal oscillatory rhythmic brain activity that precedes phenotypic alterations and is partly responsible for the spread of the disease pathology. Synaptic hyperactivity is thought to be because of alteration in the homeostasis of phasic and tonic synaptic inhibition, which is orchestrated by the GABA
MeSH term(s)	Humans ; Alzheimer Disease/metabolism ; Alzheimer Disease/physiopathology ; Extracellular Matrix/metabolism ; gamma-Aminobutyric Acid/metabolism ; Interneurons/metabolism ; Interneurons/physiology ; Receptors, GABA-A/metabolism
Chemical Substances	gamma-Aminobutyric Acid (56-12-2) ; Receptors, GABA-A
Language	English
Publishing date	2022-11-21
Publishing country	Switzerland
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't
ZDB-ID	1051484-3
ISSN	1750-3639 ; 1015-6305
ISSN (online)	1750-3639
ISSN	1015-6305
DOI	10.1111/bpa.13129
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Zs.A 3585: Show issues

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Article ; Online: Mental health and service use of parents with and without borderline intellectual functioning.

Rudra, Sonya / McManus, Sally / Hassiotis, Angela / Ali, Afia

Psychological medicine

2023 Volume 54, Issue 7, Page(s) 1294–1308

Abstract: Background: People with borderline intellectual functioning (BIF) encounter greater social adversities than the general population and have an increased prevalence of mental illness. However, little is known about the socio-demographic characteristics ... ...

Abstract	Background: People with borderline intellectual functioning (BIF) encounter greater social adversities than the general population and have an increased prevalence of mental illness. However, little is known about the socio-demographic characteristics and mental health of parents with BIF. Methods: A secondary data analysis of the Adult Psychiatric Morbidity Survey 2014 was conducted. Logistic regression models were fitted to compare differences in socio-demographic, mental health and service-use characteristics between parents and non-parents with and without BIF, and to investigate if the relationship between parent status and mental health outcomes was modified by BIF status, sex, and employment. Results: Data from 6872 participants was analyzed; 69.1% were parents. BIF parents had higher odds of common mental disorder, severe mental illness, post-traumatic stress disorder, self-harm/suicide and were more likely to see their General Practitioner (GP) and to receive mental health treatment than non-BIF parents. BIF parents did not have a higher prevalence of mental health problems than BIF non-parents. Being a parent, after adjusting for BIF status and other confounders, was associated with increased odds of having a common mental disorder, visits to see a GP and treatment for mental health. Female parents had higher odds of treatment for mental health problems. Conclusions: Being a parent is associated with elevated rates of common mental disorders. There is a higher burden of mental health problems and service use in people with BIF. A greater provision of specialist support services including ascertainment is indicated for this group.
MeSH term(s)	Adult ; Humans ; Female ; Mental Health ; Psychotic Disorders ; Stress Disorders, Post-Traumatic ; Surveys and Questionnaires ; Intellectual Disability/epidemiology ; Learning Disabilities/psychology
Language	English
Publishing date	2023-10-25
Publishing country	England
Document type	Journal Article
ZDB-ID	217420-0
ISSN	1469-8978 ; 0033-2917
ISSN (online)	1469-8978
ISSN	0033-2917
DOI	10.1017/S0033291723003136
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Article ; Online: Analysing trends of psychiatric disorders, treatment and service use across time in adults with borderline intellectual impairment: A cross-sectional study of private households.

Lim, Amanda / Totsika, Vaso / Ali, Afia

Journal of psychiatric research

2022 Volume 151, Page(s) 339–346

Abstract: While there is evidence that mental health problems are more prevalent in people with borderline intellectual functioning (BIF) compared to the general population, it is not known to what extent this has varied or changed over time and whether there have ...

Abstract	While there is evidence that mental health problems are more prevalent in people with borderline intellectual functioning (BIF) compared to the general population, it is not known to what extent this has varied or changed over time and whether there have been changes in access to services. This paper compares the prevalence rates of psychiatric disorders and monitors trends in treatment and services in this population compared to the general population. We conducted secondary analysis on the Adult Psychiatric Morbidity Surveys carried out in England in 2000, 2007 and 2014. The total sample analysed included 21,796 participants, with 12.8% of individuals identified with BIF (n = 2786). Regression models were used to examine trends in psychiatric disorders, treatment and service use across the three datasets. People with BIF had significantly higher odds of developing mood and anxiety disorders, psychosis, drug dependence and suicidal behaviour than the general population, increasing at each subsequent timepoint. They received significantly more pharmacological treatments than the general population but have had increasingly more access to general practitioners, community care and daycare services over time. This study shows increasing prevalence rates of several mental disorders in people with BIF. Access to day-care, community care and healthcare services has increased over time for this group but not formal psychiatric care. These changes over time underline some of the problems this population faces, emphasizing a need to recognize that this is a population often overlooked in research and clinical practice.
MeSH term(s)	Adult ; Anxiety Disorders ; Cross-Sectional Studies ; Humans ; Intellectual Disability ; Learning Disabilities ; Mental Disorders/epidemiology ; Mental Disorders/psychology ; Mental Disorders/therapy ; Prevalence ; Psychotic Disorders/epidemiology ; Psychotic Disorders/therapy
Language	English
Publishing date	2022-04-25
Publishing country	England
Document type	Journal Article
ZDB-ID	3148-3
ISSN	1879-1379 ; 0022-3956
ISSN (online)	1879-1379
ISSN	0022-3956
DOI	10.1016/j.jpsychires.2022.04.026
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Article ; Online: Age-Dependent Sex Differences in Perineuronal Nets in an

Rahmani, Rayane / Rambarack, Naiomi / Singh, Jaijeet / Constanti, Andrew / Ali, Afia B

International journal of molecular sciences

2023 Volume 24, Issue 19

Abstract: Alzheimer's disease (AD) is the most common form of dementia, which disproportionately affects women. AD symptoms include progressive memory loss associated with amyloid-β (Aβ) plaques and dismantled synaptic mechanisms. Perineuronal nets (PNNs) are ... ...

Abstract	Alzheimer's disease (AD) is the most common form of dementia, which disproportionately affects women. AD symptoms include progressive memory loss associated with amyloid-β (Aβ) plaques and dismantled synaptic mechanisms. Perineuronal nets (PNNs) are important components of the extracellular matrix with a critical role in synaptic stabilisation and have been shown to be influenced by microglia, which enter an activated state during AD. This study aimed to investigate whether sex differences affected the density of PNNs alongside the labelling of microglia and Aβ plaques density.We performed neurochemistry experiments using acute brain slices from both sexes of the
MeSH term(s)	Female ; Male ; Mice ; Humans ; Animals ; Aged ; Alzheimer Disease/metabolism ; Sex Characteristics ; Mice, Transgenic ; Amyloid beta-Peptides/metabolism ; Brain/metabolism ; Plaque, Amyloid/metabolism ; Disease Models, Animal ; Amyloid beta-Protein Precursor/genetics ; Amyloid beta-Protein Precursor/metabolism
Chemical Substances	Amyloid beta-Peptides ; Amyloid beta-Protein Precursor
Language	English
Publishing date	2023-10-05
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms241914917
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Article ; Online: Presubiculum principal cells are preserved from degeneration in knock-in APP/TAU mouse models of Alzheimer's disease.

Islam, Anam / Saito, Takashi / Saido, Takaomi / Ali, Afia B

Seminars in cell & developmental biology

2022 Volume 139, Page(s) 55–72

Abstract: The presubiculum (PRS) is an integral component of the perforant pathway that has recently been recognised as a relatively unscathed region in clinical Alzheimer's disease (AD), despite neighbouring components of the perforant pathway, CA1 and the ... ...

Abstract	The presubiculum (PRS) is an integral component of the perforant pathway that has recently been recognised as a relatively unscathed region in clinical Alzheimer's disease (AD), despite neighbouring components of the perforant pathway, CA1 and the entorhinal cortex, responsible for formation of episodic memory and storage, showing severe hallmarks of AD including, amyloid-beta (Aβ) plaques, tau tangles and marked gliosis. However, the question remains whether this anatomical resilience translates into functional resilience of the PRS neurons. Using neuroanatomy combined with whole-cell electrophysiological recordings, we investigated whether the unique spatial profile of the PRS was replicable in two knock-in mouse models of AD, APP
MeSH term(s)	Mice ; Humans ; Animals ; Infant ; Alzheimer Disease/metabolism ; Gliosis/metabolism ; Gliosis/pathology ; Mice, Transgenic ; Parahippocampal Gyrus/metabolism ; Parahippocampal Gyrus/pathology ; Amyloid beta-Peptides/genetics ; Amyloid beta-Peptides/metabolism ; Plaque, Amyloid/metabolism ; Plaque, Amyloid/pathology ; Disease Models, Animal ; Amyloid beta-Protein Precursor/genetics ; Amyloid beta-Protein Precursor/metabolism
Chemical Substances	Amyloid beta-Peptides ; Amyloid beta-Protein Precursor
Language	English
Publishing date	2022-03-12
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1312473-0
ISSN	1096-3634 ; 1084-9521
ISSN (online)	1096-3634
ISSN	1084-9521
DOI	10.1016/j.semcdb.2022.03.001
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Zs.A 2918: Show issues

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Article ; Online: A systematic review of psychosocial interventions for people with intellectual disabilities and dementia.

Muralidhar, Malvika / Spector, Aimee / Hui, Esther K / Liu, Lisa / Ali, Afia

Aging & mental health

2023 Volume 28, Issue 3, Page(s) 385–395

Abstract: Objectives: As the life expectancy of individuals with intellectual disabilities (ID) continues to increase, there is an increased risk of developing dementia. While psychosocial interventions are gaining prominence, evidence is limited for people with ... ...

Abstract	Objectives: As the life expectancy of individuals with intellectual disabilities (ID) continues to increase, there is an increased risk of developing dementia. While psychosocial interventions are gaining prominence, evidence is limited for people with both dementia and ID. This review discusses the effectiveness of direct psychosocial interventions and adaptations to facilitate delivery within this population. Methods: The review followed the PRISMA guidelines. Five electronic databases, grey literature, and reference lists of included articles were searched for relevant studies. 10 eligible studies were appraised and analysed by narrative synthesis. Results: Ten distinct interventions were identified and categorised based on their purpose and delivery. All interventions were beneficial in improving a range of outcomes, though some studies were of low quality and most had small samples. Common adaptations included simplification of tasks and material, higher staff-to-client ratio, and alternative communication methods. Conclusion: There is emerging evidence for several psychosocial interventions for people with ID and dementia, though further research is required on effectiveness and generalisability. The adaptations discussed may guide implementation into routine care and contribute to current policies and guidelines on improving ID and dementia care.
MeSH term(s)	Humans ; Psychosocial Intervention ; Intellectual Disability/therapy ; Narration ; Dementia/therapy ; Dementia/psychology
Language	English
Publishing date	2023-10-09
Publishing country	England
Document type	Systematic Review ; Journal Article ; Review
ZDB-ID	1474804-6
ISSN	1364-6915 ; 1360-7863
ISSN (online)	1364-6915
ISSN	1360-7863
DOI	10.1080/13607863.2023.2265322
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Article ; Online: A qualitative exploration of stigma experience and inclusion among adults with mild to moderate intellectual disability in an Indonesian context.

Handoyo, Restu / Ali, Afia / Scior, Katrina / Hassiotis, Angela

Journal of intellectual disabilities : JOID

2021 , Page(s) 17446295211002349

Abstract: Background: People with intellectual disability are among the most stigmatised groups in society. There is a paucity of studies reporting on how stigma is experienced in low- and middle-income countries. This study aims to explore the experience of ... ...

Abstract	Background: People with intellectual disability are among the most stigmatised groups in society. There is a paucity of studies reporting on how stigma is experienced in low- and middle-income countries. This study aims to explore the experience of stigma among adults with mild/moderate intellectual disability and the extent of their inclusion in Indonesian society. Method: Fifteen adults with mild/moderate intellectual disability were purposively recruited from three service providers and were interviewed using a semi-structured interview schedule. The data were analysed using thematic analysis. Results: The findings suggest that adults with intellectual disability experience stigma in multiple settings (family, school, community), have limited access to social activities, and internalised the experienced stigma. Conclusion: This study adds to the international understanding of stigma experienced by adults with mild/moderate intellectual disability in daily life and their inclusion in society in a middle-income country.
Language	English
Publishing date	2021-04-26
Publishing country	England
Document type	Journal Article
ZDB-ID	2071898-6
ISSN	1744-6309 ; 1469-0047 ; 1744-6295
ISSN (online)	1744-6309
ISSN	1469-0047 ; 1744-6295
DOI	10.1177/17446295211002349
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Article: Alzheimer's Disease Enhanced Tonic Inhibition is Correlated With Upregulated Astrocyte GABA Transporter-3/4 in a Knock-In

Aldabbagh, Yousif / Islam, Anam / Zhang, Weicong / Whiting, Paul / Ali, Afia B

Frontiers in pharmacology

2022 Volume 13, Page(s) 822499

Abstract: Cognitive decline is a major symptom in Alzheimer's disease (AD), which is strongly associated with synaptic excitatory-inhibitory imbalance. Here, we investigated whether astrocyte-specific GABA transporter 3/4 (GAT3/4) is altered ... ...

Abstract	Cognitive decline is a major symptom in Alzheimer's disease (AD), which is strongly associated with synaptic excitatory-inhibitory imbalance. Here, we investigated whether astrocyte-specific GABA transporter 3/4 (GAT3/4) is altered in
Language	English
Publishing date	2022-02-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2022.822499
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