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  1. Article ; Online: Acute Myocarditis Induced by Hepatitis E: An Uncommon Association.

    Emeriaud, Héloïse / Huet, Fabien / Roubille, François / Pasquié, Jean-Luc

    CJC open

    2022  Volume 4, Issue 8, Page(s) 729–731

    Abstract: Acute myocarditis is often caused by viral infections. Hepatitis E infection inflicts over 20 million people worldwide each year. Common extra-hepatic manifestations of hepatitis E infection include neurologic, hematologic, and renal sequelae. ...

    Abstract Acute myocarditis is often caused by viral infections. Hepatitis E infection inflicts over 20 million people worldwide each year. Common extra-hepatic manifestations of hepatitis E infection include neurologic, hematologic, and renal sequelae.
    Language English
    Publishing date 2022-04-30
    Publishing country United States
    Document type Case Reports
    ISSN 2589-790X
    ISSN (online) 2589-790X
    DOI 10.1016/j.cjco.2022.04.008
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Colchicine: protection of the brain beyond the heart?

    Huet, Fabien / Delbaere, Quentin / Fauconnier, Jeremy / Lacampagne, Alain / Delmas, Clément / Roubille, François

    Expert review of clinical immunology

    2022  Volume 18, Issue 2, Page(s) 101–103

    MeSH term(s) Brain ; Colchicine/therapeutic use ; Heart ; Humans ; Myocardium
    Chemical Substances Colchicine (SML2Y3J35T)
    Language English
    Publishing date 2022-01-31
    Publishing country England
    Document type Editorial
    ZDB-ID 2274260-8
    ISSN 1744-8409 ; 1744-666X
    ISSN (online) 1744-8409
    ISSN 1744-666X
    DOI 10.1080/1744666X.2022.2035218
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6661: Show issues Location:
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  3. Article ; Online: Total Burden of Events: A New Standard Stressing the Positive Impact of Inflammation Modulation.

    Roubille, François / Huet, Fabien / Duflos, Claire

    Journal of the American College of Cardiology

    2020  Volume 76, Issue 14, Page(s) 1671–1673

    MeSH term(s) Cardiovascular Diseases ; Colchicine ; Humans ; Inflammation ; Interleukin-1beta ; Reference Standards
    Chemical Substances Interleukin-1beta ; Colchicine (SML2Y3J35T)
    Keywords covid19
    Language English
    Publishing date 2020-10-01
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 605507-2
    ISSN 1558-3597 ; 0735-1097
    ISSN (online) 1558-3597
    ISSN 0735-1097
    DOI 10.1016/j.jacc.2020.08.036
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1846: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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    Zs.MO 196: Show issues

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  4. Article: Anti-Inflammatory Drug Candidates for Prevention and Treatment of Cardiovascular Diseases.

    Delbaere, Quentin / Chapet, Nicolas / Huet, Fabien / Delmas, Clément / Mewton, Nathan / Prunier, Fabrice / Angoulvant, Denis / Roubille, François

    Pharmaceuticals (Basel, Switzerland)

    2023  Volume 16, Issue 1

    Abstract: Incidence and mortality rates for cardiovascular disease are declining, but it still remains a major cause of morbidity and mortality. Drug treatments to slow the progression of atherosclerosis focus on reducing cholesterol levels. The paradigm shift to ... ...

    Abstract Incidence and mortality rates for cardiovascular disease are declining, but it still remains a major cause of morbidity and mortality. Drug treatments to slow the progression of atherosclerosis focus on reducing cholesterol levels. The paradigm shift to consider atherosclerosis an inflammatory disease by itself has led to the development of new treatments. In this article, we discuss the pathophysiology of inflammation and focus attention on therapeutics targeting different inflammatory pathways of atherosclerosis and myocardial infarction. In atherosclerosis, colchicine is included in new recommendations, and eight randomized clinical trials are testing new drugs in different inflammatory pathways. After a myocardial infarction, no drug has shown a significant benefit, but we present four randomized clinical trials with new treatments targeting inflammation.
    Language English
    Publishing date 2023-01-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph16010078
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  5. Article: Enhancing Oral Delivery of Biologics: A Non-Competitive and Cross-Reactive Anti-Leptin Receptor Nanofitin Demonstrates a Gut-Crossing Capacity in an Ex Vivo Porcine Intestinal Model.

    Masloh, Solene / Chevrel, Anne / Culot, Maxime / Perrocheau, Anaëlle / Kalia, Yogeshvar N / Frehel, Samuel / Gaussin, Rémi / Gosselet, Fabien / Huet, Simon / Zeisser Labouebe, Magali / Scapozza, Leonardo

    Pharmaceutics

    2024  Volume 16, Issue 1

    Abstract: Biotherapeutics exhibit high efficacy in targeted therapy, but their oral delivery is impeded by the harsh conditions of the gastrointestinal (GI) tract and limited intestinal absorption. This article presents a strategy to overcome the challenges of ... ...

    Abstract Biotherapeutics exhibit high efficacy in targeted therapy, but their oral delivery is impeded by the harsh conditions of the gastrointestinal (GI) tract and limited intestinal absorption. This article presents a strategy to overcome the challenges of poor intestinal permeability by using a protein shuttle that specifically binds to an intestinal target, the leptin receptor (LepR), and exploiting its capacity to perform a receptor-mediated transport. Our proof-of-concept study focuses on the characterization and transport of robust affinity proteins, known as Nanofitins, across an ex vivo porcine intestinal model. We describe the potential to deliver biologically active molecules across the mucosa by fusing them with the Nanofitin 1-F08 targeting the LepR. This particular Nanofitin was selected for its absence of competition with leptin, its cross-reactivity with LepR from human, mouse, and pig hosts, and its shuttle capability associated with its ability to induce a receptor-mediated transport. This study paves the way for future in vivo demonstration of a safe and efficient oral-to-systemic delivery of targeted therapies.
    Language English
    Publishing date 2024-01-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics16010116
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  6. Article ; Online: Absolute Change in High Sensitivity Cardiac Troponin I for Three Hours is Useful for Diagnosing Acute Myocardial Infarction in the Emergency Department: How to Get to Best Benefit From HS-Troponins in Clinical Practice?

    Huet, Fabien / Dupuy, Anne Marie / Cristol, Jean Paul / Roubille, François

    Annals of laboratory medicine

    2020  Volume 40, Issue 6, Page(s) 488–489

    MeSH term(s) Emergency Service, Hospital ; Humans ; Myocardial Infarction ; Troponin I ; Troponin T
    Chemical Substances Troponin I ; Troponin T
    Language English
    Publishing date 2020-06-17
    Publishing country Korea (South)
    Document type Letter ; Comment
    ZDB-ID 2677441-0
    ISSN 2234-3814 ; 2234-3814
    ISSN (online) 2234-3814
    ISSN 2234-3814
    DOI 10.3343/alm.2020.40.6.488
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Anti-Inflammatory Drug Candidates for Prevention and Treatment of Cardiovascular Diseases

    Quentin Delbaere / Nicolas Chapet / Fabien Huet / Clément Delmas / Nathan Mewton / Fabrice Prunier / Denis Angoulvant / François Roubille

    Pharmaceuticals, Vol 16, Iss 78, p

    2023  Volume 78

    Abstract: Incidence and mortality rates for cardiovascular disease are declining, but it still remains a major cause of morbidity and mortality. Drug treatments to slow the progression of atherosclerosis focus on reducing cholesterol levels. The paradigm shift to ... ...

    Abstract Incidence and mortality rates for cardiovascular disease are declining, but it still remains a major cause of morbidity and mortality. Drug treatments to slow the progression of atherosclerosis focus on reducing cholesterol levels. The paradigm shift to consider atherosclerosis an inflammatory disease by itself has led to the development of new treatments. In this article, we discuss the pathophysiology of inflammation and focus attention on therapeutics targeting different inflammatory pathways of atherosclerosis and myocardial infarction. In atherosclerosis, colchicine is included in new recommendations, and eight randomized clinical trials are testing new drugs in different inflammatory pathways. After a myocardial infarction, no drug has shown a significant benefit, but we present four randomized clinical trials with new treatments targeting inflammation.
    Keywords anti-inflammatory ; atherosclerosis ; drugs ; myocardial infarction ; Medicine ; R ; Pharmacy and materia medica ; RS1-441
    Subject code 610
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Is hypertriglyceridemia atherogenic?

    Huet, Fabien / Roubille, Camille / Roubille, François

    Current opinion in lipidology

    2019  Volume 30, Issue 4, Page(s) 291–299

    Abstract: Purpose of review: Hypertriglyceridemia occurs mainly because of metabolic disorders secondary to diabetes, alcohol intake, and/or overweight. Genetic factors have also been clearly identified in most severe cases. Triglycerides are generally considered ...

    Abstract Purpose of review: Hypertriglyceridemia occurs mainly because of metabolic disorders secondary to diabetes, alcohol intake, and/or overweight. Genetic factors have also been clearly identified in most severe cases. Triglycerides are generally considered as 'bystanders' for cardiovascular diseases. However, biological and basic research provides strong data suggesting that triglyceride-rich lipoproteins could be involved in the pathophysiology of cardiovascular diseases.
    Recent findings: The REDUCE-IT trial recently showed that icosapent ethyl reduces major cardiovascular events and related death.
    Summary: For many years, low-density lipoproteins (LDLs) have been considered the Holy Grail for atherosclerotic cardiovascular disease management. New data from basic research in biology, epidemiology, genetics, and preliminary clinical trials support the hypothesis that triglyceride-rich lipoproteins could be the causal factors for atherosclerotic cardiovascular disease; hence, triglyceride should be taken into consideration in the management of these patients. Omega-3-fatty acids used in the REDUCE-IT trial reduced the residual cardiovascular risk efficiently beyond statins. However, its effect has to be completely understood as it seems to be unrelated to LDLc or triglyceride reduction, but linked to pleiotropic effects involving inflammation, platelet adhesion, and plaque instability reduction, paving the way for trials that will target more specific potential pathophysiologic pathways.
    MeSH term(s) Animals ; Atherosclerosis/complications ; Humans ; Hypertriglyceridemia/complications ; Hypertriglyceridemia/metabolism ; Hypertriglyceridemia/physiopathology ; Risk Factors
    Language English
    Publishing date 2019-06-13
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1045394-5
    ISSN 1473-6535 ; 0957-9672
    ISSN (online) 1473-6535
    ISSN 0957-9672
    DOI 10.1097/MOL.0000000000000622
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3010: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: Colchicine to prevent sympathetic denervation after acute myocardial infarction: the COLD-MI trial.

    Huet, Fabien / Mariano-Goulart, Denis / Aguilhon, Sylvain / Delbaere, Quentin / Lacampagne, Alain / Fauconnier, Jérémy / Leclercq, Florence / Macia, Jean-Christophe / Akodad, Mariama / Jammoul, Nidal / Prunier, Fabrice / Mewton, Nathan / Angoulvant, Denis / Lozza, Catherine / Soltani, Sonia / Rodier, Annabelle / Grandemange, Sylvie / Dupuy, Anne-Marie / Cristol, Jean-Paul /
    Amico, Mailis / Nagot, Nicolas / Roubille, François

    European heart journal

    2024  Volume 45, Issue 9, Page(s) 725–727

    MeSH term(s) Humans ; Colchicine/therapeutic use ; Myocardial Infarction/complications ; Sympathectomy
    Chemical Substances Colchicine (SML2Y3J35T)
    Language English
    Publishing date 2024-03-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 603098-1
    ISSN 1522-9645 ; 0195-668X
    ISSN (online) 1522-9645
    ISSN 0195-668X
    DOI 10.1093/eurheartj/ehae042
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1563: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Zs.MO 640: Show issues

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