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Article ; Online: Correction: Association of Biochemical Parameters and Screening for Mutations in the MCU Gene in Alzheimer's Disease Patients.

Venugopal, Anila / Iyer, Mahalaxmi / Narayanasamy, Arul / Ravimanickam, T / Gopalakrishnan, Abilash Valsala / Yadav, Mukesh Kumar / Kumar, Nachimuthu Senthil / Vellingiri, Balachandar

Molecular neurobiology

2024

Language	English
Publishing date	2024-01-22
Publishing country	United States
Document type	Published Erratum
ZDB-ID	645020-9
ISSN	1559-1182 ; 0893-7648
ISSN (online)	1559-1182
ISSN	0893-7648
DOI	10.1007/s12035-024-03929-8
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Article ; Online: Association of Biochemical Parameters and Screening for Mutations in the MCU Gene in Alzheimer's Disease Patients.

Venugopal, Anila / Iyer, Mahalaxmi / Narayanasamy, Arul / Ravimanickam, T / Gopalakrishnan, Abilash Valsala / Yadav, Mukesh Kumar / Kumar, Nachimuthu Senthil / Vellingiri, Balachandar

Molecular neurobiology

2023

Abstract: The most prevalent form of dementia, Alzheimer's disease (AD) is a chronic illness that is on the rise among the geriatric population. Even though research into its biochemical, genetic, and cytogenetic pathways has advanced, its aetiology is still ... ...

Abstract	The most prevalent form of dementia, Alzheimer's disease (AD) is a chronic illness that is on the rise among the geriatric population. Even though research into its biochemical, genetic, and cytogenetic pathways has advanced, its aetiology is still unclear and complex. In this study, we recruited sixty-eight participants diagnosed with AD where the cytogenetic, biochemical parameters and genetic mutations were analysed. Our results revealed chromosomal aberrations such as aneuploidies in the peripheral blood of Alzheimer's disease patients. Biochemical parameters revealed no statistical significance in the study though a pattern could be observed in the serum levels. Further few novel mutations at the c.21 C > T, c.56G > A were observed in the MCU gene of mitochondrial calcium uniporter. All these findings reveal the need for a larger cohort study to gain a better and more detailed understanding of the aetiology of Alzheimer's disease.
Language	English
Publishing date	2023-12-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	645020-9
ISSN	1559-1182 ; 0893-7648
ISSN (online)	1559-1182
ISSN	0893-7648
DOI	10.1007/s12035-023-03820-y
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Article ; Online: Assessment of tRNA

Venkatesan, Dhivya / Iyer, Mahalaxmi / Raj, Neethu / Gopalakrishnan, Abilash Valsala / Narayanasamy, Arul / Kumar, Nachimuthu Senthil / Vellingiri, Balachandar

Journal of molecular neuroscience : MN

2023 Volume 73, Issue 11-12, Page(s) 912–920

Abstract: Parkinson's disease (PD) is speculated with genetic and environmental factors. At molecular level, the mitochondrial impact is stated to be one of the causative reasons for PD. In this study, we investigated the mitochondrial membrane potential (MMP), ... ...

Abstract	Parkinson's disease (PD) is speculated with genetic and environmental factors. At molecular level, the mitochondrial impact is stated to be one of the causative reasons for PD. In this study, we investigated the mitochondrial membrane potential (MMP), reactive oxygen species (ROS) and adenosine triphosphate (ATP) levels along with mitochondrial tRNA alterations among three age categories of PD. By determining the genetic and organellar functionality using molecular techniques, the ROS levels were reported to be high with decreased MMP and ATP in the late-onset age group than in other two age categories. Likewise, the tRNA significancy in tRNA
MeSH term(s)	Humans ; RNA, Transfer, Thr/genetics ; RNA, Transfer, Thr/metabolism ; RNA, Transfer, Gln/genetics ; RNA, Transfer, Gln/metabolism ; Parkinson Disease/genetics ; Parkinson Disease/metabolism ; Reactive Oxygen Species/metabolism ; India ; Mitochondria/genetics ; Mitochondria/metabolism ; Adenosine Triphosphate/metabolism
Chemical Substances	RNA, Transfer, Thr ; RNA, Transfer, Gln ; Reactive Oxygen Species ; Adenosine Triphosphate (8L70Q75FXE)
Language	English
Publishing date	2023-10-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	1043392-2
ISSN	1559-1166 ; 0895-8696
ISSN (online)	1559-1166
ISSN	0895-8696
DOI	10.1007/s12031-023-02154-7
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Article ; Online: Correction: Concurrent Assessment of Oxidative Stress and MT-ATP6 Gene Profiling to Facilitate Diagnosis of Autism Spectrum Disorder (ASD) in Tamil Nadu Population.

Vellingiri, Balachandar / Venkatesan, Dhivya / Iyer, Mahalaxmi / Mohan, Gomathi / Krishnan, Padmavathi / Krishna, Krothapalli Sai / R, Sangeetha / Narayanasamy, Arul / Gopalakrishnan, Abilash Valsala / Kumar, Nachimuthu Senthil / Subramaniam, Mohana Devi

Journal of molecular neuroscience : MN

2023 Volume 73, Issue 6, Page(s) 485

Language	English
Publishing date	2023-07-17
Publishing country	United States
Document type	Published Erratum
ZDB-ID	1043392-2
ISSN	1559-1166 ; 0895-8696
ISSN (online)	1559-1166
ISSN	0895-8696
DOI	10.1007/s12031-023-02137-8
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Ontology-Enabled Emotional Sentiment Analysis on COVID-19 Pandemic-Related Twitter Streams.

Narayanasamy, Senthil Kumar / Srinivasan, Kathiravan / Mian Qaisar, Saeed / Chang, Chuan-Yu

Frontiers in public health

2021 Volume 9, Page(s) 798905

Abstract: The exponential growth of social media users has changed the dynamics of retrieving the potential information from user-generated content and transformed the paradigm of information-retrieval mechanism with the novel developments on the concept of "web ... ...

Abstract	The exponential growth of social media users has changed the dynamics of retrieving the potential information from user-generated content and transformed the paradigm of information-retrieval mechanism with the novel developments on the concept of "web of data". In this regard, our proposed Ontology-Based Sentiment Analysis provides two novel approaches: First, the emotion extraction on tweets related to COVID-19 is carried out by a well-formed taxonomy that comprises possible emotional concepts with fine-grained properties and polarized values. Second, the potential entities present in the tweet can be analyzed for semantic associativity. The extraction of emotions can be performed in two cases: (i) words directly associated with the emotional concepts present in the taxonomy and (ii) words indirectly present in the emotional concepts. Though the latter case is very challenging in processing the tweets to find the hidden patterns and extract the meaningful facts associated with it, our proposed work is able to extract and detect almost 81% of true positives and considerably able to detect the false negatives. Finally, the proposed approach's superior performance is witnessed from its comparison with other peer-level approaches.
MeSH term(s)	COVID-19 ; Emotions ; Humans ; Pandemics ; SARS-CoV-2 ; Sentiment Analysis ; Social Media
Language	English
Publishing date	2021-12-06
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2711781-9
ISSN	2296-2565 ; 2296-2565
ISSN (online)	2296-2565
ISSN	2296-2565
DOI	10.3389/fpubh.2021.798905
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Concurrent Assessment of Oxidative Stress and MT-ATP6 Gene Profiling to Facilitate Diagnosis of Autism Spectrum Disorder (ASD) in Tamil Nadu Population.

Vellingiri, Balachandar / Venkatesan, Dhivya / Iyer, Mahalaxmi / Mohan, Gomathi / Krishnan, Padmavathi / Sai Krishna, Krothapalli / R, Sangeetha / Narayanasamy, Arul / Gopalakrishnan, Abilash Valsala / Kumar, Nachimuthu Senthil / Subramaniam, Mohana Devi

Journal of molecular neuroscience : MN

2023 Volume 73, Issue 4-5, Page(s) 214–224

Abstract: Autism spectrum disorder (ASD) is a neurodevelopmental disability that causes social impairment, debilitated verbal or nonverbal conversation, and restricted/repeated behavior. Recent research reveals that mitochondrial dysfunction and oxidative stress ... ...

Abstract	Autism spectrum disorder (ASD) is a neurodevelopmental disability that causes social impairment, debilitated verbal or nonverbal conversation, and restricted/repeated behavior. Recent research reveals that mitochondrial dysfunction and oxidative stress might play a pivotal role in ASD condition. The goal of this case-control study was to investigate oxidative stress and related alterations in ASD patients. In addition, the impact of mitochondrial DNA (mtDNA) mutations, particularly MT-ATP6, and its link with oxidative stress in ASD was studied. We found that ASD patient's plasma had lower superoxide dismutase (SOD) and higher catalase (CAT) activity, resulting in lower SOD/CAT ratio. MT-ATP6 mutation analysis revealed that four variations, 8865 G>A, 8684 C>T, 8697 G>A, and 8836 A>G, have a frequency of more than 10% with missense and synonymous (silent) mutations. It was observed that abnormalities in mitochondrial complexes (I, III, V) are more common in ASD, and it may have resulted in MT-ATP6 changes or vice versa. In conclusion, our findings authenticate that oxidative stress and genetics both have an equal and potential role behind ASD and we recommend to conduct more such concurrent research to understand their unique mechanism for better diagnosis and therapeutic for ASD.
MeSH term(s)	Humans ; Autism Spectrum Disorder/diagnosis ; Autism Spectrum Disorder/genetics ; Case-Control Studies ; India ; DNA, Mitochondrial/genetics ; Oxidative Stress ; Antioxidants ; Superoxide Dismutase ; Mitochondrial Proton-Translocating ATPases/genetics
Chemical Substances	DNA, Mitochondrial ; Antioxidants ; Superoxide Dismutase (EC 1.15.1.1) ; MT-ATP6 protein, human ; Mitochondrial Proton-Translocating ATPases (EC 3.6.3.-)
Language	English
Publishing date	2023-03-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	1043392-2
ISSN	1559-1166 ; 0895-8696
ISSN (online)	1559-1166
ISSN	0895-8696
DOI	10.1007/s12031-023-02111-4
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Analysis of blood lead level and its clinical significance among occupational exposed painters in chennai based population: A cross sectional study.

S, Ragunanthanan / Vaiyakkani, Govardhini / S, Senthil Kumar / Ramachandran, Arunkumar / Rajendran, Karthick / Krishnasamy, Narayanasamy / Panneerselvam, Priyadarshini / Pamarthi, Jayakrishna / Rajaram, Muthukumaran

Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)

2023 Volume 79, Page(s) 127257

Abstract: Introduction and aim: Lead is a ubiquitous element found in the earth crust. There is no known physiologic role of lead in human body and hence any amount of lead present in human tissue considered as a contamination. Several studies on lead toxicity ... ...

Abstract	Introduction and aim: Lead is a ubiquitous element found in the earth crust. There is no known physiologic role of lead in human body and hence any amount of lead present in human tissue considered as a contamination. Several studies on lead toxicity show that, occupational exposure remains the main source for lead toxicity and is emerging as important public health problem. Burden and severity of occupational exposure of lead and its clinical significance are gaining more interest in the field of toxicology. Only limited studies are available and there is scarcity of epidemiology data to assess the blood lead levels of workers and the contribution of common workplace practices to lead exposure in India especially from our region. So, the current study is designed to assess the blood lead levels (BLL) and its clinical significance among high risk workers especially painters working in the construction and public private sector in Chennai based population. Materials and methods: This cross-sectional case control study included 122 painters and 122 healthy individuals. A detailed questionnaire about demographic details, personal habits, work related safety precautions, presenting symptoms of lead toxicity were given to painter followed by detailed medical examination and blood investigations including blood lead levels were collected and statistically analyzed. The t-test were used to compare mean blood lead levels and to investigate the associations between specific job type, use of self-protection device,sex, service years and occurrence of non-specific symptoms with BLLs. Results: The mean BLL of the painters were less than the recommended threshold level. Among painters 13.1% were categorized under BLL > 10 μg/dL. The higher BLL among the painters were directly proportional to year of experience and poor usage of personal protective materials. The levels of Hb, HCT and eosinophil were much correlated with lead toxicity. A marginal significance were observed in some parameters especially urea and creatinine when compared with control. The Cognitive dysfunction, hypertension and renal dysfunction were also observed among the painters. Conclusion: The BLL in painters among our group were minimal compared to biological reference value. Duration of exposure and association of patient's clinical features like cognitive dysfunction, hypertension and renal dysfunction conditions were observed and this should be carefully monitored and study on huge population of painters with longitudinal aspect is recommended to rule out the clinical correlation of lead toxicity.
MeSH term(s)	Humans ; Lead ; Cross-Sectional Studies ; Clinical Relevance ; Case-Control Studies ; India/epidemiology ; Occupational Exposure/adverse effects ; Occupational Exposure/analysis ; Lead Poisoning/epidemiology ; Hypertension
Chemical Substances	Lead (2P299V784P)
Language	English
Publishing date	2023-06-30
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1236267-0
ISSN	1878-3252 ; 1611-602X ; 0946-672X
ISSN (online)	1878-3252 ; 1611-602X
ISSN	0946-672X
DOI	10.1016/j.jtemb.2023.127257
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Article ; Online: Ontology-Enabled Emotional Sentiment Analysis on COVID-19 Pandemic-Related Twitter Streams

Senthil Kumar Narayanasamy / Kathiravan Srinivasan / Saeed Mian Qaisar / Chuan-Yu Chang

Frontiers in Public Health, Vol

2021 Volume 9

Abstract	The exponential growth of social media users has changed the dynamics of retrieving the potential information from user-generated content and transformed the paradigm of information-retrieval mechanism with the novel developments on the concept of “web of data”. In this regard, our proposed Ontology-Based Sentiment Analysis provides two novel approaches: First, the emotion extraction on tweets related to COVID-19 is carried out by a well-formed taxonomy that comprises possible emotional concepts with fine-grained properties and polarized values. Second, the potential entities present in the tweet can be analyzed for semantic associativity. The extraction of emotions can be performed in two cases: (i) words directly associated with the emotional concepts present in the taxonomy and (ii) words indirectly present in the emotional concepts. Though the latter case is very challenging in processing the tweets to find the hidden patterns and extract the meaningful facts associated with it, our proposed work is able to extract and detect almost 81% of true positives and considerably able to detect the false negatives. Finally, the proposed approach's superior performance is witnessed from its comparison with other peer-level approaches.
Keywords	sentiment analysis ; emotion ontology ; natural language processing ; twitter streams ; latent Dirichlet allocation ; SPARQL ; Public aspects of medicine ; RA1-1270
Subject code	006
Language	English
Publishing date	2021-12-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Frequency of hereditary hemochromatosis gene mutations and their effects on iron overload among beta thalassemia patients of Chennai residents

Bhuvana Selvaraj / Sangeetha Soundararajan / Shettu Narayanasamy / Ganesan Subramanian / Senthil Kumar Ramanathan

AIMS Molecular Science, Vol 8, Iss 4, Pp 233-

2021 Volume 247

Abstract: Hereditary Hemochromatosis (HH) is an autosomal recessive disorder of iron metabolism associated with HFE gene mutations, characterized by increased iron absorption and accumulation leading to multi-organ damage caused by iron overload toxicity. Beta ... ...

Abstract	Hereditary Hemochromatosis (HH) is an autosomal recessive disorder of iron metabolism associated with HFE gene mutations, characterized by increased iron absorption and accumulation leading to multi-organ damage caused by iron overload toxicity. Beta thalassemia is caused by a mutation in the human beta globin gene. Imbalanced production of globin chain results in beta thalassemia, where the unpaired alpha chains precipitates in red cell precursors leading to ineffective erythropoiesis and reduced RBC survival. Both HH and beta thalassemia condition results in rapid accumulation of iron lead to iron overload in tissues and organs. The study aims to analyze the frequency of HFE variants among beta thalassemia cases and their effect on iron overload. The frequency of three HFE variants C282Y, H63D, S65C was analyzed by PCR RFLP method among Beta Thalassemia Trait (BTT) (n = 203), Beta Thalassemia Major (BTM) (n = 19) and age and sex-matched control samples (n = 200). The present study furnished allele frequency of H63D variant in BTT, BTM and controls 8.13, 15.8 and 6% respectively. Ten out of 33 heterozygous H63D variants exhibited iron overload with higher ferritin levels indicating HFE variant might aggravate the absorption of iron. The C282Y variant was present in heterozygous state in 1 case among beta thalassemia carriers. The C282Y variant was absent among BTM and control cases. S65C HFE variant was absent in the present study. Iron overload was completely absent in the control cases among all three HFE genotypes. Hence it is inferred from the present investigation, analysis of HFE genes and iron status will remarkably help to reason out the probable reason behind the iron status and support in proper management of beta thalassemia cases.
Keywords	hereditary hemochromatosis ; beta thalassemia ; hfe ; iron overload ; ferritin ; Biology (General) ; QH301-705.5
Subject code	570
Language	English
Publishing date	2021-11-01T00:00:00Z
Publisher	AIMS Press
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Characterization of Musa paradisiaca L. Cellulosic Natural Fibers from Agro-discarded Blossom Petal Waste

Prithivirajan, R. / Narayanasamy, P. / Al-Dhabi, Naif Abdullah / Balasundar, P. / Kumar, R. Shyam / Ponmurugan, K. / Ramkumar, T. / Senthil, S.

Journal of natural fibers

2020 Volume 17, Issue 10/12, Page(s) 1640

Language	English
Document type	Article
ZDB-ID	2182715-1
ISSN	1544-0478
Database	Current Contents Nutrition, Environment, Agriculture

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