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  1. Article: Transcription factor network governing pluripotency.

    Niwa, Hitoshi

    Nihon rinsho. Japanese journal of clinical medicine

    2018  Volume 73 Suppl 5, Page(s) 80–84

    MeSH term(s) Cellular Reprogramming ; Pluripotent Stem Cells/physiology ; Transcription Factors
    Chemical Substances Transcription Factors
    Language Japanese
    Publishing date 2018-11-19
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 390903-7
    ISSN 0047-1852
    ISSN 0047-1852
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 429: Show issues Location:
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  2. Article ; Online: Ensemble of old and new techniques escorts ESCs to bona fide embryo-like structures.

    Niwa, Hitoshi / Mwalilino, Lusubilo

    Cell stem cell

    2022  Volume 29, Issue 10, Page(s) 1423–1425

    Abstract: Three recent studies from the Zernicka-Goetz and Hanna groups (Amadei et al., 2022; Tarazi et al., 2022; Lau et al., 2022) report the development of mouse embryo-like structures from stem cells. Using a combination of stem cell-derived sources, they show ...

    Abstract Three recent studies from the Zernicka-Goetz and Hanna groups (Amadei et al., 2022; Tarazi et al., 2022; Lau et al., 2022) report the development of mouse embryo-like structures from stem cells. Using a combination of stem cell-derived sources, they show that mouse embryo-like structures develop key features mimicking post-gastrulation embryos.
    MeSH term(s) Animals ; Embryo, Mammalian ; Gastrulation ; Mice
    Language English
    Publishing date 2022-09-30
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2375354-7
    ISSN 1875-9777 ; 1934-5909
    ISSN (online) 1875-9777
    ISSN 1934-5909
    DOI 10.1016/j.stem.2022.09.004
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  3. Article ; Online: Stepwise pluripotency transitions in mouse stem cells.

    Endoh, Mitsuhiro / Niwa, Hitoshi

    EMBO reports

    2022  Volume 23, Issue 9, Page(s) e55010

    Abstract: Pluripotent cells in mouse embryos, which first emerge in the inner cell mass of the blastocyst, undergo gradual transition marked by changes in gene expression, developmental potential, polarity, and morphology as they develop from the pre-implantation ... ...

    Abstract Pluripotent cells in mouse embryos, which first emerge in the inner cell mass of the blastocyst, undergo gradual transition marked by changes in gene expression, developmental potential, polarity, and morphology as they develop from the pre-implantation until post-implantation gastrula stage. Recent studies of cultured mouse pluripotent stem cells (PSCs) have clarified the presence of intermediate pluripotent stages between the naïve pluripotent state represented by embryonic stem cells (ESCs-equivalent to the pre-implantation epiblast) and the primed pluripotent state represented by epiblast stem cells (EpiSCs-equivalent to the late post-implantation gastrula epiblast). In this review, we discuss these recent findings in light of our knowledge on peri-implantation mouse development and consider the implications of these new PSCs to understand their temporal sequence and the feasibility of using them as model system for pluripotency.
    MeSH term(s) Animals ; Blastocyst/metabolism ; Cell Differentiation ; Embryonic Stem Cells/metabolism ; Germ Layers/metabolism ; Mice ; Pluripotent Stem Cells
    Language English
    Publishing date 2022-07-29
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2020896-0
    ISSN 1469-3178 ; 1469-221X
    ISSN (online) 1469-3178
    ISSN 1469-221X
    DOI 10.15252/embr.202255010
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  4. Article ; Online: The principles that govern transcription factor network functions in stem cells.

    Niwa, Hitoshi

    Development (Cambridge, England)

    2018  Volume 145, Issue 6

    Abstract: Tissue-specific transcription factors primarily act to define the phenotype of the cell. The power of a single transcription factor to alter cell fate is often minimal, as seen in gain-of-function analyses, but when multiple transcription factors ... ...

    Abstract Tissue-specific transcription factors primarily act to define the phenotype of the cell. The power of a single transcription factor to alter cell fate is often minimal, as seen in gain-of-function analyses, but when multiple transcription factors cooperate synergistically it potentiates their ability to induce changes in cell fate. By contrast, transcription factor function is often dispensable in the maintenance of cell phenotype, as is evident in loss-of-function assays. Why does this phenomenon, commonly known as redundancy, occur? Here, I discuss the role that transcription factor networks play in collaboratively regulating stem cell fate and differentiation by providing multiple explanations for their functional redundancy.
    MeSH term(s) Animals ; Cell Differentiation/physiology ; Embryonic Stem Cells/cytology ; Embryonic Stem Cells/physiology ; Gene Expression Regulation/physiology ; Humans ; Signal Transduction ; Transcription Factors
    Chemical Substances Transcription Factors
    Language English
    Publishing date 2018--14
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 90607-4
    ISSN 1477-9129 ; 0950-1991
    ISSN (online) 1477-9129
    ISSN 0950-1991
    DOI 10.1242/dev.157420
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  5. Article ; Online: Generation of Mitochondrial Toxin Rodent Models of Parkinson's Disease Using 6-OHDA , MPTP , and Rotenone.

    Maegawa, Hiroharu / Niwa, Hitoshi

    Methods in molecular biology (Clifton, N.J.)

    2021  Volume 2322, Page(s) 95–110

    Abstract: Several animal models are employed to discover novel treatments for the symptoms of Parkinson's disease (PD). PD models can be divided into two models: neurotoxin models and genetic models. Among neurotoxins to produce PD models, 6-hydroxydopamine (6- ... ...

    Abstract Several animal models are employed to discover novel treatments for the symptoms of Parkinson's disease (PD). PD models can be divided into two models: neurotoxin models and genetic models. Among neurotoxins to produce PD models, 6-hydroxydopamine (6-OHDA), 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), and rotenone, which inhibit the mitochondrial complex I, are widely used. Animal models of PD using these neurotoxins are also known as mitochondrial toxin models. Here this chapter describes the preparation of these mitochondrial toxin models.
    MeSH term(s) 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine/pharmacology ; Animals ; Disease Models, Animal ; Dopamine/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Mitochondria/drug effects ; Neurotoxins/pharmacology ; Oxidopamine/pharmacology ; Parkinson Disease/drug therapy ; Parkinson Disease/metabolism ; Rats ; Rats, Inbred Lew ; Rats, Sprague-Dawley ; Rats, Wistar ; Rodentia ; Rotenone/pharmacology
    Chemical Substances Neurotoxins ; Rotenone (03L9OT429T) ; Oxidopamine (8HW4YBZ748) ; 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (9P21XSP91P) ; Dopamine (VTD58H1Z2X)
    Language English
    Publishing date 2021-05-27
    Publishing country United States
    Document type Journal Article
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-1495-2_10
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  6. Article ; Online: Long-lasting adverse effects of short-term stress during the suckling-mastication transition period on masticatory function and intraoral sensation in rats.

    Katagiri, Ayano / Yamada, Masaharu / Sato, Hajime / Toyoda, Hiroki / Niwa, Hitoshi / Kato, Takafumi

    Odontology

    2024  

    Abstract: Early-life stress affects brain development, eventually resulting in adverse behavioral and physical health consequences in adulthood. The present study assessed the hypothesis that short-term early-life stress during infancy before weaning, a period for ...

    Abstract Early-life stress affects brain development, eventually resulting in adverse behavioral and physical health consequences in adulthood. The present study assessed the hypothesis that short-term early-life stress during infancy before weaning, a period for the maturation of mastication and sleep, poses long-lasting adverse effects on masticatory function and intraoral sensations later in life.Rat pups were exposed to either maternal separation (MS) or intermittent hypoxia (IH-Infancy) for 6 h/day in the light/sleep phase from postnatal day (P)17 to P20 to generate "neglect" and "pediatric obstructive sleep apnea" models, respectively. The remaining rats were exposed to IH during P45-P48 (IH-Adult). Masticatory ability was evaluated based on the rats' ability to chew pellets and bite pasta throughout the growth period (P21-P70). Intraoral chemical and mechanical sensitivities were assessed using two-bottle preference drinking tests, and hind paw pain thresholds were measured in adulthood (after P60).No differences were found in body weight, grip force, and hind paw sensitivity in MS, IH-Infancy, and IH-Adult rats compared with naïve rats. Masticatory ability was lower in MS and IH-Infancy rats from P28 to P70 than in naïve rats. MS and IH-Infancy rats exhibited intraoral hypersensitivity to capsaicin and mechanical stimulations in adulthood. The IH-Adult rats did not display inferior masticatory ability or intraoral hypersensitivity.In conclusion, short-term early-life stress during the suckling-mastication transition period potentially causes a persistent decrease in masticatory ability and intraoral hypersensitivity in adulthood. The period is a "critical window" for the maturation of oral motor and sensory functions.
    Language English
    Publishing date 2024-01-10
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2092085-4
    ISSN 1618-1255 ; 1618-1247
    ISSN (online) 1618-1255
    ISSN 1618-1247
    DOI 10.1007/s10266-023-00887-w
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  7. Article ; Online: Investigation of the cellular reprogramming phenomenon referred to as stimulus-triggered acquisition of pluripotency (STAP).

    Niwa, Hitoshi

    Scientific reports

    2016  Volume 6, Page(s) 28003

    Abstract: In January 2014, it was reported that strong external stimuli, such as a transient low-pH stressor, was capable of inducing the reprogramming of mammalian somatic cells, resulting in the generation of pluripotent cells. This cellular reprograming event ... ...

    Abstract In January 2014, it was reported that strong external stimuli, such as a transient low-pH stressor, was capable of inducing the reprogramming of mammalian somatic cells, resulting in the generation of pluripotent cells. This cellular reprograming event was designated 'stimulus-triggered acquisition of pluripotency' (STAP) by the authors of these reports. However, after multiple instances of scientific misconduct in the handling and presentation of the data were brought to light, both reports were retracted. To investigate the actual scientific significance of the purported STAP phenomenon, we sought to repeat the original experiments based on the methods presented in the retracted manuscripts and other relevant information. As a result, we have concluded that the STAP phenomenon as described in the original studies is not reproducible.
    Language English
    Publishing date 2016-06-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/srep28003
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  8. Article ; Online: Correction for Ito et al., "Draft Genome Sequence of Lactiplantibacillus pentosus AWA1501, Isolated from Awa-bancha".

    Ito, Fumiya / Niwa, Ryo / Syaputri, Yolani / Ikagawa, Yuichiro / Mizuno, Tomofumi / Horie, Masanori / Iwahashi, Hitoshi

    Microbiology resource announcements

    2023  Volume 12, Issue 3, Page(s) e0006423

    Language English
    Publishing date 2023-02-27
    Publishing country United States
    Document type Journal Article ; Published Erratum
    ISSN 2576-098X
    ISSN (online) 2576-098X
    DOI 10.1128/mra.00064-23
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  9. Article ; Online: Evaluation of the effects of manual acupuncture and electroacupuncture at LI4 and LI11 on perception thresholds: a prospective crossover trial.

    Oyamaguchi, Aiko / Hanamoto, Hiroshi / Tanaka, Yoshiki / Takahashi, Sayo / Niwa, Hitoshi

    Acupuncture in medicine : journal of the British Medical Acupuncture Society

    2023  Volume 41, Issue 4, Page(s) 206–214

    Abstract: Objective: The objective of the study was to investigate and compare the effects of manual acupuncture (MA) and electroacupuncture (EA) on current perception thresholds (CPTs) using quantitative methods.: Methods: Twenty-nine healthy volunteers ... ...

    Abstract Objective: The objective of the study was to investigate and compare the effects of manual acupuncture (MA) and electroacupuncture (EA) on current perception thresholds (CPTs) using quantitative methods.
    Methods: Twenty-nine healthy volunteers participated in this prospective crossover trial, in which three acupuncture methods were compared: control, MA, and EA. Acupuncture needles were inserted to a depth of 15 mm at LI4 and LI11 on the left side and retained for 30 min with or without electrical stimulation at a frequency of 2 Hz (EA and MA, respectively). The needles were removed and participants rested for 30 min. CPT in the left mental region was measured at 2000, 250, and 5 Hz, corresponding to the activation of Aβ, Aδ, and C-fibers, respectively, at four time points: baseline, T
    Results: Significant effects of time course on CPT were observed (
    Conclusions: Both MA and EA increased the sensory thresholds of Aβ, Aδ, and C-fibers in the mental region for ⩾30 min after needle removal. Additional of electrical stimulation may not confer additional benefits over needling alone.
    Trial registration number: UMIN000017983 (University Hospital Medical Information Network Clinical Trials Registry).
    MeSH term(s) Humans ; Electroacupuncture ; Cross-Over Studies ; Prospective Studies ; Acupuncture Points ; Acupuncture Therapy/methods ; Perception
    Language English
    Publishing date 2023-01-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 1360533-1
    ISSN 1759-9873 ; 0964-5284
    ISSN (online) 1759-9873
    ISSN 0964-5284
    DOI 10.1177/09645284221131339
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    Zs.A 4628: Show issues Location:
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  10. Article ; Online: Variations in fungal and bacterial microbiome and chemical composition among fermenting Kishu-Narezushi batches.

    Kubo, Miki / Niwa, Ryo / Ohno, Tomoki / Iwahashi, Hitoshi

    Bioscience, biotechnology, and biochemistry

    2022  Volume 86, Issue 12, Page(s) 1705–1717

    Abstract: Kishu-Narezushi is a spontaneously fermented food comprising fish, rice, and salt. During spontaneous fermentation, the microbiome may differ among batches, even when manufactured in the same way. In addition, analyses of changes in the chemical ... ...

    Abstract Kishu-Narezushi is a spontaneously fermented food comprising fish, rice, and salt. During spontaneous fermentation, the microbiome may differ among batches, even when manufactured in the same way. In addition, analyses of changes in the chemical composition of the product are important for clarifying flavor characteristics. We collected basic information on the microbiome and chemical composition of Kishu-Narezushi using multiple batches of fermentation and evaluated whether the microbiome was homogeneous. The fungal microbiome of Kishu-Narezushi was dominated by Saccharomycetales and Trichosporonales. The bacterial microbiome was diverse, although seven specific genera of lactic acid bacteria were identified. Glutamic acid, histidine, and serine levels decreased after ∼10 days of fermentation. Succinic acid, characteristic of Kishu-Narezushi, accumulated upon the consumption of glutamic acid. Though the microbiome was diverse, the chemical composition was similar among the batches.
    MeSH term(s) Animals ; Glutamic Acid ; Bacteria ; Microbiota ; Fermentation ; Lactobacillales
    Chemical Substances Glutamic Acid (3KX376GY7L)
    Language English
    Publishing date 2022-10-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 1106450-x
    ISSN 1347-6947 ; 0916-8451
    ISSN (online) 1347-6947
    ISSN 0916-8451
    DOI 10.1093/bbb/zbac165
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