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  1. Article ; Online: Open questions about povidone-iodine based preventive measures. Comment to Martínez Lamas et al.

    Steinmeyer, Reinhard

    Oral diseases

    2020  Volume 27, Issue 5, Page(s) 1334–1335

    MeSH term(s) Povidone-Iodine
    Chemical Substances Povidone-Iodine (85H0HZU99M)
    Keywords covid19
    Language English
    Publishing date 2020-08-31
    Publishing country Denmark
    Document type Letter ; Comment
    ZDB-ID 1290529-x
    ISSN 1601-0825 ; 1354-523X
    ISSN (online) 1601-0825
    ISSN 1354-523X
    DOI 10.1111/odi.13589
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  3. Article: Auswirkung des Trinkwasserfluoridgehaltes auf die Zahngesundheit von ERstklsslern in einem Gebiet mit natürlich erhöhter Fluoridkonzentration zu Beginn des 21. Jahrhunderts

    Steinmeyer, Reinhard

    Das Gesundheitswesen

    2011  Volume 73, Issue 9, Page(s) 483–490

    Keywords Zahnkaries ; Fluorid ; Trinkwasser ; Kariesrückgang
    Language German
    Document type Article
    Note Literaturangaben
    ZDB-ID 1101426-x
    ISSN 1439-4421 ; 0941-3790 ; 0949-7013
    ISSN (online) 1439-4421
    ISSN 0941-3790 ; 0949-7013
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  4. Article ; Online: Discovery of IRAK4 Inhibitors

    Bothe, Ulrich / Günther, Judith / Nubbemeyer, Reinhard / Siebeneicher, Holger / Ring, Sven / Bömer, Ulf / Peters, Michaele / Rausch, Alexandra / Denner, Karsten / Himmel, Herbert / Sutter, Andreas / Terebesi, Ildiko / Lange, Martin / Wengner, Antje M / Guimond, Nicolas / Thaler, Tobias / Platzek, Johannes / Eberspächer, Uwe / Schäfer, Martina /
    Steuber, Holger / Zollner, Thomas M / Steinmeyer, Andreas / Schmidt, Nicole

    Journal of medicinal chemistry

    2024  Volume 67, Issue 2, Page(s) 1225–1242

    Abstract: Interleukin-1 receptor-associated kinase 4 (IRAK4) plays a critical role in innate inflammatory processes. Here, we describe the discovery of two clinical candidate IRAK4 inhibitors, ...

    Abstract Interleukin-1 receptor-associated kinase 4 (IRAK4) plays a critical role in innate inflammatory processes. Here, we describe the discovery of two clinical candidate IRAK4 inhibitors,
    MeSH term(s) Animals ; Humans ; Interleukin-1 Receptor-Associated Kinases ; High-Throughput Screening Assays ; Binding Sites ; Inflammation ; Indazoles ; Pyridines
    Chemical Substances Interleukin-1 Receptor-Associated Kinases (EC 2.7.11.1) ; zabedosertib (N1GRK350ZM) ; IRAK4 protein, human (EC 2.7.11.1) ; Indazoles ; Pyridines
    Language English
    Publishing date 2024-01-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 218133-2
    ISSN 1520-4804 ; 0022-2623
    ISSN (online) 1520-4804
    ISSN 0022-2623
    DOI 10.1021/acs.jmedchem.3c01714
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  5. Article ; Online: Discovery and Characterization of BAY 1214784, an Orally Available Spiroindoline Derivative Acting as a Potent and Selective Antagonist of the Human Gonadotropin-Releasing Hormone Receptor as Proven in a First-In-Human Study in Postmenopausal Women.

    Panknin, Olaf / Wagenfeld, Andrea / Bone, Wilhelm / Bender, Eckhard / Nowak-Reppel, Katrin / Fernández-Montalván, Amaury E / Nubbemeyer, Reinhard / Bäurle, Stefan / Ring, Sven / Schmees, Norbert / Prien, Olaf / Schäfer, Martina / Friedrich, Christian / Zollner, Thomas M / Steinmeyer, Andreas / Mueller, Thomas / Langer, Gernot

    Journal of medicinal chemistry

    2020  Volume 63, Issue 20, Page(s) 11854–11881

    Abstract: The growth of uterine fibroids is sex hormone-dependent and commonly associated with highly incapacitating symptoms. Most treatment options consist of the control of these hormonal effects, ultimately blocking proliferative estrogen signaling ( ...

    Abstract The growth of uterine fibroids is sex hormone-dependent and commonly associated with highly incapacitating symptoms. Most treatment options consist of the control of these hormonal effects, ultimately blocking proliferative estrogen signaling (
    MeSH term(s) Administration, Oral ; Animals ; Caco-2 Cells ; Dose-Response Relationship, Drug ; Drug Discovery ; Female ; Hepatocytes/chemistry ; Hepatocytes/metabolism ; Humans ; Indoles/administration & dosage ; Indoles/chemistry ; Indoles/pharmacology ; Microsomes, Liver/chemistry ; Microsomes, Liver/metabolism ; Molecular Structure ; Postmenopause ; Rats ; Rats, Wistar ; Receptors, LHRH/antagonists & inhibitors ; Receptors, LHRH/metabolism ; Spiro Compounds/administration & dosage ; Spiro Compounds/chemistry ; Spiro Compounds/pharmacology ; Structure-Activity Relationship
    Chemical Substances GNRHR protein, human ; Indoles ; Receptors, LHRH ; Spiro Compounds ; indoline (6DPT9AB2NK)
    Language English
    Publishing date 2020-10-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 218133-2
    ISSN 1520-4804 ; 0022-2623
    ISSN (online) 1520-4804
    ISSN 0022-2623
    DOI 10.1021/acs.jmedchem.0c01076
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  6. Article ; Online: Discovery and Characterization of the Potent and Selective P2X4 Inhibitor

    Werner, Stefan / Mesch, Stefanie / Hillig, Roman C / Ter Laak, Antonius / Klint, Julie / Neagoe, Ioana / Laux-Biehlmann, Alexis / Dahllöf, Henrik / Bräuer, Nico / Puetter, Vera / Nubbemeyer, Reinhard / Schulz, Simone / Bairlein, Michaela / Zollner, Thomas M / Steinmeyer, Andreas

    Journal of medicinal chemistry

    2019  Volume 62, Issue 24, Page(s) 11194–11217

    Abstract: The P2X4 receptor is a ligand-gated ion channel that is expressed on a variety of cell types, especially those involved in inflammatory and immune processes. High-throughput screening led to a new class of P2X4 inhibitors with substantial CYP 3A4 ... ...

    Abstract The P2X4 receptor is a ligand-gated ion channel that is expressed on a variety of cell types, especially those involved in inflammatory and immune processes. High-throughput screening led to a new class of P2X4 inhibitors with substantial CYP 3A4 induction in human hepatocytes. A structure-guided optimization with respect to decreased pregnane X receptor (PXR) binding was started. It was found that the introduction of larger and more polar substituents on the ether linker led to less PXR binding while maintaining the P2X4 inhibitory potency. This translated into significantly reduced CYP 3A4 induction for compounds
    MeSH term(s) Acetamides/chemistry ; Acetamides/pharmacology ; Animals ; Apoptosis ; Cell Proliferation ; Cells, Cultured ; Cytochrome P-450 CYP3A/metabolism ; Cytochrome P-450 CYP3A Inducers/chemistry ; Cytochrome P-450 CYP3A Inducers/pharmacology ; Drug Discovery ; Enzyme Induction ; Female ; Gene Expression Regulation ; Humans ; Inflammation/drug therapy ; Inflammation/metabolism ; Inflammation/pathology ; Ligands ; Male ; Mice ; Mice, Inbred C57BL ; Pain/drug therapy ; Pain/metabolism ; Pain/pathology ; Purinergic P2X Receptor Antagonists/chemistry ; Purinergic P2X Receptor Antagonists/pharmacology ; Rats ; Rats, Wistar ; Receptors, Purinergic P2X4/chemistry
    Chemical Substances Acetamides ; Cytochrome P-450 CYP3A Inducers ; Ligands ; Purinergic P2X Receptor Antagonists ; Receptors, Purinergic P2X4 ; Cytochrome P-450 CYP3A (EC 1.14.14.1)
    Language English
    Publishing date 2019-12-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 218133-2
    ISSN 1520-4804 ; 0022-2623
    ISSN (online) 1520-4804
    ISSN 0022-2623
    DOI 10.1021/acs.jmedchem.9b01304
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  7. Article ; Online: Osteopontin: a fibrosis-related marker molecule in cardiac remodeling of enterovirus myocarditis in the susceptible host.

    Szalay, Gudrun / Sauter, Martina / Haberland, Michael / Zuegel, Ulrich / Steinmeyer, Andreas / Kandolf, Reinhard / Klingel, Karin

    Circulation research

    2009  Volume 104, Issue 7, Page(s) 851–859

    Abstract: The characteristics of dilated cardiomyopathy (DCM) resulting from chronic viral myocarditis are remodeling processes of the extracellular matrix. Based on our findings of enhanced osteopontin (OPN) expression in inflamed human hearts, we further ... ...

    Abstract The characteristics of dilated cardiomyopathy (DCM) resulting from chronic viral myocarditis are remodeling processes of the extracellular matrix. Based on our findings of enhanced osteopontin (OPN) expression in inflamed human hearts, we further investigated in the murine model of acute and chronic coxsackievirus (CV)B3-myocarditis the role of OPN regarding its involvement in resolution of cardiac virus infection and fibrosis. In hearts of A.BY/SnJ mice susceptible to chronic CVB3-myocarditis, a pronounced increase of OPN expression levels was detected by microarray analysis and quantitative RT-PCR during acute stages of myocarditis. Combined immunohistochemistry and in situ hybridization identified infiltrating macrophages as main OPN producers. In contrast to resistant C57BL/6 and OPN gene-deficient mice, transcription levels of matrix metalloproteinase-3, TIMP1 (tissue inhibitor of metalloproteinases-1), uPA (urokinase-type plasminogen activator), and transforming growth factor beta1 were elevated in susceptible mice, and as a consequence, procollagen-1alpha mRNA expression and fibrosis was considerably enhanced. Treatment of infected susceptible mice with the vitamin D analog ZK 191784 led to decreased myocardial expression levels of OPN, metalloproteinase-3, TIMP1, uPA, and procollagen-1alpha and subsequently to reduced fibrosis. Concurrently, the fibrosis-relevant signaling molecules pERK (phosphorylated extracellular signal-regulated kinase) and pAkt (phosphorylated Akt), increased in A.BY/SnJ mice, were diminished in ZK 191784-treated mice. Here, we show that high expression levels of OPN in acute myocarditis are associated with consecutive development of extensive fibrosis that can be reduced by treatment with a vitamin D analog. Thus, OPN may serve as a diagnostic tool as well as a potential therapeutic target to limit cardiac remodeling in chronic myocarditis.
    MeSH term(s) Acute Disease ; Animals ; Biomarkers/metabolism ; Calcitriol/analogs & derivatives ; Calcitriol/pharmacology ; Cardiomyopathy, Dilated/metabolism ; Cardiomyopathy, Dilated/pathology ; Cardiomyopathy, Dilated/physiopathology ; Cardiomyopathy, Dilated/virology ; Chronic Disease ; Collagen Type I/metabolism ; Coxsackievirus Infections/metabolism ; Coxsackievirus Infections/pathology ; Coxsackievirus Infections/physiopathology ; Coxsackievirus Infections/virology ; Disease Models, Animal ; Enterovirus B, Human/pathogenicity ; Extracellular Signal-Regulated MAP Kinases/metabolism ; Fibrosis ; Humans ; Macrophages/metabolism ; Macrophages/virology ; Matrix Metalloproteinase 3/metabolism ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Myocarditis/metabolism ; Myocarditis/pathology ; Myocarditis/physiopathology ; Myocarditis/virology ; Myocardium/metabolism ; Myocardium/pathology ; Osteopontin/deficiency ; Osteopontin/genetics ; Osteopontin/metabolism ; Phosphorylation ; Proto-Oncogene Proteins c-akt/metabolism ; RNA, Messenger/metabolism ; Rats ; Time Factors ; Tissue Inhibitor of Metalloproteinase-1/metabolism ; Transforming Growth Factor beta1/metabolism ; Urokinase-Type Plasminogen Activator/metabolism ; Ventricular Remodeling/drug effects
    Chemical Substances Biomarkers ; Collagen Type I ; RNA, Messenger ; SPP1 protein, human ; Spp1 protein, mouse ; Tissue Inhibitor of Metalloproteinase-1 ; Transforming Growth Factor beta1 ; ZK 191784 ; collagen type I, alpha 1 chain ; Osteopontin (106441-73-0) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1) ; Extracellular Signal-Regulated MAP Kinases (EC 2.7.11.24) ; Urokinase-Type Plasminogen Activator (EC 3.4.21.73) ; Matrix Metalloproteinase 3 (EC 3.4.24.17) ; Mmp3 protein, mouse (EC 3.4.24.17) ; Calcitriol (FXC9231JVH)
    Language English
    Publishing date 2009-04-10
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80100-8
    ISSN 1524-4571 ; 0009-7330 ; 0931-6876
    ISSN (online) 1524-4571
    ISSN 0009-7330 ; 0931-6876
    DOI 10.1161/CIRCRESAHA.109.193805
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  8. Article ; Online: Articular Joint Lubricants during Osteoarthritis and Rheumatoid Arthritis Display Altered Levels and Molecular Species.

    Kosinska, Marta Krystyna / Ludwig, Taryn E / Liebisch, Gerhard / Zhang, Ruiyan / Siebert, Hans-Christian / Wilhelm, Jochen / Kaesser, Ulrich / Dettmeyer, Reinhard B / Klein, Heiko / Ishaque, Bernd / Rickert, Markus / Schmitz, Gerd / Schmidt, Tannin A / Steinmeyer, Juergen

    PloS one

    2015  Volume 10, Issue 5, Page(s) e0125192

    Abstract: Background: Hyaluronic acid (HA), lubricin, and phospholipid species (PLs) contribute independently or together to the boundary lubrication of articular joints that is provided by synovial fluid (SF). Our study is the first reporting quantitative data ... ...

    Abstract Background: Hyaluronic acid (HA), lubricin, and phospholipid species (PLs) contribute independently or together to the boundary lubrication of articular joints that is provided by synovial fluid (SF). Our study is the first reporting quantitative data about the molecular weight (MW) forms of HA, lubricin, and PLs in SF from cohorts of healthy donors, patients with early (eOA)- or late (lOA)-stage osteoarthritis (OA), and patients with active rheumatoid arthritis (RA).
    Methods: We used human SF from unaffected controls, eOA, lOA, and RA. HA and lubricin levels were measured by enzyme-linked immunosorbent assay. PLs was quantified by electrospray ionization tandem mass spectrometry. Fatty acids (FAs) were analyzed by gas chromatography, coupled with mass spectrometry. The MW distribution of HA was determined by agarose gel electrophoresis.
    Results: Compared with control SF, the concentrations of HA and lubricin were lower in OA and RA SF, whereas those of PLs were higher in OA and RA SF. Moreover, the MW distribution of HA shifted toward the lower ranges in OA and RA SF. We noted distinct alterations between cohorts in the relative distribution of PLs and the degree of FA saturation and chain lengths of FAs.
    Conclusions: The levels, composition, and MW distribution of all currently known lubricants in SF--HA, lubricin, PLs--vary with joint disease and stage of OA. Our study is the first delivering a comprehensive view about all joint lubricants during health and widespread joint diseases. Thus, we provide the framework to develop new optimal compounded lubricants to reduce joint destruction.
    MeSH term(s) Adult ; Age Factors ; Aged ; Arthritis, Rheumatoid/metabolism ; Demography ; Female ; Glycoproteins/metabolism ; Humans ; Hyaluronic Acid/metabolism ; Knee Joint/pathology ; Lubricants/metabolism ; Male ; Middle Aged ; Molecular Weight ; Osteoarthritis/metabolism ; Phospholipids/metabolism ; Synovial Fluid/chemistry ; Young Adult
    Chemical Substances Glycoproteins ; Lubricants ; Phospholipids ; lubricin ; Hyaluronic Acid (9004-61-9)
    Language English
    Publishing date 2015
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0125192
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  9. Book: Cloning of adult mammals

    Steinmeyer, Reinhard

    special reference to the prospects of primary diploid androgenesis ; a review

    1983  

    Author's details Reinhard Steinmeyer
    Language Undetermined
    Size Getr. Zählung
    Document type Book
    Database Special collection on veterinary medicine and general parasitology

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  10. Book: Die potentielle Bedeutung verschiedener Klonverfahren für die Nutz- und Versuchstierzucht unter besonderer Berücksichtigung ihrer Prognose bei Säugetieren

    Steinmeyer, Reinhard

    1981  

    Author's details Reinhard Steinmeyer
    Language Undetermined
    Size Getr. Zähl
    Document type Book
    Database Special collection on veterinary medicine and general parasitology

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