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Article ; Online: Transfer of cetirizine/levocetirizine into human breast milk and estimation of drug exposure to infants through breastfeeding: A human lactation study from the ConcePTION project.

Nordeng, Hedvig / Wegler, Christine / Lindqvist, Annika / Melander, Erik / Magnusson, Mikaela / Gandia, Peggy / Panchaud, Alice / Baranczewski, Pawel / Spigset, Olav

Basic & clinical pharmacology & toxicology

2023 Volume 134, Issue 1, Page(s) 153–164

Abstract: Data on drug transfer into human breast milk are sparse. This study aimed to quantify concentrations of cetirizine and levocetirizine in breast milk and to estimate drug exposure to infants. Breastfeeding women at least 8 weeks postpartum and using ... ...

Abstract	Data on drug transfer into human breast milk are sparse. This study aimed to quantify concentrations of cetirizine and levocetirizine in breast milk and to estimate drug exposure to infants. Breastfeeding women at least 8 weeks postpartum and using cetirizine or its pure (R)-enantiomer levocetirizine were eligible to participate. Breast milk samples were collected at six predefined times during a dose interval (0, 2, 4, 8, 12 and 24 h after drug intake) at steady state. Infant drug exposure was estimated by calculating the absolute infant dose (AID) and the weight-adjusted relative infant dose (RID). In total, 32 women were eligible for final inclusion, 31 women using cetirizine and one woman using levocetirizine. Means of the individual maximum and average cetirizine milk concentrations were 41.0 and 16.8 μg/L, respectively. Maximum concentrations occurred on average 2.4 h after intake, and the mean half-life in milk was 7.0 h. Estimated AID and RID for cetirizine in a day were 2.5 μg/kg and 1.9%, respectively. The corresponding values for levocetirizine were 1.1 μg/kg and 1.9%. No severe adverse events were reported. Our findings demonstrate that the transfer of cetirizine and levocetirizine into breast milk is low and compatible with breastfeeding.
MeSH term(s)	Infant ; Humans ; Female ; Cetirizine/adverse effects ; Breast Feeding ; Milk, Human ; Lactation
Chemical Substances	levocetirizine (6U5EA9RT2O) ; Cetirizine (YO7261ME24)
Language	English
Publishing date	2023-11-13
Publishing country	England
Document type	Journal Article
ZDB-ID	2134679-3
ISSN	1742-7843 ; 1742-7835
ISSN (online)	1742-7843
ISSN	1742-7835
DOI	10.1111/bcpt.13948
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Going public: reflections on developing the DöBra research program for health-promoting palliative care in Sweden.

Lindqvist, Olav / Tishelman, Carol

Progress in palliative care

2016 Volume 24, Issue 1, Page(s) 19–24

Abstract: ... ...

Abstract	Introduction
Language	English
Publishing date	2016-02-18
Publishing country	England
Document type	Journal Article
ISSN	0969-9260
ISSN	0969-9260
DOI	10.1080/09699260.2015.1103497
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Article ; Online: Living with bodily changes in hormone-refractory prostate cancer.

Lindqvist, Olav

Seminars in oncology nursing

2011 Volume 27, Issue 4, Page(s) 309–316

Abstract: Objectives: To review the current knowledge on living with bodily changes in hormone refractory prostate cancer (HRPC), treatment options, and common symptoms, and suggestions for improving our understanding of the experience of HRPC.: Data source: ... ...

Abstract	Objectives: To review the current knowledge on living with bodily changes in hormone refractory prostate cancer (HRPC), treatment options, and common symptoms, and suggestions for improving our understanding of the experience of HRPC. Data source: Existing literature, research, and clinical experience. Conclusion: Alleviation of bodily problems and providing care for men with HRPC is of utmost importance. It is important to talk about their situation and everyday life before asking about expected changes and problems related to the disease and its treatments. Implications for nursing practice: A preliminary framework is suggested for understanding the experience of HRPC from a nursing perspective. These results support an existing body of knowledge emphasizing the paramount importance of symptom alleviation, but indicate another motivation, that of freeing time, when time is so limited. The importance of dialogue between patients and health care providers is highlighted.
MeSH term(s)	Aged ; Aged, 80 and over ; Antineoplastic Agents, Hormonal/therapeutic use ; Humans ; Male ; Middle Aged ; Prostatic Neoplasms/nursing ; Prostatic Neoplasms/physiopathology ; Quality of Life
Chemical Substances	Antineoplastic Agents, Hormonal
Language	English
Publishing date	2011-11
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	632682-1
ISSN	1878-3449 ; 0749-2081
ISSN (online)	1878-3449
ISSN	0749-2081
DOI	10.1016/j.soncn.2011.07.009
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Article ; Online: Developing and using a structured, conversation-based intervention for clarifying values and preferences for end-of-life in the advance care planning-naïve Swedish context: Action research within the DöBra research program.

Tishelman, Carol / Eneslätt, Malin / Menkin, Elizabeth / Lindqvist, Olav

Death studies

2019 Volume 46, Issue 4, Page(s) 803–815

Abstract: Sweden has no systematic advance care planning (ACP), nor legal recognition of end-of-life proxies. We describe our experiences and reflections from a participatory action research process, aiming at developing and initially using a conversation-based, ... ...

Abstract	Sweden has no systematic advance care planning (ACP), nor legal recognition of end-of-life proxies. We describe our experiences and reflections from a participatory action research process, aiming at developing and initially using a conversation-based, structured ACP approach among community-dwelling, older adults in Sweden. Eco-mapping and DöBra cards were used with 65 people to catalyze discussions on preferences for the end-of-life. We found great individual variation in both Eco-map depictions of social networks and prioritization of the 37 DöBra card items. The DöBra cards were concluded to be a viable tool for stimulating person-centered conversations on preferences for future end-of-life care.
MeSH term(s)	Advance Care Planning ; Aged ; Communication ; Death ; Health Services Research ; Humans ; Sweden ; Terminal Care
Language	English
Publishing date	2019-12-20
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	632596-8
ISSN	1091-7683 ; 0748-1187
ISSN (online)	1091-7683
ISSN	0748-1187
DOI	10.1080/07481187.2019.1701145
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Article ; Online: Between a rock and a hard place: Registered nurses' accounts of their work situation in cancer care in Swedish acute care hospitals.

Smeds Alenius, Lisa / Lindqvist, Rikard / Ball, Jane E / Sharp, Lena / Lindqvist, Olav / Tishelman, Carol

European journal of oncology nursing : the official journal of European Oncology Nursing Society

2020 Volume 47, Page(s) 101778

Abstract: Purpose: Hospital organizational features related to registered nurses' (RNs') practice environment are often studied using quantitative measures. These are however unable to capture nuances of experiences of the practice environment from the ... ...

Abstract	Purpose: Hospital organizational features related to registered nurses' (RNs') practice environment are often studied using quantitative measures. These are however unable to capture nuances of experiences of the practice environment from the perspective of individual RNs. The aim of this study is therefore to investigate individual RNs' experiences of their work situation in cancer care in Swedish acute care hospitals. Methods: This study is based on a qualitative framework analysis of data derived from an open-ended question by 200 RNs working in specialized or general cancer care hospital units, who responded to the Swedish RN4CAST survey on nurse work environment. Antonovsky's salutogenic concepts "meaningfulness", "comprehensibility", and "manageability" were applied post-analysis to support interpretation of results. Results: RNs describe a tension between expectations to uphold safe, high quality care, and working in an environment where they are unable to influence conditions for care delivery. A lacking sense of agency, on individual and collective levels, points to organizational factors impeding RNs' use of their competence in clinical decision-making and in governing practice within their professional scope. Conclusions: RNs in this study appear to experience work situations which, while often described as meaningful, generally appear neither comprehensible nor manageable. The lack of an individual and collective sense of agency found here could potentially erode RNs' sense of meaningfulness and readiness to invest in their work.
MeSH term(s)	Adult ; Attitude of Health Personnel ; Female ; Health Care Surveys ; Hospital Units/organization & administration ; Hospitals ; Humans ; Job Satisfaction ; Male ; Middle Aged ; Neoplasms/nursing ; Nursing Staff, Hospital/psychology ; Nursing Staff, Hospital/statistics & numerical data ; Patient Safety ; Qualitative Research ; Sweden ; Workplace/organization & administration ; Young Adult
Language	English
Publishing date	2020-06-12
Publishing country	Scotland
Document type	Journal Article
ZDB-ID	2017117-1
ISSN	1532-2122 ; 1462-3889
ISSN (online)	1532-2122
ISSN	1462-3889
DOI	10.1016/j.ejon.2020.101778
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Article ; Online: GPR162 is a beta cell CART receptor.

Lindqvist, Andreas / Abels, Mia / Shcherbina, Liliya / Ngara, Mtakai / Kryvokhyzha, Dmytro / Chriett, Sabrina / Riva, Matteo / Fajul, Abul / Barghouth, Mohammad / Luan, Cheng / Eliasson, Lena / Larsen, Olav / Rosenkilde, Mette M / Zhang, Enming / Renström, Erik / Wierup, Nils

iScience

2023 Volume 26, Issue 12, Page(s) 108416

Abstract: Cocaine and amphetamine-regulated transcript (CART) is expressed in pancreatic islet cells and neuronal elements. We have previously established insulinotropic actions of CART in human and rodent islets. The receptor for CART in the pancreatic beta cells ...

Abstract	Cocaine and amphetamine-regulated transcript (CART) is expressed in pancreatic islet cells and neuronal elements. We have previously established insulinotropic actions of CART in human and rodent islets. The receptor for CART in the pancreatic beta cells is unidentified. We used RNA sequencing of
Language	English
Publishing date	2023-11-10
Publishing country	United States
Document type	Journal Article
ISSN	2589-0042
ISSN (online)	2589-0042
DOI	10.1016/j.isci.2023.108416
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Family members´ experiences of the end-of-life care environments in acute care settings - a photo-elicitation study.

Hajradinovic, Yvonne / Tishelman, Carol / Lindqvist, Olav / Goliath, Ida

International journal of qualitative studies on health and well-being

2018 Volume 13, Issue 1, Page(s) 1511767

Abstract: Purpose: This article explores experiences of the acute-care environment as a setting for end-of-life (EoL) care from the perspective of family members of a dying person.: Method: We used participant-produced photographs in conjunction with follow-up ...

Abstract	Purpose: This article explores experiences of the acute-care environment as a setting for end-of-life (EoL) care from the perspective of family members of a dying person. Method: We used participant-produced photographs in conjunction with follow-up interviews with nine family members to persons at the EoL, cared for in two acute-care settings. Results: The interpretive description analysis process resulted in three constructed themes-Aesthetic and un-aesthetic impressions, Space for privacy and social relationships, and Need for guidance in crucial times. Aspects of importance in the physical setting related to aesthetics, particularly in regard to sensory experience, and to a need for enough privacy to facilitate the maintenance of social relationships. Interactions between the world of family members and that of professionals were described as intrinsically related to guidance about both the material and immaterial environment at crucial times. Conclusion: The care environment, already recognized to have an impact in relation to patients, is concluded to also affect the participating family members in this study in a variety of ways.
MeSH term(s)	Adult ; Attitude ; Critical Care ; Environment Design ; Esthetics ; Family ; Female ; Humans ; Interpersonal Relations ; Male ; Middle Aged ; Photography ; Privacy ; Professional-Family Relations ; Surveys and Questionnaires ; Terminal Care ; Young Adult
Language	English
Publishing date	2018-09-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	2232726-5
ISSN	1748-2631 ; 1748-2623
ISSN (online)	1748-2631
ISSN	1748-2623
DOI	10.1080/17482631.2018.1511767
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: WA3 Room for death - international museum - visitors' preferences regarding the end of their life.

Lindqvist, Olav / Tishelman, Carol

BMJ supportive & palliative care

2015 Volume 5 Suppl 1, Page(s) A1

Abstract: Background: Just as pain medications aim to relieve physical suffering, supportive surrounding for death and dying may facilitate well-being and comfort. However, little has been written of the experience of or preferences for settings for death and ... ...

Abstract	Background: Just as pain medications aim to relieve physical suffering, supportive surrounding for death and dying may facilitate well-being and comfort. However, little has been written of the experience of or preferences for settings for death and dying. Aim: We investigate preferences for and reflections about settings for end-of-life (EoL) in an international sample of museum visitors. Methods: Data derive from a project teaming artists and craftspeople together to create prototypes of space for difficult conversations in EoL settings. These prototypes were presented in a museum exhibition, "Room for Death", in Stockholm in 2012. As project consultants, we contributed a question to the public viewing the exhibition: "How would you like it to be around you when you are dying?" and analysed responses with a phenomenographic approach. Results: Five-hundred twelve responses were obtained from visitors from 46 countries. Responses were categorised in the following inductively- derived categories of types of deaths: The "Familiar", "Larger-than life", "Lone", "Mediated" "Calm and peaceful", "Sensuous", "'Green'", and "Distanced" death. Responses could relate to one category or be composites uniting different categories in individual combinations. Conclusion: These data provide insight into different facets of contemporary reflections about death and dying. Despite the selective sample, the findings give reason to consider how underlying assumptions and care provision in established forms for EoL care may differ from people's preferences. This project can be seen as an example of innovative endeavours to promote public awareness of issues related to death and dying, within the framework of health-promoting palliative care.
Language	English
Publishing date	2015-04
Publishing country	England
Document type	Journal Article
ISSN	2045-4368
ISSN (online)	2045-4368
DOI	10.1136/bmjspcare-2015-000906.3
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Room for Death--International museum-visitors' preferences regarding the end of their life.

Lindqvist, Olav / Tishelman, Carol

Social science & medicine (1982)

2015 Volume 139, Page(s) 1–8

Abstract: Just as pain medications aim to relieve physical suffering, supportive surrounding for death and dying may facilitate well-being and comfort. However, little has been written of the experience of or preferences for the surroundings in which death and ... ...

Abstract	Just as pain medications aim to relieve physical suffering, supportive surrounding for death and dying may facilitate well-being and comfort. However, little has been written of the experience of or preferences for the surroundings in which death and dying take place. In this study, we aim to complement our research from perspectives of patients, family members and staff, with perspectives from an international sample of the general public. Data derives from a project teaming artists and craftspeople together to create prototypes of space for difficult conversations in end-of-life (EoL) settings. These prototypes were presented in a museum exhibition, "Room for Death", in Stockholm in 2012. As project consultants, palliative care researchers contributed a question to the public viewing the exhibition, to explore their reflections: "How would you like it to be around you when you are dying?" Five-hundred and twelve responses were obtained from visitors from 46 countries. While preliminary analysis pointed to many similarities in responses across countries, continued analysis with a phenomenographic approach allowed us to distinguish different foci related to how preferences for surroundings for EoL were conceptualized. Responses were categorized in the following inductively-derived categories: The familiar death, The 'larger-than life' death, The lone death, The mediated death, The calm and peaceful death, The sensuous death, The 'green' death, and The distanced death. The responses could relate to a single category or be composites uniting different categories in individual combinations, and provide insight into different facets of contemporary reflections about death and dying. Despite the selective sample, these data give reason to consider how underlying assumptions and care provision in established forms for end-of-life care may differ from people's preferences. This project can be seen as an example of innovative endeavors to promote public awareness of issues related to death and dying, within the framework of health-promoting palliative care.
MeSH term(s)	Attitude to Death ; Communication ; Death ; Decision Making ; Humans ; Patient Preference/psychology ; Quality of Life/psychology ; Surveys and Questionnaires
Language	English
Publishing date	2015-08
Publishing country	England
Document type	Journal Article
ZDB-ID	4766-1
ISSN	1873-5347 ; 0037-7856 ; 0277-9536
ISSN (online)	1873-5347
ISSN	0037-7856 ; 0277-9536
DOI	10.1016/j.socscimed.2015.06.016
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Article ; Online: Family members´ experiences of the end-of-life care environments in acute care settings – a photo-elicitation study

Yvonne Hajradinovic / Carol Tishelman / Olav Lindqvist / Ida Goliath

International Journal of Qualitative Studies on Health & Well-Being, Vol 13, Iss

2018 Volume 1

Abstract: Purpose: This article explores experiences of the acute-care environment as a setting for end-of-life (EoL) care from the perspective of family members of a dying person. Method: We used participant-produced photographs in conjunction with follow-up ... ...

Abstract	Purpose: This article explores experiences of the acute-care environment as a setting for end-of-life (EoL) care from the perspective of family members of a dying person. Method: We used participant-produced photographs in conjunction with follow-up interviews with nine family members to persons at the EoL, cared for in two acute-care settings. Results: The interpretive description analysis process resulted in three constructed themes—Aesthetic and un-aesthetic impressions, Space for privacy and social relationships, and Need for guidance in crucial times. Aspects of importance in the physical setting related to aesthetics, particularly in regard to sensory experience, and to a need for enough privacy to facilitate the maintenance of social relationships. Interactions between the world of family members and that of professionals were described as intrinsically related to guidance about both the material and immaterial environment at crucial times. Conclusion: The care environment, already recognized to have an impact in relation to patients, is concluded to also affect the participating family members in this study in a variety of ways.
Keywords	acute care ; care environment ; end-of-life ; family members ; hospital ; photo-elicitation ; visual research methods ; Medicine (General) ; R5-920
Subject code	360
Language	English
Publishing date	2018-01-01T00:00:00Z
Publisher	Taylor & Francis Group
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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