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  1. Article ; Online: Double dissociation of dopamine and subthalamic nucleus stimulation on effortful cost/benefit decision making.

    Pagnier, Guillaume J / Asaad, Wael F / Frank, Michael J

    Current biology : CB

    2024  Volume 34, Issue 3, Page(s) 655–660.e3

    Abstract: Deep brain stimulation (DBS) and dopaminergic therapy (DA) are common interventions for Parkinson's disease (PD). Both treatments typically improve patient outcomes, and both can have adverse side effects on decision making (e.g., impulsivity). ...

    Abstract Deep brain stimulation (DBS) and dopaminergic therapy (DA) are common interventions for Parkinson's disease (PD). Both treatments typically improve patient outcomes, and both can have adverse side effects on decision making (e.g., impulsivity).
    MeSH term(s) Humans ; Dopamine/therapeutic use ; Subthalamic Nucleus/physiology ; Deep Brain Stimulation ; Neuropsychological Tests ; Parkinson Disease/therapy ; Decision Making/physiology
    Chemical Substances Dopamine (VTD58H1Z2X)
    Language English
    Publishing date 2024-01-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 1071731-6
    ISSN 1879-0445 ; 0960-9822
    ISSN (online) 1879-0445
    ISSN 0960-9822
    DOI 10.1016/j.cub.2023.12.045
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3208: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Automated artifact injection into sensing-capable brain modulation devices for neural-behavioral synchronization and the influence of device state.

    Alarie, Michaela E / Provenza, Nicole R / Herron, Jeffrey A / Asaad, Wael F

    Brain stimulation

    2023  Volume 16, Issue 5, Page(s) 1358–1360

    MeSH term(s) Artifacts ; Brain ; Deep Brain Stimulation ; Head
    Language English
    Publishing date 2023-09-09
    Publishing country United States
    Document type Letter ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2394410-9
    ISSN 1876-4754 ; 1935-861X
    ISSN (online) 1876-4754
    ISSN 1935-861X
    DOI 10.1016/j.brs.2023.09.005
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6740: Show issues Location:
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  3. Article: Exploring the Role of the Pulvinar Nucleus of the Thalamus in Occipital Lobe Epilepsy: A Case Report.

    Abdulrazeq, Hael / Kimata, Anna R / Blum, Andrew / Malik, Athar N / Asaad, Wael F

    Cureus

    2024  Volume 16, Issue 1, Page(s) e52534

    Abstract: Understanding the role of the pulvinar nucleus may be critical for guiding circuit-targeted neurosurgical intervention in some patients. In this report, a 33-year-old female presented with focal onset occipital epilepsy with secondary generalization and ... ...

    Abstract Understanding the role of the pulvinar nucleus may be critical for guiding circuit-targeted neurosurgical intervention in some patients. In this report, a 33-year-old female presented with focal onset occipital epilepsy with secondary generalization and with a previously radiated arteriovenous malformation within the right primary visual cortex. Phase II monitoring demonstrated the pulvinar nucleus was not involved in subclinical seizures restricted to the primary visual cortex, but it did become involved in clinical events with more extensive seizure spread into higher visual cortical regions. She underwent responsive neurostimulation (RNS) with implantation of leads within the primary visual cortex. This case demonstrates the late propagation of epileptic activity from the visual cortex to the pulvinar nucleus and illustrates the pulvinar nucleus' connections with higher-order visual areas.
    Language English
    Publishing date 2024-01-18
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.52534
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  4. Article ; Online: The temporal cost of deploying attention limits accurate target identification in rapid serial visual presentation.

    Kimata, Anna R / Zheng, Bryan / Watanabe, Takeo / Asaad, Wael F

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 3590

    Abstract: Lag-1 sparing is a common exception to the attentional blink, where a target presented directly after T1 can be identified and reported accurately. Prior work has proposed potential mechanisms for lag 1 sparing, including the boost and bounce model and ... ...

    Abstract Lag-1 sparing is a common exception to the attentional blink, where a target presented directly after T1 can be identified and reported accurately. Prior work has proposed potential mechanisms for lag 1 sparing, including the boost and bounce model and the attentional gating model. Here, we apply a rapid serial visual presentation task to investigate the temporal limitations of lag 1 sparing by testing three distinct hypotheses. We found that endogenous engagement of attention to T2 requires between 50 and 100 ms. Critically, faster presentation rates yielded lower T2 performance, whereas decreased image duration did not impair T2 detection and report. These observations were reinforced by subsequent experiments controlling for short-term learning and capacity-dependent visual processing effects. Thus, lag-1 sparing was limited by the intrinsic dynamics of attentional boost engagement rather than by earlier perceptual bottlenecks such as insufficient exposure to images in the stimulus stream or visual processing capacity limitations. Taken together, these findings support the boost and bounce theory over earlier models that focus only on attentional gating or visual short-term memory storage, informing our understanding of how the human visual system deploys attention under challenging temporal constraints.
    MeSH term(s) Humans ; Attentional Blink ; Learning ; Memory, Short-Term ; Rivers ; Visual Perception
    Language English
    Publishing date 2023-03-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-30748-z
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  5. Article ; Online: Al-Zahrawi (936-1013 AD): On the Surgical Treatment of Neurological Disorders by the Father of Operative Surgery.

    Abdulrazeq, Hael F / Ali, Rohaid / Najib, Hebah / Doberstein, Curt / Oyelese, Adetokunbo / Gokaslan, Ziya / Malik, Athar N / Asaad, Wael F / Greenblatt, Samuel

    World neurosurgery

    2024  Volume 184, Page(s) 236–240.e1

    Abstract: Background: Medical knowledge during the medieval ages flourished under the influence of great scholars of the Islamic Golden age such as Ibn Sina (Latinized as Avicenna), Abu Bakr al-Razi (Rhazes), and Abu al-Qasim Khalaf ibn al-Abbas al-Zahrawi, known ...

    Abstract Background: Medical knowledge during the medieval ages flourished under the influence of great scholars of the Islamic Golden age such as Ibn Sina (Latinized as Avicenna), Abu Bakr al-Razi (Rhazes), and Abu al-Qasim Khalaf ibn al-Abbas al-Zahrawi, known as Albucasis. Much has been written on al-Zahrawi's innovation in various disciplines of medicine and surgery. In this article, we focus for on the contributions of al-Zahrawi toward the treatment of neurological disorders in the surgical chapters of his medical encyclopedia, Kitab al-Tasrif (The Method of Medicine).
    Methods: Excerpts from a modern copy of volume 30 of al-Zahrawi's Kitab al-Tasrif were reviewed and translated by the primary author from Arabic to English, to further provide specific details regarding his neurosurgical knowledge. In addition, a literature search was performed using PubMed and Google Scholar to review prior reports on al-Zahrawi's neurosurgical instructions.
    Results: In addition to what is described in the literature of al-Zahrawi's teachings in cranial and spine surgery, we provide insight into his diagnosis and management of cranial and spinal trauma, the devices he used, and prognostication of various traumatic injuries.
    Conclusions: Al-Zahrawi was a renowned physician during the Islamic Golden age who made significant contributions to the diagnosis and treatment of neurological conditions, particularly cranial and spinal cord injuries. He developed innovative surgical techniques for trephination and spinal traction, which are still used in modern neurosurgery. His insights make him worthy of recognition as an important figure in the history of neurological surgery.
    MeSH term(s) Humans ; Male ; Nervous System Diseases/surgery ; Neurosurgery/history ; Neurosurgical Procedures ; Spinal Injuries ; Spinal Cord Injuries ; Medicine, Arabic/history
    Language English
    Publishing date 2024-02-06
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2534351-8
    ISSN 1878-8769 ; 1878-8750
    ISSN (online) 1878-8769
    ISSN 1878-8750
    DOI 10.1016/j.wneu.2024.01.169
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1159: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  6. Article ; Online: Concurrent decoding of distinct neurophysiological fingerprints of tremor and bradykinesia in Parkinson's disease.

    Lauro, Peter M / Lee, Shane / Amaya, Daniel E / Liu, David D / Akbar, Umer / Asaad, Wael F

    eLife

    2023  Volume 12

    Abstract: Parkinson's disease (PD) is characterized by distinct motor phenomena that are expressed asynchronously. Understanding the neurophysiological correlates of these motor states could facilitate monitoring of disease progression and allow improved ... ...

    Abstract Parkinson's disease (PD) is characterized by distinct motor phenomena that are expressed asynchronously. Understanding the neurophysiological correlates of these motor states could facilitate monitoring of disease progression and allow improved assessments of therapeutic efficacy, as well as enable optimal closed-loop neuromodulation. We examined neural activity in the basal ganglia and cortex of 31 subjects with PD during a quantitative motor task to decode tremor and bradykinesia - two cardinal motor signs of PD - and relatively asymptomatic periods of behavior. Support vector regression analysis of microelectrode and electrocorticography recordings revealed that tremor and bradykinesia had nearly opposite neural signatures, while effective motor control displayed unique, differentiating features. The neurophysiological signatures of these motor states depended on the signal type and location. Cortical decoding generally outperformed subcortical decoding. Within the subthalamic nucleus (STN), tremor and bradykinesia were better decoded from distinct subregions. These results demonstrate how to leverage neurophysiology to more precisely treat PD.
    MeSH term(s) Humans ; Parkinson Disease/therapy ; Tremor ; Hypokinesia/therapy ; Neurophysiology ; Basal Ganglia ; Deep Brain Stimulation/methods
    Language English
    Publishing date 2023-05-30
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.84135
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  7. Article: Predictors of Mortality in Traumatic Intracranial Hemorrhage: A National Trauma Data Bank Study.

    Wu, Esther / Marthi, Siddharth / Asaad, Wael F

    Frontiers in neurology

    2020  Volume 11, Page(s) 587587

    Abstract: Background/Objective: ...

    Abstract Background/Objective:
    Language English
    Publishing date 2020-11-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564214-5
    ISSN 1664-2295
    ISSN 1664-2295
    DOI 10.3389/fneur.2020.587587
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  8. Article ; Online: Bilateral thalamic responsive neurostimulation for multifocal, bilateral frontotemporal epilepsy: illustrative case.

    Phillips, Ronald K / Aghagoli, Ghazal / Blum, Andrew S / Asaad, Wael F

    Journal of neurosurgery. Case lessons

    2022  Volume 3, Issue 12

    Abstract: Background: Patients with refractory, bilateral, multifocal epilepsy have few treatment options that typically include a combination of antiseizure medications (ASMs) and vagus nerve stimulation (VNS). A man in his 40s presented with epilepsy refractory ...

    Abstract Background: Patients with refractory, bilateral, multifocal epilepsy have few treatment options that typically include a combination of antiseizure medications (ASMs) and vagus nerve stimulation (VNS). A man in his 40s presented with epilepsy refractory to a combination of five ASMs plus VNS; he was still experiencing 7-10 seizures per week. His seizure network involved multiple foci in both frontal and temporal lobes. Bilateral depth electrodes were implanted into the centromedian/parafascicular (CM/PF) complex of the thalamus and connected to the responsive neurostimulation (RNS) system for closed-loop stimulation and neurophysiological monitoring.
    Observations: The patient reported clear improvement in his seizures since the procedure, with a markedly reduced number of seizures and decreased seizure intensity. He also reported stretches of seizure freedom not typical of his preoperative baseline, and his remaining seizures were milder, more often with preserved awareness. Generalized seizures with loss of consciousness have decreased to about one per month. RNS data confirmed a right-sided predominance of the bilateral seizure onsets.
    Lessons: In this patient with multifocal, bilateral frontotemporal epilepsy, RNS of the CM/PF thalamic complex combined with VNS was found to be beneficial. The RNS device was able to detect seizures propagating through the thalamus, and stimulation produced a decrease in seizure burden and intensity.
    Language English
    Publishing date 2022-03-21
    Publishing country United States
    Document type Journal Article
    ISSN 2694-1902
    ISSN (online) 2694-1902
    DOI 10.3171/CASE21672
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  9. Article ; Online: Author Correction: Bridging the literacy gap for surgical consents: an AI-human expert collaborative approach.

    Ali, Rohaid / Connolly, Ian D / Tang, Oliver Y / Mirza, Fatima N / Johnston, Benjamin / Abdulrazeq, Hael F / Lim, Rachel K / Galamaga, Paul F / Libby, Tiffany J / Sodha, Neel R / Groff, Michael W / Gokaslan, Ziya L / Telfeian, Albert E / Shin, John H / Asaad, Wael F / Zou, James / Doberstein, Curtis E

    NPJ digital medicine

    2024  Volume 7, Issue 1, Page(s) 93

    Language English
    Publishing date 2024-04-12
    Publishing country England
    Document type Published Erratum
    ISSN 2398-6352
    ISSN (online) 2398-6352
    DOI 10.1038/s41746-024-01099-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Laser amygdalohippocampotomy reduces contralateral hippocampal sub-clinical activity in bitemporal epilepsy: A case illustration of responsive neurostimulator ambulatory recordings.

    Abdulrazeq, Hael F / Kimata, Anna R / Shao, Belinda / Svokos, Konstantina / Ayub, Neishay / Nie, Duyu / Asaad, Wael F

    Epilepsy & behavior reports

    2023  Volume 25, Page(s) 100636

    Abstract: Responsive neurostimulation (RNS) is a valuable tool in the diagnosis and treatment of medication refractory epilepsy (MRE) and provides clinicians with better insights into patients' seizure patterns. In this case illustration, we present a patient with ...

    Abstract Responsive neurostimulation (RNS) is a valuable tool in the diagnosis and treatment of medication refractory epilepsy (MRE) and provides clinicians with better insights into patients' seizure patterns. In this case illustration, we present a patient with bilateral hippocampal RNS for presumed bilateral mesial temporal lobe epilepsy. The patient subsequently underwent a right sided LITT amygdalohippocampotomy based upon chronic RNS data revealing predominance of seizures from that side. Analyzing electrocorticography (ECOG) from the RNS system, we identified the frequency of high amplitude discharges recorded from the left hippocampal lead pre- and post- right LITT amygdalohippocampotomy. A reduction in contralateral interictal epileptiform activity was observed through RNS recordings over a two-year period, suggesting the potential dependency of the contralateral activity on the primary epileptogenic zone. These findings suggest that early targeted surgical resection or laser ablation by leveraging RNS data can potentially impede the progression of dependent epileptiform activity and may aid in preserving neurocognitive networks. RNS recordings are essential in shaping further management decisions for our patient with a presumed bitemporal epilepsy.
    Language English
    Publishing date 2023-12-01
    Publishing country United States
    Document type Case Reports
    ISSN 2589-9864
    ISSN (online) 2589-9864
    DOI 10.1016/j.ebr.2023.100636
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