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  1. Book ; Online ; E-Book: Current trends in bioinformatics

    Wadhwa, Gulshan / Shanmughavel, P. / Singh, Atul Kumar / Bellare, Jayesh R.

    an insight

    2018  

    Author's details Gulshan Wadhwa, P. Shanmughavel, Atul Kumar Singh, Jayesh R. Bellare editors
    Keywords Life sciences ; Microarrays ; Proteomics ; Bioinformatics ; Computational biology
    Subject code 570.285
    Language English
    Size 1 Online-Ressource (XV, 332 Seiten)
    Publisher Springer
    Publishing place Singapore
    Publishing country Singapore
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT019774558
    ISBN 978-981-10-7483-7 ; 9789811074813 ; 981-10-7483-6 ; 981107481X
    DOI 10.1007/978-981-10-7483-7
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Discovery of anticancer compound possessing potential to bind γ-secretase catalytic subunit and inhibit notch promoter activity.

    Singh, Atul Kumar / Prajapati, Kumari Sunita / Kumar, Shashank

    Journal of biomolecular structure & dynamics

    2024  , Page(s) 1–16

    Abstract: Gamma secretase (GS) is an important therapeutic target in anticancer drug discovery. Increased GS activity activates notch signaling pathway which is associated with cancer stemness and drug resistance in cancer cells. A total of 69,075 natural and ... ...

    Abstract Gamma secretase (GS) is an important therapeutic target in anticancer drug discovery. Increased GS activity activates notch signaling pathway which is associated with cancer stemness and drug resistance in cancer cells. A total of 69,075 natural and their derivative compounds were screened to identify the lead compound on the basis of
    Language English
    Publishing date 2024-02-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 49157-3
    ISSN 1538-0254 ; 0739-1102
    ISSN (online) 1538-0254
    ISSN 0739-1102
    DOI 10.1080/07391102.2024.2315323
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2093: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Utilization of

    Kumar, Jitendra / Kumar, Anuj / Maurya, Atul Kumar / Gupta, Hariome Sharan / Singh, Surendra Pal / Sharma, Chhaya

    ACS omega

    2024  Volume 9, Issue 2, Page(s) 2740–2751

    Abstract: The utilization of waste generated by natural resources is a crucial problem nowadays. The current study describes the utilization of pineapple ( ...

    Abstract The utilization of waste generated by natural resources is a crucial problem nowadays. The current study describes the utilization of pineapple (
    Language English
    Publishing date 2024-01-04
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.3c07697
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Flavonoids as emerging notch signaling pathway modulators in cancer.

    Singh, Atul Kumar / Kumar, Shashank

    Journal of Asian natural products research

    2023  Volume 25, Issue 12, Page(s) 1155–1167

    Abstract: Notch signaling is an evolutionary conserved pathway important for the developmental processes and implicated in the tumor formation. Notch signaling pathway (NSP) inhibitors have been tested in clinical trials alone or in combination with the ... ...

    Abstract Notch signaling is an evolutionary conserved pathway important for the developmental processes and implicated in the tumor formation. Notch signaling pathway (NSP) inhibitors have been tested in clinical trials alone or in combination with the chemotherapy but none got clinical approval due to severe toxicity in patients. Flavonoids inhibit NSP by inhibiting notch receptor cleavage and/or inhibiting transcriptional regulation by Notch intracellular domain (NICD). Interestingly, some flavonoids are reported to inhibit NSP by mediating the microRNA expression. NSP inhibitory flavonoid(s) in combination with standard therapy is might be an effective strategy in cancer treatment.
    MeSH term(s) Humans ; Flavonoids/pharmacology ; Signal Transduction ; Neoplasms/drug therapy ; Receptors, Notch/genetics ; Receptors, Notch/metabolism
    Chemical Substances Flavonoids ; Receptors, Notch
    Language English
    Publishing date 2023-04-20
    Publishing country England
    Document type Journal Article
    ZDB-ID 2077926-4
    ISSN 1477-2213 ; 1028-6020
    ISSN (online) 1477-2213
    ISSN 1028-6020
    DOI 10.1080/10286020.2023.2202854
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Flavonoids as emerging notch signaling pathway modulators in cancer

    Singh, Atul Kumar / Kumar, Shashank

    Journal of Asian Natural Products Research. 2023 Dec. 2, v. 25, no. 12 p.1155-1167

    2023  

    Abstract: Notch signaling is an evolutionary conserved pathway important for the developmental processes and implicated in the tumor formation. Notch signaling pathway (NSP) inhibitors have been tested in clinical trials alone or in combination with the ... ...

    Abstract Notch signaling is an evolutionary conserved pathway important for the developmental processes and implicated in the tumor formation. Notch signaling pathway (NSP) inhibitors have been tested in clinical trials alone or in combination with the chemotherapy but none got clinical approval due to severe toxicity in patients. Flavonoids inhibit NSP by inhibiting notch receptor cleavage and/or inhibiting transcriptional regulation by Notch intracellular domain (NICD). Interestingly, some flavonoids are reported to inhibit NSP by mediating the microRNA expression. NSP inhibitory flavonoid(s) in combination with standard therapy is might be an effective strategy in cancer treatment.
    Keywords cancer therapy ; drug therapy ; flavonoids ; microRNA ; neoplasms ; toxicity ; transcription (genetics) ; phytochemical ; anticancer ; therapeutic ; co-treatment
    Language English
    Dates of publication 2023-1202
    Size p. 1155-1167.
    Publishing place Taylor & Francis
    Document type Article ; Online
    ZDB-ID 2077926-4
    ISSN 1477-2213 ; 1028-6020
    ISSN (online) 1477-2213
    ISSN 1028-6020
    DOI 10.1080/10286020.2023.2202854
    Database NAL-Catalogue (AGRICOLA)

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  6. Article ; Online: Shield your slit lamp with a face shield!

    Singh, Atul Kumar / Malik, Robin

    Indian journal of ophthalmology

    2022  Volume 70, Issue 9, Page(s) 3423–3424

    MeSH term(s) Humans ; Protective Devices ; Slit Lamp ; Slit Lamp Microscopy
    Language English
    Publishing date 2022-08-25
    Publishing country India
    Document type Letter
    ZDB-ID 187392-1
    ISSN 1998-3689 ; 0301-4738
    ISSN (online) 1998-3689
    ISSN 0301-4738
    DOI 10.4103/ijo.IJO_752_22
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 329: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 598: Show issues

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  7. Article: Analysis of clinical sign and symptoms and biochemical parameters of post-COVID patients.

    Mahmood, Tariq / Singh, Niraj Kumar / Singh, Atul Kumar

    Lung India : official organ of Indian Chest Society

    2022  Volume 39, Issue 2, Page(s) 214–215

    Language English
    Publishing date 2022-03-09
    Publishing country India
    Document type Letter
    ZDB-ID 2410801-7
    ISSN 0974-598X ; 0970-2113
    ISSN (online) 0974-598X
    ISSN 0970-2113
    DOI 10.4103/lungindia.lungindia_165_21
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Naringin dihydrochalcone potentially binds to catalytic domain of matrix metalloproteinase-2: molecular docking, MM-GBSA, and molecular dynamics simulation approach.

    Singh, Atul Kumar / Kumar, Shashank

    Natural product research

    2022  Volume 37, Issue 11, Page(s) 1851–1855

    Abstract: Matrix metalloproteinase-2 (MMP2), an extracellular matrix remodulating protein's increased activity causes cancer-metastasis. Potential MMP2 inhibitors showed sever side-effects in clinical trials. Present study is focused on identification natural MMP2 ...

    Abstract Matrix metalloproteinase-2 (MMP2), an extracellular matrix remodulating protein's increased activity causes cancer-metastasis. Potential MMP2 inhibitors showed sever side-effects in clinical trials. Present study is focused on identification natural MMP2 inhibitor by applying molecular docking, MM-GBSA binding energy estimation and molecular dynamics (MD) simulations. Commercially available flavonoid compound library was used to screen the molecules potentially binding with catalytic domain of MMP2 protein compared to standard MMP2 inhibitor ARP
    MeSH term(s) Molecular Dynamics Simulation ; Molecular Docking Simulation ; Catalytic Domain ; Matrix Metalloproteinase 2 ; Protein Binding
    Chemical Substances Matrix Metalloproteinase 2 (EC 3.4.24.24) ; naringin (N7TD9J649B)
    Language English
    Publishing date 2022-09-01
    Publishing country England
    Document type Journal Article
    ZDB-ID 2185747-7
    ISSN 1478-6427 ; 1478-6419
    ISSN (online) 1478-6427
    ISSN 1478-6419
    DOI 10.1080/14786419.2022.2118746
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Naringin dihydrochalcone potentially binds to catalytic domain of matrix metalloproteinase-2: molecular docking, MM-GBSA, and molecular dynamics simulation approach

    Singh, Atul Kumar / Kumar, Shashank

    Natural Product Research. 2023 June 3, v. 37, no. 11 p.1851-1855

    2023  

    Abstract: Matrix metalloproteinase-2 (MMP2), an extracellular matrix remodulating protein’s increased activity causes cancer-metastasis. Potential MMP2 inhibitors showed sever side-effects in clinical trials. Present study is focused on identification natural MMP2 ...

    Abstract Matrix metalloproteinase-2 (MMP2), an extracellular matrix remodulating protein’s increased activity causes cancer-metastasis. Potential MMP2 inhibitors showed sever side-effects in clinical trials. Present study is focused on identification natural MMP2 inhibitor by applying molecular docking, MM-GBSA binding energy estimation and molecular dynamics (MD) simulations. Commercially available flavonoid compound library was used to screen the molecules potentially binding with catalytic domain of MMP2 protein compared to standard MMP2 inhibitor ARP₁₀₀. Naringin dihydrochalcone (NDC) showed interaction with the important residues (His120, Leu82 and Val117) present at the MMP2 catalytic domain in comparison to known inhibitor ARP₁₀₀ (dock score ≈ −13 and −8 kcal/mole respectively). Lower ligand-protein binding energy (-67.31 kcal/mole) obtained in MM-GBSA and the MD simulation trajectory analysis showed significant stable and energetically favourable binding of NDC at the catalytic site of MMP2. In conclusion, anti-metastatic potential of NDC should be validated in in vitro and in vivo experiments.
    Keywords active sites ; adverse effects ; energy ; extracellular matrix ; gelatinase A ; molecular dynamics ; naringin ; research ; Flavonoids ; phytochemical ; metastasis ; cancer ; MMP2
    Language English
    Dates of publication 2023-0603
    Size p. 1851-1855.
    Publishing place Taylor & Francis
    Document type Article ; Online
    ZDB-ID 2185747-7
    ISSN 1478-6427 ; 1478-6419
    ISSN (online) 1478-6427
    ISSN 1478-6419
    DOI 10.1080/14786419.2022.2118746
    Database NAL-Catalogue (AGRICOLA)

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  10. Article: High-Resolution Ultrasound in Evaluation of Peripheral Neuropathy in Patients of Hansen's Disease.

    Rai, Tulika / Singh, Atul M / Indal, Manish / Kumar, Ishan

    Indian dermatology online journal

    2024  Volume 15, Issue 2, Page(s) 213–217

    Abstract: Introduction: Hansen's disease (HD) is a major public health problem in developing countries. It causes peripheral neuropathy, and if left untreated, it leads to deformities. It is important to diagnose such cases early, and prompt treatment should be ... ...

    Abstract Introduction: Hansen's disease (HD) is a major public health problem in developing countries. It causes peripheral neuropathy, and if left untreated, it leads to deformities. It is important to diagnose such cases early, and prompt treatment should be given to patients to preserve nerve function.
    Materials and methods: A total of 40 patients with HD who were already on multi-drug therapy (MDT) or treatment-naive were included in this study. These were clinically diagnosed cases of HD as per the Ridley-Jopling classification, and these patients were subjected to high-resolution ultrasonography (HRUS). A total of 19 controls were also included. The patients were clinically evaluated, and HRUS of bilateral ulnar nerves (UNs) was performed in all cases and controls. The other peripheral nerves, if clinically thickened, were evaluated using HRUS.
    Results: The cross-sectional area (CSA) of the UN in cases was significantly thickened as compared to controls. There was no difference in the CSA of patients on MDT as compared to treatment naïve patients. In two patients with pure neuritic HD, the clinical examination missed the bilateral nerve enlargement, and only unilateral nerve thickening was clinically appreciated. However, bilateral thickening was detected on HRUS.
    Conclusion: HRUS is a non-invasive and sensitive diagnostic tool that gives significant information on nerve structure and morphology. HRUS adds a new dimension to diagnosing HD, particularly the pure neuritic type, with the assessment of early nerve damage, which can prevent disabilities. HRUS is an objective diagnostic tool that can complement the clinical examination.
    Language English
    Publishing date 2024-02-13
    Publishing country India
    Document type Journal Article
    ZDB-ID 2585814-2
    ISSN 2249-5673 ; 2229-5178
    ISSN (online) 2249-5673
    ISSN 2229-5178
    DOI 10.4103/idoj.idoj_271_23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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