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Article ; Online: A NiO-nanostructure-based electrochemical sensor functionalized with supramolecular structures for the ultra-sensitive detection of the endocrine disruptor bisphenol S in an aquatic environment.

Hyder, Ali / Ali, Akbar / Buledi, Jamil Ahmed / Memon, Roomia / Al-Anzi, Bader S / Memon, Ayaz Ali / Kazi, Mohsin / Solangi, Amber Rehana / Yang, Jun / Thebo, Khalid Hussain

Physical chemistry chemical physics : PCCP

2024 Volume 26, Issue 14, Page(s) 10940–10950

Abstract: Herein, NiO nanoparticles (NPs) functionalized with ... ...

Abstract	Herein, NiO nanoparticles (NPs) functionalized with a
Language	English
Publishing date	2024-04-03
Publishing country	England
Document type	Journal Article
ZDB-ID	1476244-4
ISSN	1463-9084 ; 1463-9076
ISSN (online)	1463-9084
ISSN	1463-9076
DOI	10.1039/d4cp00138a
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Article: Pharmacological p38 MAPK inhibitor SB203580 enhances AML stem cell line KG1a chemosensitivity to daunorubicin by promoting late apoptosis, cell growth arrest in S-phase, and miR-328-3p upregulation.

Bahattab, Sara / Assiri, Ali / Alhaidan, Yazeid / Trivilegio, Thadeo / AlRoshody, Rehab / Huwaizi, Sarah / Almuzzaini, Bader / Alamro, Abir / Abudawood, Manal / Alehaideb, Zeyad / Matou-Nasri, Sabine

Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society

2024 Volume 32, Issue 6, Page(s) 102055

Abstract: Acute myeloid leukaemia (AML) is characterized by uncontrolled proliferation of myeloid progenitor cells and impaired maturation, leading to immature cell accumulation in the bone marrow and bloodstream, resulting in hematopoietic dysfunction. ... ...

Abstract	Acute myeloid leukaemia (AML) is characterized by uncontrolled proliferation of myeloid progenitor cells and impaired maturation, leading to immature cell accumulation in the bone marrow and bloodstream, resulting in hematopoietic dysfunction. Chemoresistance, hyperactivity of survival pathways, and miRNA alteration are major factors contributing to treatment failure and poor outcomes in AML patients. This study aimed to investigate the impact of the pharmacological p38 mitogen-activated protein kinase (MAPK) inhibitor SB203580 on the chemoresistance potential of AML stem cell line KG1a to the therapeutic drug daunorubicin (DNR). KG1a and chemosensitive leukemic HL60 cells were treated with increasing concentrations of DNR. Cell Titer-Glo®, flow cytometry, phosphokinase and protein arrays, Western blot technology, and reverse transcription-quantitative polymerase chain reaction (RT-qPCR) were employed for assessment of cell viability, half-maximal inhibitory concentration (IC
Language	English
Publishing date	2024-03-30
Publishing country	Saudi Arabia
Document type	Journal Article
ZDB-ID	1378024-4
ISSN	1319-0164
ISSN	1319-0164
DOI	10.1016/j.jsps.2024.102055
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Article: A global test of Allen’s rule in rodents

Alhajeri, Bader H / Fourcade, Yoan / Upham, Nathan S / Alhaddad, Hasan

Global ecology and biogeography. 2020 Dec., v. 29, no. 12

2020

Abstract: AIM: We test whether geographical variation in the length of appendages in rodent species follows predictions of Allen's rule (a positive relationship between appendage length and temperature) at a broad taxonomic scale (order Rodentia). We also test ... ...

Abstract	AIM: We test whether geographical variation in the length of appendages in rodent species follows predictions of Allen's rule (a positive relationship between appendage length and temperature) at a broad taxonomic scale (order Rodentia). We also test whether the applicability of this rule varies based on the unit of analysis (species or assemblage), the appendage examined (tail, hind foot, ear), body size, occupied habitat, geographical range size, life mode and saltatorial ability. LOCATION: World‐wide. TIME PERIOD: Current. MAJOR TAXA STUDIED: Rodents (order Rodentia). METHODS: We assembled data on the morphology, ecology and phylogeny for ≤ 2,212 rodent species, representing c. 86% of all the described rodent species and c. 95% of the described genera. We tested the predicted Allen's rule associations among size‐corrected appendage lengths and both latitudinal and climatic variables (temperature and precipitation). We applied a cross‐species approach based on phylogenetic regressions and a cross‐assemblage approach based on spatial regressions in equal‐area 1.5° grid cells. RESULTS: Support for Allen's rule was greatest for the tail and was stronger across assemblages than across species. We detected a negative relationship between tail length and (absolute) latitude, which was accounted for by a positive association between tail length and temperature of the coldest month. This association was greatest in desert species. In addition, we observed a negative relationship between ear length and precipitation. MAIN CONCLUSIONS: In rodents, Allen's rule is confirmed only for tails, and this association seems to be driven by adaptation to the cold, rather than warm temperatures. Habitat type seems to influence conformity to this rule. Conformity to Allen's rule is likely to be the result of complex evolutionary trade‐offs between temperature regulation and other essential species traits.
Keywords	Rodentia ; appendages ; biogeography ; body size ; cells ; climatic factors ; ears ; feet ; geographical variation ; habitats ; latitude ; length ; phylogeny ; prediction ; rodents ; tail ; temperature
Language	English
Dates of publication	2020-12
Size	p. 2248-2260.
Publishing place	John Wiley & Sons, Ltd
Document type	Article
Note	NAL-light ; JOURNAL ARTICLE
ZDB-ID	2021283-5
ISSN	1466-8238 ; 1466-822X ; 0960-7447
ISSN (online)	1466-8238
ISSN	1466-822X ; 0960-7447
DOI	10.1111/geb.13198
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Application of Deep Learning System Technology in Identification of Women’s Breast Cancer

Latefa Hamad Al Fryan / Mahasin Ibrahim Shomo / Malik Bader Alazzam

Medicina, Vol 59, Iss 487, p

2023 Volume 487

Abstract: Background and Objectives : The classification of breast cancer is performed based on its histological subtypes using the degree of differentiation. However, there have been low levels of intra- and inter-observer agreement in the process. The use of ... ...

Abstract	Background and Objectives : The classification of breast cancer is performed based on its histological subtypes using the degree of differentiation. However, there have been low levels of intra- and inter-observer agreement in the process. The use of convolutional neural networks (CNNs) in the field of radiology has shown potential in categorizing medical images, including the histological classification of malignant neoplasms. Materials and Methods : This study aimed to use CNNs to develop an automated approach to aid in the histological classification of breast cancer, with a focus on improving accuracy, reproducibility, and reducing subjectivity and bias. The study identified regions of interest (ROIs), filtered images with low representation of tumor cells, and trained the CNN to classify the images. Results : The major contribution of this research was the application of CNNs as a machine learning technique for histologically classifying breast cancer using medical images. The study resulted in the development of a low-cost, portable, and easy-to-use AI model that can be used by healthcare professionals in remote areas. Conclusions : This study aimed to use artificial neural networks to improve the accuracy and reproducibility of the process of histologically classifying breast cancer and reduce the subjectivity and bias that can be introduced by human observers. The results showed the potential for using CNNs in the development of an automated approach for the histological classification of breast cancer.
Keywords	deep learning ; breast cancer ; CNN ; K-means algorithm ; clustering segmentation ; Medicine (General) ; R5-920
Subject code	006
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Artemisia sieberi Besser essential oil inhibits the growth and migration of breast cancer cells via induction of S-phase arrest, caspase-independent cell death and downregulation of ERK.

Break, Mohammed Khaled Bin / Hussein, Weiam / Huwaimel, Bader / Alafnan, Ahmed / Almansour, Khaled / Alafnan, Dalal / Alshammari, Abdullah Salem / Alanazi, Ibrahim Awadh / Alshammari, Dera Salah / Alanzi, Fares Saud / Alsnaideh, Faisal Fahad / Almuhaysin, Abduldaem / Alanazi, Yasir Salem / Algharbi, Saleh / AlHarbi, Sami

Journal of ethnopharmacology

2023 Volume 312, Page(s) 116492

Abstract: Ethnopharmacological relevance: Artemisia sieberi Besser is a medicinal herb that has been traditionally used across the Middle East for the treatment of cancer. Further pharmacological studies on its extracts revealed that they possess cytotoxic ... ...

Abstract	Ethnopharmacological relevance: Artemisia sieberi Besser is a medicinal herb that has been traditionally used across the Middle East for the treatment of cancer. Further pharmacological studies on its extracts revealed that they possess cytotoxic activity against certain cancer cells, however, there were no studies conducted on the anticancer potential of Artemisia sieberi essential oil (ASEO). Aim of the study: To evaluate the anticancer potential of ASEO, elucidate the oil's mode of action for the first time and investigate its chemical composition. Materials and methods: Artemisia sieberi was collected from Hail, Saudi Arabia, and its essential oil was obtained via hydrodistillation. The oil's activity against HCT116, HepG2, A549 and MCF-7 cells was assessed using SRB assay, while its anti-metastatic potential was assessed via a migration assay. Cell-cycle analysis and apoptosis assay were conducted via flow cytometry, while protein expression levels were investigated using Western blotting. The oil's chemical constituents were identified using GCMS. Results: ASEO exerted its highest cytotoxic activity against MCF-7 with an IC Conclusion: ASEO possessed in vitro anticancer activity and modulated the ERK signalling pathway. This is the first study to explore the anticancer potential of ASEO in detail and reflects the significance of investigating essential oils from medicinal plants that have been traditionally used against cancer. This work might pave the way for further in vivo studies that could result in developing the oil into a natural effective anticancer treatment.
MeSH term(s)	Humans ; Female ; Oils, Volatile/chemistry ; Artemisia/chemistry ; Down-Regulation ; Breast Neoplasms/drug therapy ; Apoptosis ; Plants, Medicinal/metabolism ; Caspases/metabolism
Chemical Substances	Oils, Volatile ; Caspases (EC 3.4.22.-)
Language	English
Publishing date	2023-04-12
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2023.116492
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Article: Beyond gene ontology (GO): using biocuration approach to improve the gene nomenclature and functional annotation of rice S-domain kinase subfamily.

Naithani, Sushma / Dikeman, Daemon / Garg, Priyanka / Al-Bader, Noor / Jaiswal, Pankaj

PeerJ

2021 Volume 9, Page(s) e11052

Abstract: The S-domain subfamily of receptor-like kinases (SDRLKs) in plants is poorly characterized. Most ...

Abstract	The S-domain subfamily of receptor-like kinases (SDRLKs) in plants is poorly characterized. Most members of this subfamily are currently assigned gene function based on the
Language	English
Publishing date	2021-03-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	2703241-3
ISSN	2167-8359
ISSN	2167-8359
DOI	10.7717/peerj.11052
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Article ; Online: Schluckstörungen bei tracheo(s)tomierten Patienten.

Bader, Carl-Albert / Keilmann, Annerose

Laryngo- rhino- otologie

2017 Volume 96, Issue 5, Page(s) 280–292

Abstract: ... ...

Title translation	Swallowing Disorders in Tracheo(s)tomized Patients.
Abstract	Objective
Language	German
Publishing date	2017-05
Publishing country	Germany
Document type	English Abstract ; Journal Article
ZDB-ID	96005-6
ISSN	1438-8685 ; 0340-1588 ; 0935-8943
ISSN (online)	1438-8685
ISSN	0340-1588 ; 0935-8943
DOI	10.1055/s-0043-103279
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Ul II Zs.95: Show issues

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Article ; Online: Adaptation in U.S. Corn Belt increases resistance to soil carbon loss with climate change.

Zhang, Yao / Marx, Ernie / Williams, Stephen / Gurung, Ram / Ogle, Stephen / Horton, Radley / Bader, Daniel / Paustian, Keith

Scientific reports

2020 Volume 10, Issue 1, Page(s) 13799

Abstract: ... soybean production in the U.S. Corn Belt using climate data from three models. Without adaptation, yields ...

Abstract	Increasing the amount of soil organic carbon (SOC) has agronomic benefits and the potential to mitigate climate change. Previous regional predictions of SOC trends under climate change often ignore or do not explicitly consider the effect of crop adaptation (i.e., changing planting dates and varieties). We used the DayCent biogeochemical model to examine the effect of adaptation on SOC for corn and soybean production in the U.S. Corn Belt using climate data from three models. Without adaptation, yields of both corn and soybean tended to decrease and the decomposition of SOC tended to increase leading to a loss of SOC with climate change compared to a baseline scenario with no climate change. With adaptation, the model predicted a substantially higher crop yield. The increase in yields and associated carbon input to the SOC pool counteracted the increased decomposition in the adaptation scenarios, leading to similar SOC stocks under different climate change scenarios. Consequently, we found that crop management adaptation to changing climatic conditions strengthen agroecosystem resistance to SOC loss. However, there are differences spatially in SOC trends. The northern part of the region is likely to gain SOC while the southern part of the region is predicted to lose SOC.
Language	English
Publishing date	2020-08-14
Publishing country	England
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-020-70819-z
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Article ; Online: BRCA1 and S phase DNA repair pathways restrict LINE-1 retrotransposition in human cells.

Mita, Paolo / Sun, Xiaoji / Fenyö, David / Kahler, David J / Li, Donghui / Agmon, Neta / Wudzinska, Aleksandra / Keegan, Sarah / Bader, Joel S / Yun, Chi / Boeke, Jef D

Nature structural & molecular biology

2020 Volume 27, Issue 2, Page(s) 179–191

Abstract: ... active in the S/G2 phase as potent inhibitors and regulators of L1 activity. In particular, BRCA1, an E3 ...

Abstract	Long interspersed element-1 (LINE-1, or L1) is the only autonomous retrotransposon that is active in human cells. Different host factors have been shown to influence L1 mobility; however, systematic analyses of these factors are limited. Here, we developed a high-throughput microscopy-based retrotransposition assay that identified the double-stranded break (DSB) repair and Fanconi anemia (FA) factors active in the S/G2 phase as potent inhibitors and regulators of L1 activity. In particular, BRCA1, an E3 ubiquitin ligase with a key role in several DNA repair pathways, directly affects L1 retrotransposition frequency and structure and plays a distinct role in controlling L1 ORF2 protein translation through L1 mRNA binding. These results suggest the existence of a 'battleground' at the DNA replication fork between homologous recombination (HR) factors and L1 retrotransposons and reveal a potential role for L1 in the genotypic evolution of tumors characterized by BRCA1 and HR repair deficiencies.
MeSH term(s)	BRCA1 Protein/genetics ; BRCA1 Protein/metabolism ; CRISPR-Cas Systems ; Cell Line ; DNA Breaks, Double-Stranded ; DNA Repair ; Fanconi Anemia/genetics ; Fanconi Anemia/metabolism ; Gene Deletion ; HEK293 Cells ; HeLa Cells ; Homologous Recombination ; Humans ; Long Interspersed Nucleotide Elements ; Microscopy ; S Phase
Chemical Substances	BRCA1 Protein ; BRCA1 protein, human
Language	English
Publishing date	2020-02-10
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2126708-X
ISSN	1545-9985 ; 1545-9993
ISSN (online)	1545-9985
ISSN	1545-9993
DOI	10.1038/s41594-020-0374-z
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Zs.A 4101: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article: Hashimoto`s Encephalopathy Presenting with Progressive Cerebellar Ataxia.

Algahtani, Hussein A / Fatani, Anmar N / Shirah, Bader H / Algahtani, Raghad H

Neurosciences (Riyadh, Saudi Arabia)

2019 Volume 24, Issue 4, Page(s) 315–319

Abstract: Hashimoto`s encephalopathy is a rare neurological syndrome occurring in patients with autoimmune ... thyroid disease. The diagnosis of Hashimoto`s encephalopathy is based on the clinical picture with the presence ... with Hashimoto`s disease is a rare occurrence. In this article, we present a case who had progressive non ...

Abstract	Hashimoto`s encephalopathy is a rare neurological syndrome occurring in patients with autoimmune thyroid disease. The diagnosis of Hashimoto`s encephalopathy is based on the clinical picture with the presence of serum anti-thyroid antibodies regardless of the thyroid disorder. Acquired cerebellar ataxia associated with Hashimoto`s disease is a rare occurrence. In this article, we present a case who had progressive non-familial autoimmune pancerebellar disease in association with an increased level of thyroid peroxidase and thyroglobulin antibodies. The patient was managed aggressively with both intravenous immunoglobulins and plasma exchange, which stopped the progression of the disease and allowed for slow improvement. Early diagnosis of Hashimoto`s encephalopathy with autoimmune cerebellar ataxia and intervention with immunomodulatory therapy are of paramount importance. Close monitoring after steroid therapy is important since some patients with this rare disease might be resistant to steroid therapy and require aggressive immunomodulatory therapy.
MeSH term(s)	Adult ; Autoantibodies/blood ; Cerebellar Ataxia/etiology ; Cerebellar Ataxia/pathology ; Cerebellar Ataxia/therapy ; Encephalitis/complications ; Encephalitis/pathology ; Encephalitis/therapy ; Female ; Hashimoto Disease/complications ; Hashimoto Disease/pathology ; Hashimoto Disease/therapy ; Humans ; Immunotherapy ; Iodide Peroxidase/immunology ; Thyroglobulin/immunology
Chemical Substances	Autoantibodies ; Thyroglobulin (9010-34-8) ; Iodide Peroxidase (EC 1.11.1.8)
Language	English
Publishing date	2019-12-11
Publishing country	Saudi Arabia
Document type	Case Reports ; Journal Article
ZDB-ID	2214806-1
ISSN	1319-6138
ISSN	1319-6138
DOI	10.17712/nsj.2019.4.20190016
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