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  1. Article ; Online: Sophie's choice

    Debasish Basu

    Indian Journal of Social Psychiatry, Vol 36, Iss 5, Pp 93-

    The costs of the COVID-19 pandemic versus the costs of its “treatment”

    2020  Volume 94

    Keywords Psychiatry ; RC435-571 ; covid19
    Language English
    Publishing date 2020-01-01T00:00:00Z
    Publisher Wolters Kluwer Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Sophie's choice

    Basu, Debasish

    Indian Journal of Social Psychiatry

    The costs of the COVID-19 pandemic versus the costs of its “treatment”

    2020  Volume 36, Issue 5, Page(s) 93

    Keywords covid19
    Language English
    Publisher Medknow
    Publishing country in
    Document type Article ; Online
    ZDB-ID 645115-9
    ISSN 0971-9962
    ISSN 0971-9962
    DOI 10.4103/ijsp.ijsp_234_20
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    Zs.B 3287: Show issues Location:
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  3. Article ; Online: EnCPdock: a web-interface for direct conjoint comparative analyses of complementarity and binding energetics in inter-protein associations.

    Biswas, Gargi / Mukherjee, Debasish / Dutta, Nalok / Ghosh, Prithwi / Basu, Sankar

    Journal of molecular modeling

    2023  Volume 29, Issue 8, Page(s) 239

    Abstract: Context: Protein-protein interaction (PPI) is a key component linked to virtually all cellular processes. Be it an enzyme catalysis ('classic type functions' of proteins) or a signal transduction ('non-classic'), proteins generally function involving ... ...

    Abstract Context: Protein-protein interaction (PPI) is a key component linked to virtually all cellular processes. Be it an enzyme catalysis ('classic type functions' of proteins) or a signal transduction ('non-classic'), proteins generally function involving stable or quasi-stable multi-protein associations. The physical basis for such associations is inherent in the combined effect of shape and electrostatic complementarities (Sc, EC) of the interacting protein partners at their interface, which provides indirect probabilistic estimates of the stability and affinity of the interaction. While Sc is a necessary criterion for inter-protein associations, EC can be favorable as well as disfavored (e.g., in transient interactions). Estimating equilibrium thermodynamic parameters (∆G
    Methods: Here, we present EnCPdock ( https://www.scinetmol.in/EnCPdock/ ), a user-friendly web-interface for the direct conjoint comparative analyses of complementarity and binding energetics in proteins. EnCPdock returns an AI-predicted ∆G
    MeSH term(s) Models, Molecular ; Proteins/chemistry ; Protein Binding
    Chemical Substances Proteins
    Language English
    Publishing date 2023-07-10
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1284729-X
    ISSN 0948-5023 ; 1610-2940
    ISSN (online) 0948-5023
    ISSN 1610-2940
    DOI 10.1007/s00894-023-05626-0
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  4. Article ; Online: Neurocognitive Dysfunctions in People with Concurrent Cannabis Use and Opioid Dependence: A Cross-Sectional, Controlled Study.

    Ghosh, Abhishek / Shaktan, Alka / Verma, Abhishek / Basu, Debasish / Rana, Devender K / Nehra, Ritu / Ahuja, Chirag K / Modi, Manish / Singh, Paramjit

    Journal of psychoactive drugs

    2024  , Page(s) 1–13

    Abstract: Cannabis and opioid co-dependence is independently associated with cognitive impairments. We examined neurocognitive dysfunctions in people with concurrent opioid dependence with cannabis dependence (OD+CD) or cannabis use (OD+CU) compared to those with ... ...

    Abstract Cannabis and opioid co-dependence is independently associated with cognitive impairments. We examined neurocognitive dysfunctions in people with concurrent opioid dependence with cannabis dependence (OD+CD) or cannabis use (OD+CU) compared to those with only opioid dependence (OD) and healthy controls (HC). We selected adult participants, any sex, who met the diagnosis of OD (
    Language English
    Publishing date 2024-01-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 392405-1
    ISSN 2159-9777 ; 0279-1072
    ISSN (online) 2159-9777
    ISSN 0279-1072
    DOI 10.1080/02791072.2024.2308213
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Assist-linked brief intervention to reduce risky pattern of substance use in male workers employed at a tertiary care hospital in India: A randomized controlled trial.

    Prasad, Sambhu / Basu, Debasish / Mattoo, Surendra K / Subodh, B N

    Indian journal of psychiatry

    2023  Volume 65, Issue 1, Page(s) 36–44

    Abstract: Background: Substance use in workplace leads to adverse effects both on the employees and on the workplace. Existing research focuses on alcohol-related harm, while workplace use of other substances has been neglected. There are no randomized controlled ...

    Abstract Background: Substance use in workplace leads to adverse effects both on the employees and on the workplace. Existing research focuses on alcohol-related harm, while workplace use of other substances has been neglected. There are no randomized controlled studies of brief interventions in Indian hospital settings.
    Aim: To evaluate the efficacy of World Health Organization (WHO) alcohol, smoking, and substance involvement screening test (ASSIST)-linked brief intervention (ALBI) for reducing risky patterns of substance use in male workers at a tertiary-care hospital in North India.
    Material and methods: The study was conducted in two phases. In Phase-I, a random list of 400 employees was generated from the entire pool of male hospital workers, of which 360 participated. Data on the ASSIST risk categories (mild, moderate, and high) were generated from Phase I. In Phase-II, moderate- or high-risk subjects ('ASSIST screen-positive') were randomized into intervention and control groups, with 35 screen-positive subjects in each group. The intervention group was provided a 15-30-min structured session per ALBI protocol, while the control group was given a 15-30-min general talk on health-related consequences associated with substance use. The subjects were compared on ASSIST score, WHO quality-of-life brief version (WHOQOL-BREF) and readiness to change questionnaire (RCQ) at baseline and at 3-month follow up.
    Results: The prevalence of moderate-to-high-risk use of tobacco, alcohol, and cannabis in the total sample was 28.6%, 27.5%, and 6.9%, respectively. At 3-months postintervention follow-up of the randomized sample, recipients of ALBI had significant reduction of ASSIST scores for all substances compared to the control group (
    Conclusion: ALBI was effective in reducing risky substance use, increasing readiness to change and improving the QOL of the subjects at workplace setting.
    Language English
    Publishing date 2023-01-13
    Publishing country India
    Document type Journal Article
    ZDB-ID 221523-8
    ISSN 0019-5545
    ISSN 0019-5545
    DOI 10.4103/indianjpsychiatry.indianjpsychiatry_660_21
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 2038: Show issues Location:
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  6. Article: The toll of opioid dependence: A research report on the possible role of Toll-like receptor-4 and related immune markers in opioid dependence.

    Mahintamani, Tathagata / Basu, Debasish / Ghosh, Abhishek / Luthra-Guptasarma, Manni

    Indian journal of psychiatry

    2023  Volume 65, Issue 6, Page(s) 626–634

    Abstract: Background: The opioid receptors in the central nervous system and immune system contribute to its reinforcing effect. Xenobiotics-associated molecular pattern of opioids interacts with Toll-like receptor-4 (TLR-4) on the glial cell surface and ... ...

    Abstract Background: The opioid receptors in the central nervous system and immune system contribute to its reinforcing effect. Xenobiotics-associated molecular pattern of opioids interacts with Toll-like receptor-4 (TLR-4) on the glial cell surface and increases dopaminergic activity in the nucleus accumbens in preclinical studies. We wanted to examine whether treatment with buprenorphine-naloxone (BNX) might be associated with changes in immunological markers in individuals with opioid dependence (OD).
    Methods: We recruited 30 individuals with OD on buprenorphine and 30 age- and sex-matched healthy controls (HCs). We measured the neutrophil (N), lymphocyte (L), CD-4, and CD-8 T-cell count and estimated plasma TLR-4 level in the HC group once. We measured the immunological markers, craving, pain, and perceived stress in the OD group at the treatment initiation (baseline) and after 4 weeks (±2 weeks) of treatment with BNX.
    Results: The mean severity score on the OD questionnaire was 72.8 (SD 5.4). At baseline, OD had a higher N: L ratio and lower lymphocyte percentage than HC. Plasma TLR-4 concentration increased significantly after 1 month of treatment (
    Conclusion: The increase in TLR-4 after treatment with BNX may indicate the rescue from nonprescription opioid-induced immunosuppression or the introduction of a novel xenobiotics-associated molecular pattern of BNX.
    Language English
    Publishing date 2023-06-19
    Publishing country India
    Document type Journal Article
    ZDB-ID 221523-8
    ISSN 0019-5545
    ISSN 0019-5545
    DOI 10.4103/indianjpsychiatry.indianjpsychiatry_314_22
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  7. Article ; Online: Is there any association between cognitive deficits and immune markers in Acute and Transient psychotic disorders? A pilot study.

    Sahoo, Swapnajeet / Kale, Akshayee / Basu, Debasish / Minz, Ranjana W

    Asian journal of psychiatry

    2023  Volume 89, Page(s) 103754

    Abstract: Background: There are studies to support association between immune function and cognition in patients with schizophrenia (SZ). However, there are no such study which had tried to explore the same in patients with Acute and transient psychotic disorders ...

    Abstract Background: There are studies to support association between immune function and cognition in patients with schizophrenia (SZ). However, there are no such study which had tried to explore the same in patients with Acute and transient psychotic disorders (ATPDs), which is considered to similar in presentation to SZ.
    Methods: This is an extended analysis of the study published in which we had recruited 19 subjects with ATPDs in acute phase of illness were age-/gender-matched with patients schizophrenia in remission. Clinical assessment and immune-marker levels (IL-6,IL-8,IL-17) were carried out along with follow -up repeat immune-marker levels assessment in the ATPD group was conducted after remission status was ensured (at least 3 months after resolution of acute phase). Cognitive assessment was done on Montreal Cognitive Assessment Scale (MoCA) in both the groups (ATPD in both phases and in SZ).
    Results: The mean MoCA total score was 12.05 (SD-5.0) in the acute phase and 27.05 (SD-2.46) in the remission phase in the ATPD group which was statistically significant. When compared with patients with SZ in remission, patients with ATPD in remission performed better in all domains of MoCA, however only statistically significant differences in the total MoCA score and in the visuospatial domain scores of MoCA. No significant association between any of the immune marker levels (IL-6, Il-8 and IL-17) with any domains of the MoCA in patients with ATPD neither in the acute phase nor in the remission phase was found. Additionally, no significant association between the cognitive scores in the MoCA domains of the patients with schizophrenia and immune marker levels was found too.
    Conclusion: To conclude, the present study's findings suggested that there existed definite cognitive deficits in patients with ATPDs in both acute and remission phase and in patients with SZ. However, the study could not establish any relationship/association between cognitive deficits/scores in patients with ATPDs in both phases as well as in patients with SZ with immune marker levels.
    MeSH term(s) Humans ; Pilot Projects ; Interleukin-17 ; Interleukin-6 ; Interleukin-8 ; Psychotic Disorders/complications ; Cognitive Dysfunction/diagnosis ; Cognitive Dysfunction/etiology ; Cognition ; Biomarkers ; Neuropsychological Tests
    Chemical Substances Interleukin-17 ; Interleukin-6 ; Interleukin-8 ; Biomarkers
    Language English
    Publishing date 2023-08-24
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 2456678-0
    ISSN 1876-2026 ; 1876-2018
    ISSN (online) 1876-2026
    ISSN 1876-2018
    DOI 10.1016/j.ajp.2023.103754
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Efficacy of screening and brief intervention for hazardous alcohol use in patients with mood disorders: A randomized clinical trial from a psychiatric out-patient clinic in India.

    Sinha, Ankit / Kohli, Adarsh / Ghosh, Abhishek / Basu, Debasish

    Asian journal of psychiatry

    2022  Volume 73, Page(s) 103138

    Abstract: Aim: To determine the efficacy of individual-based, face-to-face screening and brief intervention (SBI) for hazardous alcohol use among treatment-seeking outpatients with mood disorders.: Methods: It was a parallel-group, single-blind, randomized ... ...

    Abstract Aim: To determine the efficacy of individual-based, face-to-face screening and brief intervention (SBI) for hazardous alcohol use among treatment-seeking outpatients with mood disorders.
    Methods: It was a parallel-group, single-blind, randomized controlled trial of 84 participants who met the selection criteria for hazardous alcohol use, defined by alcohol use disorder identification test (AUDIT) score 8-19. Participants were randomly allocated to either SBI or general advice group. Both groups had received a standard care for mood disorders. The outcome was assessed after 3 months. The primary outcome was a change in the mean AUDIT score and the secondary outcomes were a change in frequency of heavy episodic drinking and stages of motivation.
    Results: Majority (60%) had major depressive episodes. There was no significant difference in baseline demography and clinical variables between the groups. Both intention to treat and per-protocol analyses showed a small but significant effect of SBI on mean AUDIT score. Age, baseline AUDIT, and motivation did not moderate the effect. SBI was associated with a significant decrease in the frequency of heavy drinking and improvement in stages of motivation.
    Conclusion: SBI among patients with mood disorders had a small but significant effect on alcohol use.
    MeSH term(s) Alcohol Drinking ; Alcoholism/diagnosis ; Alcoholism/therapy ; Crisis Intervention ; Depressive Disorder, Major/diagnosis ; Depressive Disorder, Major/therapy ; Humans ; Mass Screening/methods ; Mood Disorders/diagnosis ; Mood Disorders/therapy ; Outpatients ; Single-Blind Method
    Language English
    Publishing date 2022-04-26
    Publishing country Netherlands
    Document type Journal Article ; Randomized Controlled Trial
    ZDB-ID 2456678-0
    ISSN 1876-2026 ; 1876-2018
    ISSN (online) 1876-2026
    ISSN 1876-2018
    DOI 10.1016/j.ajp.2022.103138
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  9. Article ; Online: Repression-free utrophin-A 5'UTR variants.

    Malik, Debasish / Basu, Utpal

    Molecular biology research communications

    2020  Volume 8, Issue 3, Page(s) 129–133

    Abstract: Mutation in the dystrophin gene results Duchenne Muscular Dystrophy (DMD), an X-linked fatal neuromuscular disorder. Dystrophin deficiency can be compensated by upregulation of utrophin, an autosomal homologue of dystrophin. But the expression of ... ...

    Abstract Mutation in the dystrophin gene results Duchenne Muscular Dystrophy (DMD), an X-linked fatal neuromuscular disorder. Dystrophin deficiency can be compensated by upregulation of utrophin, an autosomal homologue of dystrophin. But the expression of utrophin in adults is restricted to myotendinous and neuromuscular junctions. Therefore utrophin upregulation throughout the muscle fiber can only be achieved if we understand regulatory mechanisms behind its expression. Utrophin-A 5'UTR mediated repression of translation was reported earlier. In this article, we present evidences of two transcript variants of utrophin-A that do not confer repression to the downstream reporter ORF in mouse myoblast C2C12 cells. These repression-free variants may be targeted for utrophin upregulation.
    Language English
    Publishing date 2020-01-03
    Publishing country Iran
    Document type Journal Article
    ISSN 2345-2005
    ISSN (online) 2345-2005
    DOI 10.22099/mbrc.2019.34240.1421
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  10. Article ; Online: WHO qualityRights tool kit

    Debasish Basu

    Indian Journal of Medical Research, Vol 139, Iss 1, Pp 183-

    Assessing and improving quality and human rights in mental health and social care facilities

    2014  Volume 184

    Keywords Medicine ; R
    Language English
    Publishing date 2014-01-01T00:00:00Z
    Publisher Wolters Kluwer Medknow Publications
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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