LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 1745

Search options

  1. Article ; Online: Optimally generate policy-based evidence before scaling.

    List, John A

    Nature

    2024  Volume 626, Issue 7999, Page(s) 491–499

    Abstract: Social scientists have increasingly turned to the experimental method to understand human behaviour. One critical issue that makes solving social problems difficult is scaling up the idea from a small group to a larger group in more diverse situations. ... ...

    Abstract Social scientists have increasingly turned to the experimental method to understand human behaviour. One critical issue that makes solving social problems difficult is scaling up the idea from a small group to a larger group in more diverse situations. The urgency of scaling policies impacts us every day, whether it is protecting the health and safety of a community or enhancing the opportunities of future generations. Yet, a common result is that, when we scale up ideas, most experience a 'voltage drop'-that is, on scaling, the cost-benefit profile depreciates considerably. Here I argue that, to reduce voltage drops, we must optimally generate policy-based evidence. Optimality requires answering two crucial questions: what information should be generated and in what sequence. The economics underlying the science of scaling provides insights into these questions, which are in some cases at odds with conventional approaches. For example, there are important situations in which I advocate flipping the traditional social science research model to an approach that, from the beginning, produces the type of policy-based evidence that the science of scaling demands. To do so, I propose augmenting efficacy trials by including relevant tests of scale in the original discovery process, which forces the scientist to naturally start with a recognition of the big picture: what information do I need to have scaling confidence?
    MeSH term(s) Humans ; Social Sciences/methods ; Social Sciences/standards ; Behavioral Research/methods ; Cost-Benefit Analysis ; Sample Size
    Language English
    Publishing date 2024-02-14
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/s41586-023-06972-y
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  2. Article: Global and local priming in a multi-modal context.

    List, Alexandra

    Frontiers in human neuroscience

    2023  Volume 16, Page(s) 1043475

    Abstract: Perceptual information can be processed at many different scales, from featural details to entire scenes. Attentional selection of different scales has been studied using hierarchical stimuli, with research elucidating a variety of biases in local and ... ...

    Abstract Perceptual information can be processed at many different scales, from featural details to entire scenes. Attentional selection of different scales has been studied using hierarchical stimuli, with research elucidating a variety of biases in local and global attentional selection (due to, e.g., stimulus properties, brain injury, and experience). In this study, the emphasis is on biases produced through recent experience, or level-specific priming effects, which have been demonstrated within both the visual and auditory modalities. Namely, when individuals attend to local information, they are subsequently biased to attend locally (and similarly so with global attention). Here, these level-specific priming effects are investigated in a multi-modal context to determine whether cross-modal interactions occur between visual and auditory modalities during hierarchical processing. Specifically, the study addresses if attentional selection of local or global information in the visual modality subsequently biases auditory attentional selection to that level, and vice versa (i.e., level-priming). Though expected identity priming effects emerged in the study, no cross-modal
    Language English
    Publishing date 2023-02-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2425477-0
    ISSN 1662-5161
    ISSN 1662-5161
    DOI 10.3389/fnhum.2022.1043475
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  3. Book ; Online: The Scale-Up Effect in Early Childhood and Public Policy : Why Interventions Lose Impact at Scale and What We Can Do About It

    List, John A. / Suskind, Dana / Supplee, Lauren H.

    2021  

    Keywords Business studies: general ; Pre-school & kindergarten ; Education ; economics, early childhood, education, public policy, children, behavioral economics, BE, social psychology, parent, intervention, scaling
    Size 1 Online-Ressource
    Publisher Taylor and Francis
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021051685
    ISBN 9780367822972 ; 0367822970
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    More links

    Kategorien

  4. Book ; Online: Chapter: Introduction - Field Experiments

    Samek, Anya / List, John A.

    2018  

    Abstract: This research review discusses the most critical and influential articles that utilise field experimentation to answer questions of economic importance. Field experiments have gained popularity in recent years, allowing researchers to infer causal ... ...

    Abstract This research review discusses the most critical and influential articles that utilise field experimentation to answer questions of economic importance. Field experiments have gained popularity in recent years, allowing researchers to infer causal effects of different market environments, policies and interventions. The articles analysed here provide insights into market functioning and individual and group decision-making across a wide range of domains, including marketplace transactions, labor decisions, charitable giving, financial planning, and education and health-related decision-making. This research review will be an important resource for students new to the methodology and applications of field experiments and academics alike
    Keywords Management. Industrial management ; Economic theory. Demography
    Size 1 electronic resource ( p.)
    Publisher Edward Elgar Publishing
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT020098466
    ISBN 9781784716134 ; 1784716138
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    More links

    Kategorien

  5. Book ; Online: Civil Society, Conflict and Violence

    List, Regina A. / Dorner, Wolfgang

    (CIVICUS Global Study of Civil Society Series)

    2012  

    Series title CIVICUS Global Study of Civil Society Series
    Keywords Sociology ; International relations
    Language 0|e
    Size 1 electronic resource (208 pages)
    Publisher Bloomsbury Academic
    Publishing place London
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021620468
    ISBN 9781780931029 ; 1780931026
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    More links

    Kategorien

  6. Article ; Online: Economics of Scale-Lessons for Radiologists.

    Jha, Saurabh / List, John A

    Journal of the American College of Radiology : JACR

    2023  Volume 21, Issue 5, Page(s) 840–842

    MeSH term(s) Radiologists/economics ; United States ; Humans ; Radiology/economics
    Language English
    Publishing date 2023-11-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2274861-1
    ISSN 1558-349X ; 1546-1440
    ISSN (online) 1558-349X
    ISSN 1546-1440
    DOI 10.1016/j.jacr.2023.11.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  7. Article ; Online: Editorial Commentary: Lower Trapezius Transfer May Be Indicated for Surgical Management of Massive Irreparable Rotator Cuff Tears in Younger, Non-Arthritic Patients.

    Waterman, Brian R / van der List, Jelle P / Fiegen, Anthony

    Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association

    2024  Volume 40, Issue 3, Page(s) 960–962

    Abstract: Although shoulder rotator cuff repair fixation constructs and suture anchor design have evolved, repair of massive or functionally irreparable tears historically has relied on tendon mobilization and compression, optimizing footprint biology, and ... ...

    Abstract Although shoulder rotator cuff repair fixation constructs and suture anchor design have evolved, repair of massive or functionally irreparable tears historically has relied on tendon mobilization and compression, optimizing footprint biology, and attempting a tension-free repair. However, despite these efforts, rates of failure of complete healing may be high, ranging from 20% to 94%. This has led to a search for alternative approaches, including bridging grafts, subacromial balloons, superior capsular reconstructions, biologic tuberoplasties, bursal acromial grafts, and, ultimately, renewed interest in tendon transfers. The latissimus dorsi transfer was traditionally a preferred tendon-transfer technique for posterosuperior massive cuff tears, but inconsistent outcomes have resulted in declining popularity. Recently, the lower trapezius transfer (LTT) has gained acceptance for the treatment of posterosuperior tears, particularly with external rotation weakness and lag signs. The LTT is biomechanically superior to the latissimus dorsi transfer, offering a more native vector of pull and in-phase activation. LTT could be indicated for younger patients with massive cuff tears. However, LTT is relatively contraindicated in patients with cuff tear arthropathy; combined loss of elevation and external rotation; irreparable subscapularis tear; teres minor involvement; and/or those of advanced age or unable to comply with rigid rehabilitation guidelines.
    MeSH term(s) Humans ; Rotator Cuff Injuries/surgery ; Superficial Back Muscles/surgery ; Treatment Outcome ; Rotator Cuff/surgery ; Acromion ; Tendon Transfer/methods ; Range of Motion, Articular/physiology
    Language English
    Publishing date 2024-01-12
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 632528-2
    ISSN 1526-3231 ; 0749-8063
    ISSN (online) 1526-3231
    ISSN 0749-8063
    DOI 10.1016/j.arthro.2023.08.067
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  8. Article ; Online: Making mouse transcriptomics deconvolution accessible with immunedeconv.

    Merotto, Lorenzo / Sturm, Gregor / Dietrich, Alexander / List, Markus / Finotello, Francesca

    Bioinformatics advances

    2024  Volume 4, Issue 1, Page(s) vbae032

    Abstract: Summary: Transcriptome deconvolution has emerged as a reliable technique to estimate cell-type abundances from bulk RNA sequencing data. Unlike their human equivalents, methods to quantify the cellular composition of complex tissues from murine ... ...

    Abstract Summary: Transcriptome deconvolution has emerged as a reliable technique to estimate cell-type abundances from bulk RNA sequencing data. Unlike their human equivalents, methods to quantify the cellular composition of complex tissues from murine transcriptomics are sparse and sometimes not easy to use. We extended the immunedeconv R package to facilitate the deconvolution of mouse transcriptomics, enabling the quantification of murine immune-cell types using 13 different methods. Through immunedeconv, we further offer the possibility of tweaking cell signatures used by deconvolution methods, providing custom annotations tailored for specific cell types and tissues. These developments strongly facilitate the study of the immune-cell composition of mouse models and further open new avenues in the investigation of the cellular composition of other tissues and organisms.
    Availability and implementation: The R package and the documentation are available at https://github.com/omnideconv/immunedeconv.
    Language English
    Publishing date 2024-02-28
    Publishing country England
    Document type Journal Article
    ISSN 2635-0041
    ISSN (online) 2635-0041
    DOI 10.1093/bioadv/vbae032
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  9. Article ; Online: Editorial Commentary: Meniscal Allograft Transplantation Is Effective for Adolescents With Meniscal Insufficiency, Although Outcomes May Decline Over Time.

    van der List, Jelle P / Trasolini, Nicholas A / Waterman, Brian R

    Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association

    2024  Volume 40, Issue 4, Page(s) 1195–1196

    Abstract: Over the last several years, there has been a shift from arthroscopic partial meniscectomy to meniscal repair, especially in the younger patient. In case of a necessary partial meniscectomy, some patients have unremittent symptoms of pain and effusion ... ...

    Abstract Over the last several years, there has been a shift from arthroscopic partial meniscectomy to meniscal repair, especially in the younger patient. In case of a necessary partial meniscectomy, some patients have unremittent symptoms of pain and effusion corresponding to the postmeniscectomy syndrome. In these patients without large coronal malalignment, meniscal allograft transplantation is a valuable option to restore contact pressures, promote a chondroprotective microenvironment, and potentially delay secondary surgical interventions symptoms. In the adolescent population, meniscal allograft transplantation has been shown to effectively improve patient-reported outcomes with a low conversion to arthroplasty. However, these treatments are far from ideal, and prevention is certainly better than the cure: timely diagnosis of meniscus injuries, appropriate treatment with meniscus repair rather than partial meniscectomy, even in the complex tear patterns, and consideration of corrective osteotomy for milder cases of malalignment.
    MeSH term(s) Humans ; Adolescent ; Menisci, Tibial/transplantation ; Tibial Meniscus Injuries/surgery ; Meniscus ; Meniscectomy ; Allografts
    Language English
    Publishing date 2024-01-16
    Publishing country United States
    Document type Editorial
    ZDB-ID 632528-2
    ISSN 1526-3231 ; 0749-8063
    ISSN (online) 1526-3231
    ISSN 0749-8063
    DOI 10.1016/j.arthro.2023.09.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  10. Article ; Online: Oral appliance influence on jaw function in obstructive sleep apnea.

    Tegelberg, Åke / Nohlert, Eva / List, Thomas / Isacsson, Göran

    American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics

    2023  Volume 164, Issue 5, Page(s) 682–689

    Abstract: Introduction: Oral appliance (OA) therapy in obstructive sleep apnea (OSA) could be a risk factor for normal jaw function, given the prolonged effect of an OA in keeping the mandible in a protruded position away from a normal position. This study aimed ... ...

    Abstract Introduction: Oral appliance (OA) therapy in obstructive sleep apnea (OSA) could be a risk factor for normal jaw function, given the prolonged effect of an OA in keeping the mandible in a protruded position away from a normal position. This study aimed to assess changes in symptoms and clinical findings related to jaw function after 1 year of treating OSA with an OA.
    Methods: In this follow-up clinical trial, 302 patients with OSA were assigned to treatment with either monobloc or bibloc OA. Baseline and 1-year follow-up assessment included using the Jaw Functional Limitation Scale, self-reported symptoms and signs related to jaw function. The clinical examination of jaw function included mandibular mobility, dental occlusion, and tenderness in the temporomandibular joints and masticatory muscles. Descriptive analyses of variables are presented for the per-protocol population. To evaluate differences between the baseline and the 1-year follow-up, paired Student t tests and the McNemar change test was used.
    Results: One-hundred and ninety-two patients completed the 1-year follow-up (male 73%, mean aged 55 ± 11 years). There was no change in the Jaw Functional Limitation Scale score at the follow-up (nonsignificant). The patients described no change in symptoms at the follow-up, except for improvements in morning headache (P <0.001) and increased frequency of difficulties in opening the mouth or chewing on awakening (P = 0.002). Subjectively reported changes in dental occlusion during biting/chewing increased significantly at the follow-up (P = 0.009).
    Conclusions: No changes in measurements of jaw mobility, dental occlusion, or pain on palpation of the temporomandibular joints or masticatory muscles were seen at the follow-up. Thus, using an OA in treating OSA had limited influence on jaw functions and related symptoms. Moreover, the risk of developing pain and functional impairment in the masticatory system was infrequent, indicating that this treatment is safe and can be recommended.
    MeSH term(s) Humans ; Male ; Adult ; Middle Aged ; Aged ; Temporomandibular Joint ; Pain ; Mandible ; Temporomandibular Joint Disorders/therapy ; Mandibular Advancement ; Sleep Apnea, Obstructive/therapy ; Treatment Outcome
    Language English
    Publishing date 2023-06-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 356699-7
    ISSN 1097-6752 ; 0889-5406 ; 0002-9416
    ISSN (online) 1097-6752
    ISSN 0889-5406 ; 0002-9416
    DOI 10.1016/j.ajodo.2023.04.018
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

To top