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Article ; Online: Effect of Interfacial Modification on the Low-Temperature Fatigue Properties of Polymer/MXene Flexible Pressure Sensors.

Men, Hai-Jiao / Huang, Bing-Jing / Li, Jian-Chang

ACS applied materials & interfaces

2024 Volume 16, Issue 6, Page(s) 7489–7499

Abstract: Maintaining an excellent force-electric response under cyclic bending at low temperatures is still challenging for resistive-type electrically conductive polymer composite-based pressure sensors. In this study, the effect of low temperature on the ... ...

Abstract	Maintaining an excellent force-electric response under cyclic bending at low temperatures is still challenging for resistive-type electrically conductive polymer composite-based pressure sensors. In this study, the effect of low temperature on the fatigue failure of flexible MXene/polymer pressure sensors was systematically investigated through the silane functionalization of MXene nanosheets embedded with different polymer matrixes. The results show that the MXene/polymer interfaces are the primary factors affecting the temperature-dependent bending fatigue of the Cu/MXene/polymer/Cu sensor. Using finite element analysis and theoretical calculations, we reveal that the MXene/polymer interfaces are affected by free volume changes and the molecular chain motion under different temperatures. At room temperature, the well-distributed free volume in the polydimethylsiloxane (PDMS) matrix permits local segmental mobility that promotes the affinity between the polymer and MXene. As the temperature decreases, the free volume in the matrix shrinks with less space left for molecular chains to slide relatively, weakening the polymer/MXene interfacial bonding strength. However, for PDMS/MXene sensors with the interface modified using the silane coupling agent KH550, the nanoconstrained structure formed by strong hydrogen bonds and covalent bonds at the PDMS/MXene interface can hinder the mobility of polymer chains, which greatly helps to dissipate the inter/intrachain friction. It thus alleviates the debonding energy dissipation during cyclic bending at subzero temperatures.
Language	English
Publishing date	2024-02-01
Publishing country	United States
Document type	Journal Article
ISSN	1944-8252
ISSN (online)	1944-8252
DOI	10.1021/acsami.3c15243
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Article ; Online: Palladium-catalyzed denitrogenation/vinylation of benzotriazinones with vinylene carbonate.

Nan, Jiang / Huang, Qiong / Men, Xinran / Yang, Shuai / Wang, Jing / Ma, Yangmin

Chemical communications (Cambridge, England)

2024 Volume 60, Issue 26, Page(s) 3571–3574

Abstract: Herein, a novel Pd-catalyzed denitrogenation/vinylation of benzotriazinones using vinylene carbonate as the vinylation reagent is reported. This transformation demonstrates an unprecedented skeletal editing approach, effectively converting NN to CC ... ...

Abstract	Herein, a novel Pd-catalyzed denitrogenation/vinylation of benzotriazinones using vinylene carbonate as the vinylation reagent is reported. This transformation demonstrates an unprecedented skeletal editing approach, effectively converting NN to CC fragments
Language	English
Publishing date	2024-03-26
Publishing country	England
Document type	Journal Article
ZDB-ID	1472881-3
ISSN	1364-548X ; 1359-7345 ; 0009-241X
ISSN (online)	1364-548X
ISSN	1359-7345 ; 0009-241X
DOI	10.1039/d4cc00059e
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Article ; Online: Association with the plasma atherogenic index with hepatic steatosis and fibrosis in the US population.

Li, Yijing / Men, Xiaoping / Liu, Yangyang / Jiang, Haiyan / Bi, Chaoran / Qu, Yanan / Wang, Kuisong / Wang, Xinyang / Jing, Jing / Liu, Yanjing

Medicine

2024 Volume 103, Issue 8, Page(s) e37152

Abstract: Plasma atherogenic index (AIP) reflects a novel intricate biochemical indicator of lipids' metabolism. The involvement of lipid metabolism for pathogenesis concerning nonalcoholic fatty liver disease (NAFLD) has been established. However, the precise ... ...

Abstract	Plasma atherogenic index (AIP) reflects a novel intricate biochemical indicator of lipids' metabolism. The involvement of lipid metabolism for pathogenesis concerning nonalcoholic fatty liver disease (NAFLD) has been established. However, the precise association across AIP and hepatic steatosis and fibrosis remains unclear. This present investigation explored the potential correlation across AIP, hepatic steatosis and fibrosis. Data were acquired through National Health and Nutrition Examination Survey (NHANES) from 2017 to 2020. Hepatic steatosis was detected through the controlled attenuation parameter (CAP), while hepatic fibrosis was examined via liver stiffness measurement (LSM). The study employed multiple linear, Fitted smoothed curves and subgroup analyses were used for investigating relationships between the AIP, CAP, and LSM. The study recruited 6239 participants. In multivariate linear regression analysis, findings indicated a remarkable correlation between AIP and exacerbated NAFLD risk [odds ratio (95% confidence interval), 1.17 (1.12, 1.21)]. Analysis further revealed a positive link across AIP and hepatic steatosis, as indicated through the CAP [β (95% CI), 4.07 (3.32, 4.82)]. Tests for non-linearity, revealed a non-linear correlation between AIP and CAP (inflection point = 0.22). Subgroup analyses assessed the consistency of the link across AIP and CAP, indicating that the association remained comparable across all subgroups. Following the adjustment for all relevant variables, the linear regression analysis revealed a lack of statistical significance across the AIP and hepatic fibrosis. [LSM, β (95% CI), -0.39 (-1.06, 0.28), P = .2501]. Smooth-fitting curves examined the link across AIP and LSM and showed a U-shaped pattern, indicating their positive correlation with AIP less than 0.48. However, no significant correlation was observed with AIP more than 0.48. This study highlighted a substantial positive relationship across AIP and hepatic steatosis, as measured through CAP, and suggests that it may be used as an efficient and rapid measure for clinical prediction of hepatic steatosis.
MeSH term(s)	Humans ; Non-alcoholic Fatty Liver Disease/epidemiology ; Non-alcoholic Fatty Liver Disease/pathology ; Liver/pathology ; Nutrition Surveys ; Biopsy ; Elasticity Imaging Techniques ; Liver Cirrhosis/diagnosis
Language	English
Publishing date	2024-02-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	80184-7
ISSN	1536-5964 ; 0025-7974
ISSN (online)	1536-5964
ISSN	0025-7974
DOI	10.1097/MD.0000000000037152
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Article ; Online: Photocatalytic Reduction of Cr (VI) over g-C

Liang, Juan / Jing, Chengjun / Wang, Jiarong / Men, Yupawang

Molecules (Basel, Switzerland)

2021 Volume 26, Issue 22

Abstract: Graphitic carbon nitride (g- ... ...

Abstract	Graphitic carbon nitride (g-C
Language	English
Publishing date	2021-11-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules26227054
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Article: [Genetic Analysis of a Chinese Pedigree with Hereditary Spherocytosis Caused by Copy Number Variation Deletion of

Chen, Xiang-Lei / Li, Jing-Gang / Men, Qian / Li, Xin

Zhongguo shi yan xue ye xue za zhi

2023 Volume 31, Issue 1, Page(s) 183–188

Abstract: Objective: To investigate the molecular mechanism of the disease based on the clinical characterization and genetic mutation analysis in a family with hereditary spherocytosis.: Methods: The proband with jaundice and anemia was referred to Yidu ... ...

Abstract	Objective: To investigate the molecular mechanism of the disease based on the clinical characterization and genetic mutation analysis in a family with hereditary spherocytosis. Methods: The proband with jaundice and anemia was referred to Yidu Central Hospital of Weifang in May 2021. Peripheral blood samples were collected from six members of the family. Second-generation sequencing was used to screen the pathological mutations, and the clinically significant variant sites were selected. Then the relevant databases were used to analyze the variant sites, and RT-qPCR was used to detect the relative mRNA levels of candidate gene. The structure and function of SPTB protein were analyzed by UniProt and SMART databases. Results: We infer that the Conclusion: The CNV deletion of
MeSH term(s)	Humans ; DNA Copy Number Variations ; East Asian People ; Mutation ; Pedigree ; Spectrin/genetics ; Spherocytosis, Hereditary/genetics ; Spherocytosis, Hereditary/diagnosis
Chemical Substances	Spectrin (12634-43-4) ; SPTB protein, human
Language	Chinese
Publishing date	2023-02-10
Publishing country	China
Document type	English Abstract ; Journal Article
ZDB-ID	2404306-0
ISSN	1009-2137
ISSN	1009-2137
DOI	10.19746/j.cnki.issn.1009-2137.2023.01.029
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Article ; Online: Treatment of Ulcerative Colitis by Cationic Liposome Delivered NLRP3 siRNA.

Huang, Jing / Dai, Mengmeng / He, Mingxia / Bu, Weicheng / Cao, Liwen / Jing, Jing / Cao, Run / Zhang, Hailong / Men, Ke

International journal of nanomedicine

2023 Volume 18, Page(s) 4647–4662

Abstract: Purpose: The abnormal activation of NLRP3 inflammasome is related to the occurrence and development of ulcerative colitis (UC). However, the ideal drug and delivery system remain important factors limiting the targeting of NLRP3 inflammasome in UC ... ...

Abstract	Purpose: The abnormal activation of NLRP3 inflammasome is related to the occurrence and development of ulcerative colitis (UC). However, the ideal drug and delivery system remain important factors limiting the targeting of NLRP3 inflammasome in UC therapy. Gene therapy by delivering siRNA is effective in treating various diseases. Therefore, delivering siNLRP3 using an ideal vector for UC treatment is necessary. Materials and methods: Nanoparticles delivering siNLRP3 were developed based on cationic liposome (CLP/siNLRP3). Their ability to inhibit NLRP3 inflammasome activation was monitored using Western blot (WB) and Enzyme-linked Immunosorbent Assay (ELISA). The ASC oligomerization in LPS-primed peritoneal macrophages (PMs) was detected by WB and immunofluorescence. Moreover, we assessed the role of CLP/siNLRP3 on dextran sodium sulfate (DSS)-induced UC by examining NLRP3 levels, pro-inflammatory cytokines expression, and disease-associated index (DAI). Flow cytometry (FCM) was used to detect the contents of macrophages and T cells. Finally, we assessed the safety of CLP/siNLRP3. Results: The prepared CLP was spherical, with a small particle size (94 nm) and low permeability. The CLP could efficiently protect siNLRP3 from degradation and then deliver siNLRP3 into PMs, inhibiting NLRP3 inflammasome activation. Also, the CLP/siNLRP3 could inhibit the secretion of mature IL-1β and IL-18 from PMs, thereby achieving a favorable anti-inflammation effect. In vivo, CLP/siNLRP3 could effectively alleviate intestinal injury in UC mice, which was attributed to down-regulating levels of IL-1β and IL-18, inhibiting infiltration of macrophages and other immune cells, and the polarization of M1 macrophages. Finally, pathological testing of tissue sections and blood biochemical tests showed no significant toxic effects of CLP/siNLRP3. Conclusion: We introduced a prospective approach for the efficient delivery of siRNA in vitro and in vivo with high safety and stability, which was found to have great potential in treating NLRP3-driven diseases in an RNA-silencing manner.
MeSH term(s)	Animals ; Mice ; RNA, Small Interfering/genetics ; Interleukin-18 ; Liposomes ; NLR Family, Pyrin Domain-Containing 3 Protein/genetics ; Colitis, Ulcerative/chemically induced ; Colitis, Ulcerative/therapy ; Inflammasomes ; Cations
Chemical Substances	RNA, Small Interfering ; Interleukin-18 ; Liposomes ; NLR Family, Pyrin Domain-Containing 3 Protein ; Inflammasomes ; Cations
Language	English
Publishing date	2023-08-16
Publishing country	New Zealand
Document type	Journal Article
ZDB-ID	2364941-0
ISSN	1178-2013 ; 1176-9114
ISSN (online)	1178-2013
ISSN	1176-9114
DOI	10.2147/IJN.S413149
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Article ; Online: Comprehensive Analysis of TICRR in Hepatocellular Carcinoma Based on Bioinformatics Analysis.

Chen, Jing-Jing / Zhang, Lu-Lu / Liu, Zhen / Men, Wan Qi / Chen, Fang / Shen, Jilu

Biochemical genetics

2023 Volume 62, Issue 1, Page(s) 1–17

Abstract: Hepatocellular carcinoma (HCC) is one of the leading cause of cancer-associated death in the world. However, due to the complexity of HCC, it is urgent for us to find a reliable and accurate biomarker for HCC gene therapy.TopBP1-interacting checkpoint ... ...

Abstract	Hepatocellular carcinoma (HCC) is one of the leading cause of cancer-associated death in the world. However, due to the complexity of HCC, it is urgent for us to find a reliable and accurate biomarker for HCC gene therapy.TopBP1-interacting checkpoint and replication regulator (TICRR), known as Treslin in vertebrate and sld3 in yeast, is involved in the tumorigenesis, progression, matastasis, diagnosis, and predicting prognosis of HCC. Disappointingly, the mechanism of TICRR expression in HCC is still not described in detail and requires further analysis. In this study, TCGA ( www.tcga-data.nci.nih.gov/tcga/ ) datasets and GEO ( www.ncbi.nlm.nih.gov/geo ) datasets were used to analyze the expression of TICRR in HCC, the relevance of TICRR mRNA expression and clinicopathological characteristics in patients with HCC, and the relationship between TICRR expression and immune infiltration level in Patients with HCC. Based on MethSurv database, the impact of TICRR in patients with HCC was investigated. In addition, GO/KEGG enrichment analysis of TICRR co-expression was performed using the R package. TICRR was found drastically highly expressed in a variety of cancer types including HCC.ROC curve analysis showed that TICRR had higher accuracy in predicting HCC compared with AFP. The expression level of TICRR was marked positively correlated with tumor stage and prognosis in Patients with HCC.GO/KEGG enrichment analysis showed that TICRR was associated with cell division and cell cycle as well as p53 signaling pathway. In addition, patients with high TICRR methylation of cg05841809, cg09403165, and cg03312532 CpG sites were significantly correlated with poor prognosis of HCC. This study demonstrated that increased TICRR expression in HCC might play an important role in the tumorigenesis, progression, diagnosis, and predicting prognosis of HCC. Therefore, TICRR might be used as a promising diagnostic and prognostic biomarker for HCC gene therapy.
MeSH term(s)	Humans ; Carcinoma, Hepatocellular/genetics ; Liver Neoplasms/genetics ; Carcinogenesis ; Computational Biology ; Biomarkers ; Cell Cycle Proteins
Chemical Substances	Biomarkers ; TICRR protein, human ; Cell Cycle Proteins
Language	English
Publishing date	2023-06-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	2168-4
ISSN	1573-4927 ; 0006-2928
ISSN (online)	1573-4927
ISSN	0006-2928
DOI	10.1007/s10528-023-10378-w
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Article ; Online: Tissue Clearing and 3-D Visualization of Vasculature with the PEGASOS Method.

Jing, Dian / Men, Yi / Zhao, Hu

Methods in molecular biology (Clifton, N.J.)

2021 Volume 2319, Page(s) 1–13

Abstract: Tissue clearing techniques turn tissue transparent through a series of chemical and physical treatments. They have provided a useful tool for three-dimensional (3-D) imaging to study tissue spatial organization and interactions. Many tissue clearing ... ...

Abstract	Tissue clearing techniques turn tissue transparent through a series of chemical and physical treatments. They have provided a useful tool for three-dimensional (3-D) imaging to study tissue spatial organization and interactions. Many tissue clearing methods have been developed in recent years. Each method has its own application range depending on the purposes of the study. Three criteria for selecting an appropriate clearing method include clearing transparency, fluorescence preservation, and broad tissue applicability. PEG-associated solvent system (PEGASOS) emerged recently as a solvent-based tissue clearing method capable of rendering diverse tissues highly transparent while preserving fluorescence. Combined with vascular labeling techniques, PEGASOS method enables 3-D visualization of vasculature in whole tissues at subcellular resolution. Here, we describe the standard PEGASOS passive immersion protocol and several compatible vascular labeling techniques. Methods of 3-D imaging, data processing, and annotations are also briefly introduced.
MeSH term(s)	Animals ; Blood Vessels/diagnostic imaging ; Brain/diagnostic imaging ; Femur/diagnostic imaging ; Fluorescence ; Image Processing, Computer-Assisted ; Imaging, Three-Dimensional/methods ; Immunohistochemistry ; Kidney/diagnostic imaging ; Lung/diagnostic imaging ; Mandible/diagnostic imaging ; Mice ; Mice, Transgenic ; Polyethylene Glycols/chemistry ; Solvents/chemistry
Chemical Substances	Solvents ; Polyethylene Glycols (3WJQ0SDW1A)
Language	English
Publishing date	2021-07-30
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	1940-6029
ISSN (online)	1940-6029
DOI	10.1007/978-1-0716-1480-8_1
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Article ; Online: A robust COF@MXene membrane for ultra-high flux of water-in-oil emulsion separation.

Wang, Jing / Xu, Xiangqian / Zhou, Yujian / Ma, Wen / Wang, Fushan / Zhou, Yongjun / Men, Xuehu

Chemical communications (Cambridge, England)

2023 Volume 59, Issue 57, Page(s) 8858–8861

Abstract: A facile covalent assembly strategy is proposed for the preparation of superhydrophobic COF-stabilized MXene separation membranes. Ultra-high separation fluxes of up to 54 280 L ... ...

Abstract	A facile covalent assembly strategy is proposed for the preparation of superhydrophobic COF-stabilized MXene separation membranes. Ultra-high separation fluxes of up to 54 280 L m
Language	English
Publishing date	2023-07-13
Publishing country	England
Document type	Journal Article
ZDB-ID	1472881-3
ISSN	1364-548X ; 1359-7345 ; 0009-241X
ISSN (online)	1364-548X
ISSN	1359-7345 ; 0009-241X
DOI	10.1039/d3cc01951a
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Article ; Online: Morphological changes and bioaccumulation in response to cadmium exposure in

Xu, Hongyan / Xie, Zhanling / Guo, Jing / Men, Qing

Canadian journal of microbiology

2021 Volume 67, Issue 11, Page(s) 789–798

Abstract: ... ...

Abstract	Morchella
MeSH term(s)	Ascomycota ; Bioaccumulation ; Biodegradation, Environmental ; Cadmium/analysis ; Cadmium/toxicity
Chemical Substances	Cadmium (00BH33GNGH)
Language	English
Publishing date	2021-07-06
Publishing country	Canada
Document type	Journal Article
ZDB-ID	280534-0
ISSN	1480-3275 ; 0008-4166
ISSN (online)	1480-3275
ISSN	0008-4166
DOI	10.1139/cjm-2020-0571
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