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  1. Article: Editorial: Dry eye disease syndrome.

    Navas, Alejandro / Graue-Hernández, Enrique O / Perez, Victor L / Garfias, Yonathan

    Frontiers in medicine

    2023  Volume 9, Page(s) 1104593

    Language English
    Publishing date 2023-01-04
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2022.1104593
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Managing a Pigmented Corneal Ulcer in a 58-Year-Old Patient.

    Acosta, Alejandro / Ramirez Marquez, Estefania / Aguayo, Angel / Perez, Alejandro / Rivera, Lília / Oliver, Armando L

    Cureus

    2023  Volume 15, Issue 10, Page(s) e46850

    Abstract: We report on a case study involving a 58-year-old male with a pigmented corneal ulcer. The patient presented with a two-month history of an unresolved corneal ulcer in the oculus sinister (OS), accompanied by increasing ocular discomfort. His best ... ...

    Abstract We report on a case study involving a 58-year-old male with a pigmented corneal ulcer. The patient presented with a two-month history of an unresolved corneal ulcer in the oculus sinister (OS), accompanied by increasing ocular discomfort. His best corrected visual acuity (BCVA) was 20/20 oculus dexter and hand motion OS. Examination of OS revealed mild conjunctival injection, diffuse corneal edema, and the presence of a central pigmented lesion. Microbiological analysis via culture identified the causative agent as Ochroconis fungi, belonging to the dematiaceous species. Subsequently, the patient's condition was managed through a comprehensive regimen that included multiple topical antifungal agents, a topical antibiotic, and povidone-iodine drops. After two months of treatment, the patient exhibited improvement in his condition. His BCVA improved to counting fingers at a distance of two feet OS.
    Language English
    Publishing date 2023-10-11
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.46850
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Combined Predictive Model for Endoscopic Third Ventriculostomy Success in Adults and Children.

    Sistiaga, Iñigo L / Catalán-Uribarrena, Gregorio / Pérez-Fernández, Silvia / Carrasco, Alejandro / Iglesias, Jone / Ruiz de Gopegui, Edurne / Pomposo, Iñigo

    World neurosurgery

    2024  

    Abstract: Background: The selection of patients in whom endoscopic third ventriculostomy (ETV) can be effective remains poorly defined. The ETV success score (ETVSS) and the presence of bowing of the third ventricle have been identified as independent factors for ...

    Abstract Background: The selection of patients in whom endoscopic third ventriculostomy (ETV) can be effective remains poorly defined. The ETV success score (ETVSS) and the presence of bowing of the third ventricle have been identified as independent factors for predicting success, each with limitations. The objective of this study is to elaborate a combined predictive model to predict ETV success in a mixed cohort of patients.
    Methods: Demographic, intraoperative, postoperative, and radiologic variables were analyzed in all ventriculostomies performed consecutively at a single institution from December 2004 to December 2022. Qualitative and quantitative measurements of preoperative, immediate, and late postoperative magnetic resonance imaging were conducted. Univariate analysis and logistic regression models were performed.
    Results: 118 ETVs were performed in the selected period. Of these procedures, 106 met the inclusion criteria. The overall success rate was 71.7%, with a median follow-up of 3.64 years (interquartile range, 1.06-5.62). The median age was 36.1 years (interquartile range, 11.7-53.5). 35.84% were children (median, 7.81 years). Among the 80 patients with third ventricle bowing, the success rate was 88.8% (P < 0.001). Larger third ventricle dimensions on preoperative mid-sagittal magnetic resonance imaging were associated with increased ETV success. The model with the best receiver operating characteristic curves, with an area under the curve of 0.918 (95% confidence interval, 0.856-0.979) includes sex, ETVSS, presence of complications, and third ventricle bowing.
    Conclusions: The presence of bowing of the third ventricle is strongly associated with a higher ETV success rate. However, a combined predictive model that integrates it with the ETVSS is the most appropriate approach for selecting patients for ETV.
    Language English
    Publishing date 2024-02-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2534351-8
    ISSN 1878-8769 ; 1878-8750
    ISSN (online) 1878-8769
    ISSN 1878-8750
    DOI 10.1016/j.wneu.2024.02.119
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  4. Article: Review and New Perspectives on Non-Layered Manganese Compounds as Electrode Material for Sodium-Ion Batteries.

    Alcántara, Ricardo / Pérez-Vicente, Carlos / Lavela, Pedro / Tirado, José L / Medina, Alejandro / Stoyanova, Radostina

    Materials (Basel, Switzerland)

    2023  Volume 16, Issue 21

    Abstract: After more than 30 years of delay compared to lithium-ion batteries, sodium analogs are now emerging in the market. This is a result of the concerns regarding sustainability and production costs of the former, as well as issues related to safety and ... ...

    Abstract After more than 30 years of delay compared to lithium-ion batteries, sodium analogs are now emerging in the market. This is a result of the concerns regarding sustainability and production costs of the former, as well as issues related to safety and toxicity. Electrode materials for the new sodium-ion batteries may contain available and sustainable elements such as sodium itself, as well as iron or manganese, while eliminating the common cobalt cathode compounds and copper anode current collectors for lithium-ion batteries. The multiple oxidation states, abundance, and availability of manganese favor its use, as it was shown early on for primary batteries. Regarding structural considerations, an extraordinarily successful group of cathode materials are layered oxides of sodium, and transition metals, with manganese being the major component. However, other technologies point towards Prussian blue analogs, NASICON-related phosphates, and fluorophosphates. The role of manganese in these structural families and other oxide or halide compounds has until now not been fully explored. In this direction, the present review paper deals with the different Mn-containing solids with a non-layered structure already evaluated. The study aims to systematize the current knowledge on this topic and highlight new possibilities for further study, such as the concept of entatic state applied to electrodes.
    Language English
    Publishing date 2023-10-30
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2487261-1
    ISSN 1996-1944
    ISSN 1996-1944
    DOI 10.3390/ma16216970
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  5. Article ; Online: Effects of Maternal Stress on Breast Milk Production and the Microbiota of Very Premature Infants.

    Fernández-Tuñas, María Del Carmen / Pérez-Muñuzuri, Alejandro / Trastoy-Pena, Rocío / Pérez Del Molino, María Luisa / Couce, María L

    Nutrients

    2023  Volume 15, Issue 18

    Abstract: Perinatal stress experienced by mothers of very premature newborns may influence the mother's milk and the infant's intestinal microbiota. This prospective study of mothers of very preterm infants fed with mother's own milk (MOM) was carried out in a ... ...

    Abstract Perinatal stress experienced by mothers of very premature newborns may influence the mother's milk and the infant's intestinal microbiota. This prospective study of mothers of very preterm infants fed with mother's own milk (MOM) was carried out in a tertiary hospital over a 2-year period. The assessment of maternal stress in 45 mothers of 52 very preterm newborns using the parental stress scale (PSS:NICU) revealed an inverse relationship between stress and MOM production in the first days of life (
    Language English
    Publishing date 2023-09-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu15184006
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  6. Article ; Online: Combining Steam and Flue Gas as a Strategy to Support Energy Efficiency: A Comprehensive Review of the Associated Mechanisms.

    Pérez, Romel / Osma, Laura / García Duarte, Hugo Alejandro

    ACS omega

    2024  Volume 9, Issue 14, Page(s) 15732–15743

    Abstract: Conventional steam injection projects have long been an iconic process in the development of heavy oil reserves; nevertheless, they face significant challenges in terms of energy efficiency, environmental compliance, and economic viability. Factors such ... ...

    Abstract Conventional steam injection projects have long been an iconic process in the development of heavy oil reserves; nevertheless, they face significant challenges in terms of energy efficiency, environmental compliance, and economic viability. Factors such as oil price fluctuations, the imperative for an energy transition, and the push to reduce carbon footprints are hindering new or ongoing implementations of traditional steam injection technologies. In response to these challenges, hybrid methods, such as the combination of steam and flue gas, are emerging as an opportunity to optimize thermal processes to improve oil recovery, energy efficiency, and environmental sustainability and extend reservoir productivity life. Steam injection enhances oil recovery by reducing the viscosity of crude oil, improving oil mobility and facilitating its extraction. The utilization of flue gas in steam injection processes has a significant impact on oil recovery and energy efficiency, leveraging industrial byproducts. This not only lowers operating costs but also reduces environmental emissions, aligned with energy transition trends. Incorporating the flue gas into a steam-based process in heavy oil reservoirs has emerged as a promising thermally enhanced oil recovery strategy. This work presents a comprehensive review based on experimental, numerical, and field studies of hybrid steam and flue gas technology as an EOR process. The main recovery mechanisms associated with the process are analyzed. In addition, the laboratory equipment required for experimental evaluations is presented, and reservoir modeling, kinetic and compositional effects on reservoir fluids, and the reduction in heat losses in the steam injection process are discussed. Furthermore, field implementations are reviewed to evaluate lessons learned and experiences on an operative scale. The combination of steam and flue gas represents an opportunity for carbon utilization and geological carbon sequestration. This dual functionality underscores its potential to enhance oil recovery and address carbon-related environmental concerns.
    Language English
    Publishing date 2024-03-27
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.3c09889
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  7. Article ; Online: Antimicrobial Activity and Phytochemical Characterization of

    Rodríguez-Díaz, Maité / Pérez, Fabián E / Manosalva, Paloma M / Cerda, Juan I / Martínez-Contreras, Consuelo F / Mora, Aracely Y / Villagra, Nicolás A / Bucarey, Sergio A / Barriga, Andrés / Escobar, Jorge / Martínez, José L / Hidalgo, Alejandro A

    Molecules (Basel, Switzerland)

    2024  Volume 29, Issue 7

    Abstract: Few sclerophyllous plants from the central coast of Chile have been systematically studied. This work describes the phytochemical composition and antimicrobial properties ... ...

    Abstract Few sclerophyllous plants from the central coast of Chile have been systematically studied. This work describes the phytochemical composition and antimicrobial properties of
    MeSH term(s) Quercetin ; Baccharis ; Chile ; Tandem Mass Spectrometry ; Phytochemicals/pharmacology ; Flavonoids/pharmacology ; Plant Extracts/pharmacology ; Quinic Acid/analogs & derivatives
    Chemical Substances Quercetin (9IKM0I5T1E) ; caffeoylquinic acid ; Phytochemicals ; Flavonoids ; Plant Extracts ; Quinic Acid (058C04BGYI)
    Language English
    Publishing date 2024-04-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules29071654
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  8. Article ; Online: The vehicle of administration, feed or water, and prandial state influence the oral bioavailability of amoxicillin in piglets.

    Decundo, Julieta M / Dieguez, Susana N / Martínez, Guadalupe / Amanto, Fabián A / Gaudio, Denisa S Pérez / Soraci, Alejandro L

    Veterinary research communications

    2024  

    Abstract: Feed and water components may interact with drugs and affect their dissolution and bioavailability. The impact of the vehicle of administration (feed and water) and the prandial condition of weaner piglets on amoxicillin´s oral bioavailability was ... ...

    Abstract Feed and water components may interact with drugs and affect their dissolution and bioavailability. The impact of the vehicle of administration (feed and water) and the prandial condition of weaner piglets on amoxicillin´s oral bioavailability was evaluated. First, amoxicillin's in vitro dissolution and stability in purified, soft, and hard water, as well as release kinetics from feed in simulated gastric and intestinal media were assessed. Then, pharmacokinetic parameters and bioavailability were determined in fasted and fed pigs using soft water, hard water, or feed as vehicles of administration following a balanced incomplete block design. Amoxicillin showed similar dissolution profiles in soft and hard water, distinct from the dissolution profile obtained with purified water. Complete dissolution was only achieved in purified water, and merely reached 50% in soft or hard water. Once dissolved, antibiotic concentrations decreased by around 20% after 24 h in all solutions. Korsmeyer-Peppas model best described amoxicillin release from feed in simulated gastric and intestinal media. Feed considerably reduced antibiotic dissolution in both simulated media. In vivo, amoxicillin exhibited significantly higher bioavailability when delivered via water to fasted than to fed animals, while in-feed administration yielded the lowest values. All treatments showed a similar rate of drug absorption. In conclusion, we demonstrated that water and feed components, as well as feed present in gastrointestinal tract of piglets decrease amoxicillin´s oral bioavailability. Therefore, the use of oral amoxicillin as a broad-spectrum antibiotic to treat systemic infections in pigs should be thoroughly revised.
    Language English
    Publishing date 2024-04-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 406735-6
    ISSN 1573-7446 ; 0165-7380
    ISSN (online) 1573-7446
    ISSN 0165-7380
    DOI 10.1007/s11259-024-10378-0
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  9. Article: Laboratory-based determinants of simulated time trial performance in cyclists.

    Valenzuela, Pedro L / Alejo, Lidia B / Montalvo-Pérez, Almudena / Revuelta, Carlos / Ojanguren, Diego / Lucia, Alejandro / Barranco-Gil, David

    Biology of sport

    2023  Volume 40, Issue 4, Page(s) 1169–1176

    Abstract: Different laboratory-based variables are individually associated with cycling performance, but scarce evidence exists on which of them, when all assessed in combination, could best explain cycling performance. The present study aimed to examine the ... ...

    Abstract Different laboratory-based variables are individually associated with cycling performance, but scarce evidence exists on which of them, when all assessed in combination, could best explain cycling performance. The present study aimed to examine the combined association between laboratory-based endurance, strength/power and body composition indicators with time trial performance in high-level cyclists. Ninety-four male cyclists were recruited (age: 20 ± 3.5 years, maximum oxygen uptake [V̇O
    Language English
    Publishing date 2023-04-06
    Publishing country Poland
    Document type Journal Article
    ZDB-ID 639281-7
    ISSN 0860-021X
    ISSN 0860-021X
    DOI 10.5114/biolsport.2023.122484
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  10. Article ; Online: Collision tumor: Multinodular and vacuolating neuronal tumor with isocitrate dehydrogenase-mutant diffuse astrocytoma.

    Kumar, Vinodh A / Perez, Alejandro / Young, Angela L / Jones, Julia / O'Brien, Barbara J / Lang, Frederick F / Huse, Jason T / Fuller, Gregory N

    Neuropathology : official journal of the Japanese Society of Neuropathology

    2024  

    Abstract: Herein, we report a case of a collision tumor involving a multinodular and vacuolating neuronal tumor (MVNT) and a diffuse astrocytoma. A collision tumor between these two entities has not previously been reported. The patient is a 35-year-old woman who ... ...

    Abstract Herein, we report a case of a collision tumor involving a multinodular and vacuolating neuronal tumor (MVNT) and a diffuse astrocytoma. A collision tumor between these two entities has not previously been reported. The patient is a 35-year-old woman who presented with new-onset hearing loss and ringing in her right ear. Magnetic resonance imaging identified a non-enhancing mass involving the gray matter and subcortical white matter of the left middle frontal gyrus. Additionally, tiny clustered nodules were noted along the underlying subcortical ribbon and superficial subcortical white matter of the left superior frontal gyrus. The patient underwent a left frontal craniotomy and complete resection of the mass. Histologic examination of the resected specimen demonstrated a collision tumor consisting of a diffuse astrocytoma (isocitrate dehydrogenase [IDH] mutant, central nervous system [CNS] World Health Organization [WHO] grade 2) and an MVNT, with the latter demonstrating characteristic morphologic and immunohistochemical features.
    Language English
    Publishing date 2024-02-27
    Publishing country Australia
    Document type Case Reports
    ZDB-ID 1483794-8
    ISSN 1440-1789 ; 0919-6544
    ISSN (online) 1440-1789
    ISSN 0919-6544
    DOI 10.1111/neup.12968
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