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Book: Optical coherence tomography in neurological diseases

Calabresi, Peter A. / Balcer, Laura J. / Frohman, Elliot M.

(Cambridge medicine)

2015

Author's details	ed. by Peter A. Calabresi ; Laura J. Balcer ; Elliot M. Frohman
Series title	Cambridge medicine
Keywords	Nervous System Diseases / diagnosis ; Tomography, Optical Coherence
Subject code	616.8/04757
Language	English
Size	IX, 224 S. : zahlr. Ill., graph. Darst.
Publisher	Cambridge Univ. Press
Publishing place	Cambridge
Publishing country	Great Britain
Document type	Book
HBZ-ID	HT018651638
ISBN	978-1-107-04130-1 ; 1-107-04130-9
Database	Catalogue ZB MED Medicine, Health

In stock of ZB MED Cologne/Königswinter

Shelf mark	Loan status	Location
2015 A 1912	available for loan (reading room)	Lesesaal EG

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Article: Pain in Multiple Sclerosis: Understanding Pathophysiology, Diagnosis, and Management Through Clinical Vignettes.

Racke, Michael K / Frohman, Elliot M / Frohman, Teresa

Frontiers in neurology

2022 Volume 12, Page(s) 799698

Abstract: Neuropathic pain and other pain syndromes occur in the vast majority of patients with multiple sclerosis at some time during their disease course. Pain can become chronic and paroxysmal. In this review, we will utilize clinical vignettes to describe ... ...

Abstract	Neuropathic pain and other pain syndromes occur in the vast majority of patients with multiple sclerosis at some time during their disease course. Pain can become chronic and paroxysmal. In this review, we will utilize clinical vignettes to describe various pain syndromes associated with multiple sclerosis and their pathophysiology. These syndromes vary from central neuropathic pain or Lhermitte's phenomenon associated with central nervous system lesions to trigeminal neuralgia and optic neuritis pain associated with nerve lesions. Muscular pain can also arise due to spasticity. In addition, we will discuss strategies utilized to help patients manage these symptoms.
Language	English
Publishing date	2022-01-13
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2564214-5
ISSN	1664-2295
ISSN	1664-2295
DOI	10.3389/fneur.2021.799698
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: The menagerie of neurology: Animal signs and the refinement of clinical acumen.

Beh, Shin C / Frohman, Teresa / Frohman, Elliot M

Neurology. Clinical practice

2018 Volume 4, Issue 3, Page(s) e1–e9

Abstract: Neurology is a field known for "eponymophilia." While eponym use has been a controversial issue in medicine, animal-related metaphoric descriptions continue to flourish in neurologic practice, particularly with the advent of neuroimaging. To provide ... ...

Abstract	Neurology is a field known for "eponymophilia." While eponym use has been a controversial issue in medicine, animal-related metaphoric descriptions continue to flourish in neurologic practice, particularly with the advent of neuroimaging. To provide practicing and trainee neurologists with a useful reference for all these colorful eponyms, we performed a literature review and summarized the various animal eponyms in the practice of neurology (and their etiologic implications) to date. We believe that the ability to recognize animal-like attributes in clinical neurology and neuroradiology may be attributed to a visual phenomenon known as pareidolia. We propose that animal eponyms are a useful method of recognizing clinical and radiologic patterns that aid in the diagnostic process and therefore are effective aidesmémoire and communicative tools that enliven and improve the practice of neurology.
Language	English
Publishing date	2018-02-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	2645818-4
ISSN	2163-0933 ; 2163-0402
ISSN (online)	2163-0933
ISSN	2163-0402
DOI	10.1212/01.CPJ.0000437693.10265.a2
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Article: Neuroinflammatory disorders of the brain and inner ear: a systematic review of auditory function in patients with migraine, multiple sclerosis, and neurodegeneration to support the idea of an innovative 'window of discovery'.

Di Stadio, Arianna / De Luca, Pietro / Koohi, Nehzat / Kaski, Diego / Ralli, Massimo / Giesemann, Anja / Hartung, Hans-Peter / Altieri, Marta / Messineo, Daniela / Warnecke, Athanasia / Frohman, Teresa / Frohman, Elliot M

Frontiers in neurology

2023 Volume 14, Page(s) 1204132

Abstract: Background: Hearing can be impaired in many neurological conditions and can even represent a forme : Methods: A systematic review of the literature was performed, searching for papers with case-control studies that analyzed the hearing and migraine ... ...

Abstract	Background: Hearing can be impaired in many neurological conditions and can even represent a forme Methods: A systematic review of the literature was performed, searching for papers with case-control studies that analyzed the hearing and migraine function in patients with neuro-inflammatory, neurodegenerative disorders. With data extracted from these papers, the risk of patients with neurological distortion product otoacoustic emission (DPOAE) was then calculated. Results: Patients with neurological disorders (headache, Parkinson's disease, and multiple sclerosis) had a higher risk of having peripheral auditory deficits when compared to healthy individuals. Conclusion: Existing data lend credence to the hypothesis that inflammatory mediators transmitted via fluid exchange across this communication window, thereby represents a key pathobiological mechanism capable of culminating in hearing disturbances associated with neuroimmunological and neuroinflammatory disorders of the nervous system.
Language	English
Publishing date	2023-08-10
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2564214-5
ISSN	1664-2295
ISSN	1664-2295
DOI	10.3389/fneur.2023.1204132
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Article ; Online: In memoriam: The legacies of John F. Kurtzke and Richard T. Johnson.

Kildebeck, Eric J / Frohman, Elliot M

Nature reviews. Neurology

2016 Volume 12, Issue 5, Page(s) 256–257

Language	English
Publishing date	2016-05
Publishing country	England
Document type	Journal Article
ZDB-ID	2491514-2
ISSN	1759-4766 ; 1759-4758
ISSN (online)	1759-4766
ISSN	1759-4758
DOI	10.1038/nrneurol.2016.47
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Zs.A 6257: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
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Article: Targeting Neuroinflammation to Alleviate Chronic Olfactory Dysfunction in Long COVID: A Role for Investigating Disease-Modifying Therapy (DMT)?

Di Stadio, Arianna / Bernitsas, Evanthia / La Mantia, Ignazio / Brenner, Michael J / Ralli, Massimo / Vaira, Luigi Angelo / Colizza, Andrea / Cavaliere, Carlo / Laudani, Matteo / Frohman, Teresa C / De Vincentiis, Marco / Frohman, Elliot M / Altieri, Marta

Life (Basel, Switzerland)

2023 Volume 13, Issue 1

Abstract: Chronic olfactory dysfunction after SARS-CoV-2 infection occurs in approximately 10% of patients with COVID-19-induced anosmia, and it is a growing public health concern. A regimen of olfactory training and anti-neuroinflammatory therapy with co- ... ...

Abstract	Chronic olfactory dysfunction after SARS-CoV-2 infection occurs in approximately 10% of patients with COVID-19-induced anosmia, and it is a growing public health concern. A regimen of olfactory training and anti-neuroinflammatory therapy with co-ultramicronized palmitoylethanolamide with luteolin (um-PEA-LUT) has shown promising results in clinical trials; however, approximately 15% of treated patients do not achieve full recovery of a normal olfactory threshold, and almost 5% have no recovery. Disease-modifying therapies (DMTs), which are used to treat autoimmune neuroinflammation in multiple sclerosis (MS), have not been studied for treating persistent inflammation in refractory post-COVID-19 smell disorder. This study evaluated COVID-19-related smell loss and MS-related smell loss, comparing the responses to different therapies. Forty patients with MS and 45 reporting post-COVID-19 olfactory disorders were included in the study. All patients underwent nasal endoscopy and were evaluated by using validated Sniffin' Sticks testing. The patients with long COVID were treated for three months with um-PEA-LUT plus olfactory training. The patients with MS were treated with DMTs. Olfactory functions before and after treatment were analyzed in both groups. At the experimental endpoint, 13 patients in the COVID-19 group treated with um-PEA-LUT had residual olfactory impairment versus 10 patients in the MS group treated with DMTs. The severity of the persistent olfactory loss was lower in the MS group, and the patients with MS treated with IFN-beta and glatiramer acetate had the preservation of olfactory function. These data provide a rationale for considering prospective trials investigating the efficacy of DMTs for post-COVID-19 olfactory disorders that are refractory to um-PEA-LUT with olfactory training. This study is the first to consider the role of DMT in treating refractory post-viral olfactory loss in patients with long COVID.
Language	English
Publishing date	2023-01-13
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662250-6
ISSN	2075-1729
ISSN	2075-1729
DOI	10.3390/life13010226
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Article ; Online: A Randomized Prospective Trial Comparing Repository Corticotropin Injection and Intravenous Methylprednisolone for Neuroprotection in Acute Optic Neuritis.

Bennett, Jeffrey L / Grove, Nathan C / Johnson, Ruth K / Mizenko, Christopher / DuPont, Joan C / Wagner, Brandie D / Lynch, Anne M / Frohman, Teresa C / Shindler, Kenneth S / Frohman, Elliot M

Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society

2023 Volume 43, Issue 3, Page(s) 323–329

Abstract: Background: Repository corticotrophin injection (RCI, Acthar Gel) and intravenous methylprednisolone (IVMP) improve the rate but not the extent of visual recovery following acute optic neuritis. RCI has adrenal-stimulating and melanocortin receptor- ... ...

Abstract	Background: Repository corticotrophin injection (RCI, Acthar Gel) and intravenous methylprednisolone (IVMP) improve the rate but not the extent of visual recovery following acute optic neuritis. RCI has adrenal-stimulating and melanocortin receptor-stimulating properties that may endow it with unique anti-inflammatory properties relative to IVMP. Methods: Individuals with acute optic neuritis of less than 2 weeks duration were prospectively enrolled and randomized 1:1 to receive either RCI or IVMP. Peripapillary retinal nerve fiber layer (pRNFL) and ganglion cell plus inner plexiform layer thickness (GC + IPL) were serially evaluated by OCT. In addition, patient-reported outcomes (PROs) for changes in fatigue, mood, visual function, depression, and quality of life (QOL) were measured, and high and low contrast visual acuity were recorded. Results: Thirty-seven subjects were enrolled (19 RCI; 18 IVMP); the average time from symptom to treatment was 8.8 days. At 6 months, there was no difference in the primary outcome: loss of average pRNFL thickness in the affected eye (RCI vs IVMP: -13.1 vs -11.7 µm, P = 0.88) 6 months after randomization. Additional outcomes also showed no difference between treatment groups: 6-month attenuation of GC + IPL thickness (RCI vs IVMP: -13.8 vs -12.0 µm, P = 0.58) and frequency of pRNFL swelling at 1 month (RCI vs IVMP: 63% vs 72%, P = 0.73) and 3 months (RCI vs IVMP: 26% vs 31%, P = 0.99). Both treatments resulted in improvement in visual function and PROs. Conclusions: Treatment of acute optic neuritis with RCI or IVMP produced no clinically meaningful differences in optic nerve structure or visual function.
MeSH term(s)	Humans ; Methylprednisolone/therapeutic use ; Quality of Life ; Neuroprotection ; Prospective Studies ; Optic Neuritis/diagnosis ; Optic Neuritis/drug therapy ; Adrenocorticotropic Hormone ; Tomography, Optical Coherence/methods
Chemical Substances	Methylprednisolone (X4W7ZR7023) ; Adrenocorticotropic Hormone (9002-60-2)
Language	English
Publishing date	2023-06-01
Publishing country	United States
Document type	Randomized Controlled Trial ; Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	1189901-3
ISSN	1536-5166 ; 1070-8022
ISSN (online)	1536-5166
ISSN	1070-8022
DOI	10.1097/WNO.0000000000001878
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Article ; Online: Optical coherence tomography angiography measurements in multiple sclerosis: a systematic review and meta-analysis.

Mohammadi, Soheil / Gouravani, Mahdi / Salehi, Mohammad Amin / Arevalo, J Fernando / Galetta, Steven L / Harandi, Hamid / Frohman, Elliot M / Frohman, Teresa C / Saidha, Shiv / Sattarnezhad, Neda / Paul, Friedemann

Journal of neuroinflammation

2023 Volume 20, Issue 1, Page(s) 85

Abstract: Background and objectives: Recent literature on multiple sclerosis (MS) demonstrates the growing implementation of optical coherence tomography-angiography (OCT-A) to discover potential qualitative and quantitative changes in the retina and optic nerve. ...

Abstract	Background and objectives: Recent literature on multiple sclerosis (MS) demonstrates the growing implementation of optical coherence tomography-angiography (OCT-A) to discover potential qualitative and quantitative changes in the retina and optic nerve. In this review, we analyze OCT-A studies in patients with MS and examine its utility as a surrogate or precursor to changes in central nervous system tissue. Methods: PubMed and EMBASE were systematically searched to identify articles that applied OCT-A to evaluate the retinal microvasculature measurements in patients with MS. Quantitative data synthesis was performed on all measurements which were evaluated in at least two unique studies with the same OCT-A devices, software, and study population compared to controls. A fixed-effects or random-effects model was applied for the meta-analysis based on the heterogeneity level. Results: The study selection process yielded the inclusion of 18 studies with a total of 1552 evaluated eyes in 673 MS-associated optic neuritis (MSON) eyes, 741 MS without optic neuritis (MSNON eyes), and 138 eyes without specification for the presence of optic neuritis (ON) in addition to 1107 healthy control (HC) eyes. Results indicated that MS cases had significantly decreased whole image superficial capillary plexus (SCP) vessel density when compared to healthy control subjects in the analyses conducted on Optovue and Topcon studies (both P < 0.0001). Likewise, the whole image vessel densities of deep capillary plexus (DCP) and radial peripapillary capillary (RPC) were significantly lower in MS cases compared to HC (all P < 0.05). Regarding optic disc area quadrants, MSON eyes had significantly decreased mean RPC vessel density compared to MSNON eyes in all quadrants except for the inferior (all P < 0.05). Results of the analysis of studies that used prototype Axsun machine revealed that MSON and MSNON eyes both had significantly lower ONH flow index compared to HC (both P < 0.0001). Conclusions: This systematic review and meta-analysis of the studies reporting OCT-A measurements of people with MS confirmed the tendency of MS eyes to exhibit reduced vessel density in the macular and optic disc areas, mainly in SCP, DCP, and RPC vessel densities.
MeSH term(s)	Humans ; Tomography, Optical Coherence/methods ; Multiple Sclerosis/diagnostic imaging ; Retina ; Angiography ; Retinal Vessels/diagnostic imaging ; Optic Neuritis ; Fluorescein Angiography/methods
Language	English
Publishing date	2023-03-27
Publishing country	England
Document type	Meta-Analysis ; Systematic Review ; Journal Article ; Review
ZDB-ID	2156455-3
ISSN	1742-2094 ; 1742-2094
ISSN (online)	1742-2094
ISSN	1742-2094
DOI	10.1186/s12974-023-02763-4
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Article ; Online: Cerebellar Control of Eye Movements.

Beh, Shin C / Frohman, Teresa C / Frohman, Elliot M

Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society

2017 Volume 37, Issue 1, Page(s) 87–98

Abstract: Background: The cerebellum plays a central role in the online, real-time control, and long-term modulation of eye movements.: Evidence acquisition: We reviewed the latest (fifth) edition of Leigh and Zee's textbook, The Neurology of Eye Movements, ... ...

Abstract	Background: The cerebellum plays a central role in the online, real-time control, and long-term modulation of eye movements. Evidence acquisition: We reviewed the latest (fifth) edition of Leigh and Zee's textbook, The Neurology of Eye Movements, and literature in PUBMED using the following terms: cerebellum, flocculus, paraflocculus, vermis, oculomotor vermis, dorsal vermis, caudal fastigial nucleus, fastigial oculomotor region, uvula, nodulus, ansiform lobule, eye movements, saccades, ipsipulsion, contrapulsion, smooth pursuit, vergence, convergence, divergence, gaze-holding, down beat nystagmus, vestibulo-ocular reflex (VOR), angular VOR, translational VOR, skew deviation, velocity storage. Results: The cerebellum is vital in optimizing the performance of all classes of gaze-shifting and gaze-stabilizing reflexes. The flocculus-paraflocculus are crucial to VOR gain and direction, pulse-step matching for saccades, pursuit gain, and gaze-holding. The ocular motor vermis and caudal fastigial nuclei are essential in saccadic adaptation and accuracy, and pursuit gain. The nodulus and ventral uvula are involved in processing otolothic signals and VOR responses, including velocity storage. Conclusions: The cerebellum guarantees the precision of ocular movements to optimize visual performance and occupies a central role in all classes of eye movements both in real-time control and in long-term calibration and learning (i.e., adaptation).
MeSH term(s)	Animals ; Cerebellum/physiology ; Eye Movements/physiology ; Humans ; Reflex, Vestibulo-Ocular/physiology
Language	English
Publishing date	2017-03
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1189901-3
ISSN	1536-5166 ; 1070-8022
ISSN (online)	1536-5166
ISSN	1070-8022
DOI	10.1097/WNO.0000000000000456
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Article: Acute optic neuritis: a clinical paradigm for evaluation of neuroprotective and restorative strategies?

Qureshi, Sara S / Frohman, Elliot M

Neural regeneration research

2015 Volume 10, Issue 10, Page(s) 1599–1601

Language	English
Publishing date	2015-11-21
Publishing country	India
Document type	Journal Article
ZDB-ID	2388460-5
ISSN	1876-7958 ; 1673-5374
ISSN (online)	1876-7958
ISSN	1673-5374
DOI	10.4103/1673-5374.165286
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