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  1. Article ; Online: The overwhelming role of ballistic photons in ultrasonically guided light through tissue.

    Edrei, Eitan / Scarcelli, Giuliano

    Nature communications

    2022  Volume 13, Issue 1, Page(s) 1873

    MeSH term(s) Light ; Photons ; Scattering, Radiation ; Ultrasonography
    Language English
    Publishing date 2022-04-06
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-022-29157-z
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  2. Article ; Online: The overwhelming role of ballistic photons in ultrasonically guided light through tissue

    Eitan Edrei / Giuliano Scarcelli

    Nature Communications, Vol 13, Iss 1, Pp 1-

    2022  Volume 2

    Keywords Science ; Q
    Language English
    Publishing date 2022-04-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Adaptive optics in spectroscopy and densely labeled-fluorescence applications.

    Edrei, Eitan / Scarcelli, Giuliano

    Optics express

    2019  Volume 26, Issue 26, Page(s) 33865–33877

    Abstract: Adaptive optics systems have been integrated in many imaging modalities in order to correct for aberrations that are introduced by samples and optical elements. Usually, the optical system has access to a guide star (i.e., a point-like structure that is ... ...

    Abstract Adaptive optics systems have been integrated in many imaging modalities in order to correct for aberrations that are introduced by samples and optical elements. Usually, the optical system has access to a guide star (i.e., a point-like structure that is smaller than the diffraction limit). This guide star can be used as a beacon for adaptive optics enhancement. In contrast, for spectroscopy and densely-labeled fluorescent samples, the signal is diffused throughout the entire beam path and is not confined to a well-defined point-like structure. Here, we show analytically and experimentally that, in these scenarios, adaptive optics systems are expected to yield significantly lower signal enhancement than when a guide star is available. We discuss adaptive optics' performance degradation for different imaging modalities (e.g., confocal, multi-photon microscopy) and identify solutions to overcome low signal enhancements.
    Language English
    Publishing date 2019-01-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1491859-6
    ISSN 1094-4087 ; 1094-4087
    ISSN (online) 1094-4087
    ISSN 1094-4087
    DOI 10.1364/OE.26.033865
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  4. Article ; Online: A trade-off between speckle size and intensity enhancement of a focal point behind a scattering layer.

    Edrei, Eitan / Scarcelli, Giuliano

    Scientific reports

    2019  Volume 9, Issue 1, Page(s) 11256

    Abstract: Focusing light through highly scattering materials by modifying the phase profile of the illuminating beam has attracted a great deal of attention in the past decade paving the way towards novel applications. Here we report on a tradeoff between two ... ...

    Abstract Focusing light through highly scattering materials by modifying the phase profile of the illuminating beam has attracted a great deal of attention in the past decade paving the way towards novel applications. Here we report on a tradeoff between two seemingly independent quantities of critical importance in the focusing process: the size of the focal point obtained behind a scattering medium and the maximum achievable intensity of such focal point. We theoretically derive and experimentally demonstrate the practical limits of intensity enhancement of the focal point and relate them to the intrinsic properties of the scattering phenomenon. We demonstrate that the intensity enhancement limitation becomes dominant when the focusing plane gets closer to the scattering layer thus limiting the ability to obtain tight focusing at high contrast, which has direct relevance for the many applications exploring scattering materials as a platform for high resolution focusing and imaging.
    Language English
    Publishing date 2019-08-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-019-47679-3
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  5. Article ; Online: A trade-off between speckle size and intensity enhancement of a focal point behind a scattering layer

    Eitan Edrei / Giuliano Scarcelli

    Scientific Reports, Vol 9, Iss 1, Pp 1-

    2019  Volume 7

    Abstract: Abstract Focusing light through highly scattering materials by modifying the phase profile of the illuminating beam has attracted a great deal of attention in the past decade paving the way towards novel applications. Here we report on a tradeoff between ...

    Abstract Abstract Focusing light through highly scattering materials by modifying the phase profile of the illuminating beam has attracted a great deal of attention in the past decade paving the way towards novel applications. Here we report on a tradeoff between two seemingly independent quantities of critical importance in the focusing process: the size of the focal point obtained behind a scattering medium and the maximum achievable intensity of such focal point. We theoretically derive and experimentally demonstrate the practical limits of intensity enhancement of the focal point and relate them to the intrinsic properties of the scattering phenomenon. We demonstrate that the intensity enhancement limitation becomes dominant when the focusing plane gets closer to the scattering layer thus limiting the ability to obtain tight focusing at high contrast, which has direct relevance for the many applications exploring scattering materials as a platform for high resolution focusing and imaging.
    Keywords Medicine ; R ; Science ; Q
    Subject code 535
    Language English
    Publishing date 2019-08-01T00:00:00Z
    Publisher Nature Publishing Group
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article: Brillouin micro-spectroscopy through aberrations via sensorless adaptive optics.

    Edrei, Eitan / Scarcelli, Giuliano

    Applied physics letters

    2018  Volume 112, Issue 16, Page(s) 163701

    Abstract: Brillouin spectroscopy is a powerful optical technique for non-contact viscoelastic characterizations which has recently found applications in three-dimensional mapping of biological samples. Brillouin spectroscopy performances are rapidly degraded by ... ...

    Abstract Brillouin spectroscopy is a powerful optical technique for non-contact viscoelastic characterizations which has recently found applications in three-dimensional mapping of biological samples. Brillouin spectroscopy performances are rapidly degraded by optical aberrations and have therefore been limited to homogenous transparent samples. In this work, we developed an adaptive optics (AO) configuration designed for Brillouin scattering spectroscopy to engineer the incident wavefront and correct for aberrations. Our configuration does not require direct wavefront sensing and the injection of a "guide-star"; hence, it can be implemented without the need for sample pre-treatment. We used our AO-Brillouin spectrometer in aberrated phantoms and biological samples and obtained improved precision and resolution of Brillouin spectral analysis; we demonstrated 2.5-fold enhancement in Brillouin signal strength and 1.4-fold improvement in axial resolution because of the correction of optical aberrations.
    Language English
    Publishing date 2018-05-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1469436-0
    ISSN 1077-3118 ; 0003-6951
    ISSN (online) 1077-3118
    ISSN 0003-6951
    DOI 10.1063/1.5027838
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  7. Article ; Online: Chip-scale atomic wave-meter enabled by machine learning.

    Edrei, Eitan / Cohen, Niv / Gerstel, Elam / Gamzu-Letova, Shani / Mazurski, Noa / Levy, Uriel

    Science advances

    2022  Volume 8, Issue 15, Page(s) eabn3391

    Abstract: The quest for miniaturized optical wave-meters and spectrometers has accelerated the design of novel approaches in the field. Particularly, random spectrometers (RS) using the one-to-one correlation between the wavelength and an output random ... ...

    Abstract The quest for miniaturized optical wave-meters and spectrometers has accelerated the design of novel approaches in the field. Particularly, random spectrometers (RS) using the one-to-one correlation between the wavelength and an output random interference pattern emerged as a promising tool combining high spectral resolution and cost-effectiveness. Recently, a chip-scale platform for RS has been demonstrated with a markedly reduced footprint. Yet, despite the evident advantages of such modalities, they are very susceptible to environmental fluctuations and require an external calibration process. To address these challenges, we demonstrate a paradigm shift in the field, enabled by the integration of atomic vapor with a photonic chip and the use of a machine learning classification algorithm. Our approach provides a random wave-meter on chip device with accurate calibration and enhanced robustness against environmental fluctuations. The demonstrated device is expected to pave the way toward fully integrated spectrometers advancing the field of silicon photonics.
    Language English
    Publishing date 2022-04-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2810933-8
    ISSN 2375-2548 ; 2375-2548
    ISSN (online) 2375-2548
    ISSN 2375-2548
    DOI 10.1126/sciadv.abn3391
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  8. Article ; Online: Spectrally Gated Microscopy (SGM) with Meta Optics for Parallel Three-Dimensional Imaging.

    Edrei, Eitan / Weiss, Aharon / Engelberg, Jacob / Zektzer, Roy / Mazurski, Noa / Levy, Uriel

    ACS nano

    2021  Volume 15, Issue 11, Page(s) 17375–17383

    Abstract: Volumetric imaging with high spatiotemporal resolution is of utmost importance for various applications ranging from aerospace and defense to real-time imaging of dynamic biological processes. To facilitate three-dimensional sectioning, current ... ...

    Abstract Volumetric imaging with high spatiotemporal resolution is of utmost importance for various applications ranging from aerospace and defense to real-time imaging of dynamic biological processes. To facilitate three-dimensional sectioning, current technology relies on mechanisms to reject light from adjacent out-of-focus planes either spatially or by other means. Yet, the combination of rapid acquisition time and high axial resolution is still elusive, motivating a persistent pursuit for emerging imaging approaches. Here we introduce and experimentally demonstrate a concept named spectrally gated microscopy (SGM), which enables a single-shot interrogation over the full axial dimension while maintaining a submicron sectioning resolution. SGM utilizes two important features enabled by flat optics (i.e., metalenses or diffractive lenses), namely, a short focal length and strong chromatic aberrations. Using SGM we demonstrate three-dimensional imaging of millimeter-scale samples while scanning only the lateral dimension, presenting a significant advantage over state-of-the-art technology.
    MeSH term(s) Microscopy ; Imaging, Three-Dimensional ; Lenses ; Optics and Photonics
    Language English
    Publishing date 2021-10-11
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1936-086X
    ISSN (online) 1936-086X
    DOI 10.1021/acsnano.1c06646
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  9. Article ; Online: Memory-effect based deconvolution microscopy for super-resolution imaging through scattering media.

    Edrei, Eitan / Scarcelli, Giuliano

    Scientific reports

    2016  Volume 6, Page(s) 33558

    Abstract: High-resolution imaging through turbid media is a fundamental challenge of optical sciences that has attracted a lot of attention in recent years for its wide range of potential applications. Here, we demonstrate that the resolution of imaging systems ... ...

    Abstract High-resolution imaging through turbid media is a fundamental challenge of optical sciences that has attracted a lot of attention in recent years for its wide range of potential applications. Here, we demonstrate that the resolution of imaging systems looking behind a highly scattering medium can be improved below the diffraction-limit. To achieve this, we demonstrate a novel microscopy technique enabled by the optical memory effect that uses a deconvolution image processing and thus it does not require iterative focusing, scanning or phase retrieval procedures. We show that this newly established ability of direct imaging through turbid media provides fundamental and practical advantages such as three-dimensional refocusing and unambiguous object reconstruction.
    Language English
    Publishing date 2016-09-16
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/srep33558
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  10. Article: Optical imaging through dynamic turbid media using the Fourier-domain shower-curtain effect.

    Edrei, Eitan / Scarcelli, Giuliano

    Optica

    2016  Volume 3, Issue 1, Page(s) 71–74

    Abstract: Several phenomena have been recently exploited to circumvent scattering and have succeeded in imaging or focusing light through turbid layers. However, the requirement for the turbid medium to be steady during the imaging process remains a fundamental ... ...

    Abstract Several phenomena have been recently exploited to circumvent scattering and have succeeded in imaging or focusing light through turbid layers. However, the requirement for the turbid medium to be steady during the imaging process remains a fundamental limitation of these methods. Here we introduce an optical imaging modality that overcomes this challenge by taking advantage of the so-called shower-curtain effect, adapted to the spatial-frequency domain via speckle correlography. We present high resolution imaging of objects hidden behind millimeter-thick tissue or dense lens cataracts. We demonstrate our imaging technique to be insensitive to rapid medium movements (> 5 m/s) beyond any biologically-relevant motion. Furthermore, we show this method can be extended to several contrast mechanisms and imaging configurations.
    Language English
    Publishing date 2016-01-13
    Publishing country United States
    Document type Journal Article
    ISSN 2334-2536
    ISSN 2334-2536
    DOI 10.1364/OPTICA.3.000071
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