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Article ; Online: Fatal outcome of first case of

van Ommen, Anne Margje Lisa Naomi / Slavenburg, Serena / Diepersloot, Rob / de Vries Feyens, Cornelia Adriana

European heart journal. Case reports

2020 Volume 4, Issue 1, Page(s) 1–4

Abstract: Background: Infective endocarditis is a relatively common disease in a cardiologist's daily practice. Nowadays more detailed information about pathogens is provided to us by diagnostics such as MALDI Biotyper Massa Spectrometer. We present a case of ... ...

Abstract	Background: Infective endocarditis is a relatively common disease in a cardiologist's daily practice. Nowadays more detailed information about pathogens is provided to us by diagnostics such as MALDI Biotyper Massa Spectrometer. We present a case of endocarditis lenta in which Case summary: A 58-year-old man was admitted with high suspicion of endocarditis lenta complicated by severe kidney dysfunction and anaemia. He was treated with penicillin and gentamycin. Transthoracic echocardiogram revealed a large vegetation at the mitral valve and MALDI Biotyper Massa Spectrometer (Microflex) revealed Discussion: Streptococcus sinensis
Language	English
Publishing date	2020-01-25
Publishing country	England
Document type	Case Reports
ISSN	2514-2119
ISSN (online)	2514-2119
DOI	10.1093/ehjcr/ytz237
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Article ; Online: Rapid, random-access, and quantification of hepatitis B virus using the Cepheid Xpert HBV viral load assay.

Auzin, Ali M / Slavenburg, Serena / Peters, Cas / Boland, Greet / Rahamat-Langendoen, Janette / Melchers, Willem J G / Schuurman, Rob

Journal of medical virology

2020 Volume 93, Issue 6, Page(s) 3999–4003

Abstract: Background: Monitoring viral load (VL) is an essential part of the management of patients chronically infected with hepatitis B virus (HBV). The commercial HBV VL assays currently available are generally performed on high-throughput platforms for batch ... ...

Abstract	Background: Monitoring viral load (VL) is an essential part of the management of patients chronically infected with hepatitis B virus (HBV). The commercial HBV VL assays currently available are generally performed on high-throughput platforms for batch wise testing of plasma samples, with relatively long turn-around-times. Rapid VL testing could provide immediate input to clinical decision making. Methods: One hundred two stored plasma samples from 102 patients who were previously tested for HBV VL by the Cobas Ampliprep/Taqman or Cobas 4800 (Roche, Pleasanton, CA), were analyzed by the recently introduced Cepheid Xpert HBV Viral Load Assay. Thirty-one of the 102 samples were negative for HBV DNA and 71 out of 102 samples had a detectable VL. HBV DNA loads ranged from <20 to 5E8 IU/mL. HBV genotypes (A, B, C, D, E, and G) were known for 52 of the VL positive samples. Correlation of VL results between both assays was determined by the Pearson correlation coefficient (r Results: HBV VLs correlated well between both assays, across all genotypes (Pearson correlation coefficient r Conclusion: High correlation was observed between the Roche Cobas HBV Viral Load tests and the Xpert HBV Viral Load Assay, thus enabling rapid, random access, and accurate HBV VL assessment.
MeSH term(s)	DNA, Viral/blood ; Genotype ; Hepatitis B/blood ; Hepatitis B/diagnosis ; Hepatitis B/virology ; Hepatitis B virus/classification ; Hepatitis B virus/genetics ; Hepatitis B virus/isolation & purification ; Humans ; Limit of Detection ; Molecular Diagnostic Techniques/methods ; Molecular Diagnostic Techniques/standards ; Sensitivity and Specificity ; Viral Load/instrumentation ; Viral Load/methods
Chemical Substances	DNA, Viral
Language	English
Publishing date	2020-08-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	752392-0
ISSN	1096-9071 ; 0146-6615
ISSN (online)	1096-9071
ISSN	0146-6615
DOI	10.1002/jmv.26392
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Zs.A 1320: Show issues

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Article ; Online: Large outbreak of typhoid fever on a river cruise ship used as accommodation for asylum seekers, the Netherlands, 2022.

Ooms, Daisy / de Vries, Anne / Koedijk, Femke Dh / Generaal, Ellen / Friesema, Ingrid Hm / Rouvroye, Maxine / van Lelyveld, Steven Fl / van den Beld, Maaike Jc / Notermans, Daan W / van Schelven, Patrick / van den Brink, Janine Fh / Hartog, Tanja / Veenstra, Thijs / Slavenburg, Serena / Sinnige, Jan C / Ruijs, Wilhelmina Lm

Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin

2023 Volume 29, Issue 5

Abstract: On 6 April 2022, the Public Health Service of Kennemerland, the Netherlands, was notified about an outbreak of fever and abdominal complaints on a retired river cruise ship, used as shelter for asylum seekers. The diagnosis typhoid fever was confirmed on ...

Abstract	On 6 April 2022, the Public Health Service of Kennemerland, the Netherlands, was notified about an outbreak of fever and abdominal complaints on a retired river cruise ship, used as shelter for asylum seekers. The diagnosis typhoid fever was confirmed on 7 April. An extensive outbreak investigation was performed. Within 47 days, 72 typhoid fever cases were identified among asylum seekers (n = 52) and staff (n = 20), of which 25 were hospitalised. All recovered after treatment. Consumption of food and tap water on the ship was associated with developing typhoid fever. The freshwater and wastewater tanks shared a common wall with severe corrosion and perforations, enabling wastewater to leak into the freshwater tank at high filling levels.
MeSH term(s)	Humans ; Typhoid Fever/diagnosis ; Typhoid Fever/epidemiology ; Typhoid Fever/microbiology ; Ships ; Rivers ; Refugees ; Netherlands/epidemiology ; Wastewater ; Salmonella typhi/genetics ; Disease Outbreaks
Chemical Substances	Wastewater
Language	English
Publishing date	2023-10-27
Publishing country	Sweden
Document type	Journal Article
ZDB-ID	1338803-4
ISSN	1560-7917 ; 1025-496X
ISSN (online)	1560-7917
ISSN	1025-496X
DOI	10.2807/1560-7917.ES.2024.29.5.2300211
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Article ; Online: Treatment of chronic hepatitis C in haemodialysis patients requires more ribavirin.

Slavenburg, Serena / Drenth, Joost P H

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association

2008 Volume 23, Issue 7, Page(s) 2430; author reply 2430–1

MeSH term(s)	Adult ; Antiviral Agents/therapeutic use ; Dose-Response Relationship, Drug ; Drug Therapy, Combination ; Hepatitis C, Chronic/drug therapy ; Humans ; Interferon-alpha/therapeutic use ; Kidney Failure, Chronic/therapy ; Male ; Polyethylene Glycols/therapeutic use ; Recombinant Proteins ; Renal Dialysis ; Ribavirin/therapeutic use ; Treatment Outcome
Chemical Substances	Antiviral Agents ; Interferon-alpha ; Recombinant Proteins ; Polyethylene Glycols (30IQX730WE) ; interferon alfa-2a (47RRR83SK7) ; Ribavirin (49717AWG6K) ; peginterferon alfa-2a (Q46947FE7K)
Language	English
Publishing date	2008-07
Publishing country	England
Document type	Case Reports ; Letter ; Comment
ZDB-ID	90594-x
ISSN	1460-2385 ; 0931-0509
ISSN (online)	1460-2385
ISSN	0931-0509
DOI	10.1093/ndt/gfn022
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Article ; Online: Pneumonitis as a consequence of (peg)interferon-ribavirin combination therapy for hepatitis C: a review of the literature.

Slavenburg, Serena / Heijdra, Yvonne F / Drenth, Joost P H

Digestive diseases and sciences

2009 Volume 55, Issue 3, Page(s) 579–585

Abstract: Combination of peginterferon and ribavirin is the current therapy for chronic hepatitis C infection (HCV). Interstitial pneumonitis is a rare side-effect of HCV therapy and is an important cause of dose reduction or discontinuation, impairing success of ... ...

Abstract	Combination of peginterferon and ribavirin is the current therapy for chronic hepatitis C infection (HCV). Interstitial pneumonitis is a rare side-effect of HCV therapy and is an important cause of dose reduction or discontinuation, impairing success of antiviral therapy. We performed a review of the literature in order to present diagnostic modalities and possible treatments for pneumonitis and to offer guidelines. We searched for cases where pneumonitis as a side-effect of HCV treatment was documented. First we performed a literature search via PubMed and Web of Science interface and second we searched three drug toxicity databases. We systematically analyzed all case reports with respect to clinical manifestations, type of treatment, and outcome. A literature search revealed 19 articles, containing 25 case descriptions, while we traced 33 cases from the drug toxicity databases. Pneumonitis presented with any of the combination of fever, dyspnea, and cough and can arise with any type of (conventional or pegylated) interferon. Mortality secondary to pneumonitis was seen in 7% of cases, exclusively with peginterferon alpha-2b. In most cases therapy was discontinued and steroids were started. Interferon-induced pneumonitis during HCV treatment is a severe complication and should be recognized in order to prevent further pulmonary damage and/or death.
MeSH term(s)	Aged ; Antiviral Agents/administration & dosage ; Antiviral Agents/adverse effects ; Drug Therapy, Combination/adverse effects ; Female ; Hepatitis C, Chronic/drug therapy ; Humans ; Interferon alpha-2 ; Interferon-alpha/administration & dosage ; Interferon-alpha/adverse effects ; Lung Diseases, Interstitial/chemically induced ; Male ; Middle Aged ; Polyethylene Glycols/administration & dosage ; Polyethylene Glycols/adverse effects ; Recombinant Proteins ; Ribavirin/administration & dosage ; Ribavirin/adverse effects
Chemical Substances	Antiviral Agents ; Interferon alpha-2 ; Interferon-alpha ; Recombinant Proteins ; Polyethylene Glycols (3WJQ0SDW1A) ; Ribavirin (49717AWG6K) ; peginterferon alfa-2b (G8RGG88B68)
Keywords	covid19
Language	English
Publishing date	2009-04-28
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	304250-9
ISSN	1573-2568 ; 0163-2116
ISSN (online)	1573-2568
ISSN	0163-2116
DOI	10.1007/s10620-009-0797-1
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Article ; Online: Comparison of health-related quality of life between populations.

Slavenburg, Serena / van Oijen, Martijn G H / Spiegel, Brennan M R

Liver international : official journal of the International Association for the Study of the Liver

2008 Volume 28, Issue 2, Page(s) 285–6; author reply 286–7

MeSH term(s)	Data Collection/methods ; Hepatitis B, Chronic/physiopathology ; Hepatitis B, Chronic/psychology ; Hepatitis C, Chronic/physiopathology ; Hepatitis C, Chronic/psychology ; Humans ; Liver Cirrhosis, Biliary/physiopathology ; Liver Cirrhosis, Biliary/psychology ; Quality of Life ; Surveys and Questionnaires
Language	English
Publishing date	2008-02
Publishing country	United States
Document type	Comment ; Letter
ZDB-ID	2102783-3
ISSN	1478-3231 ; 1478-3223
ISSN (online)	1478-3231
ISSN	1478-3223
DOI	10.1111/j.1478-3231.2007.01622.x
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Article: Pneumonitis as A Consequence of (Peg)Interferon-Ribavirin Combination Therapy for Hepatitis C: a Review of the Literature

Slavenburg, Serena / Heijdra, Yvonne F / Drenth, Joost P. H

Digestive diseases and sciences. 2010 Mar., v. 55, no. 3

2010

Abstract	Combination of peginterferon and ribavirin is the current therapy for chronic hepatitis C infection (HCV). Interstitial pneumonitis is a rare side-effect of HCV therapy and is an important cause of dose reduction or discontinuation, impairing success of antiviral therapy. We performed a review of the literature in order to present diagnostic modalities and possible treatments for pneumonitis and to offer guidelines. We searched for cases where pneumonitis as a side-effect of HCV treatment was documented. First we performed a literature search via PubMed and Web of Science interface and second we searched three drug toxicity databases. We systematically analyzed all case reports with respect to clinical manifestations, type of treatment, and outcome. A literature search revealed 19 articles, containing 25 case descriptions, while we traced 33 cases from the drug toxicity databases. Pneumonitis presented with any of the combination of fever, dyspnea, and cough and can arise with any type of (conventional or pegylated) interferon. Mortality secondary to pneumonitis was seen in 7% of cases, exclusively with peginterferon α-2b. In most cases therapy was discontinued and steroids were started. Interferon-induced pneumonitis during HCV treatment is a severe complication and should be recognized in order to prevent further pulmonary damage and/or death.
Keywords	covid19
Language	English
Dates of publication	2010-03
Size	p. 579-585.
Publisher	Springer US
Publishing place	Boston
Document type	Article
ZDB-ID	304250-9
ISSN	1573-2568 ; 0163-2116
ISSN (online)	1573-2568
ISSN	0163-2116
DOI	10.1007/s10620-009-0797-1
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Article ; Online: Optimal length of antiviral therapy in patients with hepatitis C virus genotypes 2 and 3: a meta-analysis.

Slavenburg, Serena / Weggelaar, Ines / van Oijen, Martijn G H / Drenth, Joost P H

Antiviral therapy

2009 Volume 14, Issue 8, Page(s) 1139–1148

Abstract: Background: Current guidelines recommend a duration of 24 weeks of treatment with pegylated interferon and ribavirin for patients infected with chronic hepatitis C virus (HCV) genotypes 2 and 3. Several trials investigated whether shorter treatment ... ...

Abstract	Background: Current guidelines recommend a duration of 24 weeks of treatment with pegylated interferon and ribavirin for patients infected with chronic hepatitis C virus (HCV) genotypes 2 and 3. Several trials investigated whether shorter treatment duration is equally effective in achieving sustained virological response (SVR). Our aim was to determine the optimal length of treatment in patients with HCV genotypes 2 and 3. Methods: Systematic literature identified eight randomized controlled trials (RCTs). Meta-analyses were carried out on SVR data from three studies randomized at baseline and five studies randomized at rapid virological response (RVR) to either 12-16 weeks or a 24-week course. Results: Pooled SVR data were higher in standard treatment in RCTs that randomized at baseline, with a relative risk (RR) of 0.88 (95% confidence interval [CI] 0.76-1.01). The pooled proportion of SVR rates of RCTs that randomized at RVR were similar in the short treatment group (82%) as in the standard treatment (83%), with the pooled effect given by a RR of 1.00 (95% CI 0.92-1.09). Conclusions: A shorter course (12-16 weeks) of combination therapy does not impair efficacy compared with a 24-week course in HCV genotypes 2 and 3 patients who achieve an RVR. HCV patients without RVR should consider 24 weeks of treatment.
MeSH term(s)	Adult ; Antiviral Agents/administration & dosage ; Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use ; Drug Administration Schedule ; Drug Therapy, Combination ; Female ; Genotype ; Hepacivirus/classification ; Hepacivirus/drug effects ; Hepacivirus/genetics ; Hepatitis C, Chronic/drug therapy ; Hepatitis C, Chronic/virology ; Humans ; Interferon-alpha/administration & dosage ; Interferon-alpha/pharmacology ; Interferon-alpha/therapeutic use ; Interferons/administration & dosage ; Interferons/pharmacology ; Interferons/therapeutic use ; Male ; Middle Aged ; Polyethylene Glycols/administration & dosage ; Polyethylene Glycols/pharmacology ; Polyethylene Glycols/therapeutic use ; Randomized Controlled Trials as Topic ; Recombinant Proteins ; Ribavirin/administration & dosage ; Ribavirin/pharmacology ; Ribavirin/therapeutic use ; Time Factors ; Treatment Outcome
Chemical Substances	Antiviral Agents ; Interferon-alpha ; Recombinant Proteins ; Polyethylene Glycols (30IQX730WE) ; interferon alfa-2b (43K1W2T1M6) ; interferon alfa-2a (47RRR83SK7) ; Ribavirin (49717AWG6K) ; Interferons (9008-11-1) ; peginterferon alfa-2b (G8RGG88B68) ; peginterferon alfa-2a (Q46947FE7K)
Language	English
Publishing date	2009
Publishing country	England
Document type	Journal Article ; Meta-Analysis ; Research Support, Non-U.S. Gov't
ZDB-ID	1339842-8
ISSN	2040-2058 ; 1359-6535
ISSN (online)	2040-2058
ISSN	1359-6535
DOI	10.3851/IMP1464
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Zs.A 4877: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 174: Show issues

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Article ; Online: Ribavirin plasma concentration measurements in patients with hepatitis C: early ribavirin concentrations predict steady-state concentrations.

Slavenburg, Serena / Huntjens-Fleuren, Hanneke W H A / Dofferhoff, Ton S M / Richter, Clemens / Koopmans, Peter P / Verwey-Van Wissen, Corrien P W G M / Drenth, Joost P H / Burger, David M

Therapeutic drug monitoring

2011 Volume 33, Issue 1, Page(s) 40–44

Abstract: Background: Ribavirin is an essential component in the treatment of chronic hepatitis C (HCV) infection. Although ribavirin dose is weight-based, data in the literature suggest large between-patient variability in plasma ribavirin concentrations. Recent ...

Abstract	Background: Ribavirin is an essential component in the treatment of chronic hepatitis C (HCV) infection. Although ribavirin dose is weight-based, data in the literature suggest large between-patient variability in plasma ribavirin concentrations. Recent studies indicate that higher ribavirin exposure results in higher sustained viral response rates. Monitoring ribavirin concentration is suggested in the literature, but it is unclear at what time point during treatment plasma ribavirin concentrations should be monitored. Aim: To investigate the association between early plasma ribavirin concentrations and ribavirin dosing with steady-state (Css) concentration and the between- and within-patient variability in plasma ribavirin concentration in clinical practice. Methods: We performed a prospective observational cohort study in patients with HCV who received pegylated interferon in combination with oral weight-based ribavirin (12-15 mg/kg) twice daily. Trough plasma ribavirin concentrations at Weeks 1, 2, 4, 8, 12, 16, 20, and 24 were studied using a validated high-performance liquid chromatography assay. Results: In total, 53 patients (37 male, 16 female) with a mean age of 51 years (range, 26-68 years) were included and 209 samples were collected. There was a significant correlation between Week 2 as well as Week 4 and plasma ribavirin Css (r = 0.589 and r = 0.714, P < 0.05, respectively). Ribavirin Css was reached at Week 8 of HCV treatment. There was no correlation between dose in mg/kg and Css (r = 0.181, P = 0.263). The between- and within-patient coefficients of variation of plasma ribavirin concentrations at Week 8 and beyond were 43% and 13%, respectively. Conclusion: In HCV-infected patients, ribavirin steady-state concentrations can be predicted by measurement of concentrations made early after the start of therapy.
MeSH term(s)	Adult ; Aged ; Antiviral Agents/adverse effects ; Antiviral Agents/blood ; Antiviral Agents/pharmacokinetics ; Antiviral Agents/therapeutic use ; Cohort Studies ; Drug Monitoring ; Drug Therapy, Combination ; Female ; HIV Infections/complications ; HIV Infections/drug therapy ; Hepatitis C/blood ; Hepatitis C/complications ; Hepatitis C/drug therapy ; Hepatitis C, Chronic/drug therapy ; Humans ; Interferon-alpha/adverse effects ; Interferon-alpha/therapeutic use ; Male ; Middle Aged ; Prospective Studies ; Recombinant Proteins ; Ribavirin/adverse effects ; Ribavirin/blood ; Ribavirin/pharmacokinetics ; Ribavirin/therapeutic use
Chemical Substances	Antiviral Agents ; Interferon-alpha ; Recombinant Proteins ; interferon alfa-2b (43K1W2T1M6) ; interferon alfa-2a (47RRR83SK7) ; Ribavirin (49717AWG6K)
Language	English
Publishing date	2011-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	424443-6
ISSN	1536-3694 ; 0163-4356
ISSN (online)	1536-3694
ISSN	0163-4356
DOI	10.1097/FTD.0b013e318205f892
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Article: Prevalence of hepatitis C in the general population in the Netherlands.

Slavenburg, S / Verduyn-Lunel, F M / Hermsen, J T / Melchers, W J G / te Morsche, R H M / Drenth, J P H

The Netherlands journal of medicine

2008 Volume 66, Issue 1, Page(s) 13–17

Abstract: ... serological findings were confirmed using a specific second immunoassay. HCV RNA (genotype 1b) was found ... in the sera of two persons.: Conclusion: The HCV prevalence in our sample of the Dutch population was 0.2 ...

Abstract	Background: Chronic hepatitis C virus (HCV) is transmitted by blood-blood contact and this leads to high HCV prevalence in risk populations such as haemophilia patients and intravenous drug users. The prevalence in the general Dutch population is unknown, although it appears to be very low in screened blood donors (0.0169%). Aim: The objective of this study is to estimate the prevalence of HCV in a general population sample living in an urbanized region in the Netherlands. Methods: We randomly selected 2200 EDTA blood samples that had been submitted for analysis of biochemical parameters to a regional servicing laboratory for general practitioners (SHO, Arnhem/Nijmegen, the Netherlands). HCV antibody testing was performed using a three-step approach. For initial screening, an enzyme immunoassay (Bioelisa HCV 4.0, Biokit, Spain) was used. Positive samples were subjected to a second, microparticle enzyme-linked immunoassay (AxSYM HCV version 3.0, Abbott laboratories, IL , USA). Genotypes were determined by Line Probe Assay. Results: A total of four persons (two females, two males) (0.2%) tested positive for HCV antibodies. The average OD/cut-off ratio of the screening assay was 2.9 (range 1.0 to 7.3) and serological findings were confirmed using a specific second immunoassay. HCV RNA (genotype 1b) was found in the sera of two persons. Conclusion: The HCV prevalence in our sample of the Dutch population was 0.2% which accords with earlier estimates from prevalence studies in the Netherlands.
MeSH term(s)	Chronic Disease ; Epidemiologic Studies ; Female ; Genotype ; Hepacivirus/isolation & purification ; Hepatitis C/epidemiology ; Hepatitis C/immunology ; Humans ; Male ; Mass Screening ; Middle Aged ; Netherlands/epidemiology ; Prevalence ; Prospective Studies
Language	English
Publishing date	2008-01
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	193149-0
ISSN	1872-9061 ; 0300-2977
ISSN (online)	1872-9061
ISSN	0300-2977
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