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  1. Article ; Online: Recent Advanced Applications of Ionic Liquid for Future Iontronics.

    Ono, Shimpei

    Chemical record (New York, N.Y.)

    2023  Volume 23, Issue 8, Page(s) e202300045

    Abstract: Recently, electronic devices that make use of a state called the electric double layers (EDL) of ion have opened up a wide range of research opportunities, from novel physical phenomena in solid-state materials to next-generation low-power consumption ... ...

    Abstract Recently, electronic devices that make use of a state called the electric double layers (EDL) of ion have opened up a wide range of research opportunities, from novel physical phenomena in solid-state materials to next-generation low-power consumption devices. They are considered to be the future iontronics devices. EDLs behave as nanogap capacitors, resulting the high density of charge carriers is induced at semiconductor/electrolyte by applying only a few volts of the bias voltage. This enables the low-power operation of electronic devices as well as new functional devices. Furthermore, by controlling the motion of ions, ions can be used as semi-permanent charge to form electrets. In this article, we are going to introduce the recent advanced application of iontronics devices as well as energy harvesters making use of ion-based electrets, leading to the future iontronics research.
    Language English
    Publishing date 2023-04-26
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2044646-9
    ISSN 1528-0691 ; 1527-8999
    ISSN (online) 1528-0691
    ISSN 1527-8999
    DOI 10.1002/tcr.202300045
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Management of Scar Contractures of the Hand-Our Therapeutic Strategy and Challenges.

    Cho, Hoyu / Ono, Shimpei / Chung, Kevin C

    Journal of clinical medicine

    2024  Volume 13, Issue 5

    Abstract: The essence of treating scar contractures lies in covering the skin deficit after releasing the contractures, typically using flaps or skin grafts. However, the specific characteristics of scar contractures, such as their location, shape, and size, vary ... ...

    Abstract The essence of treating scar contractures lies in covering the skin deficit after releasing the contractures, typically using flaps or skin grafts. However, the specific characteristics of scar contractures, such as their location, shape, and size, vary among patients, which makes surgical planning challenging. To achieve excellent outcomes in the treatment of scar contractures, we have developed a dimensional classification system for these contractures. This system categorizes them into four types: type 1 (superficial linear), type 2-d (deep linear), type 2-s (planar scar contractures confined to the superficial layer), and type 3 (planar scar contractures that reach the deep layer, i.e., three-dimensional scar contractures). Additionally, three factors should be considered when determining surgical approaches: the size of the defect, the availability of healthy skin around the defect, and the blood circulation in the defect bed. Type 1 and type 2-d are linear scars; thus, the scar is excised and sutured in a straight line, and the contracture is released using z-plasty or its modified methods. For type 2-s, after releasing the scar contracture band, local flaps are indicated for small defects, pedicled perforator flaps for medium defects, and free flaps and distant flaps for large defects. Type 2-s has good blood circulation in the defect bed, so full-thickness skin grafting is also a suitable option regardless of the defect's size. In type 3, releasing the deep scar contracture will expose important structures with poor blood circulation, such as tendons, joints, and bones. Thus, a surgical plan using flaps, rather than skin grafts, is recommended. A severity classification and treatment strategy for scar contractures have not yet been established. By objectively classifying and quantifying scar contractures, we believe that better treatment outcomes can be achieved.
    Language English
    Publishing date 2024-03-06
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm13051516
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  3. Article: Application of the Chelator-Based Clickable Radiotheranostic Platform to Moderate-Molecular-Weight Ligands.

    Nakashima, Kazuma / Iikuni, Shimpei / Watanabe, Hiroyuki / Ono, Masahiro

    ACS medicinal chemistry letters

    2022  Volume 13, Issue 10, Page(s) 1642–1647

    Abstract: We have reported that the chelator-based clickable radiotheranostic platform, ADIBO-DOTADG-ALB (ADA), has favorable properties as a radiotheranostic platform for low-molecular-weight ligands. In this study, we evaluated the applicability of ADA to ... ...

    Abstract We have reported that the chelator-based clickable radiotheranostic platform, ADIBO-DOTADG-ALB (ADA), has favorable properties as a radiotheranostic platform for low-molecular-weight ligands. In this study, we evaluated the applicability of ADA to moderate-molecular-weight ligands to expand the utility of the ADA platform. As a moderate-molecular-weight ligand, we selected exendin-4, a peptide-based agonist to glucagon-like peptide-1 receptor (GLP-1R). An exendin-4-incorporated ADA derivative, exendin-4-Cys
    Language English
    Publishing date 2022-09-02
    Publishing country United States
    Document type Journal Article
    ISSN 1948-5875
    ISSN 1948-5875
    DOI 10.1021/acsmedchemlett.2c00320
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  4. Article: The History of Propeller Flaps.

    Hyakusoku, Hiko / Ono, Shimpei

    Seminars in plastic surgery

    2020  Volume 34, Issue 3, Page(s) 133–138

    Abstract: Several pedicled flaps were developed by Hyakusoku at the Nippon Medical School Hospital, Tokyo, Japan, in the 1980s to treat a large number of patients with postburn contractures. In this setting, the propeller flaps were described for the first time in ...

    Abstract Several pedicled flaps were developed by Hyakusoku at the Nippon Medical School Hospital, Tokyo, Japan, in the 1980s to treat a large number of patients with postburn contractures. In this setting, the propeller flaps were described for the first time in 1991. The term
    Language English
    Publishing date 2020-09-22
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2077828-4
    ISSN 1535-2188
    ISSN 1535-2188
    DOI 10.1055/s-0040-1715157
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4383: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Development of novel

    Saito, Kosuke / Watanabe, Hiroyuki / Iikuni, Shimpei / Ono, Masahiro

    Nuclear medicine and biology

    2022  Volume 106-107, Page(s) 72–79

    Abstract: Introduction: Type 2 diabetes mellitus (T2DM) accounts for the majority of diabetes mellitus cases, and β-cell function and mass may be involved in its pathophysiology. The deposition of islet amyloid in pancreas islets is one of the mechanisms of ... ...

    Abstract Introduction: Type 2 diabetes mellitus (T2DM) accounts for the majority of diabetes mellitus cases, and β-cell function and mass may be involved in its pathophysiology. The deposition of islet amyloid in pancreas islets is one of the mechanisms of progression of T2DM. Therefore, the development of imaging techniques for islet amyloid deposition contributes to the early-phase diagnosis and elucidation of the pathogenic mechanism of T2DM. We have reported that pyridyl benzofuran (PBF) is a promising scaffold for islet amyloid imaging probes. In this study, we designed [
    Methods: We synthesized dedpa-PBF and dedpa-(PBF)
    Results: In the in vitro saturation binding assay, the affinity of [
    Conclusion: [
    MeSH term(s) Animals ; Benzofurans/chemistry ; Diabetes Mellitus, Type 2/metabolism ; Humans ; Islet Amyloid Polypeptide/chemistry ; Islets of Langerhans/metabolism ; Mice ; Tissue Distribution
    Chemical Substances Benzofurans ; Islet Amyloid Polypeptide
    Language English
    Publishing date 2022-01-14
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1138098-6
    ISSN 1872-9614 ; 0883-2897 ; 0969-8051
    ISSN (online) 1872-9614
    ISSN 0883-2897 ; 0969-8051
    DOI 10.1016/j.nucmedbio.2022.01.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1090: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  6. Article ; Online: Structure-Activity Relationships and Pharmacokinetics of

    Iikuni, Shimpei / Ohara, Takaki / Watanabe, Hiroyuki / Ono, Masahiro

    Molecular pharmaceutics

    2022  Volume 19, Issue 8, Page(s) 2832–2839

    Abstract: Insulinomas are neuroendocrine tumors that are derived from pancreatic β-cells, and they often overexpress the glucagon-like peptide-1 receptor (GLP-1R). Radiolabeled exendin-4 derivatives have been used to noninvasively detect the GLP-1R during the ... ...

    Abstract Insulinomas are neuroendocrine tumors that are derived from pancreatic β-cells, and they often overexpress the glucagon-like peptide-1 receptor (GLP-1R). Radiolabeled exendin-4 derivatives have been used to noninvasively detect the GLP-1R during the diagnosis and preoperative localization of insulinomas; however, their marked renal accumulation can hinder the imaging of pancreatic tail lesions. In this study, we designed and synthesized
    MeSH term(s) Albumins/metabolism ; Animals ; Exenatide/metabolism ; Glucagon-Like Peptide-1 Receptor/metabolism ; Humans ; Indium ; Insulinoma/diagnosis ; Mice ; Pancreatic Neoplasms/metabolism ; Peptides/metabolism ; Structure-Activity Relationship ; Tissue Distribution ; Tomography, Emission-Computed, Single-Photon
    Chemical Substances Albumins ; Glucagon-Like Peptide-1 Receptor ; Peptides ; Indium (045A6V3VFX) ; Exenatide (9P1872D4OL)
    Language English
    Publishing date 2022-06-27
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2138405-8
    ISSN 1543-8392 ; 1543-8384
    ISSN (online) 1543-8392
    ISSN 1543-8384
    DOI 10.1021/acs.molpharmaceut.2c00201
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6250: Show issues Location:
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  7. Article ; Online: Synthesis and Evaluation of

    Kaide, Sho / Watanabe, Hiroyuki / Iikuni, Shimpei / Hasegawa, Masato / Ono, Masahiro

    ACS chemical neuroscience

    2022  Volume 13, Issue 20, Page(s) 2982–2990

    Abstract: In the brains of patients with synucleinopathies such as Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy, α-synuclein (α-syn) aggregates deposit abnormally to induce neurodegeneration, although the mechanism is unclear. Thus, ...

    Abstract In the brains of patients with synucleinopathies such as Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy, α-synuclein (α-syn) aggregates deposit abnormally to induce neurodegeneration, although the mechanism is unclear. Thus,
    MeSH term(s) Animals ; alpha-Synuclein/metabolism ; Chalcones/metabolism ; Amyloid beta-Peptides/metabolism ; Chalcone/pharmacology ; Chalcone/metabolism ; Tissue Distribution ; Brain/diagnostic imaging ; Brain/metabolism ; Disease Models, Animal
    Chemical Substances alpha-Synuclein ; Iodine-125 (GVO776611R) ; Chalcones ; Amyloid beta-Peptides ; Chalcone (5S5A2Q39HX)
    Language English
    Publishing date 2022-10-05
    Publishing country United States
    Document type Journal Article
    ISSN 1948-7193
    ISSN (online) 1948-7193
    DOI 10.1021/acschemneuro.2c00473
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  8. Article ; Online: Development of a novel radiotheranostic platform with a DOTA-based trifunctional chelating agent.

    Nakashima, Kazuma / Iikuni, Shimpei / Watanabe, Hiroyuki / Ono, Masahiro

    Chemical communications (Cambridge, England)

    2021  Volume 57, Issue 52, Page(s) 6432–6435

    Abstract: Radiotheranostics has attracted attention as a powerful strategy for treating cancer patients with precision medicine. We designed and synthesized a novel DOTA-based trifunctional agent, ADIBO-DOTADG-ALB (ADA), which allowed compounds with targeting ... ...

    Abstract Radiotheranostics has attracted attention as a powerful strategy for treating cancer patients with precision medicine. We designed and synthesized a novel DOTA-based trifunctional agent, ADIBO-DOTADG-ALB (ADA), which allowed compounds with targeting ligands, radiometals, and an albumin binder to be readily prepared. ADA exhibited promising properties as a theranostic platform.
    Language English
    Publishing date 2021-05-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/d1cc00823d
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  9. Article ; Online: Electrical mapping of thermoelectric power factor in WO

    Shimizu, Sunao / Kishi, Tomoya / Ogane, Goki / Tokiwa, Kazuyasu / Ono, Shimpei

    Scientific reports

    2022  Volume 12, Issue 1, Page(s) 7202

    Abstract: With growing environmental awareness and considerable research investment in energy saving, the concept of energy harvesting has become a central topic in the field of materials science. The thermoelectric energy conversion, which is a classic physical ... ...

    Abstract With growing environmental awareness and considerable research investment in energy saving, the concept of energy harvesting has become a central topic in the field of materials science. The thermoelectric energy conversion, which is a classic physical phenomenon, has emerged as an indispensable thermal management technology. In addition to conventional experimental investigations of thermoelectric materials, seeking promising materials or structures using computer-based approaches such as machine learning has been considered to accelerate research in recent years. However, the tremendous experimental efforts required to evaluate materials may hinder us from reaping the benefits of the fast-developing computer technology. In this study, an electrical mapping of the thermoelectric power factor is performed in a wide temperature-carrier density regime. An ionic gating technique is applied to an oxide semiconductor WO
    Language English
    Publishing date 2022-05-03
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-022-10908-3
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  10. Article ; Online: Development of an

    Iikuni, Shimpei / Kamei, Ichiro / Ohara, Takaki / Watanabe, Hiroyuki / Ono, Masahiro

    Molecular pharmaceutics

    2022  Volume 19, Issue 3, Page(s) 1019–1027

    Abstract: Insulinomas are neuroendocrine tumors that are mainly found in the pancreas. Surgical resection is currently the first-line treatment for insulinomas; thus, it is vital to preoperatively determine their locations. The marked expression of the glucagon- ... ...

    Abstract Insulinomas are neuroendocrine tumors that are mainly found in the pancreas. Surgical resection is currently the first-line treatment for insulinomas; thus, it is vital to preoperatively determine their locations. The marked expression of the glucagon-like peptide-1 receptor (GLP-1R) is seen in pancreatic β-cells and almost all insulinomas. Radiolabeled derivatives of exendin-4, a GLP-1R agonist, have been used with nuclear medicine imaging techniques for the
    MeSH term(s) Albumins/metabolism ; Animals ; Exenatide/chemistry ; Glucagon-Like Peptide-1 Receptor/metabolism ; Insulinoma/diagnosis ; Kidney/metabolism ; Mice ; Pancreatic Neoplasms/metabolism ; Tissue Distribution ; Tomography, Emission-Computed, Single-Photon
    Chemical Substances Albumins ; Glucagon-Like Peptide-1 Receptor ; Exenatide (9P1872D4OL)
    Language English
    Publishing date 2022-02-09
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2138405-8
    ISSN 1543-8392 ; 1543-8384
    ISSN (online) 1543-8392
    ISSN 1543-8384
    DOI 10.1021/acs.molpharmaceut.2c00068
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6250: Show issues Location:
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