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  1. Article ; Online: Jeffrey W. Pollard (1950-2023).

    Graham, Nicola / Petitprez, Florent / Webb, Sheila / Giannakis, Nikolas / Cohen, Camille / Webb, Jess / Soong, Daniel Y H / Kitamura, Takanori

    Nature cancer

    2023  Volume 4, Issue 7, Page(s) 927

    Language English
    Publishing date 2023-07-27
    Publishing country England
    Document type Editorial
    ISSN 2662-1347
    ISSN (online) 2662-1347
    DOI 10.1038/s43018-023-00596-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Discussant comment on an examination of the effect of CEO social ties and CEO reputation on nonprofessional investors' say-on-pay judgments by Steve Kaplan, Janet Samuels, Jeffrey Cohen

    Schmidt, Regan N / Cohen, Jeffrey / Kaplan, Steven E / Samuels, Janet A

    Journal of business ethics : JOBE Vol. 126, No. 1 , p. 119-123

    2015  Volume 126, Issue 1, Page(s) 119–123

    Author's details Regan N. Schmidt
    Language English
    Publisher Springer
    Publishing place Dordrecht
    Document type Article
    ZDB-ID 868017-6 ; 1478688-6
    ISSN 1573-0697 ; 0167-4544
    ISSN (online) 1573-0697
    ISSN 0167-4544
    Database ECONomics Information System

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  3. Book ; Online: EBV Infection and Human Primary Immune Deficiencies

    Meyts, Isabelle / Cohen, Jeffrey I.

    2020  

    Keywords Medicine ; Immunology ; Epstein-Barr virus ; immune deficiency ; lymphoproliferative disease ; hemophagocytic lymphohistiocytosis ; B-cell lymphoma
    Size 1 electronic resource (132 pages)
    Publisher Frontiers Media SA
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021230602
    ISBN 9782889635719 ; 2889635716
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  4. Article ; Online: Herpesvirus latency.

    Cohen, Jeffrey I

    The Journal of clinical investigation

    2020  Volume 130, Issue 7, Page(s) 3361–3369

    Abstract: Herpesviruses infect virtually all humans and establish lifelong latency and reactivate to infect other humans. Latency requires multiple functions: maintaining the herpesvirus genome in the nuclei of cells; partitioning the viral genome to daughter ... ...

    Abstract Herpesviruses infect virtually all humans and establish lifelong latency and reactivate to infect other humans. Latency requires multiple functions: maintaining the herpesvirus genome in the nuclei of cells; partitioning the viral genome to daughter cells in dividing cells; avoiding recognition by the immune system by limiting protein expression; producing noncoding viral RNAs (including microRNAs) to suppress lytic gene expression or regulate cellular protein expression that could otherwise eliminate virus-infected cells; modulating the epigenetic state of the viral genome to regulate viral gene expression; and reactivating to infect other hosts. Licensed antivirals inhibit virus replication, but do not affect latency. Understanding of the mechanisms of latency is leading to novel approaches to destroy latently infected cells or inhibit reactivation from latency.
    MeSH term(s) Animals ; Antiviral Agents/therapeutic use ; Gene Expression Regulation, Viral/physiology ; Herpesviridae/physiology ; Herpesviridae Infections/drug therapy ; Herpesviridae Infections/genetics ; Herpesviridae Infections/metabolism ; Humans ; Virus Activation/drug effects ; Virus Activation/physiology ; Virus Latency/drug effects ; Virus Latency/physiology
    Chemical Substances Antiviral Agents
    Language English
    Publishing date 2020-05-04
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Intramural ; Review
    ZDB-ID 3067-3
    ISSN 1558-8238 ; 0021-9738
    ISSN (online) 1558-8238
    ISSN 0021-9738
    DOI 10.1172/JCI136225
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Ua VI Zs.184: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Philip A. Brunell, MD: Remembering a Pioneer of Varicella Research.

    Cohen, Jeffrey I / Gershon, Anne A / Grose, Charles

    Journal of the Pediatric Infectious Diseases Society

    2023  Volume 12, Issue 5, Page(s) 262–264

    MeSH term(s) Humans ; Chickenpox ; Herpesvirus 3, Human ; Herpes Zoster ; Chickenpox Vaccine
    Chemical Substances Chickenpox Vaccine
    Language English
    Publishing date 2023-04-28
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Intramural
    ZDB-ID 2668791-4
    ISSN 2048-7207 ; 2048-7193
    ISSN (online) 2048-7207
    ISSN 2048-7193
    DOI 10.1093/jpids/piad029
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: New activities for old antibiotics.

    Cohen, Jeffrey I

    Nature microbiology

    2018  Volume 3, Issue 5, Page(s) 531–532

    MeSH term(s) Aminoglycosides ; Anti-Bacterial Agents ; Humans ; Microbiota ; Protein Synthesis Inhibitors ; Virus Diseases
    Chemical Substances Aminoglycosides ; Anti-Bacterial Agents ; Protein Synthesis Inhibitors
    Language English
    Publishing date 2018-04-25
    Publishing country England
    Document type Journal Article ; Comment
    ISSN 2058-5276
    ISSN (online) 2058-5276
    DOI 10.1038/s41564-018-0152-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Author Correction: New activities for old antibiotics.

    Cohen, Jeffrey I

    Nature microbiology

    2018  Volume 3, Issue 7, Page(s) 844

    Abstract: In the version of this News and Views originally published, the author made an incorrect reference to 'mice deficient in Mx1'. This has now been corrected so that the text instead refers to 'mice congenic for Mx1'. The full corrected sentence reads as " ... ...

    Abstract In the version of this News and Views originally published, the author made an incorrect reference to 'mice deficient in Mx1'. This has now been corrected so that the text instead refers to 'mice congenic for Mx1'. The full corrected sentence reads as "Pretreatment of mice congenic for Mx1, an ISG that is critical for protection of animals from influenza, with intranasal neomycin significantly improved survival; however, about 50% of the mice died."
    Language English
    Publishing date 2018-06-19
    Publishing country England
    Document type Published Erratum
    ISSN 2058-5276
    ISSN (online) 2058-5276
    DOI 10.1038/s41564-018-0185-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Editorial: EBV Infection and Human Primary Immune Deficiencies.

    Cohen, Jeffrey I / Meyts, Isabelle

    Frontiers in immunology

    2020  Volume 11, Page(s) 130

    MeSH term(s) Epstein-Barr Virus Infections/immunology ; Humans ; Immunocompromised Host/immunology ; Primary Immunodeficiency Diseases/immunology ; Primary Immunodeficiency Diseases/virology
    Language English
    Publishing date 2020-02-07
    Publishing country Switzerland
    Document type Editorial ; Introductory Journal Article ; Research Support, N.I.H., Intramural
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2020.00130
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Herpesviruses in the Activated Phosphatidylinositol-3-Kinase-δ Syndrome.

    Cohen, Jeffrey I

    Frontiers in immunology

    2018  Volume 9, Page(s) 237

    Abstract: The phosphatidylinositol-3-kinase (PI3K)/Akt pathway is important for multiple stages of herpesvirus replication including virus entry, replication, latency, and reactivation. Recently, patients with gain-of-function mutations in the p110δ-catalytic ... ...

    Abstract The phosphatidylinositol-3-kinase (PI3K)/Akt pathway is important for multiple stages of herpesvirus replication including virus entry, replication, latency, and reactivation. Recently, patients with gain-of-function mutations in the p110δ-catalytic subunit of PI3K or in the p85-regulatory subunit of PI3K have been reported. These patients have constitutively active PI3K with hyperactivation of Akt. They present with lymphoproliferation and often have infections, particularly recurrent respiratory infections and/or severe virus infections. The most frequent virus infections are due to Epstein-Barr virus (EBV) and cytomegalovirus (CMV); patients often present with persistent EBV and/or CMV viremia, EBV lymphoproliferative disease, or CMV lymphadenitis. No patients have been reported with CMV pneumonia, colitis, or retinitis. Other herpesvirus infections have included herpes simplex pneumonia, recurrent zoster, and varicella after vaccination with the varicella vaccine. Additional viral infections have included adenovirus viremia, severe warts, and extensive Molluscum contagiosum virus infection. The increased susceptibility to virus infections in these patients is likely due to a reduced number of long-lived memory CD8 T cells and an increased number of terminally differentiated effector CD8 T cells.
    MeSH term(s) Class I Phosphatidylinositol 3-Kinases/antagonists & inhibitors ; Class I Phosphatidylinositol 3-Kinases/drug effects ; Class I Phosphatidylinositol 3-Kinases/genetics ; Class I Phosphatidylinositol 3-Kinases/immunology ; Class I Phosphatidylinositol 3-Kinases/metabolism ; Cytomegalovirus/immunology ; Cytomegalovirus/isolation & purification ; Cytomegalovirus Infections/drug therapy ; Cytomegalovirus Infections/genetics ; Cytomegalovirus Infections/immunology ; Cytomegalovirus Infections/virology ; Epstein-Barr Virus Infections/drug therapy ; Epstein-Barr Virus Infections/genetics ; Epstein-Barr Virus Infections/immunology ; Epstein-Barr Virus Infections/virology ; Gain of Function Mutation ; Genetic Predisposition to Disease ; Herpesvirus 4, Human/immunology ; Herpesvirus 4, Human/isolation & purification ; Humans ; Immunologic Deficiency Syndromes/genetics ; Immunologic Deficiency Syndromes/immunology ; Immunologic Deficiency Syndromes/virology ; Immunosuppressive Agents/pharmacology ; Immunosuppressive Agents/therapeutic use ; Phosphatidylinositol 3-Kinases/genetics ; Phosphatidylinositol 3-Kinases/immunology ; Phosphatidylinositol 3-Kinases/metabolism ; Proto-Oncogene Proteins c-akt/immunology ; Proto-Oncogene Proteins c-akt/metabolism ; T-Lymphocytes/immunology ; T-Lymphocytes/metabolism ; Viremia/drug therapy ; Viremia/genetics ; Viremia/immunology ; Viremia/virology
    Chemical Substances Immunosuppressive Agents ; PIK3R1 protein, human (EC 2.7.1.-) ; Phosphatidylinositol 3-Kinases (EC 2.7.1.-) ; Class I Phosphatidylinositol 3-Kinases (EC 2.7.1.137) ; PIK3CD protein, human (EC 2.7.1.137) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1)
    Language English
    Publishing date 2018-02-23
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Intramural ; Review
    ZDB-ID 2606827-8
    ISSN 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2018.00237
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Vaccination to Reduce Reactivation of Herpes Simplex Virus Type 2.

    Cohen, Jeffrey I

    The Journal of infectious diseases

    2017  Volume 215, Issue 6, Page(s) 844–846

    MeSH term(s) Herpes Genitalis ; Herpesvirus 2, Human/immunology ; Humans ; Vaccination ; Vaccines
    Chemical Substances Vaccines
    Language English
    Publishing date 2017-04-28
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Intramural ; Comment
    ZDB-ID 3019-3
    ISSN 1537-6613 ; 0022-1899
    ISSN (online) 1537-6613
    ISSN 0022-1899
    DOI 10.1093/infdis/jix006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uh II Zs.50: Show issues Location:
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    Zs.MO 445: Show issues

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