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  1. Article ; Online: An Infectious Rous Sarcoma Virus Gag Mutant That Is Defective in Nuclear Cycling.

    Ricaña, Clifton L / Johnson, Marc C

    Journal of virology

    2021  Volume 95, Issue 20, Page(s) e0064821

    Abstract: During retroviral replication, unspliced viral genomic RNA (gRNA) must escape the nucleus for translation into viral proteins and packaging into virions. "Complex" retroviruses, such as human immunodeficiency virus (HIV), ... ...

    Abstract During retroviral replication, unspliced viral genomic RNA (gRNA) must escape the nucleus for translation into viral proteins and packaging into virions. "Complex" retroviruses, such as human immunodeficiency virus (HIV), use
    MeSH term(s) Active Transport, Cell Nucleus/genetics ; Active Transport, Cell Nucleus/physiology ; Animals ; Cell Line ; Cell Nucleus/virology ; Gene Products, gag/genetics ; Gene Products, gag/metabolism ; Genome, Viral/genetics ; Humans ; Mice ; RNA, Viral/genetics ; Retroviridae/genetics ; Rous sarcoma virus/genetics ; Rous sarcoma virus/metabolism ; Virion/metabolism ; Virus Assembly
    Chemical Substances Gene Products, gag ; RNA, Viral
    Language English
    Publishing date 2021-07-28
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 80174-4
    ISSN 1098-5514 ; 0022-538X
    ISSN (online) 1098-5514
    ISSN 0022-538X
    DOI 10.1128/JVI.00648-21
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Design Optimization for Rough Terrain Traversal Using a Compliant, Continuum-Joint, Quadruped Robot.

    Sherrod, Vallan / Johnson, Curtis C / Killpack, Marc D

    Frontiers in robotics and AI

    2022  Volume 9, Page(s) 860020

    Abstract: Legged robots have the potential to cover terrain not accessible to wheel-based robots and vehicles. This makes them better suited to perform tasks such as search and rescue in real-world unstructured environments. In addition, pneumatically-actuated, ... ...

    Abstract Legged robots have the potential to cover terrain not accessible to wheel-based robots and vehicles. This makes them better suited to perform tasks such as search and rescue in real-world unstructured environments. In addition, pneumatically-actuated, compliant robots may be more suited than their rigid counterparts to real-world unstructured environments with humans where unintentional contact or impact may occur. In this work, we define design metrics for legged robots that evaluate their ability to traverse unstructured terrain, carry payloads, find stable footholds, and move in desired directions. These metrics are demonstrated and validated in a multi-objective design optimization of 10 variables for a 16 degree of freedom, pneumatically actuated, continuum joint quadruped. We also present and validate approximations to preserve numerical tractability for any similar high degree of freedom optimization problem. Finally, we show that the design trends uncovered by our optimization hold in two hardware experiments using robot legs with continuum joints that are built based on the optimization results.
    Language English
    Publishing date 2022-07-11
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2781824-X
    ISSN 2296-9144 ; 2296-9144
    ISSN (online) 2296-9144
    ISSN 2296-9144
    DOI 10.3389/frobt.2022.860020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Book ; Conference proceedings: Program Evaluation, Human Capital, and Labor Market Public Policy: a Research Conference in Honor of Mark C. Berger

    Johnson, William R

    (Journal of labor economics ; 24.2006,3)

    2006  

    Institution Program Evaluation, Human Capital, and Labor Market Public Policy: a Research Conference in Honor of Mark C. Berger
    Event/congress Program Evaluation, Human Capital, and Labor Market Public Policy: a Research Conference in Honor of Mark C. Berger (2004.10.07-08, LexingtonKy.)
    Author's details William R. Johnson, coed
    Series title Journal of labor economics ; 24.2006,3
    Keywords Arbeitsmarkttheorie ; Aktivierende Arbeitsmarktpolitik ; Bildungsertrag ; Bildungspolitik ; Arbeitsmarkt ; Lohn ; USA
    Language English
    Size S. 379 - 728, graph. Darst.
    Publisher Univ. of Chicago Press
    Publishing place Chicago, Ill
    Document type Book ; Conference proceedings
    Note Enth. 9 Beitr.
    Database Library catalogue of the German National Library of Science and Technology (TIB), Hannover

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  4. Book ; Conference proceedings: Program Evaluation, Human Capital, and Labor Market Public Policy: a Research Conference in Honor of Mark C. Berger

    Johnson, William Richard

    (Journal of labor economics ; 24.2006,3)

    2006  

    Institution Program Evaluation, Human Capital, and Labor Market Public Policy: a Research Conference in Honor of Mark C. Berger
    Event/congress Program Evaluation, Human Capital, and Labor Market Public Policy: a Research Conference in Honor of Mark C. Berger (2004.10.07-08, LexingtonKy.)
    Author's details William R. Johnson, coed
    Series title Journal of labor economics ; 24.2006,3
    Keywords Arbeitsmarkttheorie ; Aktivierende Arbeitsmarktpolitik ; Bildungsertrag ; Bildungspolitik ; Arbeitsmarkt ; Lohn ; USA
    Language English
    Size S. 379 - 728, graph. Darst.
    Document type Book ; Conference proceedings
    Note Enth. 9 Beitr.
    Database ECONomics Information System

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  5. Article: Eye on the ball: an interview with Dr. C. Stephen Johnson and Mark McGwire. Interview by J. David Kopp.

    Johnson, C S / McGwire, M

    Journal of the American Optometric Association

    1999  Volume 70, Issue 2, Page(s) 79–84

    MeSH term(s) Astigmatism/complications ; Baseball ; Contact Lenses ; Depth Perception ; Eyeglasses ; Humans ; Myopia/complications ; Physician-Patient Relations ; Vision, Low/etiology ; Vision, Low/therapy ; Visual Acuity
    Language English
    Publishing date 1999-02
    Publishing country United States
    Document type Interview
    ZDB-ID 410349-x
    ISSN 0003-0244
    ISSN 0003-0244
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Convergent Evolution in SARS-CoV-2 Spike Creates a Variant Soup from Which New COVID-19 Waves Emerge.

    Focosi, Daniele / Quiroga, Rodrigo / McConnell, Scott / Johnson, Marc C / Casadevall, Arturo

    International journal of molecular sciences

    2023  Volume 24, Issue 3

    Abstract: The first 2 years of the COVID-19 pandemic were mainly characterized by recurrent mutations of SARS-CoV-2 Spike protein at residues K417, L452, E484, N501 and P681 emerging independently across different variants of concern (Alpha, Beta, Gamma, and Delta) ...

    Abstract The first 2 years of the COVID-19 pandemic were mainly characterized by recurrent mutations of SARS-CoV-2 Spike protein at residues K417, L452, E484, N501 and P681 emerging independently across different variants of concern (Alpha, Beta, Gamma, and Delta). Such homoplasy is a marker of convergent evolution. Since Spring 2022 and the third year of the pandemic, with the advent of Omicron and its sublineages, convergent evolution has led to the observation of different lineages acquiring an additional group of mutations at different amino acid residues, namely R346, K444, N450, N460, F486, F490, Q493, and S494. Mutations at these residues have become increasingly prevalent during Summer and Autumn 2022, with combinations showing increased fitness. The most likely reason for this convergence is the selective pressure exerted by previous infection- or vaccine-elicited immunity. Such accelerated evolution has caused failure of all anti-Spike monoclonal antibodies, including bebtelovimab and cilgavimab. While we are learning how fast coronaviruses can mutate and recombine, we should reconsider opportunities for economically sustainable escape-proof combination therapies, and refocus antibody-mediated therapeutic efforts on polyclonal preparations that are less likely to allow for viral immune escape.
    MeSH term(s) Humans ; SARS-CoV-2/genetics ; COVID-19 ; Pandemics ; Spike Glycoprotein, Coronavirus/genetics ; Antibodies, Neutralizing
    Chemical Substances spike protein, SARS-CoV-2 ; Spike Glycoprotein, Coronavirus ; Antibodies, Neutralizing
    Language English
    Publishing date 2023-01-23
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24032264
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: The Effect of a Statewide Policy on High School Emergency Action Plans.

    Johnson, Samuel T / Koester, Michael C / Bovbjerg, Viktor E / Norcross, Marc F

    Sports (Basel, Switzerland)

    2022  Volume 10, Issue 10

    Abstract: Institutions sponsoring athletics must be prepared for emergencies. Due to this, more governing bodies are requiring a sports-related emergency action plan (EAP). Yet, the effects of these policies are unknown. We compared adoption of EAPs and associated ...

    Abstract Institutions sponsoring athletics must be prepared for emergencies. Due to this, more governing bodies are requiring a sports-related emergency action plan (EAP). Yet, the effects of these policies are unknown. We compared adoption of EAPs and associated best practices in Oregon high schools before and after a policy requiring an EAP. Athletic directors were invited to complete a survey during the year before the policy went into effect and again the following year. We assessed whether the school had a written EAP and if they did, was the EAP venue specific, available at the venue, distributed to personnel, and annually reviewed and rehearsed. Pre/post-policy proportions were analyzed using Fisher exact tests for all schools and then schools that completed both surveys. There was a significant increase of schools that reported having an EAP after the policy went into effect (all schools: 55% to 99% [p < 0.001] and schools responding both years: 60% to 98% [p < 0.001]). Venue specific EAPs also significantly increased but only when analyzing all responses (59% to 71% [p = 0.03]). No best practice recommendations related to EAP availability, distribution, review, or rehearsal changed after the policy. Schools met the minimum requirements of the policy, but other related best practices did not significantly improve.
    Language English
    Publishing date 2022-10-20
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704239-X
    ISSN 2075-4663 ; 2075-4663
    ISSN (online) 2075-4663
    ISSN 2075-4663
    DOI 10.3390/sports10100161
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Head-to-head comparison of [

    Aguero, Cinthya / Dhaynaut, Maeva / Amaral, Ana C / Moon, S-H / Neelamegam, Ramesh / Scapellato, Margaret / Carazo-Casas, Carlos / Kumar, Sunny / El Fakhri, Georges / Johnson, Keith / Frosch, Matthew P / Normandin, Marc D / Gómez-Isla, Teresa

    Acta neuropathologica

    2024  Volume 147, Issue 1, Page(s) 25

    Abstract: We and others have shown that [ ...

    Abstract We and others have shown that [
    MeSH term(s) Humans ; Neurodegenerative Diseases/pathology ; Melanins/metabolism ; Brain/pathology ; Tauopathies/pathology ; Monoamine Oxidase/metabolism ; DNA-Binding Proteins/metabolism ; tau Proteins/metabolism ; Positron-Emission Tomography/methods ; Alzheimer Disease/pathology ; Carbolines ; Isoquinolines ; Pyridines
    Chemical Substances PI-2620 ; 7-(6-fluoropyridin-3-yl)-5H-pyrido(4,3-b)indole (J09QS3Z3WB) ; MK-6240 ; Melanins ; Monoamine Oxidase (EC 1.4.3.4) ; DNA-Binding Proteins ; tau Proteins ; Carbolines ; Isoquinolines ; Pyridines
    Language English
    Publishing date 2024-01-27
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1079-0
    ISSN 1432-0533 ; 0001-6322
    ISSN (online) 1432-0533
    ISSN 0001-6322
    DOI 10.1007/s00401-023-02672-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Convergent Evolution in SARS-CoV-2 Spike Creates a Variant Soup from Which New COVID-19 Waves Emerge

    Daniele Focosi / Rodrigo Quiroga / Scott McConnell / Marc C. Johnson / Arturo Casadevall

    International Journal of Molecular Sciences, Vol 24, Iss 2264, p

    2023  Volume 2264

    Abstract: The first 2 years of the COVID-19 pandemic were mainly characterized by recurrent mutations of SARS-CoV-2 Spike protein at residues K417, L452, E484, N501 and P681 emerging independently across different variants of concern (Alpha, Beta, Gamma, and Delta) ...

    Abstract The first 2 years of the COVID-19 pandemic were mainly characterized by recurrent mutations of SARS-CoV-2 Spike protein at residues K417, L452, E484, N501 and P681 emerging independently across different variants of concern (Alpha, Beta, Gamma, and Delta). Such homoplasy is a marker of convergent evolution. Since Spring 2022 and the third year of the pandemic, with the advent of Omicron and its sublineages, convergent evolution has led to the observation of different lineages acquiring an additional group of mutations at different amino acid residues, namely R346, K444, N450, N460, F486, F490, Q493, and S494. Mutations at these residues have become increasingly prevalent during Summer and Autumn 2022, with combinations showing increased fitness. The most likely reason for this convergence is the selective pressure exerted by previous infection- or vaccine-elicited immunity. Such accelerated evolution has caused failure of all anti-Spike monoclonal antibodies, including bebtelovimab and cilgavimab. While we are learning how fast coronaviruses can mutate and recombine, we should reconsider opportunities for economically sustainable escape-proof combination therapies, and refocus antibody-mediated therapeutic efforts on polyclonal preparations that are less likely to allow for viral immune escape.
    Keywords SARS-CoV-2 ; Spike ; omicron ; convergent evolution ; R346 ; K444 ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Language English
    Publishing date 2023-01-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  10. Article ; Online: Where is the next SARS-CoV-2 variant of concern?

    Dennehy, John J / Gupta, Ravindra K / Hanage, William P / Johnson, Marc C / Peacock, Thomas P

    Lancet (London, England)

    2022  Volume 399, Issue 10339, Page(s) 1938–1939

    MeSH term(s) COVID-19 ; Humans ; Mutation ; SARS-CoV-2/genetics ; Spike Glycoprotein, Coronavirus/genetics
    Chemical Substances Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2
    Language English
    Publishing date 2022-05-13
    Publishing country England
    Document type Letter
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(22)00743-7
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