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Article: Professor J. B. S. Haldane's criticism.

Gates, R R

2010 Volume 29, Issue 1, Page(s) 81

Language	English
Publishing date	2010-11-17
Publishing country	England
Document type	Journal Article
ZDB-ID	281960-0
ISSN	0374-7573
ISSN	0374-7573
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Article: Apo J/clusterin expression and secretion: evidence for 15-deoxy-Δ(12,14)-PGJ(2)-dependent mechanism.

Gates, Damien / Dollin, Kiera / Connolly, Roisin / Young, Ian / Powell, Lesley / McEneny, Jane / Gleave, Martin / McGinty, Ann

Biochimica et biophysica acta

2012 Volume 1821, Issue 2, Page(s) 335–342

Abstract: Cyclooxygenase-2 (Cox-2) and Apo J/clusterin are involved in inflammatory resolution and have ... dependent manner by 15-deoxy-Δ(12,14)-prostaglandin J(2) (15d-PGJ(2)), but not PGE(2), and inhibited ...

Abstract	Cyclooxygenase-2 (Cox-2) and Apo J/clusterin are involved in inflammatory resolution and have each been reported to inhibit NF-κB signalling. Using a well-validated rat pheochromocytoma (PC12) cell culture model of Cox-2 over-expression the current study investigated inter-dependence between Cox-2 and clusterin with respect to induction of expression and impact on NF-κB signalling. Both gene expression and immunoblot analysis confirmed that intracellular and secreted levels of clusterin were elevated in Cox-2 over-expressing cells (PCXII). Clusterin expression was increased in control (PCMT) cells in a time- and dose-dependent manner by 15-deoxy-Δ(12,14)-prostaglandin J(2) (15d-PGJ(2)), but not PGE(2), and inhibited in PCXII cells by pharmacological Cox inhibition. In PCXII cells, inhibition of two transcription factors known to be activated by 15d-PGJ(2), heat shock factor 1 (HSF-1) and peroxisome proliferator activated receptor (PPAR)γ, by transcription factor oligonucleotide decoy and antagonist (GW9662) treatment, respectively, reduced clusterin expression. While PCXII cells exhibited reduced TNF-α-induced cell surface ICAM-1 expression, IkB phosphorylation and degradation were similar to control cells. With respect to the impact of Cox-2-dependent clusterin upregulation on NF-κB signalling, basal levels of IκB were similar in control and PCXII cells, and no evidence for a physical association between clusterin and phospho-IκB was obtained. Moreover, while PCXII cells exhibited reduced NF-κB transcriptional activity, this was not restored by clusterin knock-down. These results indicate that Cox-2 induces clusterin in a 15d-PGJ(2)-dependent manner, and via activation of HSF-1 and PPARγ. However, the results do not support a model whereby Cox-2/15d-PGJ(2)-dependent inhibition of NF-κB signalling involves clusterin.
MeSH term(s)	Animals ; Clusterin/metabolism ; Clusterin/secretion ; Cyclooxygenase 2/metabolism ; DNA-Binding Proteins/metabolism ; Gene Knockdown Techniques ; Heat Shock Transcription Factors ; Intercellular Adhesion Molecule-1/metabolism ; Isopropyl Thiogalactoside/pharmacology ; NF-kappa B/metabolism ; PC12 Cells ; PPAR gamma/metabolism ; Prostaglandin D2/analogs & derivatives ; Prostaglandin D2/metabolism ; Rats ; Signal Transduction/drug effects ; Transcription Factors/metabolism ; Transcription, Genetic/drug effects ; Tumor Necrosis Factor-alpha/pharmacology ; Up-Regulation/drug effects
Chemical Substances	15-deoxy-delta(12,14)-prostaglandin J2 ; Clusterin ; DNA-Binding Proteins ; Heat Shock Transcription Factors ; NF-kappa B ; PPAR gamma ; Transcription Factors ; Tumor Necrosis Factor-alpha ; Intercellular Adhesion Molecule-1 (126547-89-5) ; Isopropyl Thiogalactoside (367-93-1) ; Cyclooxygenase 2 (EC 1.14.99.1) ; Ptgs2 protein, rat (EC 1.14.99.1) ; Prostaglandin D2 (RXY07S6CZ2)
Language	English
Publishing date	2012-02
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	60-7
ISSN	1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650 ; 0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
ISSN (online)	1879-2596 ; 1879-260X ; 1872-8006 ; 1879-2642 ; 1879-2618 ; 1879-2650
ISSN	0006-3002 ; 0005-2728 ; 0005-2736 ; 0304-4165 ; 0167-4838 ; 1388-1981 ; 0167-4889 ; 0167-4781 ; 0304-419X ; 1570-9639 ; 0925-4439 ; 1874-9399
DOI	10.1016/j.bbalip.2011.11.004
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Article: Parasitoid Wasps (Hymenoptera: Apocrita) Associated with Sagittaria latifolia Willd. and Sagittaria platyphylla (Engelm.) J. G. sm. (Alismatales: Alismataceae) in the Nearctic Region

Kula, Robert R / Matthew L. Buffington / Michael W. Gates / Nathan E. Harms

Proceedings of the Entomological Society of Washington. 2017 Apr., v. 119, no. 2

2017

Abstract: ... latifolia Willd. and Sagittaria platyphylla (Engelm.) J. G. Sm. (Alismatales: Alismataceae ...

Abstract	The results of a survey of parasitoid wasps associated with herbivorous insects on Sagittaria latifolia Willd. and Sagittaria platyphylla (Engelm.) J. G. Sm. (Alismatales: Alismataceae) in the Nearctic Region are reported. The following 10 wasp species were reared from insects on S. platyphylla: Gonatocerus sp., Mestocharis tropicalis Yoshimoto, Syntomopus americanus Ashmead (all Chalcidoidea), Hexacola websteri (Crawford), Rhoptromeris sp. (both Cynipoidea), Alabagrus texanus (Cresson), Bracon sp. nr. mellitor Say, Cotesia diacrisiae (Gahan), Enicospilus glabratus (Say), and Opius (Tolbia) hoffmanni (Fischer) (all Ichneumonoidea). Three wasp species, S. americanus, Chaenusa psillosae Kula (Ichneumonoidea), and B. sp. nr. mellitor, were reared from insects on S. latifolia. All species except C. psillosae are reported as associated with a species of Sagittaria for the first time. Mesochorus discitergus Say is reported as a hyperparasitoid of C. diacrisiae for the first time and is also reported as associated with a species of Sagittaria for the first time. Opius (Tolbia) hoffmanni is reported as a parasitoid of Hydrellia sp. prob. nobilis (Loew); this is the first record of O. (T.) hoffmanni from a species of Hydrellia Robineau-Desvoidy (Diptera: Ephydridae). Mestocharis tropicalis, S. americanus, and O. (T.) hoffmanni are reported from Louisiana for the first time. Syntomopus americanus and O. (T.) hoffmanni are reported from Texas for the first time.
Keywords	Bracon ; Cotesia ; Gonatocerus ; Hydrellia ; hyperparasitoids ; Mesochorus ; Opius ; parasitic wasps ; phytophagous insects ; rearing ; Sagittaria latifolia ; surveys ; wasps ; Arctic region ; Louisiana ; Texas
Language	English
Dates of publication	2017-04
Size	p. 215-227.
Publishing place	The Entomological Society of Washington
Document type	Article
ZDB-ID	2533731-2
ISSN	0013-8797
ISSN	0013-8797
DOI	10.4289/0013-8797.119.2.215
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Changes in plasma norepinephrine to combat-related stimuli among Vietnam veterans with posttraumatic stress disorder. J Nerv Ment Dis. 179: 371-373, 1991.

Blanchard, Edward B / Kolb, Lawrence C / Prins, Annabel / Gates, Sherman / McCoy, Guy C

The Journal of nervous and mental disease

2012 Volume 200, Issue 9, Page(s) 737–739

MeSH term(s)	Combat Disorders/blood ; Combat Disorders/history ; History, 20th Century ; Humans ; Norepinephrine/blood ; Stress Disorders, Post-Traumatic/blood ; Stress Disorders, Post-Traumatic/history ; Veterans/history ; Vietnam Conflict
Chemical Substances	Norepinephrine (X4W3ENH1CV)
Language	English
Publishing date	2012-09
Publishing country	United States
Document type	Biography ; Classical Article ; Historical Article ; Journal Article
ZDB-ID	3020-x
ISSN	1539-736X ; 0022-3018
ISSN (online)	1539-736X
ISSN	0022-3018
DOI	10.1097/NMD.0b013e318266fbbb
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Article ; Online: Invited Commentary.

Gates, Jonathan

Journal of the American College of Surgeons

2023 Volume 236, Issue 6, Page(s) 1091–1092

Language	English
Publishing date	2023-03-15
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	1181115-8
ISSN	1879-1190 ; 1072-7515
ISSN (online)	1879-1190
ISSN	1072-7515
DOI	10.1097/XCS.0000000000000680
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Article ; Online: Atmospheric pressure chemical ionisation mass spectrometry for the routine analysis of low molecular weight analytes.

Gates, Paul J

European journal of mass spectrometry (Chichester, England)

2021 Volume 27, Issue 1, Page(s) 13–28

Abstract: The routine analysis of low molecular weight analytes by mass spectrometry is often complicated by the lability of the analyte's functional groups and/or the lack of moieties that can be easily charged. If a molecule is too labile this precludes analysis ...

Abstract	The routine analysis of low molecular weight analytes by mass spectrometry is often complicated by the lability of the analyte's functional groups and/or the lack of moieties that can be easily charged. If a molecule is too labile this precludes analysis by techniques such as electron ionisation or chemical ionisation as the analyte will undergo thermal decomposition prior to ionisation as well as spontaneous fragmentation during the ionisation process. If the analyte has a low propensity to form ions in electrospray ionisation (i.e., lacks acidic or basic sites) then often no analyte related ions are observed. In this paper, the robustness and versatility of the established method of atmospheric pressure chemical ionisation is demonstrated for the analysis of low molecular weight analytes. The utility of the technique is demonstrated through the analysis of 30 reference standards of varying functionality, and further by the analysis of 75 synthetic samples which were problematic when analysed by electron or electrospray ionisation. The resulting spectra are dominated by intact molecular species ([M+H]
Language	English
Publishing date	2021-04-05
Publishing country	England
Document type	Journal Article
ISSN	1751-6838
ISSN (online)	1751-6838
DOI	10.1177/14690667211005055
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Article ; Online: Mapping philanthropic support of science.

Shekhtman, Louis M / Gates, Alexander J / Barabási, Albert-László

Scientific reports

2024 Volume 14, Issue 1, Page(s) 9397

Abstract: While philanthropic support for science has increased in the past decade, there is limited quantitative knowledge about the patterns that characterize it and the mechanisms that drive its distribution. Here, we map philanthropic funding to universities ... ...

Abstract	While philanthropic support for science has increased in the past decade, there is limited quantitative knowledge about the patterns that characterize it and the mechanisms that drive its distribution. Here, we map philanthropic funding to universities and research institutions based on IRS tax forms from 685,397 non-profit organizations. We identify nearly one million grants supporting institutions involved in science and higher education, finding that in volume and scope, philanthropy is a significant source of funds, reaching an amount that rivals some of the key federal agencies like the NSF and NIH. Our analysis also reveals that philanthropic funders tend to focus locally, indicating that criteria beyond research excellence play an important role in funding decisions, and that funding relationships are stable, i.e. once a grant-giving relationship begins, it tends to continue in time. Finally, we show that the bipartite funder-recipient network displays a highly overrepresented motif indicating that funders who share one recipient also share other recipients and we show that this motif contains predictive power for future funding relationships. We discuss the policy implications of our findings on inequality in science, scientific progress, and the role of quantitative approaches to philanthropy.
MeSH term(s)	Fund Raising ; Humans ; Financing, Organized ; Science/economics ; Universities ; Research Support as Topic/economics ; United States ; Organizations, Nonprofit/economics
Language	English
Publishing date	2024-04-24
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-58367-2
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Article ; Online: Addressing Critical Pandemic Psychiatric Staffing Shortages Through Advanced Practice Provider Training and Resources.

Li, Luming / Gates, Janet

Psychiatric services (Washington, D.C.)

2023 Volume 74, Issue 7, Page(s) 770–772

MeSH term(s)	Humans ; Pandemics/prevention & control ; Psychiatry/education ; Career Choice
Language	English
Publishing date	2023-02-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	1220173-x
ISSN	1557-9700 ; 1075-2730
ISSN (online)	1557-9700
ISSN	1075-2730
DOI	10.1176/appi.ps.20220390
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Article: Investigation of enhanced geothermal system in the Basal Cambrian Sandstone Unit, Alberta, Canada.

Shi, Guangyu / Wang, Jingyi / Gates, Ian D

Heliyon

2024 Volume 10, Issue 2, Page(s) e24763

Abstract: Given the climate challenge, society is seeking low greenhouse gas emission energy sources. In jurisdictions such as Alberta, Canada where power is largely generated through the combustion of natural gas, geothermal offers a compelling option but it ... ...

Abstract	Given the climate challenge, society is seeking low greenhouse gas emission energy sources. In jurisdictions such as Alberta, Canada where power is largely generated through the combustion of natural gas, geothermal offers a compelling option but it remains unclear as to its economic and technical viability. Here, we examine the potential for an enhanced geothermal system in the Basal Cambrian Sandstone Unit in Alberta, Canada. Prior to geothermal operation, hydraulic fracturing is conducted to enhance the permeability of the thermal reservoir. This lowers the pressure drop required for circulating fluids through the system. The results show that the open-loop enhanced geothermal system realizes an energy produced to energy invested ratio from 4 to 9 depending on different operating rate. The results also suggest that applying hydraulic fracturing can accelerate energy harvesting and energy efficiency over the early stages of the process but the greater the injection rate, the smaller is this benefit of hydraulic fracturing stimulation.
Language	English
Publishing date	2024-01-17
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2024.e24763
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Article ; Online: Clinical Insights Into the Use of Speech Amplification Devices for Managing Hypophonia: Interviews With Speech-Language Pathologists.

Gates, Kelly / Knowles, Thea / Mach, Helen / Higginbotham, Jeff

American journal of speech-language pathology

2024 , Page(s) 1–23

Abstract: Purpose: The purpose of this qualitative interview study was to identify themes regarding considerations in the usage of speech amplification device usage for people with Parkinson's disease (PD) and hypophonia from the perspective of speech-language ... ...

Abstract	Purpose: The purpose of this qualitative interview study was to identify themes regarding considerations in the usage of speech amplification device usage for people with Parkinson's disease (PD) and hypophonia from the perspective of speech-language pathologists (SLPs). Method: Eligible participants included SLPs currently practicing in the United States or Canada with experience working with clients with PD for at least 2 years. Ten SLPs participated in 60-min interviews conducted via Zoom. A semistructured interview guide was created prior to the interviews. The interviews were transcribed following their completion, and an iterative coding process was used to identify themes using thematic analysis. Results: Three main themes were identified from the interviews. The first theme encapsulated how clinicians described amplification devices as a potential treatment tool, which highlighted the nuances that may impact selecting an amplification device as a treatment option such as increased hypophonia or dysarthria severity and cognitive decline. The second theme highlighted how device selection depends on the individual needs of the user. Individual client characteristics (such as disease symptoms and individual needs and preferences) may impact the choice of amplification device. The last theme outlined the importance of involving family members in all stages of device use and involving other health care team members on a case-by-case basis. Conclusions: The insights provided by the SLP participants help to understand the clinical decisions that are made when determining device candidacy, selecting a device, and evaluating device success. These insights can be used to improve research studies of augmentative management of hypophonia and guide more personalized management decisions.
Language	English
Publishing date	2024-03-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	1154406-5
ISSN	1558-9110 ; 1058-0360
ISSN (online)	1558-9110
ISSN	1058-0360
DOI	10.1044/2024_AJSLP-23-00396
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